John Laffey


Affiliate Scientist


Dr. Laffey is Anesthesiologist-in-Chief at St Michael’s Hospital, Toronto, Co-Director of the Critical Illness and Injury Research Centre at the Keenan Research Centre, St. Michael’s hospital. He is a Clinician Scientist at the Keenan Research Centre, and Professor of Anesthesia, Critical Care and Physiology at the University of Toronto. His research is focused on ARDS, particularly the mechanisms underlying ventilation induced lung injury. He has a longstanding interest in the effects and mechanisms of hypercapnic acidosis in ARDS and sepsis. His current research focus is the investigation of the therapeutic potential of cell therapies for ARDS.

Recent Publications

  1. Juffermans, NP, Rocco, PRM, Laffey, JG. Protective ventilation. Intensive Care Med. 2022; :. doi: 10.1007/s00134-022-06820-z. PubMed PMID:35939095 .
  2. ISARIC Clinical Characterization Group, Garcia-Gallo, E, Merson, L, Kennon, K, Kelly, S, Citarella, BW et al.. ISARIC-COVID-19 dataset: A Prospective, Standardized, Global Dataset of Patients Hospitalized with COVID-19. Sci Data. 2022;9 (1):454. doi: 10.1038/s41597-022-01534-9. PubMed PMID:35908040 PubMed Central PMC9339000.
  3. Rezoagli, E, Laffey, JG, Bellani, G. Monitoring Lung Injury Severity and Ventilation Intensity during Mechanical Ventilation. Semin Respir Crit Care Med. 2022;43 (3):346-368. doi: 10.1055/s-0042-1748917. PubMed PMID:35896391 .
  4. Hanley, C, Giacomini, C, Brennan, A, McNicholas, B, Laffey, JG. Insights Regarding the Berlin Definition of ARDS from Prospective Observational Studies. Semin Respir Crit Care Med. 2022;43 (3):379-389. doi: 10.1055/s-0042-1744306. PubMed PMID:35679873 .
  5. Luo, J, Pavlov, I, Tavernier, E, Laffey, JG, Guerin, C, Vines, D et al.. Rethinking the efficacy of awake prone positioning in COVID-19-related acute hypoxaemic respiratory failure - Authors' reply. Lancet Respir Med. 2022;10 (6):e54. doi: 10.1016/S2213-2600(22)00167-9. PubMed PMID:35659009 PubMed Central PMC9154732.
  6. Li Bassi, G, Laffey, JG. Mechanical Ventilation in the Critically Ill Patient. Semin Respir Crit Care Med. 2022;43 (3):319-320. doi: 10.1055/s-0042-1749449. PubMed PMID:35649431 .
  7. Rezoagli, E, McNicholas, BA, Madotto, F, Pham, T, Bellani, G, Laffey, JG et al.. Presence of comorbidities alters management and worsens outcome of patients with acute respiratory distress syndrome: insights from the LUNG SAFE study. Ann Intensive Care. 2022;12 (1):42. doi: 10.1186/s13613-022-01015-7. PubMed PMID:35596885 PubMed Central PMC9123875.
  8. Li Bassi, G, Gibbons, K, Suen, JY, Dalton, HJ, White, N, Corley, A et al.. Early short course of neuromuscular blocking agents in patients with COVID-19 ARDS: a propensity score analysis. Crit Care. 2022;26 (1):141. doi: 10.1186/s13054-022-03983-5. PubMed PMID:35581612 PubMed Central PMC9112652.
  9. Gorman, E, Shankar-Hari, M, Hopkins, P, Tunnicliffe, WS, Perkins, GD, Silversides, J et al.. Repair of acute respiratory distress syndrome by stromal cell administration (REALIST): a structured study protocol for an open-label dose-escalation phase 1 trial followed by a randomised, triple-blind, allocation concealed, placebo-controlled phase 2 trial. Trials. 2022;23 (1):401. doi: 10.1186/s13063-022-06220-0. PubMed PMID:35562778 PubMed Central PMC9099345.
  10. Russotto, V, Tassistro, E, Myatra, SN, Parotto, M, Antolini, L, Bauer, P et al.. Peri-intubation Cardiovascular Collapse in Patients Who Are Critically Ill: Insights from the INTUBE Study. Am J Respir Crit Care Med. 2022;206 (4):449-458. doi: 10.1164/rccm.202111-2575OC. PubMed PMID:35536310 .
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Affiliations & Other Activities

  • Scientist, Keenan Research Centre for Biomedical Science, St. Michael’s Hospital
  • Chief, Department of Anesthesia, St. Michael’s Hospital
  • Professor, Anesthesia, Critical Care, and Physiology, University of Toronto