John Laffey


Affiliate Scientist


Dr. Laffey is Anesthesiologist-in-Chief at St Michael’s Hospital, Toronto, Co-Director of the Critical Illness and Injury Research Centre at the Keenan Research Centre, St. Michael’s hospital. He is a Clinician Scientist at the Keenan Research Centre, and Professor of Anesthesia, Critical Care and Physiology at the University of Toronto. His research is focused on ARDS, particularly the mechanisms underlying ventilation induced lung injury. He has a longstanding interest in the effects and mechanisms of hypercapnic acidosis in ARDS and sepsis. His current research focus is the investigation of the therapeutic potential of cell therapies for ARDS.

Recent Publications

  1. Rose, L, Camporota, L, Mills, GH, Laffey, J, Perkins, GD, Shankar-Hari, M et al.. Airway pressure release ventilation: a survey of UK practice. Br J Anaesth. 2022; :. doi: 10.1016/j.bja.2022.10.017. PubMed PMID:36435668 .
  2. TEAM Study Investigators and the ANZICS Clinical Trials Group, Hodgson, CL, Bailey, M, Bellomo, R, Brickell, K, Broadley, T et al.. Early Active Mobilization during Mechanical Ventilation in the ICU. N Engl J Med. 2022;387 (19):1747-1758. doi: 10.1056/NEJMoa2209083. PubMed PMID:36286256 .
  3. Russotto, V, Bellani, G, Laffey, JG, INTUBE Study Investigators. Reply to: "Predicting Peri-intubation Cardiovascular Instability: Pre-Intubation Vital Signs are Vital". Am J Respir Crit Care Med. 2022; :. doi: 10.1164/rccm.202209-1771LE. PubMed PMID:36194888 .
  4. McNicholas, BA, Ehrmann, S, Laffey, JG. Awake prone positioning. Intensive Care Med. 2022;48 (12):1793-1795. doi: 10.1007/s00134-022-06893-w. PubMed PMID:36151334 PubMed Central PMC9510305.
  5. Sheehan, JR, Calpin, P, Kernan, M, Kelly, C, Casey, S, Murphy, D et al.. The CHARTER-Ireland trial: can nebulised heparin reduce acute lung injury in patients with SARS-CoV-2 requiring advanced respiratory support in Ireland: a study protocol and statistical analysis plan for a randomised control trial. Trials. 2022;23 (1):774. doi: 10.1186/s13063-022-06518-z. PubMed PMID:36104785 PubMed Central PMC9471050.
  6. Reyes, LF, Murthy, S, Garcia-Gallo, E, Merson, L, Ibáñez-Prada, ED, Rello, J et al.. Respiratory support in patients with severe COVID-19 in the International Severe Acute Respiratory and Emerging Infection (ISARIC) COVID-19 study: a prospective, multinational, observational study. Crit Care. 2022;26 (1):276. doi: 10.1186/s13054-022-04155-1. PubMed PMID:36100904 PubMed Central PMC9469080.
  7. Weaver, L, Saffaran, S, Chikhani, M, Laffey, JG, Scott, TE, Camporota, L et al.. Why Reduced Inspiratory Pressure Could Determine Success of Non-Invasive Ventilation in Acute Hypoxic Respiratory Failure. Annu Int Conf IEEE Eng Med Biol Soc. 2022;2022 :3265-3268. doi: 10.1109/EMBC48229.2022.9871901. PubMed PMID:36085857 .
  8. Mistry, S, Brook, BS, Saffaran, S, Chikhani, M, Hannon, DM, Laffey, JG et al.. A computational cardiopulmonary physiology simulator accurately predicts individual patient responses to changes in mechanical ventilator settings. Annu Int Conf IEEE Eng Med Biol Soc. 2022;2022 :3261-3264. doi: 10.1109/EMBC48229.2022.9871182. PubMed PMID:36083938 .
  9. Geoghegan, P, Clarke, J, Hogan, G, Keogh, A, Marsh, H, Donnelly, K et al.. Use of a novel "Split" ventilation system in bench and porcine modeling of acute respiratory distress syndrome. Physiol Rep. 2022;10 (17):e15452. doi: 10.14814/phy2.15452. PubMed PMID:36082971 PubMed Central PMC9461348.
  10. Juffermans, NP, Rocco, PRM, Laffey, JG. Protective ventilation. Intensive Care Med. 2022;48 (11):1629-1631. doi: 10.1007/s00134-022-06820-z. PubMed PMID:35939095 PubMed Central PMC9592633.
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Affiliations & Other Activities

  • Scientist, Keenan Research Centre for Biomedical Science, St. Michael’s Hospital
  • Chief, Department of Anesthesia, St. Michael’s Hospital
  • Professor, Anesthesia, Critical Care, and Physiology, University of Toronto