John Laffey


Affiliate Scientist


Dr. Laffey is Anesthesiologist-in-Chief at St Michael’s Hospital, Toronto, Co-Director of the Critical Illness and Injury Research Centre at the Keenan Research Centre, St. Michael’s hospital. He is a Clinician Scientist at the Keenan Research Centre, and Professor of Anesthesia, Critical Care and Physiology at the University of Toronto. His research is focused on ARDS, particularly the mechanisms underlying ventilation induced lung injury. He has a longstanding interest in the effects and mechanisms of hypercapnic acidosis in ARDS and sepsis. His current research focus is the investigation of the therapeutic potential of cell therapies for ARDS.

Recent Publications

  1. Fahy, Y, Laffey, JG, McNicholas, B. Sodium-Glucose Cotransporter 2 Inhibitor-induced Ketoacidosis and Non-Ketotic Acidosis: When Is There a Role for Bicarbonate?. Ann Am Thorac Soc. 2023;20 (6):911-916. doi: 10.1513/AnnalsATS.202209-780CC. PubMed PMID:37261785 .
  2. Byrnes, D, Masterson, CH, Brady, J, Alagesan, S, Gonzalez, HE, McCarthy, SD et al.. Differential Effects of Cytokine Versus Hypoxic Preconditioning of Human Mesenchymal Stromal Cells in Pulmonary Sepsis Induced by Antimicrobial-Resistant Klebsiella pneumoniae. Pharmaceuticals (Basel). 2023;16 (2):. doi: 10.3390/ph16020149. PubMed PMID:37259300 .
  3. McNicholas, BA, Rezoagli, E, Simpkin, AJ, Khanna, S, Suen, JY, Yeung, P et al.. Correction : Epidemiology and outcomes of early-onset AKI in COVID-19-related ARDS in comparison with non-COVID-19-related ARDS: insights from two prospective global cohort studies. Crit Care. 2023;27 (1):202. doi: 10.1186/s13054-023-04487-6. PubMed PMID:37237395 PubMed Central PMC10214330.
  4. Russotto, V, Lascarrou, JB, Tassistro, E, Parotto, M, Antolini, L, Bauer, P et al.. Efficacy and adverse events profile of videolaryngoscopy in critically ill patients: subanalysis of the INTUBE study. Br J Anaesth. 2023; :. doi: 10.1016/j.bja.2023.04.022. PubMed PMID:37208282 .
  5. Byrnes, D, Masterson, CH, Gonzales, HE, McCarthy, SD, O'Toole, DP, Laffey, JG et al.. Multiple Dosing and Preactivation of Mesenchymal Stromal Cells Enhance Efficacy in Established Pneumonia Induced by Antimicrobial-Resistant Klebsiella pneumoniae in Rodents. Int J Mol Sci. 2023;24 (9):. doi: 10.3390/ijms24098055. PubMed PMID:37175761 PubMed Central PMC10179238.
  6. Gorman, EA, Rynne, J, Gardiner, HJ, Rostron, AJ, Bannard-Smith, J, Bentley, AM et al.. Repair of Acute Respiratory Distress Syndrome in COVID-19 by Stromal Cells (REALIST-COVID Trial): A Multicentre, Randomised, Controlled Trial. Am J Respir Crit Care Med. 2023; :. doi: 10.1164/rccm.202302-0297OC. PubMed PMID:37154608 .
  7. McNicholas, BA, Ibarra-Estrada, M, Perez, Y, Li, J, Pavlov, I, Kharat, A et al.. Awake prone positioning in acute hypoxaemic respiratory failure. Eur Respir Rev. 2023;32 (168):. doi: 10.1183/16000617.0245-2022. PubMed PMID:37137508 PubMed Central PMC10155045.
  8. Writing Committee for the REMAP-CAP Investigators, Lawler, PR, Derde, LPG, van de Veerdonk, FL, McVerry, BJ, Huang, DT et al.. Effect of Angiotensin-Converting Enzyme Inhibitor and Angiotensin Receptor Blocker Initiation on Organ Support-Free Days in Patients Hospitalized With COVID-19: A Randomized Clinical Trial. JAMA. 2023;329 (14):1183-1196. doi: 10.1001/jama.2023.4480. PubMed PMID:37039790 .
  9. Zaaqoq, AM, Griffee, MJ, Kelly, TL, Fanning, JP, Heinsar, S, Suen, JY et al.. Cerebrovascular Complications of COVID-19 on Venovenous Extracorporeal Membrane Oxygenation. Crit Care Med. 2023; :. doi: 10.1097/CCM.0000000000005861. PubMed PMID:37010526 .
  10. Berre, ML, Paulovčáková, T, Verissimo, CM, Doyle, S, Dalton, JP, Masterson, C et al.. A new multiplex SARS-CoV-2 antigen microarray showed correlation of IgG, IgA, and IgM antibodies from patients with COVID-19 disease severity and maintenance of relative IgA and IgM antigen binding over time. PLoS One. 2023;18 (3):e0283537. doi: 10.1371/journal.pone.0283537. PubMed PMID:36996259 PubMed Central PMC10062637.
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Affiliations & Other Activities

  • Scientist, Keenan Research Centre for Biomedical Science, St. Michael’s Hospital
  • Chief, Department of Anesthesia, St. Michael’s Hospital
  • Professor, Anesthesia, Critical Care, and Physiology, University of Toronto