John Laffey


Affiliate Scientist


Dr. Laffey is Anesthesiologist-in-Chief at St Michael’s Hospital, Toronto, Co-Director of the Critical Illness and Injury Research Centre at the Keenan Research Centre, St. Michael’s hospital. He is a Clinician Scientist at the Keenan Research Centre, and Professor of Anesthesia, Critical Care and Physiology at the University of Toronto. His research is focused on ARDS, particularly the mechanisms underlying ventilation induced lung injury. He has a longstanding interest in the effects and mechanisms of hypercapnic acidosis in ARDS and sepsis. His current research focus is the investigation of the therapeutic potential of cell therapies for ARDS.

Recent Publications

  1. Huth, SF, Rothkopf, A, Smith, L, White, N, Bassi, GL, Suen, JY et al.. Variability of oxygen requirements in critically ill COVID-19 patients. J Glob Health. 2024;14 :05012. doi: 10.7189/jogh.14.05012. PubMed PMID:38390629 PubMed Central PMC10884784.
  2. Serafini, SC, van Meenen, DMP, Pisani, L, Neto, AS, Ball, L, de Abreu, MG et al.. Different ventilation intensities among various categories of patients ventilated for reasons other than ARDS--A pooled analysis of 4 observational studies. J Crit Care. 2024;81 :154531. doi: 10.1016/j.jcrc.2024.154531. PubMed PMID:38341938 .
  3. Curley, GF, O'Kane, CM, McAuley, DF, Matthay, MA, Laffey, JG. Cell-based Therapies for ARDS - Where Are We Now?. Am J Respir Crit Care Med. 2024; :. doi: 10.1164/rccm.202311-2046CP. PubMed PMID:38324017 .
  4. Camirand-Lemyre, F, Merson, L, Tirupakuzhi Vijayaraghavan, BK, Burrell, AJC, Citarella, BW, Domingue, MP et al.. Implementation of Recommendations on the Use of Corticosteroids in Severe COVID-19. JAMA Netw Open. 2023;6 (12):e2346502. doi: 10.1001/jamanetworkopen.2023.46502. PubMed PMID:38147336 PubMed Central PMC10751594.
  5. Griffee, MJ, Thomson, DA, Fanning, J, Rosenberger, D, Barnett, A, White, NM et al.. Race and ethnicity in the COVID-19 Critical Care Consortium: demographics, treatments, and outcomes, an international observational registry study. Int J Equity Health. 2023;22 (1):260. doi: 10.1186/s12939-023-02051-w. PubMed PMID:38087346 PubMed Central PMC10717789.
  6. Granton, J, Novitzky-Basso, IN, Binnie, A, Mattsson, J, DSC Study Group. Decidual stromal cells for the treatment of severe COVID-19 ARDS. Intensive Care Med. 2023;49 (12):1552-1554. doi: 10.1007/s00134-023-07262-x. PubMed PMID:37968285 .
  7. REMAP-CAP Investigators, Hills, TE, Lorenzi, E, Berry, LR, Shyamsundar, M, Al-Beidh, F et al.. Simvastatin in Critically Ill Patients with Covid-19. N Engl J Med. 2023;389 (25):2341-2354. doi: 10.1056/NEJMoa2309995. PubMed PMID:37888913 PubMed Central PMC10755839.
  8. LOVIT-COVID Investigators, on behalf of the Canadian Critical Care Trials Group, and the REMAP-CAP Investigators, Adhikari, NKJ, Hashmi, M, Tirupakuzhi Vijayaraghavan, BK, Haniffa, R, Beane, A et al.. Intravenous Vitamin C for Patients Hospitalized With COVID-19: Two Harmonized Randomized Clinical Trials. JAMA. 2023;330 (18):1745-1759. doi: 10.1001/jama.2023.21407. PubMed PMID:37877585 PubMed Central PMC10600726.
  9. Wildi, K, Livingstone, S, Ainola, C, Colombo, SM, Heinsar, S, Sato, N et al.. Application of anti-inflammatory treatment in two different ovine Acute Respiratory Distress Syndrome injury models: a preclinical randomized intervention study. Sci Rep. 2023;13 (1):17986. doi: 10.1038/s41598-023-45081-8. PubMed PMID:37863994 PubMed Central PMC10589361.
  10. Pavlov, I, Li, J, Kharat, A, Luo, J, Ibarra-Estrada, M, Perez, Y et al.. Awake prone positioning in acute hypoxaemic respiratory failure: An international expert guidance. J Crit Care. 2023;78 :154401. doi: 10.1016/j.jcrc.2023.154401. PubMed PMID:37639921 .
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Affiliations & Other Activities

  • Scientist, Keenan Research Centre for Biomedical Science, St. Michael’s Hospital
  • Chief, Department of Anesthesia, St. Michael’s Hospital
  • Professor, Anesthesia, Critical Care, and Physiology, University of Toronto