Keenan Research Seminar Series: Multicompartmental 3D Models to Study Stromal–Immune–Epithelial Interactions and Drug Responses under Reconstructed Gastrointestinal Tract Microenvironmentum Signaling Shapes Actin Architecture and Cell Migration

Bruno Sarmento is Principal Investigator, Group Leader and member of the Board of Directors at i3S – University of Porto. Bruno Sarmento is also invited Associated Professor at IUCS-CESPU. His research is focused on developing functionalized nanomedicines, namely nanoformulations for mucosal and target delivery. He has also specialized in 3D tissue engineering models to validate functionalized nanomedicines and to perform in vitro/in vivo correlation. He published more than 550 papers in international journals (total citations in Scopus 28000; H-index 82).

“Understanding how stromal, immune, and epithelial compartments interact within the intestinal microenvironment is essential for decoding tissue remodeling processes and improving therapeutic development. However, most conventional in vitro systems fail to capture the structural, cellular, and mechanical complexity of human intestinal tissue, limiting their predictive value for drug screening and mechanistic studies.

In this seminar, I will present our recent advances in engineering multicompartmental 3D in vitro models of the human intestine, designed to recapitulate key features of physiological and diseased states.”