Resuscitation Outcomes Consortium


The Resuscitation Outcomes Consortium (ROC) was created to conduct clinical research in the areas of cardiopulmonary resuscitation and traumatic injury.

ROC consists of 10 Regional Clinical Centers (RCCs) and a Data and Coordinating Center (DCC) that will provide the necessary infrastructure to conduct multiple collaborative trials to aid rapid translation of promising scientific and clinical advances to improve resuscitation outcomes. 

Featured Studies

Trial of Continuous Compressions versus Standard CPR in Patients with Out-Of-Hospital Cardiac Arrest (CCC)

This trial has reached the maximum target patient population of 23,600 across all ROC sites as of May 28, 2015. It is the largest prehospital trial on CPR to be completed! Our research finds no difference between continuous compressions during CPR and standard compressions. Results published in New England Journal of Medicine. NCT01372748

Total enrollment numbers for each Rescu Site:

Region# of patients enrolled

Amiodarone, Lidocaine or Neither for Out-Of-Hospital Cardiac Arrest Due to Ventricular Fibrillation or Tachycardia       
ALPS: Amiodarone, Lidocaine or Placebo Study

Study enrollment completed as of October 24, 2015. The ALPS trial was delayed by a number of unforeseeable issues but having crossed all those hurdles and bumpy roads. In 2012, we launched the study with 3 of our paramedic services: Halton, Peel, & Toronto. The study was launched in Durham region on Feb 9th, 2013. The last service, but not the least, Regional Municipality of York joined on April 15th, 2013. Results published in New England Journal of Medicine. NCT01401647

Total enrollment numbers for each Rescu site:

Region# of patients enrolled

Rescu thanks all participating care providers for their participation and excellent performance!!

Completed Studies

  • BLAST – Biomarker Lactate Assessment of Shock in Trauma
  • HS
    • Hypertonic Saline in Traumatic Brain Injury
    • Hypertonic Saline in Trauma Patients in Shock
  • PRIMED – Prehospital Resuscitation using an IMpedance valve and Early vs Delayed analysis
  • PROPHET – Prospective Observational Prehospital and Hospital Registry for Trauma
  • PROPPR – Pragmatic, Randomized Optimal Platelet and Plasma Ratios

For information on completed ROC studies click here