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Arthur S. Slutsky

MD, M.A.Sc., B.A.Sc.

Scientist

Email: Arthur.Slutsky@unityhealth.to
Tel: 416-864-5637

Research Programs

Biography

My major research interests relate to the lung injury caused by mechanical ventilation: so called ventilator-induced lung injury (VILI). Specifically, my lab is working on (1) biotrauma: the molecular mechanisms by which injurious forms of mechanical ventilation can lead to release of mediators; (2) the mechanisms by which these mediators can affect distal organs (e.g. kidney, liver, etc.) and lead to multiple organ dysfunction syndrome (MODS); and (3) therapeutic approaches (ventilatory and non-ventilatory) to mitigate VILI and biotrauma. My laboratory works very closely with Dr. Zhang’s laboratory, and makes use of a number of model systems including in vitro, ex vivo cell and various animal models. As well, I have a major interest in clinical trials related to mechanical ventilation, acute lung injury (ALI), acute respiratory distress syndrome (ARDS), and COVID-19.

 

Recent Publications

  1. Tran, A, Rochwerg, B, Fan, E, Belohlavek, J, Suverein, MM, Poll, MCGV et al.. Prognostic factors associated with favourable functional outcome among adult patients requiring extracorporeal cardiopulmonary resuscitation for out-of-hospital cardiac arrest: A systematic review and meta-analysis. Resuscitation. 2023;193 :110004. doi: 10.1016/j.resuscitation.2023.110004. PubMed PMID:37863420 .
  2. Villar, J, González-Martín, JM, Hernández-González, J, Armengol, MA, Fernández, C, Martín-Rodríguez, C et al.. Predicting ICU Mortality in Acute Respiratory Distress Syndrome Patients Using Machine Learning: The Predicting Outcome and STratifiCation of severity in ARDS (POSTCARDS) Study. Crit Care Med. 2023;51 (12):1638-1649. doi: 10.1097/CCM.0000000000006030. PubMed PMID:37651262 .
  3. Onodera, Y, Liang, J, Li, Y, Griffin, B, Thanabalasingam, T, Lu, C et al.. Inhalation of ACE2 as a therapeutic target on sex-bias differences in SARS-CoV-2 infection and variant of concern. iScience. 2023;26 (8):107470. doi: 10.1016/j.isci.2023.107470. PubMed PMID:37609639 PubMed Central PMC10440513.
  4. Gattinoni, L, Citerio, G, Slutsky, AS. Back to the future: ARDS guidelines, evidence, and opinions. Intensive Care Med. 2023;49 (10):1226-1228. doi: 10.1007/s00134-023-07183-9. PubMed PMID:37578520 .
  5. Saha, R, Pham, T, Sinha, P, Maddali, MV, Bellani, G, Fan, E et al.. Estimating the attributable fraction of mortality from acute respiratory distress syndrome to inform enrichment in future randomised clinical trials. Thorax. 2023;78 (10):990-1003. doi: 10.1136/thorax-2023-220262. PubMed PMID:37495364 PubMed Central PMC10581447.
  6. Matthay, MA, Arabi, Y, Arroliga, AC, Bernard, G, Bersten, AD, Brochard, LJ et al.. A New Global Definition of Acute Respiratory Distress Syndrome. Am J Respir Crit Care Med. 2023; :. doi: 10.1164/rccm.202303-0558WS. PubMed PMID:37487152 .
  7. Goligher, EC, McNamee, JJ, Dianti, J, Fan, E, Ferguson, ND, Slutsky, AS et al.. Heterogeneous Treatment Effects of Extracorporeal CO2 Removal in Acute Hypoxemic Respiratory Failure. Am J Respir Crit Care Med. 2023;208 (6):739-742. doi: 10.1164/rccm.202304-0689LE. PubMed PMID:37433221 .
  8. Lee, WL, Slutsky, AS. A negative trial for vasoactive intestinal peptide in COVID-19-associated acute hypoxaemic respiratory failure. Lancet Respir Med. 2023;11 (9):759-760. doi: 10.1016/S2213-2600(23)00218-7. PubMed PMID:37348523 PubMed Central PMC10278994.
  9. Grasselli, G, Calfee, CS, Camporota, L, Poole, D, Amato, MBP, Antonelli, M et al.. ESICM guidelines on acute respiratory distress syndrome: definition, phenotyping and respiratory support strategies. Intensive Care Med. 2023;49 (7):727-759. doi: 10.1007/s00134-023-07050-7. PubMed PMID:37326646 PubMed Central PMC10354163.
  10. Zhang, H, Slutsky, AS. Enhancing the Efficacy of Mesenchymal Stromal Cells in COVID-19-related Acute Respiratory Distress Syndrome. Am J Respir Crit Care Med. 2023;208 (3):222-224. doi: 10.1164/rccm.202306-0969ED. PubMed PMID:37321255 PubMed Central PMC10395721.
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Affiliations & Other Activities

  • Scientist, Keenan Research Centre for Biomedical Science, St. Michael’s Hospital
  • Keenan Chair in Medicine, St. Michael’s Hospital
  • Professor, Departments of Medicine, Biomedical Engineering and Surgery, University of Toronto
  • Chair, Clinical Trials Ontario