Arthur S. Slutsky

MD, M.A.Sc., B.A.Sc.

Scientist

Biography

My major research interests relate to the lung injury caused by mechanical ventilation: so called ventilator-induced lung injury (VILI). Specifically, my lab is working on (1) biotrauma: the molecular mechanisms by which injurious forms of mechanical ventilation can lead to release of mediators; (2) the mechanisms by which these mediators can affect distal organs (e.g. kidney, liver, etc.) and lead to multiple organ dysfunction syndrome (MODS); and (3) therapeutic approaches (ventilatory and non-ventilatory) to mitigate VILI and biotrauma. My laboratory works very closely with Dr. Zhang’s laboratory, and makes use of a number of model systems including in vitro, ex vivo cell and various animal models. As well, I have a major interest in clinical trials related to mechanical ventilation, acute lung injury (ALI), acute respiratory distress syndrome (ARDS), and COVID-19.

 

Recent Publications

  1. Amado-RodrĂ­guez, L, RodrĂ­guez-Garcia, R, Bellani, G, Pham, T, Fan, E, Madotto, F et al.. Mechanical ventilation in patients with cardiogenic pulmonary edema: a sub-analysis of the LUNG SAFE study. J Intensive Care. 2022;10 (1):55. doi: 10.1186/s40560-022-00648-x. PubMed PMID:36567347 PubMed Central PMC9791731.
  2. Lyu, MA, Huang, M, Zeng, K, Li, L, Khoury, JD, Nishimoto, M et al.. Allogeneic cord blood regulatory T cells can resolve lung inflammation. Cytotherapy. 2022; :. doi: 10.1016/j.jcyt.2022.10.009. PubMed PMID:36437190 .
  3. Zhu, J, Li, Y, Liang, J, Mubareka, S, Slutsky, AS, Zhang, H et al.. The Potential Protective Role of GS-441524, a Metabolite of the Prodrug Remdesivir, in Vaccine Breakthrough SARS-CoV-2 Infections. Intensive Care Res. 2022;2 (3-4):49-60. doi: 10.1007/s44231-022-00021-4. PubMed PMID:36407474 PubMed Central PMC9645326.
  4. Ranieri, VM, Rubenfeld, G, Slutsky, AS. Reply to: Defining ARDS (Again) - a Plea for Honesty. Am J Respir Crit Care Med. 2022; :. doi: 10.1164/rccm.202211-2032LE. PubMed PMID:36384004 .
  5. Reddy, MP, Subramaniam, A, Chua, C, Ling, RR, Anstey, C, Ramanathan, K et al.. Respiratory system mechanics, gas exchange, and outcomes in mechanically ventilated patients with COVID-19-related acute respiratory distress syndrome: a systematic review and meta-analysis. Lancet Respir Med. 2022;10 (12):1178-1188. doi: 10.1016/S2213-2600(22)00393-9. PubMed PMID:36335956 PubMed Central PMC9708089.
  6. Fernando, SM, Scott, M, Talarico, R, Fan, E, McIsaac, DI, Sood, MM et al.. Association of Extracorporeal Membrane Oxygenation With New Mental Health Diagnoses in Adult Survivors of Critical Illness. JAMA. 2022;328 (18):1827-1836. doi: 10.1001/jama.2022.17714. PubMed PMID:36286084 PubMed Central PMC9608013.
  7. Villar, J, Fernández, C, González-Martín, JM, Ferrando, C, Añón, JM, Del Saz-Ortíz, AM et al.. Respiratory Subsets in Patients with Moderate to Severe Acute Respiratory Distress Syndrome for Early Prediction of Death. J Clin Med. 2022;11 (19):. doi: 10.3390/jcm11195724. PubMed PMID:36233592 PubMed Central PMC9570540.
  8. Tran, A, Fernando, SM, Rochwerg, B, Barbaro, RP, Hodgson, CL, Munshi, L et al.. Prognostic factors associated with mortality among patients receiving venovenous extracorporeal membrane oxygenation for COVID-19: a systematic review and meta-analysis. Lancet Respir Med. 2022; :. doi: 10.1016/S2213-2600(22)00296-X. PubMed PMID:36228638 PubMed Central PMC9766207.
  9. Ranieri, VM, Rubenfeld, G, Slutsky, AS. Rethinking ARDS After COVID-19. If a "Better" Definition Is the Answer, What Is the Question?. Am J Respir Crit Care Med. 2022; :. doi: 10.1164/rccm.202206-1048CP. PubMed PMID:36150099 .
  10. Morris, AH, Horvat, C, Stagg, B, Grainger, DW, Lanspa, M, Orme, J et al.. Computer clinical decision support that automates personalized clinical care: a challenging but needed healthcare delivery strategy. J Am Med Inform Assoc. 2022;30 (1):178-194. doi: 10.1093/jamia/ocac143. PubMed PMID:36125018 PubMed Central PMC9748596.
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Affiliations & Other Activities

  • Scientist, Keenan Research Centre for Biomedical Science, St. Michael’s Hospital
  • Keenan Chair in Medicine, St. Michael’s Hospital
  • Professor, Departments of Medicine, Biomedical Engineering and Surgery, University of Toronto
  • Chair, Clinical Trials Ontario