Arthur S. Slutsky

MD, M.A.Sc., B.A.Sc.

Scientist

Biography

My major research interests relate to the lung injury caused by mechanical ventilation: so called ventilator-induced lung injury (VILI). Specifically, my lab is working on (1) biotrauma: the molecular mechanisms by which injurious forms of mechanical ventilation can lead to release of mediators; (2) the mechanisms by which these mediators can affect distal organs (e.g. kidney, liver, etc.) and lead to multiple organ dysfunction syndrome (MODS); and (3) therapeutic approaches (ventilatory and non-ventilatory) to mitigate VILI and biotrauma. My laboratory works very closely with Dr. Zhang’s laboratory, and makes use of a number of model systems including in vitro, ex vivo cell and various animal models. As well, I have a major interest in clinical trials related to mechanical ventilation, acute lung injury (ALI), acute respiratory distress syndrome (ARDS), and COVID-19.

 

Recent Publications

  1. Godoy, LC, Neal, MD, Goligher, EC, Cushman, M, Houston, BL, Bradbury, CA et al.. Heparin Dose Intensity and Organ Support-Free Days in Patients Hospitalized for COVID-19. JACC Adv. 2024;3 (3):100780. doi: 10.1016/j.jacadv.2023.100780. PubMed PMID:38938844 PubMed Central PMC11198374.
  2. Brown, PE, Fu, SH, Newcombe, L, Tang, X, Nagelkerke, N, Birnboim, HC et al.. Hybrid immunity from SARS-CoV-2 infection and vaccination in Canadian adults: cohort study. Elife. 2024;13 :. doi: 10.7554/eLife.89961. PubMed PMID:38916134 .
  3. Songsangvorn, N, Slutsky, AS, Burns, KEA, Zhang, H. Methodological considerations in meta-analysis: evaluating RCTs, NRS, and crossover trials for electrical impedance tomography in PEEP titration. Intensive Care Med. 2024;50 (7):1188-1189. doi: 10.1007/s00134-024-07462-z. PubMed PMID:38805041 .
  4. Fernando, SM, Qureshi, D, Talarico, R, Vigod, SN, McIsaac, DI, Sterling, LH et al.. Mental health sequelae in survivors of cardiogenic shock complicating myocardial infarction. A population-based cohort study. Intensive Care Med. 2024;50 (6):901-912. doi: 10.1007/s00134-024-07399-3. PubMed PMID:38695924 .
  5. Justice, JM, Slutsky, AS, Stanford, N, Isennock, C, Siddiqui, S, Zamir, H et al.. Assessment of Ventilation Using Adult and Pediatric Manual Resuscitators in a Simulated Adult Patient. Respir Care. 2024; :. doi: 10.4187/respcare.11588. PubMed PMID:38688544 .
  6. Nasa, P, Bos, LD, Estenssoro, E, van Haren, FM, Serpa Neto, A, Rocco, PR et al.. Consensus statements on the utility of defining ARDS and the utility of past and current definitions of ARDS-protocol for a Delphi study. BMJ Open. 2024;14 (4):e082986. doi: 10.1136/bmjopen-2023-082986. PubMed PMID:38670604 PubMed Central PMC11057280.
  7. Coiffard, B, Dianti, J, Telias, I, Brochard, LJ, Slutsky, AS, Beck, J et al.. Dyssynchronous diaphragm contractions impair diaphragm function in mechanically ventilated patients. Crit Care. 2024;28 (1):107. doi: 10.1186/s13054-024-04894-3. PubMed PMID:38566126 PubMed Central PMC10988824.
  8. Songsangvorn, N, Xu, Y, Lu, C, Rotstein, O, Brochard, L, Slutsky, AS et al.. Electrical impedance tomography-guided positive end-expiratory pressure titration in ARDS: a systematic review and meta-analysis. Intensive Care Med. 2024;50 (5):617-631. doi: 10.1007/s00134-024-07362-2. PubMed PMID:38512400 PubMed Central PMC11078723.
  9. Dianti, J, McNamee, JJ, Slutsky, AS, Fan, E, Ferguson, ND, McAuley, DF et al.. Determinants of Effect of Extracorporeal CO2 Removal in Hypoxemic Respiratory Failure. NEJM Evid. 2023;2 (5):EVIDoa2200295. doi: 10.1056/EVIDoa2200295. PubMed PMID:38320056 .
  10. Tran, A, Rochwerg, B, Fan, E, Belohlavek, J, Suverein, MM, Poll, MCGV et al.. Prognostic factors associated with favourable functional outcome among adult patients requiring extracorporeal cardiopulmonary resuscitation for out-of-hospital cardiac arrest: A systematic review and meta-analysis. Resuscitation. 2023;193 :110004. doi: 10.1016/j.resuscitation.2023.110004. PubMed PMID:37863420 .
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Affiliations & Other Activities

  • Scientist, Keenan Research Centre for Biomedical Science, St. Michael’s Hospital
  • Keenan Chair in Medicine, St. Michael’s Hospital
  • Professor, Departments of Medicine, Biomedical Engineering and Surgery, University of Toronto
  • Chair, Clinical Trials Ontario