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Arthur S. Slutsky

MD, M.A.Sc., B.A.Sc.

Scientist

Email: Arthur.Slutsky@unityhealth.to
Tel: 416-864-5637

Research Programs

Biography

My major research interests relate to the lung injury caused by mechanical ventilation: so called ventilator-induced lung injury (VILI). Specifically, my lab is working on (1) biotrauma: the molecular mechanisms by which injurious forms of mechanical ventilation can lead to release of mediators; (2) the mechanisms by which these mediators can affect distal organs (e.g. kidney, liver, etc.) and lead to multiple organ dysfunction syndrome (MODS); and (3) therapeutic approaches (ventilatory and non-ventilatory) to mitigate VILI and biotrauma. My laboratory works very closely with Dr. Zhang’s laboratory, and makes use of a number of model systems including in vitro, ex vivo cell and various animal models. As well, I have a major interest in clinical trials related to mechanical ventilation, acute lung injury (ALI), acute respiratory distress syndrome (ARDS), and COVID-19.

 

Recent Publications

  1. Coiffard, B, Dianti, J, Telias, I, Brochard, LJ, Slutsky, AS, Beck, J et al.. Dyssynchronous diaphragm contractions impair diaphragm function in mechanically ventilated patients. Crit Care. 2024;28 (1):107. doi: 10.1186/s13054-024-04894-3. PubMed PMID:38566126 PubMed Central PMC10988824.
  2. Songsangvorn, N, Xu, Y, Lu, C, Rotstein, O, Brochard, L, Slutsky, AS et al.. Electrical impedance tomography-guided positive end-expiratory pressure titration in ARDS: a systematic review and meta-analysis. Intensive Care Med. 2024; :. doi: 10.1007/s00134-024-07362-2. PubMed PMID:38512400 .
  3. Dianti, J, McNamee, JJ, Slutsky, AS, Fan, E, Ferguson, ND, McAuley, DF et al.. Determinants of Effect of Extracorporeal CO2 Removal in Hypoxemic Respiratory Failure. NEJM Evid. 2023;2 (5):EVIDoa2200295. doi: 10.1056/EVIDoa2200295. PubMed PMID:38320056 .
  4. Tran, A, Rochwerg, B, Fan, E, Belohlavek, J, Suverein, MM, Poll, MCGV et al.. Prognostic factors associated with favourable functional outcome among adult patients requiring extracorporeal cardiopulmonary resuscitation for out-of-hospital cardiac arrest: A systematic review and meta-analysis. Resuscitation. 2023;193 :110004. doi: 10.1016/j.resuscitation.2023.110004. PubMed PMID:37863420 .
  5. Villar, J, González-Martín, JM, Hernández-González, J, Armengol, MA, Fernández, C, Martín-Rodríguez, C et al.. Predicting ICU Mortality in Acute Respiratory Distress Syndrome Patients Using Machine Learning: The Predicting Outcome and STratifiCation of severity in ARDS (POSTCARDS) Study. Crit Care Med. 2023;51 (12):1638-1649. doi: 10.1097/CCM.0000000000006030. PubMed PMID:37651262 .
  6. Onodera, Y, Liang, J, Li, Y, Griffin, B, Thanabalasingam, T, Lu, C et al.. Inhalation of ACE2 as a therapeutic target on sex-bias differences in SARS-CoV-2 infection and variant of concern. iScience. 2023;26 (8):107470. doi: 10.1016/j.isci.2023.107470. PubMed PMID:37609639 PubMed Central PMC10440513.
  7. Gattinoni, L, Citerio, G, Slutsky, AS. Back to the future: ARDS guidelines, evidence, and opinions. Intensive Care Med. 2023;49 (10):1226-1228. doi: 10.1007/s00134-023-07183-9. PubMed PMID:37578520 .
  8. Saha, R, Pham, T, Sinha, P, Maddali, MV, Bellani, G, Fan, E et al.. Estimating the attributable fraction of mortality from acute respiratory distress syndrome to inform enrichment in future randomised clinical trials. Thorax. 2023;78 (10):990-1003. doi: 10.1136/thorax-2023-220262. PubMed PMID:37495364 PubMed Central PMC10581447.
  9. Matthay, MA, Arabi, Y, Arroliga, AC, Bernard, G, Bersten, AD, Brochard, LJ et al.. A New Global Definition of Acute Respiratory Distress Syndrome. Am J Respir Crit Care Med. 2024;209 (1):37-47. doi: 10.1164/rccm.202303-0558WS. PubMed PMID:37487152 PubMed Central PMC10870872.
  10. Goligher, EC, McNamee, JJ, Dianti, J, Fan, E, Ferguson, ND, Slutsky, AS et al.. Heterogeneous Treatment Effects of Extracorporeal CO2 Removal in Acute Hypoxemic Respiratory Failure. Am J Respir Crit Care Med. 2023;208 (6):739-742. doi: 10.1164/rccm.202304-0689LE. PubMed PMID:37433221 .
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Affiliations & Other Activities

  • Scientist, Keenan Research Centre for Biomedical Science, St. Michael’s Hospital
  • Keenan Chair in Medicine, St. Michael’s Hospital
  • Professor, Departments of Medicine, Biomedical Engineering and Surgery, University of Toronto
  • Chair, Clinical Trials Ontario