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C. David Mazer

MD with Great Distinction

Scientist

Email: David.Mazer@unityhealth.to
Tel: 416-864-5825

Research Programs

Biography

Please note: Dr. Mazer is not taking any summer students.

My academic interests relate to cardiovascular disease and include cardiac anesthesia and critical care. My research program focuses on perioperative blood conservation, cardiac physiology and metabolism and perioperative organ protection. I am actively engaged in translational research as an investigator in both pre-clinical and clinical studies in these areas.

Recent Publications

  1. Au, E, Zhao, K, Belley-Côté, E, Song, Y, Al-Hazzani, W, Sadeghirad, B et al.. The effect of perioperative benzodiazepine administration on postoperative nausea and vomiting: a systematic review and meta-analysis of randomised controlled trials. Br J Anaesth. 2024;132 (3):469-482. doi: 10.1016/j.bja.2023.11.045. PubMed PMID:38177006 .
  2. Wald, R, Gaudry, S, da Costa, BR, Adhikari, NKJ, Bellomo, R, Du, B et al.. Initiation of continuous renal replacement therapy versus intermittent hemodialysis in critically ill patients with severe acute kidney injury: a secondary analysis of STARRT-AKI trial. Intensive Care Med. 2023;49 (11):1305-1316. doi: 10.1007/s00134-023-07211-8. PubMed PMID:37815560 .
  3. Bagshaw, SM, Neto, AS, Smith, O, Weir, M, Qiu, H, Du, B et al.. Correction: Impact of renal-replacement therapy strategies on outcomes for patients with chronic kidney disease: a secondary analysis of the STARRT-AKI trial. Intensive Care Med. 2023;49 (3):381-383. doi: 10.1007/s00134-023-06976-2. PubMed PMID:36757471 .
  4. Rumman, RK, Verma, S, Chan, V, Mazer, D, Quan, A, Hibino, M et al.. Predictors of mitral valve haemodynamics after mitral valve repair for degenerative mitral regurgitation. Heart. 2023;109 (11):866-873. doi: 10.1136/heartjnl-2022-321753. PubMed PMID:36750353 PubMed Central PMC10314030.
  5. Jackson, AIR, Boney, O, Pearse, RM, Kurz, A, Cooper, DJ, van Klei, WA et al.. Systematic reviews and consensus definitions for the Standardised Endpoints in Perioperative Medicine (StEP) initiative: mortality, morbidity, and organ failure. Br J Anaesth. 2023;130 (4):404-411. doi: 10.1016/j.bja.2022.12.012. PubMed PMID:36697275 .
  6. Bagshaw, SM, Neto, AS, Smith, O, Weir, M, Qiu, H, Du, B et al.. Impact of renal-replacement therapy strategies on outcomes for patients with chronic kidney disease: a secondary analysis of the STARRT-AKI trial. Intensive Care Med. 2022;48 (12):1736-1750. doi: 10.1007/s00134-022-06912-w. PubMed PMID:36331570 .
  7. Kochar, A, Zheng, Y, van Diepen, S, Mehta, RH, Westerhout, CM, Mazer, DC et al.. Predictors and associated clinical outcomes of low cardiac output syndrome following cardiac surgery: insights from the LEVO-CTS trial. Eur Heart J Acute Cardiovasc Care. 2022;11 (11):818-825. doi: 10.1093/ehjacc/zuac114. PubMed PMID:36156131 .
  8. Zampieri, FG, da Costa, BR, Vaara, ST, Lamontagne, F, Rochwerg, B, Nichol, AD et al.. A Bayesian reanalysis of the Standard versus Accelerated Initiation of Renal-Replacement Therapy in Acute Kidney Injury (STARRT-AKI) trial. Crit Care. 2022;26 (1):255. doi: 10.1186/s13054-022-04120-y. PubMed PMID:36008827 PubMed Central PMC9404618.
  9. Angriman, F, Ferreyro, BL, Angeloni, N, da Costa, BR, Wald, R, Bagshaw, SM et al.. The Effect of an Accelerated Renal Replacement Therapy Initiation Is Not Modified by Baseline Risk. Ann Am Thorac Soc. 2022;19 (9):1613-1618. doi: 10.1513/AnnalsATS.202201-046RL. PubMed PMID:35587363 .
  10. McEwen, CC, Amir, T, Qiu, Y, Young, J, Kennedy, K, Grocott, HP et al.. Correction to: Morbidity and mortality in patients managed with high compared with low blood pressure targets during on-pump cardiac surgery: a systematic review and meta-analysis of randomized controlled trials. Can J Anaesth. 2022;69 (6):799-800. doi: 10.1007/s12630-022-02205-4. PubMed PMID:35165836 .
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Affiliations & Other Activities

  • Associate Scientist, Li Ka Shing Knowledge Institute,  St. Michael’s Hospital
  • Vice-Chair for Research, Department of Anesthesia, University of Toronto
  • Professor, Department of Anesthesia, University of Toronto
  • Professor, Department of Physiology (cross appointment), University of Toronto