Charles de Mestral




Dr. Charles de Mestral is a vascular surgeon at St. Michael’s Hospital and a Surgeon-Scientist in the Department of Surgery of the University of Toronto. He conducts research on clinical effectiveness, as well as the provision, quality and costs of surgical care.  His primary research focus is amputation prevention in people with diabetes and peripheral artery disease. His work is based out of the Li Ka Shing Knowledge Institute of St. Michael’s Hospital and ICES.

Please note: Dr. de Mestral is no longer accepting summer students.


Recent Publications

  1. Zhang, Q, Duncan, S, Szulc, DA, de Mestral, C, Kutryk, MJ. Development of a universal, oriented antibody immobilization method to functionalize vascular prostheses for enhanced endothelialization for potential clinical application. J Biol Eng. 2023;17 (1):37. doi: 10.1186/s13036-023-00356-6. PubMed PMID:37264409 PubMed Central PMC10236874.
  2. Li, B, Beaton, D, Eisenberg, N, Lee, DS, Wijeysundera, DN, Lindsay, TF et al.. Using machine learning to predict outcomes following carotid endarterectomy. J Vasc Surg. 2023; :. doi: 10.1016/j.jvs.2023.05.024. PubMed PMID:37211142 .
  3. Zamzam, A, McLaren, AM, Ram, E, Syed, MH, Rave, S, Lu, SH et al.. A novel Canadian multidisciplinary acute care pathway for people hospitalised with a diabetic foot ulcer. Int Wound J. 2023; :. doi: 10.1111/iwj.14214. PubMed PMID:37150835 .
  4. Jacob-Brassard, J, Al-Omran, M, Stukel, TA, Mamdani, M, Lee, DS, Papia, G et al.. The influence of diabetes on temporal trends in lower extremity revascularisation and amputation for peripheral artery disease: A population-based repeated cross-sectional analysis. Diabet Med. 2023;40 (6):e15056. doi: 10.1111/dme.15056. PubMed PMID:36721971 .
  5. Jacob-Brassard, J, Al-Omran, M, Stukel, TA, Mamdani, M, Lee, DS, de Mestral, C et al.. Regional variation in lower extremity revascularization and amputation for peripheral artery disease. J Vasc Surg. 2023;77 (4):1127-1136. doi: 10.1016/j.jvs.2022.12.032. PubMed PMID:36681257 .
  6. Gomez, D, de Mestral, C, Stukel, TA, Irish, J, Simpson, AN, Wilton, AS et al.. Characterizing the Impact of Procedure Funding on the Covid-19 Generated Procedure Gap in Ontario: A Population-Based Analysis. Ann Surg. 2022; :. doi: 10.1097/SLA.0000000000005781. PubMed PMID:36538613 .
  7. Jacob-Brassard, J, de Mestral, C. Big data: Using databases and registries. Semin Vasc Surg. 2022;35 (4):413-423. doi: 10.1053/j.semvascsurg.2022.09.002. PubMed PMID:36414357 .
  8. Muaddi, H, Stukel, TA, de Mestral, C, Nathens, A, Pautler, SE, Shayegan, B et al.. The evolving use of robotic surgery: a population-based analysis. Surg Endosc. 2023;37 (3):1870-1877. doi: 10.1007/s00464-022-09643-7. PubMed PMID:36253624 .
  9. Li, B, de Mestral, C, Mamdani, M, Al-Omran, M. Perceptions of Canadian vascular surgeons toward artificial intelligence and machine learning. J Vasc Surg Cases Innov Tech. 2022;8 (3):466-472. doi: 10.1016/j.jvscit.2022.06.018. PubMed PMID:36016703 PubMed Central PMC9396444.
  10. Nantais, J, Mansour, M, de Mestral, C, Jayaraman, S, Gomez, D. Administrative codes may have limited utility in diagnosing biliary colic in emergency department visits: A validation study. Ann Hepatobiliary Pancreat Surg. 2022;26 (3):277-280. doi: 10.14701/ahbps.21-171. PubMed PMID:35851329 PubMed Central PMC9428434.
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Affiliations & Other Activities

  • Surgeon, Division of Vascular Surgery, St. Michael’s Hospital
  • Assistant Professor, Department of Surgery, University of Toronto
  • Adjunct Scientist, Institute for Clinical Evaluative Sciences