Dr. Christer Sinderby is a physiologist who obtained a MSc at Karolinska Institute, Stockholm, and PhD degree at University of Gothenburg in the late 80’s. He trained as a postdoctoral fellow for half a decade at the Meakins Christie Laboratories, McGill University in the early 90’s and then became an independent researcher at the University of Montreal. In 2003, Dr. Sinderby took the position as a Staff Scientist in the Critical Care Department at St Michael’s Hospital, University of Toronto.

Major achievements in his career would include standardized technology for measuring diaphragm electrical activity, which 1) has been used to dissociate between neural and mechanical efforts in respiratory muscle failure and 2) led up to the invention of technology for Neurally Adjusted Ventilatory Assist in humans. This technology is now clinically used world wide.

Current research interest are: 1) neural control of mechanical ventilation, 2) patient-ventilator interaction 3) control of breathing during mechanical ventilation, especially during acute lung injury/ acute respiratory distress syndrome.

Recent Publications

  1. Coiffard, B, Dianti, J, Telias, I, Brochard, LJ, Slutsky, AS, Beck, J et al.. Dyssynchronous diaphragm contractions impair diaphragm function in mechanically ventilated patients. Crit Care. 2024;28 (1):107. doi: 10.1186/s13054-024-04894-3. PubMed PMID:38566126 PubMed Central PMC10988824.
  2. Lynch, AL, Matlock, DN, Akmyradov, C, Weisner, MD, Beck, J, Sinderby, C et al.. Tidal volume delivery during nasal intermittent positive pressure ventilation: infant cannula vs. nasal continuous positive airway pressure prongs. J Perinatol. 2024;44 (2):244-249. doi: 10.1038/s41372-023-01846-7. PubMed PMID:38129599 .
  3. Zhang, R, Xu, X, Chen, H, Beck, J, Sinderby, C, Qiu, H et al.. Predicting extubation in patients with traumatic cervical spinal cord injury using the diaphragm electrical activity during a single maximal maneuver. Ann Intensive Care. 2023;13 (1):122. doi: 10.1186/s13613-023-01217-7. PubMed PMID:38055103 PubMed Central PMC10700269.
  4. Liu, L, Li, HL, Lu, C, Patel, P, Wang, D, Beck, J et al.. Estimation of transpulmonary driving pressure during synchronized mechanical ventilation using a single lower assist maneuver (LAM) in rabbits: a comparison to measurements made with an esophageal balloon. Crit Care. 2023;27 (1):325. doi: 10.1186/s13054-023-04607-2. PubMed PMID:37626372 PubMed Central PMC10463600.
  5. Beck, J, Li, HL, Lu, C, Campbell, DM, Sinderby, C. Synchronized and proportional sub-diaphragmatic unloading in an animal model of respiratory distress. Pediatr Res. 2023;93 (4):878-886. doi: 10.1038/s41390-022-02238-x. PubMed PMID:35941145 .
  6. Ahmadipour, M, Taniguchi, D, Duchesneau, P, Aoki, FG, Phillips, G, Sinderby, C et al.. Use of High-Rate Ventilation Results in Enhanced Recellularization of Bioengineered Lung Scaffolds. Tissue Eng Part C Methods. 2021;27 (12):661-671. doi: 10.1089/ten.TEC.2021.0182. PubMed PMID:34847779 .
  7. Beck, J, Sinderby, C. Neurally Adjusted Ventilatory Assist in Newborns. Clin Perinatol. 2021;48 (4):783-811. doi: 10.1016/j.clp.2021.07.007. PubMed PMID:34774209 .
  8. Takahashi, D, Beck, J, Goto, K, Sinderby, C. Spontaneous breathing during high-frequency oscillation revealed by diaphragm electrical activity. Pediatr Neonatol. 2022;63 (1):99-100. doi: 10.1016/j.pedneo.2021.08.005. PubMed PMID:34535430 .
  9. Yuan, X, Lu, X, Chao, Y, Beck, J, Sinderby, C, Xie, J et al.. Neurally adjusted ventilatory assist as a weaning mode for adults with invasive mechanical ventilation: a systematic review and meta-analysis. Crit Care. 2021;25 (1):222. doi: 10.1186/s13054-021-03644-z. PubMed PMID:34187528 PubMed Central PMC8240429.
  10. Sklar, MC, Madotto, F, Jonkman, A, Rauseo, M, Soliman, I, Damiani, LF et al.. Duration of diaphragmatic inactivity after endotracheal intubation of critically ill patients. Crit Care. 2021;25 (1):26. doi: 10.1186/s13054-020-03435-y. PubMed PMID:33430930 PubMed Central PMC7798017.
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Affiliations & Other Activities

  • Member, iBEST