Claudia dos Santos

MD, MSc, BSc

Scientist

Biography

My major research interest is in acute lung injury, which can be caused by either biomolecular or biophysical insults to the lungs, such as an infection or the mechanical injury resulting from mechanical ventilation itself. My lab is dedicated to understanding the interaction between patients and the breathing machine and finding new ways to identify individuals who are at higher risk for developing lung injury, in addition to diagnosing, treating and monitoring improvement from injury. To accomplish our goals, we have developed various model systems from basic epithelial cell stretch models to animal models of lung injury. We exploit whole genome approaches, such as microarray technology, to identify novel molecular targets and use various computational strategies to analyze our data. We are also interested in understanding how and why critically ill patients develop multi-organ failure. To answer some of the more complex questions, my lab also collaborates actively with clinical researchers involved in state of the art clinical trials related to novel mechanical ventilation strategies.

Recent Publications

  1. Panigada, M, Spinelli, E, De Falco, S, Consonni, D, Novembrino, C, Boscolo Anzoletti, M et al.. The relationship between antithrombin administration and inflammation during veno-venous ECMO. Sci Rep. 2022;12 (1):14284. doi: 10.1038/s41598-022-17227-7. PubMed PMID:35995816 PubMed Central PMC9395326.
  2. Formosa, A, Turgeon, P, Dos Santos, CC. Role of miRNA dysregulation in sepsis. Mol Med. 2022;28 (1):99. doi: 10.1186/s10020-022-00527-z. PubMed PMID:35986237 PubMed Central PMC9389495.
  3. Walsh, CJ, Batt, J, Herridge, MS, Mathur, S, Bader, GD, Hu, P et al.. Comprehensive multi-cohort transcriptional meta-analysis of muscle diseases identifies a signature of disease severity. Sci Rep. 2022;12 (1):11260. doi: 10.1038/s41598-022-15003-1. PubMed PMID:35789175 PubMed Central PMC9253003.
  4. Maslove, DM, Tang, B, Shankar-Hari, M, Lawler, PR, Angus, DC, Baillie, JK et al.. Redefining critical illness. Nat Med. 2022;28 (6):1141-1148. doi: 10.1038/s41591-022-01843-x. PubMed PMID:35715504 .
  5. Gupta, S, Amatullah, H, Tsoporis, JN, Wei, K, Monteiro, APT, Ektesabi, AM et al.. DJ-1 binds to Rubicon to Impair LC-3 Associated Phagocytosis. Cell Death Differ. 2022;29 (10):2024-2033. doi: 10.1038/s41418-022-00993-2. PubMed PMID:35641782 PubMed Central PMC9525254.
  6. Ting, AE, Baker, EK, Champagne, J, Desai, TJ, Dos Santos, CC, Heijink, IH et al.. Proceedings of the ISCT scientific signature series symposium, "Advances in cell and gene therapies for lung diseases and critical illnesses": International Society for Cell & Gene Therapy, Burlington VT, US, July 16, 2021. Cytotherapy. 2022;24 (8):774-788. doi: 10.1016/j.jcyt.2021.11.007. PubMed PMID:35613962 .
  7. Soussi, S, Sharma, D, Jüni, P, Lebovic, G, Brochard, L, Marshall, JC et al.. Identifying clinical subtypes in sepsis-survivors with different one-year outcomes: a secondary latent class analysis of the FROG-ICU cohort. Crit Care. 2022;26 (1):114. doi: 10.1186/s13054-022-03972-8. PubMed PMID:35449071 PubMed Central PMC9022336.
  8. Gustafson, D, Ngai, M, Wu, R, Hou, H, Schoffel, AC, Erice, C et al.. Cardiovascular signatures of COVID-19 predict mortality and identify barrier stabilizing therapies. EBioMedicine. 2022;78 :103982. doi: 10.1016/j.ebiom.2022.103982. PubMed PMID:35405523 PubMed Central PMC8989492.
  9. Walsh, CJ, Escudero King, C, Gupta, M, Plant, PJ, Herridge, MJ, Mathur, S et al.. MicroRNA regulatory networks associated with abnormal muscle repair in survivors of critical illness. J Cachexia Sarcopenia Muscle. 2022;13 (2):1262-1276. doi: 10.1002/jcsm.12903. PubMed PMID:35092190 PubMed Central PMC8977950.
  10. Baghela, A, Pena, OM, Lee, AH, Baquir, B, Falsafi, R, An, A et al.. Predicting sepsis severity at first clinical presentation: The role of endotypes and mechanistic signatures. EBioMedicine. 2022;75 :103776. doi: 10.1016/j.ebiom.2021.103776. PubMed PMID:35027333 PubMed Central PMC8808161.
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Affiliations & Other Activities

  • Scientist, Keenan Research Centre for Biomedical Science, St. Michael’s Hospital
  • Clinician Scientist, Research, University of Toronto
  • Associate Professor of Medicine, Department of Medicine, University of Toronto
  • Member, Collaborative Graduate Program in Genome Biology and Bioinformatics, University of Toronto