Corinne E. Fischer



Research Programs


Dr. Fischer is a staff psychiatrist with the Mental Health Service at St. Michael’s Hospital and director of Geriatric Psychiatry at St. Michael’s Hospital, Unity Health. She is an associate scientist and co-director of Neurodegenerative Research, Division of Neuroscience Research, at the Keenan Research Centre for Biomedical Science, the Li Ka Shing Knowledge Institute, St. Michael’s Hospital, Toronto, Canada. She has an academic appointment as Associate Professor at the University of Toronto in the Division of Geriatric Psychiatry and is a full member of the Institute of Medical Science where she supervises graduate students, research fellows, residents and medical students. She is an associate editor of the Journal of Alzheimer’s disease and immediate past academic co-chair of the Neuropsychiatric Symptom Professional Interest Area ISTAART in addition to being a member of several national/international organizations including CAGP, AAGP, IPA and ISTAART.  Dr. Fischer’s main clinical and research focus centres around neuropsychiatric symptoms in Alzheimer’s disease and their clinical, imaging and pathological correlates. She is a principal investigator for a number of peer-reviewed and industry sponsored grants, including a multi-centred study of photobiomodulation therapy in moderate to severe Alzheimer’s disease.

Recent Publications

  1. Brooks, H, Wang, W, Zomorrodi, R, Blumberger, DM, Bowie, CR, Daskalakis, ZJ et al.. Cognitive function based on theta-gamma coupling vs. clinical diagnosis in older adults with mild cognitive impairment with or without major depressive disorder. Transl Psychiatry. 2024;14 (1):153. doi: 10.1038/s41398-024-02856-5. PubMed PMID:38503740 PubMed Central PMC10951346.
  2. Rashidi-Ranjbar, N, Churchill, NW, Black, SE, Kumar, S, Tartaglia, MC, Freedman, M et al.. Neuropsychiatric symptoms and brain morphology in patients with mild cognitive impairment, cerebrovascular disease and Parkinson disease: A cross sectional and longitudinal study. Int J Geriatr Psychiatry. 2024;39 (3):e6074. doi: 10.1002/gps.6074. PubMed PMID:38491809 .
  3. Marawi, T, Zhukovsky, P, Brooks, H, Bowie, CR, Butters, MA, Fischer, CE et al.. Heterogeneity of Cognition in Older Adults with Remitted Major Depressive Disorder: A Latent Profile Analysis. Am J Geriatr Psychiatry. 2024; :. doi: 10.1016/j.jagp.2024.01.225. PubMed PMID:38403532 .
  4. Anderson, JAE, Rashidi-Ranjbar, N, Nazeri, A, Chad, JA, Zhukovsky, P, Mulsant, BH et al.. Age-Related Alterations in Gray Matter Microstructure in Older People With Remitted Major Depression at Risk for Dementia. Biol Psychiatry Glob Open Sci. 2024;4 (1):374-384. doi: 10.1016/j.bpsgos.2023.08.018. PubMed PMID:38298786 PubMed Central PMC10829634.
  5. D'Souza, GM, Churchill, NW, Guan, DX, Khoury, MA, Graham, SJ, Kumar, S et al.. Interaction of Alzheimer Disease and Traumatic Brain Injury on Cortical Thickness. Alzheimer Dis Assoc Disord. ;38 (1):14-21. doi: 10.1097/WAD.0000000000000607. PubMed PMID:38285961 .
  6. Sanchez, E, Wilkinson, T, Coughlan, G, Mirza, S, Baril, AA, Ramirez, J et al.. Association of plasma biomarkers with cognition, cognitive decline, and daily function across and within neurodegenerative diseases: Results from the Ontario Neurodegenerative Disease Research Initiative. Alzheimers Dement. 2024;20 (3):1753-1770. doi: 10.1002/alz.13560. PubMed PMID:38105605 PubMed Central PMC10984487.
  7. Azami, H, Zrenner, C, Brooks, H, Zomorrodi, R, Blumberger, DM, Fischer, CE et al.. Beta to theta power ratio in EEG periodic components as a potential biomarker in mild cognitive impairment and Alzheimer's dementia. Alzheimers Res Ther. 2023;15 (1):133. doi: 10.1186/s13195-023-01280-z. PubMed PMID:37550778 PubMed Central PMC10405483.
  8. Zebarth, J, Kamal, R, Perlman, G, Ouk, M, Xiong, LY, Yu, D et al.. Perivascular spaces mediate a relationship between diabetes and other cerebral small vessel disease markers in cerebrovascular and neurodegenerative diseases. J Stroke Cerebrovasc Dis. 2023;32 (9):107273. doi: 10.1016/j.jstrokecerebrovasdis.2023.107273. PubMed PMID:37542762 .
  9. Ozzoude, M, Varriano, B, Beaton, D, Ramirez, J, Adamo, S, Holmes, MF et al.. White matter hyperintensities and smaller cortical thickness are associated with neuropsychiatric symptoms in neurodegenerative and cerebrovascular diseases. Alzheimers Res Ther. 2023;15 (1):114. doi: 10.1186/s13195-023-01257-y. PubMed PMID:37340319 PubMed Central PMC10280981.
  10. Dilliott, AA, Berberian, SA, Sunderland, KM, Binns, MA, Zimmer, J, Ozzoude, M et al.. Rare neurovascular genetic and imaging markers across neurodegenerative diseases. Alzheimers Dement. 2023;19 (12):5583-5595. doi: 10.1002/alz.13316. PubMed PMID:37272523 .
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Affiliations & Other Activities

  • Director of Geriatric Psychiatry, Psychiatry, St. Michael’s Hospital
  • Director of Memory Disorders Clinic, Psychiatry, St. Michael’s Hospital
  • Director of the Geriatric Mental Health Outreach Program, Psychiatry, St. Michael’s Hospital
  • Associate Professor, Department of Psychiatry, University of Toronto
  • Associate Member, IMS