Dalia Rotstein



Research Programs


Dr. Dalia Rotstein is an assistant professor of medicine at the University of Toronto and neurologist specialized in multiple sclerosis (MS) and other demyelinating diseases. She completed neurology residency at University of Toronto where she was co-chief resident and MS fellowship at the Brigham and Women’s Hospital/Harvard University, where she also earned a Master of Public Health degree.

Her research is focused on the epidemiology of multiple sclerosis and neuromyelitis optica spectrum disorder (NMOSD). She has a particular interest in the roles of gender, ethnicity, migration, and vitamin D in these conditions. She has performed foundational work to validate No Evidence of Disease Activity (NEDA) as an early treatment goal on MS therapy. She is the Principal Investigator for CANOPTICS, the first Canadian national prospective study to investigate adults with NMOSD, MOG Antibody Disease, and other atypical demyelinating conditions.

Dr. Rotstein founded the NMOSD Multi-Disciplinary Clinic at St. Michael’s Hospital in 2020 and the international educational program NIRVE, the Neurology International Residents Videoconferencing Exchange, in 2009. She now serves as the faculty mentor for NIRVE and enjoys mentoring students, residents and fellows. She is an associate editor for the journal Frontiers in Neurology.

Recent Publications

  1. Vyas, MV, Kapral, MK, Alonzo, R, Fang, J, Rotstein, DL. Proportion of Life Spent in Canada and the Incidence of Multiple Sclerosis in Permanent Immigrants. Neurology. 2024;102 (10):e209350. doi: 10.1212/WNL.0000000000209350. PubMed PMID:38657190 .
  2. Budhram, A, Rotstein, DL, Yang, L, Yeh, EA. Myelin oligodendrocyte glycoprotein antibody titers by fixed cell-based assay: positive predictive value and impact of sample collection timing. Front Neurol. 2024;15 :1380541. doi: 10.3389/fneur.2024.1380541. PubMed PMID:38550339 PubMed Central PMC10973151.
  3. Rotstein, DL, Freedman, MS, Lee, L, Marrie, RA, Morrow, SA, McCombe, JA et al.. Predicting time to serologic diagnosis of AQP4+ NMOSD based on clinical factors and social determinants of health. Mult Scler Relat Disord. 2024;83 :105434. doi: 10.1016/j.msard.2024.105434. PubMed PMID:38242051 .
  4. Hosseini-Moghaddam, S, Marrie, RA, Wolfson, C, Carruthers, R, Freedman, MS, Morrow, S et al.. A Canadian case control study investigating demographic and environmental factors associated with MOGAD. Mult Scler Relat Disord. 2023;79 :105023. doi: 10.1016/j.msard.2023.105023. PubMed PMID:37804766 .
  5. Marrie, RA, Maxwell, CJ, Rotstein, DL, Tsai, CC, Tremlett, H. Prodromes in demyelinating disorders, amyotrophic lateral sclerosis, Parkinson disease, and Alzheimer's dementia. Rev Neurol (Paris). 2024;180 (3):125-140. doi: 10.1016/j.neurol.2023.07.002. PubMed PMID:37567819 .
  6. Rotstein, DL, Gyang, TV, Ontaneda, D. Making Sure Multiple Sclerosis Counts and Is Counted for All-An Update on Multiple Sclerosis Prevalence by Race and Ethnicity in the United States. JAMA Neurol. 2023;80 (7):667-669. doi: 10.1001/jamaneurol.2023.0469. PubMed PMID:37184874 .
  7. Rotstein, DL, Wolfson, C, Carruthers, R, Freedman, MS, Morrow, SA, Lee, L et al.. A national case-control study investigating demographic and environmental factors associated with NMOSD. Mult Scler. 2023;29 (4-5):521-529. doi: 10.1177/13524585231151953. PubMed PMID:36803237 PubMed Central PMC10152218.
  8. Saab, G, Munoz, DG, Rotstein, DL. Chronic Cognitive Impairment in AQP4+ NMOSD With Improvement in Cognition on Eculizumab: A Report of Two Cases. Front Neurol. 2022;13 :863151. doi: 10.3389/fneur.2022.863151. PubMed PMID:35645973 PubMed Central PMC9136286.
  9. Rotstein, DL. All Bruton's tyrosine kinase inhibitors have similar efficacy and risks: No. Mult Scler. 2022;28 (10):1500-1502. doi: 10.1177/13524585221091060. PubMed PMID:35437080 PubMed Central PMC9315179.
  10. Rotstein, DL. Radiologically isolated syndrome and the possibility of preclinical disease activity in aquaporin-4 antibody NMOSD. Mult Scler. 2022;28 (4):679-680. doi: 10.1177/13524585221085732. PubMed PMID:35332816 PubMed Central PMC8958560.
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Affiliations & Other Activities

  • Neurologist, Multiple Sclerosis Clinic, St. Michael’s Hospital
  • Assistant Professor, Department of Medicine, Division of Neurology, University of Toronto.