Darrell Tan




Dr. Darrell Tan is an infectious diseases physician, clinician-scientist and Canadian Institutes of Health Research (CIHR) New Investigator whose research focuses on clinical trials in human immunodeficiency virus (HIV) prevention and HIV/sexual transmitted infection (STI) co-infection. As Director of the University of Toronto Clinical Research Unit on HIV Prevention and co-leader of the CIHR Canadian HIV Trials Network Biomedical Prevention Working Group, he is leading multiple efforts to optimize the implementation of HIV pre- and post-exposure prophylaxis (PrEP and PEP) in Canada. These include Canada’s first demonstration project of daily oral TDF/FTC-based PrEP in Toronto MSM, the development of national Clinical Practice Guidelines on PEP & PrEP use, exploration of the relationship between syndemic health problems and clinical outcomes of PEP & PrEP, studies of nurse-led PEP & PrEP, and evaluations of novel antiretroviral PEP regimens.

Additional research interests are in the interaction between HIV and common co-infections such as herpes simplex virus type 2 (HSV-2) and syphilis, and the role of systemic inflammation in driving clinical outcomes in people living with HIV. He is also Co-Principle Investigator on two CIHR-supported multicentre randomized control trials including the a trial of anti-herpes medication for attenuating HIV disease progression, and a trial of enhanced syphilis screening in HIV-positive men.

Recent Publications

  1. Grace, D, Gaspar, M, Wells, A, Sinno, J, Daroya, E, Montess, M et al.. Injectable Pre-Exposure Prophylaxis for HIV Prevention: Perspectives on the Benefits and Barriers from Gay, Bisexual, and Queer Men and Health System Stakeholders in Ontario, Canada. AIDS Patient Care STDS. 2023; :. doi: 10.1089/apc.2023.0034. PubMed PMID:37195728 .
  2. Homme, P, Truong, R, Gong, J, Ziegler, C, Freitas, C, Yeung, A et al.. Sexual health promotion for sexual and gender minorities in primary care: a scoping review protocol. BMJ Open. 2023;13 (3):e066704. doi: 10.1136/bmjopen-2022-066704. PubMed PMID:36868597 PubMed Central PMC9990650.
  3. Zhabokritsky, A, Clarke, R, Rosenes, R, Smith, G, Loutfy, M, Andany, N et al.. Correlates of Healthy Aging in Geriatric HIV (CHANGE HIV)-CTN 314. Viruses. 2023;15 (2):. doi: 10.3390/v15020517. PubMed PMID:36851731 PubMed Central PMC9968122.
  4. Sukhdeo, S, Muller, M, McGeer, A, Leis, JA, Chan, A, Gubbay, JB et al.. Environmental Surface Contamination With Monkeypox Virus in the Ambulatory Setting in Toronto, Canada. Open Forum Infect Dis. 2023;10 (2):ofac648. doi: 10.1093/ofid/ofac648. PubMed PMID:36756631 PubMed Central PMC9901272.
  5. Alsarhani, WK, Chan, CC, Boyd, SR, Hasso, M, Almeer, A, Tan, DHS et al.. Monkeypox-Associated Disciform Keratitis. Cornea. 2023;42 (5):641-644. doi: 10.1097/ICO.0000000000003171. PubMed PMID:36729600 PubMed Central PMC10060039.
  6. Chambers, C, Deeks, SL, Sutradhar, R, Cox, J, de Pokomandy, A, Grennan, T et al.. Self-reported Human Papillomavirus Vaccination and Vaccine Effectiveness Among Men Who Have Sex with Men: A Quantitative Bias Analysis. Epidemiology. 2023;34 (2):225-229. doi: 10.1097/EDE.0000000000001580. PubMed PMID:36722804 PubMed Central PMC9891269.
  7. McClymont, E, Tan, DH, Bondy, S, Albert, A, Coutlée, F, Lee, M et al.. HSV-2 infection and HPV incidence, persistence, and precancerous lesions in a cohort of HPV-vaccinated women living with HIV. Int J STD AIDS. 2023;34 (6):402-407. doi: 10.1177/09564624231154298. PubMed PMID:36702811 PubMed Central PMC10133830.
  8. Chambers, C, Deeks, SL, Sutradhar, R, Cox, J, de Pokomandy, A, Grennan, T et al.. Vaccine effectiveness against 12-month incident and persistent anal human papillomavirus infection among gay, bisexual, and other men who have sex with men. J Infect Dis. 2023; :. doi: 10.1093/infdis/jiad005. PubMed PMID:36655513 .
  9. Klein, MB, Young, J, Ortiz-Paredes, D, Wang, S, Walmsley, S, Wong, A et al.. Virological Outcomes After Switching to Abacavir/Lamivudine/Dolutegravir Combined with Adherence Support in People Living with HIV with Poor Adherence: A Phase IV, Multicentre Randomized Prospective Open Label Study (TriiADD-CTN 286). Patient Prefer Adherence. 2022;16 :3267-3281. doi: 10.2147/PPA.S379065. PubMed PMID:36536672 PubMed Central PMC9759014.
  10. Hart, TA, Noor, SW, Tavangar, F, Berlin, GW, Skakoon-Sparling, S, Tan, DHS et al.. Crystal methamphetamine use and bacterial sexually transmitted infections (STIs) among gay, bisexual and other sexual minority men in Canada. Drug Alcohol Depend. 2023;242 :109718. doi: 10.1016/j.drugalcdep.2022.109718. PubMed PMID:36516548 .
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Affiliations & Other Activities

  • Clinician-Scientist, Department of Medicine, St. Michael’s Hospital
  • Assistant Professor, Department of Medicine, University of Toronto
  • Assistant Professor, Institute of Health Policy, Management & Evaluation, University of Toronto
  • Director, HIV Prevention Clinical Research Unit, University of Toronto
  • Affiliate Scientist, Toronto General Research Institute