David Jenkins

OC, MD, FRSC, FRCP, FRCPC, PhD, DSc

Scientist

Biography

Educated at Oxford University, Dr. David Jenkins is currently a Professor in both the Departments of Nutritional Sciences and Medicine, Faculty of Medicine, University of Toronto, a Staff Physician in the Division of Endocrinology and Metabolism, the Director of the Clinical Nutrition and Risk Factor Modification Center, and a Scientist in the Li Ka Shing Knowledge Institute of St. Michael’s Hospital. He has served on committees in Canada and the United States that have formulated nutritional guidelines for the treatment of diabetes and recommendations for fibre and macronutrient intake (fat protein and carbohydrates) for the general population (including the Dietary Reference intake or DRIs) under the joint United States-Canada DRI system (RDAs) of the National Academy of Sciences (Washington, DC). He led the team that first defined and explored the concept of the glycemic index of foods. He was the first to demonstrate the breadth of metabolic effects of viscous soluble fiber (as found in fruit, certain beans, oats barley) on blood glucose and cholesterol lowering of relevance to prevention and treatment of diabetes and heart disease. His studies on combining cholesterol lowering food components (dietary portfolio) have been recognized as creating an effective dietary alternative to drug therapy (statins) for lower risk people. In an important study, he compared a dietary portfolio with all food provided with a statin in the same people and demonstrated that the effects of both were comparable. The dietary portfolio, on the basis of this and other studies including a major cross Canada real world study, was the only dietary approach referenced in 2004 Guidelines update of the US National Cholesterol Education Program (ATP III) and recommended in the Canadian Cardiovascular Society (CCS) guidelines for 2012 and the European Atherosclerosis Society consensus statement (2015). He has received many National and International awards in recognition of his contribution to nutrition research. He believes in the value of plant based diets, and that a major effort is required to mount large studies to determine the extent of their health benefits. He also believes that diets have to be environmentally sustainable.

Please note: Dr. Jenkins is currently accepting volunteer students.

Recent Publications

  1. Jayalath, VH, Lajkosz, K, Fleshner, NE, Hamilton, RJ, Jenkins, DJA. The effect of lowering cholesterol through diet on serum prostate-specific antigen levels: A secondary analysis of clinical trials. Can Urol Assoc J. 2022;16 (8):279-282. doi: 10.5489/cuaj.7975. PubMed PMID:35905298 PubMed Central PMC9343158.
  2. Lee, D, Chiavaroli, L, Ayoub-Charette, S, Khan, TA, Zurbau, A, Au-Yeung, F et al.. Important Food Sources of Fructose-Containing Sugars and Non-Alcoholic Fatty Liver Disease: A Systematic Review and Meta-Analysis of Controlled Trials. Nutrients. 2022;14 (14):. doi: 10.3390/nu14142846. PubMed PMID:35889803 PubMed Central PMC9325155.
  3. Kaspy, MS, Semnani-Azad, Z, Malik, VS, Jenkins, DJA, Hanley, AJ. Metabolomic profile of combined healthy lifestyle behaviours in humans: A systematic review. Proteomics. 2022; :e2100388. doi: 10.1002/pmic.202100388. PubMed PMID:35816426 .
  4. Talukdar, JR, Cooper, MA, Lyutvyn, L, Zeraatkar, D, Ali, R, Bierbrier, R et al.. Effects of inulin-type fructans supplementation on cardiovascular disease risk factors: a protocol for a systematic review and meta-analysis of randomised controlled trials. BMJ Open. 2022;12 (7):e058875. doi: 10.1136/bmjopen-2021-058875. PubMed PMID:35793918 PubMed Central PMC9260802.
  5. Jenkins, DJA, Sahye-Pudaruth, S, Khodabandehlou, K, Liang, F, Kasmani, M, Wanyan, J et al.. Systematic review and meta-analysis examining the relationship between postprandial hypotension, cardiovascular events, and all-cause mortality. Am J Clin Nutr. 2022; :. doi: 10.1093/ajcn/nqac158. PubMed PMID:35675216 .
  6. Di Maso, M, Augustin, LSA, Jenkins, DJA, Carioli, G, Turati, F, Grisoni, B et al.. Adherence to a cholesterol-lowering diet and the risk of prostate cancer. Food Funct. 2022;13 (10):5730-5738. doi: 10.1039/d1fo03795a. PubMed PMID:35522943 .
  7. Elliott, LJ, Keown-Stoneman, CDG, Birken, CS, Jenkins, DJA, Borkhoff, CM, Maguire, JL et al.. Vegetarian Diet, Growth, and Nutrition in Early Childhood: A Longitudinal Cohort Study. Pediatrics. 2022;149 (6):. doi: 10.1542/peds.2021-052598. PubMed PMID:35499383 .
  8. Kavanagh, ME, Chiavaroli, L, Glenn, AJ, Heijmans, G, Grant, SM, Chow, CM et al.. A Web-Based Health Application to Translate Nutrition Therapy for Cardiovascular Risk Reduction in Primary Care (PortfolioDiet.app): Quality Improvement and Usability Testing Study. JMIR Hum Factors. 2022;9 (2):e34704. doi: 10.2196/34704. PubMed PMID:35451981 PubMed Central PMC9073604.
  9. Srichaikul, K, Jenkins, DJA. The Glycemic Index, Rate of Digestion of Carbohydrate Foods, and Their Potential Link with Cardiovascular Disease. J Nutr. 2022;152 (4):920-921. doi: 10.1093/jn/nxab427. PubMed PMID:35174392 .
  10. Srichaikul, K, Hegele, RA, Jenkins, DJA. Great Chinese Famine and the Effects on Cardiometabolic Health for Future Generations. Hypertension. 2022;79 (3):532-535. doi: 10.1161/HYPERTENSIONAHA.121.18546. PubMed PMID:35138871 .
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Affiliations & Other Activities

  • Director, Clinical Nutrition and Risk Factor Modification Centre, St. Michael’s Hospital
  • Staff Physician, Division of Endocrinology, Department of Medicine, St. Michael’s Hospital
  • Professor and Canada Research Chair in Nutrition and Metabolism, Dept. of Medicine and Nutritional Sciences, Faculty of Medicine, University of Toronto
  • Canada Research Chair in Nutrition and Metabolism