David Klein




My research follows two major themes: (1) health policy and (2) sepsis and critical illness.   In the area of health policy, I co-lead the Centre for the Evaluation and Optimization of Public Healthcare Finance at IHPME with Dr. Adalsteinn Brown.  We are focused on improving healthcare capital investment and evaluation with a multidisciplinary group of collaborators.   In the area of sepsis and critical illness, I lead several efforts to develop novel diagnostics and therapeutics.  I have particular expertise in healthcare innovation and commercialization in addition to clinical development strategy.

Please note: Dr. Klein is not taking any summer students.

Recent Publications

  1. Vaara, ST, Serpa Neto, A, Bellomo, R, Adhikari, NKJ, Dreyfuss, D, Gallagher, M et al.. Regional Practice Variation and Outcomes in the Standard Versus Accelerated Initiation of Renal Replacement Therapy in Acute Kidney Injury (STARRT-AKI) Trial: A Post Hoc Secondary Analysis. Crit Care Explor. 2024;6 (2):e1053. doi: 10.1097/CCE.0000000000001053. PubMed PMID:38380940 PubMed Central PMC10878545.
  2. Klein, DE, Mackenzie, R, Hawkins, B, Koon, A. Inside "Operation Change Agent": Mallinckrodt's Plan for Capturing the Opioid Market. J Health Polit Policy Law. 2024; :. doi: 10.1215/03616878-11186127. PubMed PMID:38324355 .
  3. REMAP-CAP Investigators, Hills, TE, Lorenzi, E, Berry, LR, Shyamsundar, M, Al-Beidh, F et al.. Simvastatin in Critically Ill Patients with Covid-19. N Engl J Med. 2023;389 (25):2341-2354. doi: 10.1056/NEJMoa2309995. PubMed PMID:37888913 PubMed Central PMC10755839.
  4. LOVIT-COVID Investigators, on behalf of the Canadian Critical Care Trials Group, and the REMAP-CAP Investigators, Adhikari, NKJ, Hashmi, M, Tirupakuzhi Vijayaraghavan, BK, Haniffa, R, Beane, A et al.. Intravenous Vitamin C for Patients Hospitalized With COVID-19: Two Harmonized Randomized Clinical Trials. JAMA. 2023;330 (18):1745-1759. doi: 10.1001/jama.2023.21407. PubMed PMID:37877585 PubMed Central PMC10600726.
  5. Wald, R, Gaudry, S, da Costa, BR, Adhikari, NKJ, Bellomo, R, Du, B et al.. Initiation of continuous renal replacement therapy versus intermittent hemodialysis in critically ill patients with severe acute kidney injury: a secondary analysis of STARRT-AKI trial. Intensive Care Med. 2023;49 (11):1305-1316. doi: 10.1007/s00134-023-07211-8. PubMed PMID:37815560 .
  6. Writing Committee for the REMAP-CAP Investigators, Lawler, PR, Derde, LPG, van de Veerdonk, FL, McVerry, BJ, Huang, DT et al.. Effect of Angiotensin-Converting Enzyme Inhibitor and Angiotensin Receptor Blocker Initiation on Organ Support-Free Days in Patients Hospitalized With COVID-19: A Randomized Clinical Trial. JAMA. 2023;329 (14):1183-1196. doi: 10.1001/jama.2023.4480. PubMed PMID:37039790 PubMed Central PMC10326520.
  7. Klein, DJ, Veillard, J, Brown, A. Aligning goals of for-profit, not-for-profit, and public healthcare organizations by governing for quality: A model for change in the U.S. and other jurisdictions. Healthc Manage Forum. 2023;36 (4):246-248. doi: 10.1177/08404704231160274. PubMed PMID:36959688 PubMed Central PMC10291483.
  8. MacKenzie, R, Hawkins, B, Klein, DE, Ahmad, M, Norman, AK, Koon, AD et al.. The opioid industry document archive: New directions in research on corporate political strategy. Int J Drug Policy. 2023;114 :103997. doi: 10.1016/j.drugpo.2023.103997. PubMed PMID:36931180 .
  9. Smith, ML, Risse, G, Sziklas, V, Banks, S, Small, D, Frasnelli, J et al.. Neurophysiology, Neuropsychology, Epilepsy, 2022: Hills We Have Climbed and the Hills Ahead. Cognition and Sensory Systems in Healthy and Diseased Subjects. Epilepsy Behav. 2023;140 :109119. doi: 10.1016/j.yebeh.2023.109119. PubMed PMID:36804713 .
  10. Bagshaw, SM, Neto, AS, Smith, O, Weir, M, Qiu, H, Du, B et al.. Correction: Impact of renal-replacement therapy strategies on outcomes for patients with chronic kidney disease: a secondary analysis of the STARRT-AKI trial. Intensive Care Med. 2023;49 (3):381-383. doi: 10.1007/s00134-023-06976-2. PubMed PMID:36757471 .
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Affiliations & Other Activities

  • Head of Business Strategy, Applied Health Research Centre, Li Ka Shing Knowledge Institute, St. Michael’s Hospital
  • Staff Physician, Critical Care, St. Michael’s Hospital
  • Assistant Professor, Faculty of Medicine, University of Toronto
  • Member, Institute for Health Policy, Management, and Evaluation, Dalla Lana School of Public Health