David Klein




My research follows two major themes: (1) health policy and (2) sepsis and critical illness.   In the area of health policy, I co-lead the Centre for the Evaluation and Optimization of Public Healthcare Finance at IHPME with Dr. Adalsteinn Brown.  We are focused on improving healthcare capital investment and evaluation with a multidisciplinary group of collaborators.   In the area of sepsis and critical illness, I lead several efforts to develop novel diagnostics and therapeutics.  I have particular expertise in healthcare innovation and commercialization in addition to clinical development strategy.

Please note: Dr. Klein is not taking any summer students.

Recent Publications

  1. Das Pradhan, A, Glynn, RJ, Fruchart, JC, MacFadyen, JG, Zaharris, ES, Everett, BM et al.. Triglyceride Lowering with Pemafibrate to Reduce Cardiovascular Risk. N Engl J Med. 2022;387 (21):1923-1934. doi: 10.1056/NEJMoa2210645. PubMed PMID:36342113 .
  2. Bagshaw, SM, Neto, AS, Smith, O, Weir, M, Qiu, H, Du, B et al.. Impact of renal-replacement therapy strategies on outcomes for patients with chronic kidney disease: a secondary analysis of the STARRT-AKI trial. Intensive Care Med. 2022;48 (12):1736-1750. doi: 10.1007/s00134-022-06912-w. PubMed PMID:36331570 .
  3. Marin-Couture, E, Filion, MJ, Boukari, R, Jeejeebhoy, K, Dhaliwal, R, Brauer, P et al.. Relationship between Cardiometabolic Factors and the Response of Blood Pressure to a One-Year Primary Care Lifestyle Intervention in Metabolic Syndrome Patients. Metabolites. 2022;12 (9):. doi: 10.3390/metabo12090861. PubMed PMID:36144265 PubMed Central PMC9500796.
  4. Bas-Hoogendam, JM, Bernstein, R, Benson, BE, Buss, KA, Gunther, KE, Pérez-Edgar, K et al.. Structural Brain Correlates of Childhood Inhibited Temperament: An ENIGMA-Anxiety Mega-analysis. J Am Acad Child Adolesc Psychiatry. 2022;61 (9):1182-1188. doi: 10.1016/j.jaac.2022.04.023. PubMed PMID:36038199 PubMed Central PMC9434711.
  5. Zampieri, FG, da Costa, BR, Vaara, ST, Lamontagne, F, Rochwerg, B, Nichol, AD et al.. A Bayesian reanalysis of the Standard versus Accelerated Initiation of Renal-Replacement Therapy in Acute Kidney Injury (STARRT-AKI) trial. Crit Care. 2022;26 (1):255. doi: 10.1186/s13054-022-04120-y. PubMed PMID:36008827 PubMed Central PMC9404618.
  6. Angriman, F, Ferreyro, BL, Angeloni, N, da Costa, BR, Wald, R, Bagshaw, SM et al.. The Effect of an Accelerated Renal Replacement Therapy Initiation Is Not Modified by Baseline Risk. Ann Am Thorac Soc. 2022;19 (9):1613-1618. doi: 10.1513/AnnalsATS.202201-046RL. PubMed PMID:35587363 .
  7. Brauer, P, Royall, D, Li, A, Rodrigues, A, Green, J, Macklin, S et al.. Key process features of personalized diet counselling in metabolic syndrome: secondary analysis of feasibility study in primary care. BMC Nutr. 2022;8 (1):45. doi: 10.1186/s40795-022-00540-9. PubMed PMID:35534841 PubMed Central PMC9081667.
  8. Kashef Al-Ghetaa, R, Daniel, I, Shaw, J, Klein, D, Brown, A. The determinants of effective inter-organization information sharing in the health capital planning process. Healthc Manage Forum. 2022;35 (4):236-242. doi: 10.1177/08404704221087408. PubMed PMID:35507410 PubMed Central PMC9234776.
  9. Brauer, P, Desroches, S, Dhaliwal, R, Li, A, Wang, Y, Conklin, AI et al.. Modified Delphi Process to Identify Research Priorities and Measures for Adult Lifestyle Programs to Address Type 2 Diabetes and Other Cardiometabolic Risk Conditions. Can J Diabetes. 2022;46 (4):411-418. doi: 10.1016/j.jcjd.2022.01.003. PubMed PMID:35484054 .
  10. REMAP-CAP Writing Committee for the REMAP-CAP Investigators, Bradbury, CA, Lawler, PR, Stanworth, SJ, McVerry, BJ, McQuilten, Z et al.. Effect of Antiplatelet Therapy on Survival and Organ Support-Free Days in Critically Ill Patients With COVID-19: A Randomized Clinical Trial. JAMA. 2022;327 (13):1247-1259. doi: 10.1001/jama.2022.2910. PubMed PMID:35315874 PubMed Central PMC8941448.
Search PubMed

Affiliations & Other Activities

  • Head of Business Strategy, Applied Health Research Centre, Li Ka Shing Knowledge Institute, St. Michael’s Hospital
  • Staff Physician, Critical Care, St. Michael’s Hospital
  • Assistant Professor, Faculty of Medicine, University of Toronto
  • Member, Institute for Health Policy, Management, and Evaluation, Dalla Lana School of Public Health