David Munoz



Research Programs


Dr. David Munoz holds an MD from Navarre and MSc in Pathology from Queen’s University, Ontario. He trained in neurology and neuropathology and became a Fellow of the Royal College of Physicians and Surgeons of Canada in 1984. He has practiced in Vermont, Saskatoon, London (ON), Madrid, and Toronto, and briefly in Vancouver. He is currently a Neuropathologist and Head, Division of Pathology at St. Michael’s Hospital, Toronto, and Professor, Department of Laboratory Medicine and Pathobiology, University of Toronto. He is the author of 194 peer-reviewed papers, 20 book chapters, and co-author of one book. He has held research grants in Canada (Medical Research Council and Canadian Institutes of Health Research) and USA (National Institutes of Health).

His research interest is focused on neuropathology, particularly the mechanisms of development and progression of degenerative diseases of the brain, including Alzheimer’s disease, the non-Alzheimer dementias, movement disorders, and amyotrophic lateral sclerosis. His other research interest in neurooncology is derived from his clinical practice.

Please note: Dr. D. Munoz is not taking any summer students

Recent Publications

  1. Malik, P, Soliman, R, Chen, YA, Munoz, DG, Das, S, Bharatha, A et al.. Patterns of T2-FLAIR discordance across a cohort of adult-type diffuse gliomas and deviations from the classic T2-FLAIR mismatch sign. Neuroradiology. 2024; :. doi: 10.1007/s00234-024-03297-z. PubMed PMID:38347151 .
  2. van der Meulen, M, Ramos, RC, Voisin, MR, Patil, V, Wei, Q, Singh, O et al.. Differences in methylation profiles between long-term survivors and short-term survivors of IDH-wild-type glioblastoma. Neurooncol Adv. 2024;6 (1):vdae001. doi: 10.1093/noajnl/vdae001. PubMed PMID:38312227 PubMed Central PMC10838123.
  3. Woolman, M, Kiyota, T, Belgadi, SA, Fujita, N, Fiorante, A, Ramaswamy, V et al.. Lipidomic-Based Approach to 10 s Classification of Major Pediatric Brain Cancer Types with Picosecond Infrared Laser Mass Spectrometry. Anal Chem. 2024;96 (3):1019-1028. doi: 10.1021/acs.analchem.3c03156. PubMed PMID:38190738 PubMed Central PMC10809247.
  4. Sanchez, E, Wilkinson, T, Coughlan, G, Mirza, S, Baril, AA, Ramirez, J et al.. Association of plasma biomarkers with cognition, cognitive decline, and daily function across and within neurodegenerative diseases: Results from the Ontario Neurodegenerative Disease Research Initiative. Alzheimers Dement. 2023; :. doi: 10.1002/alz.13560. PubMed PMID:38105605 .
  5. Woulfe, J, Munoz, DG, Gray, DA, Jinnah, HA, Ivanova, A. Inosine monophosphate dehydrogenase intranuclear inclusions are markers of aging and neuronal stress in the human substantia nigra. Neurobiol Aging. 2024;134 :43-56. doi: 10.1016/j.neurobiolaging.2023.11.005. PubMed PMID:37992544 .
  6. Ivanova, A, Witiw, CD, Ishaque, AH, Munoz, DG. Lumbar Spinal Chondroma with Intradural Extension. Can J Neurol Sci. 2023; :1-3. doi: 10.1017/cjn.2023.297. PubMed PMID:37799093 .
  7. Huang, J, Brien, D, Coe, BC, Longoni, G, Mabbott, DJ, Munoz, DP et al.. Delayed oculomotor response associates with optic neuritis in youth with demyelinating disorders. Mult Scler Relat Disord. 2023;79 :104969. doi: 10.1016/j.msard.2023.104969. PubMed PMID:37660456 .
  8. Wang, JZ, Nassiri, F, Landry, AP, Patil, V, Rebchuk, A, Merali, ZA et al.. Fractionated radiotherapy for surgically resected intracranial meningiomas: A multicentre retrospective cohort study. Radiother Oncol. 2023;188 :109861. doi: 10.1016/j.radonc.2023.109861. PubMed PMID:37619659 .
  9. Ozzoude, M, Varriano, B, Beaton, D, Ramirez, J, Adamo, S, Holmes, MF et al.. White matter hyperintensities and smaller cortical thickness are associated with neuropsychiatric symptoms in neurodegenerative and cerebrovascular diseases. Alzheimers Res Ther. 2023;15 (1):114. doi: 10.1186/s13195-023-01257-y. PubMed PMID:37340319 PubMed Central PMC10280981.
  10. Vaccarino, AL, Black, SE, Gilbert Evans, S, Frey, BN, Javadi, M, Kennedy, SH et al.. Rasch analyses of the Quick Inventory of Depressive Symptomatology Self-Report in neurodegenerative and major depressive disorders. Front Psychiatry. 2023;14 :1154519. doi: 10.3389/fpsyt.2023.1154519. PubMed PMID:37333922 PubMed Central PMC10273843.
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Affiliations & Other Activities

  • Head, Division of Pathology, St. Michael’s Hospital
  • Professor, Laboratory Medicine and Pathobiology, University of Toronto