David Munoz



Research Programs


Dr. David Munoz holds an MD from Navarre and MSc in Pathology from Queen’s University, Ontario. He trained in neurology and neuropathology and became a Fellow of the Royal College of Physicians and Surgeons of Canada in 1984. He has practiced in Vermont, Saskatoon, London (ON), Madrid, and Toronto, and briefly in Vancouver. He is currently a Neuropathologist and Head, Division of Pathology at St. Michael’s Hospital, Toronto, and Professor, Department of Laboratory Medicine and Pathobiology, University of Toronto. He is the author of 194 peer-reviewed papers, 20 book chapters, and co-author of one book. He has held research grants in Canada (Medical Research Council and Canadian Institutes of Health Research) and USA (National Institutes of Health).

His research interest is focused on neuropathology, particularly the mechanisms of development and progression of degenerative diseases of the brain, including Alzheimer’s disease, the non-Alzheimer dementias, movement disorders, and amyotrophic lateral sclerosis. His other research interest in neurooncology is derived from his clinical practice.

Please note: Dr. D. Munoz is not taking any summer students

Recent Publications

  1. Eguchi, K, Malhotra, AR, Malhotra, AK, Harrington, EM, Munoz, DG, Nishimura, Y et al.. Pure extraosseous spinal epidural cavernous hemangioma presenting with acute paraplegia: a case report. Spinal Cord Ser Cases. 2022;8 (1):63. doi: 10.1038/s41394-022-00531-9. PubMed PMID:35773281 PubMed Central PMC9247050.
  2. Stewart, J, Sahgal, A, Chan, AKM, Soliman, H, Tseng, CL, Detsky, J et al.. Pattern of Recurrence of Glioblastoma Versus Grade 4 IDH-Mutant Astrocytoma Following Chemoradiation: A Retrospective Matched-Cohort Analysis. Technol Cancer Res Treat. ;21 :15330338221109650. doi: 10.1177/15330338221109650. PubMed PMID:35762826 PubMed Central PMC9247382.
  3. Saab, G, Munoz, DG, Rotstein, DL. Chronic Cognitive Impairment in AQP4+ NMOSD With Improvement in Cognition on Eculizumab: A Report of Two Cases. Front Neurol. 2022;13 :863151. doi: 10.3389/fneur.2022.863151. PubMed PMID:35645973 PubMed Central PMC9136286.
  4. Beaton, D, McLaughlin, PM, Orange, JB, Munoz, DP, Mandzia, J, Abrahao, A et al.. Caregiving concerns and clinical characteristics across neurodegenerative and cerebrovascular disorders in the Ontario neurodegenerative disease research initiative. Int J Geriatr Psychiatry. 2022;37 (6):. doi: 10.1002/gps.5727. PubMed PMID:35633037 .
  5. Khoury, MA, Bahsoun, MA, Fadhel, A, Shunbuli, S, Venkatesh, S, Ghazvanchahi, A et al.. Delusional Severity Is Associated with Abnormal Texture in FLAIR MRI. Brain Sci. 2022;12 (5):. doi: 10.3390/brainsci12050600. PubMed PMID:35624987 PubMed Central PMC9139341.
  6. Millward, CP, Armstrong, TS, Barrington, H, Bell, S, Brodbelt, AR, Bulbeck, H et al.. Development of 'Core Outcome Sets' for Meningioma in Clinical Studies (The COSMIC Project): protocol for two systematic literature reviews, eDelphi surveys and online consensus meetings. BMJ Open. 2022;12 (5):e057384. doi: 10.1136/bmjopen-2021-057384. PubMed PMID:35534067 PubMed Central PMC9086638.
  7. Ozzoude, M, Varriano, B, Beaton, D, Ramirez, J, Holmes, MF, Scott, CJM et al.. Investigating the contribution of white matter hyperintensities and cortical thickness to empathy in neurodegenerative and cerebrovascular diseases. Geroscience. 2022;44 (3):1575-1598. doi: 10.1007/s11357-022-00539-x. PubMed PMID:35294697 PubMed Central PMC9213606.
  8. Kuczynski, AM, Krajden, S, Spears, J, Kus, JV, Munoz, DG, Ostrowski, M et al.. Mycobacterium genavense Central Nervous System Infection in a Patient with AIDS. Can J Neurol Sci. 2022; :1-3. doi: 10.1017/cjn.2022.6. PubMed PMID:35220993 .
  9. Vaccarino, AL, Beaton, D, Black, SE, Blier, P, Farzan, F, Finger, E et al.. Common Data Elements to Facilitate Sharing and Re-use of Participant-Level Data: Assessment of Psychiatric Comorbidity Across Brain Disorders. Front Psychiatry. 2022;13 :816465. doi: 10.3389/fpsyt.2022.816465. PubMed PMID:35197877 PubMed Central PMC8859302.
  10. Atayde, AL, Fischer, CE, Schweizer, TA, Munoz, DG. Neuropsychiatric Inventory-Questionnaire Assessed Nighttime Behaviors in Cognitively Asymptomatic Patients with Pathologically Confirmed Alzheimer's Disease Predict More Rapid Cognitive Deterioration. J Alzheimers Dis. 2022;86 (3):1137-1147. doi: 10.3233/JAD-215276. PubMed PMID:35180114 .
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Affiliations & Other Activities

  • Head, Division of Pathology, St. Michael’s Hospital
  • Professor, Laboratory Medicine and Pathobiology, University of Toronto