David Munoz



Research Programs


Dr. David Munoz holds an MD from Navarre and MSc in Pathology from Queen’s University, Ontario. He trained in neurology and neuropathology and became a Fellow of the Royal College of Physicians and Surgeons of Canada in 1984. He has practiced in Vermont, Saskatoon, London (ON), Madrid, and Toronto, and briefly in Vancouver. He is currently a Neuropathologist and Head, Division of Pathology at St. Michael’s Hospital, Toronto, and Professor, Department of Laboratory Medicine and Pathobiology, University of Toronto. He is the author of 194 peer-reviewed papers, 20 book chapters, and co-author of one book. He has held research grants in Canada (Medical Research Council and Canadian Institutes of Health Research) and USA (National Institutes of Health).

His research interest is focused on neuropathology, particularly the mechanisms of development and progression of degenerative diseases of the brain, including Alzheimer’s disease, the non-Alzheimer dementias, movement disorders, and amyotrophic lateral sclerosis. His other research interest in neurooncology is derived from his clinical practice.

Please note: Dr. D. Munoz is not taking any summer students

Recent Publications

  1. Parr, AC, Riek, HC, Coe, BC, Pari, G, Masellis, M, Marras, C et al.. Genetic Variation in the Dopamine System is Associated with Mixed-Strategy Decision-Making in Parkinson's Patients. Eur J Neurosci. 2022; :. doi: 10.1111/ejn.15875. PubMed PMID:36453013 .
  2. Fischer, CE, Namasivayam, A, Crawford-Holland, L, Hakobyan, N, Schweizer, TA, Munoz, DG et al.. Psychotic Disorders in the Elderly: Diagnosis, Epidemiology, and Treatment. Psychiatr Clin North Am. 2022;45 (4):691-705. doi: 10.1016/j.psc.2022.07.001. PubMed PMID:36396273 .
  3. Sunderland, KM, Beaton, D, Arnott, SR, Kleinstiver, P, Kwan, D, Lawrence-Dewar, JM et al.. Characteristics of the Ontario Neurodegenerative Disease Research Initiative cohort. Alzheimers Dement. 2022; :. doi: 10.1002/alz.12632. PubMed PMID:36318754 .
  4. Dissanayake, AS, Tan, YB, Bowie, CR, Butters, MA, Flint, AJ, Gallagher, D et al.. Sex Modifies the Associations of APOEɛ4 with Neuropsychiatric Symptom Burden in Both At-Risk and Clinical Cohorts of Alzheimer's Disease. J Alzheimers Dis. 2022; :. doi: 10.3233/JAD-220586. PubMed PMID:36314203 .
  5. Wong, BM, Hudson, C, Snook, E, Tayyari, F, Jung, H, Binns, MA et al.. Retinal nerve fiber layer in frontotemporal lobar degeneration and amyotrophic lateral sclerosis. Front Neurosci. 2022;16 :964715. doi: 10.3389/fnins.2022.964715. PubMed PMID:36278002 PubMed Central PMC9583385.
  6. Lando, L, Munoz, DG, Dangboon, W, Krema, H, Altomare, F. Optic Nerve Sheath Meningioma Presenting as a Slow-Growing Intraocular Mass. J Neuroophthalmol. 2022; :. doi: 10.1097/WNO.0000000000001703. PubMed PMID:36255082 .
  7. Valcic, M, Khoury, MA, Kim, J, Fornazzari, L, Churchill, NW, Ismail, Z et al.. Determining Whether Sex and Zygosity Modulates the Association between APOE4 and Psychosis in a Neuropathologically-Confirmed Alzheimer's Disease Cohort. Brain Sci. 2022;12 (9):. doi: 10.3390/brainsci12091266. PubMed PMID:36139002 PubMed Central PMC9497154.
  8. Thatcher, MD, Chan, AT, Munoz, DG, Micieli, JA. Comparison of pre-formalin fixation and postfixation temporal artery biopsy lengths. Can J Ophthalmol. 2022; :. doi: 10.1016/j.jcjo.2022.08.006. PubMed PMID:36108789 .
  9. Eguchi, K, Malhotra, AR, Malhotra, AK, Harrington, EM, Munoz, DG, Nishimura, Y et al.. Pure extraosseous spinal epidural cavernous hemangioma presenting with acute paraplegia: a case report. Spinal Cord Ser Cases. 2022;8 (1):63. doi: 10.1038/s41394-022-00531-9. PubMed PMID:35773281 PubMed Central PMC9247050.
  10. Stewart, J, Sahgal, A, Chan, AKM, Soliman, H, Tseng, CL, Detsky, J et al.. Pattern of Recurrence of Glioblastoma Versus Grade 4 IDH-Mutant Astrocytoma Following Chemoradiation: A Retrospective Matched-Cohort Analysis. Technol Cancer Res Treat. 2022;21 :15330338221109650. doi: 10.1177/15330338221109650. PubMed PMID:35762826 PubMed Central PMC9247382.
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Affiliations & Other Activities

  • Head, Division of Pathology, St. Michael’s Hospital
  • Professor, Laboratory Medicine and Pathobiology, University of Toronto