David Munoz



Research Programs


Dr. David Munoz holds an MD from Navarre and MSc in Pathology from Queen’s University, Ontario. He trained in neurology and neuropathology and became a Fellow of the Royal College of Physicians and Surgeons of Canada in 1984. He has practiced in Vermont, Saskatoon, London (ON), Madrid, and Toronto, and briefly in Vancouver. He is currently a Neuropathologist and Head, Division of Pathology at St. Michael’s Hospital, Toronto, and Professor, Department of Laboratory Medicine and Pathobiology, University of Toronto. He is the author of 194 peer-reviewed papers, 20 book chapters, and co-author of one book. He has held research grants in Canada (Medical Research Council and Canadian Institutes of Health Research) and USA (National Institutes of Health).

His research interest is focused on neuropathology, particularly the mechanisms of development and progression of degenerative diseases of the brain, including Alzheimer’s disease, the non-Alzheimer dementias, movement disorders, and amyotrophic lateral sclerosis. His other research interest in neurooncology is derived from his clinical practice.

Please note: Dr. D. Munoz is not taking any summer students

Recent Publications

  1. Ahangari, N, Fischer, CE, Schweizer, TA, Munoz, DG. Cognitive resilience and severe Alzheimer's disease neuropathology. Aging Brain. 2023;3 :100065. doi: 10.1016/j.nbas.2023.100065. PubMed PMID:36911256 PubMed Central PMC9997171.
  2. Brien, DC, Riek, HC, Yep, R, Huang, J, Coe, B, Areshenkoff, C et al.. Classification and staging of Parkinson's disease using video-based eye tracking. Parkinsonism Relat Disord. 2023; :105316. doi: 10.1016/j.parkreldis.2023.105316. PubMed PMID:36822878 .
  3. Valcic, M, Khoury, MA, Kim, J, Fornazzari, L, Churchill, NW, Ismail, Z et al.. Correction: Valcic et al. Determining Whether Sex and Zygosity Modulates the Association between APOE4 and Psychosis in a Neuropathologically-Confirmed Alzheimer's Disease Cohort. Brain Sci. 2022, 12, 1266. Brain Sci. 2022;13 (1):. doi: 10.3390/brainsci13010064. PubMed PMID:36672138 PubMed Central PMC9831142.
  4. Attia, EM, Sharma, S, Woodley-Cook, J, Spears, J, Munoz, DG. Cervical Intramedullary Solitary Fibrous Tumor. Can J Neurol Sci. 2023; :1-3. doi: 10.1017/cjn.2023.2. PubMed PMID:36660933 .
  5. Yu, D, Liang, N, Zebarth, J, Shen, Q, Ozzoude, M, Goubran, M et al.. Soluble Epoxide Hydrolase Derived Linoleic Acid Oxylipins, Small Vessel Disease Markers, and Neurodegeneration in Stroke. J Am Heart Assoc. 2023;12 (1):e026901. doi: 10.1161/JAHA.122.026901. PubMed PMID:36583428 PubMed Central PMC9973594.
  6. Mimosa, ML, Al-Ameri, W, Simpson, JT, Nakhla, M, Boissinot, K, Munoz, DG et al.. A Novel Approach to Detect IDH Point Mutations in Gliomas Using Nanopore Sequencing: Test Validation for the Clinical Laboratory. J Mol Diagn. 2023;25 (3):133-142. doi: 10.1016/j.jmoldx.2022.12.001. PubMed PMID:36565986 .
  7. Parr, AC, Riek, HC, Coe, BC, Pari, G, Masellis, M, Marras, C et al.. Genetic variation in the dopamine system is associated with mixed-strategy decision-making in patients with Parkinson's disease. Eur J Neurosci. 2022; :. doi: 10.1111/ejn.15875. PubMed PMID:36453013 .
  8. Fischer, CE, Namasivayam, A, Crawford-Holland, L, Hakobyan, N, Schweizer, TA, Munoz, DG et al.. Psychotic Disorders in the Elderly: Diagnosis, Epidemiology, and Treatment. Psychiatr Clin North Am. 2022;45 (4):691-705. doi: 10.1016/j.psc.2022.07.001. PubMed PMID:36396273 .
  9. Sunderland, KM, Beaton, D, Arnott, SR, Kleinstiver, P, Kwan, D, Lawrence-Dewar, JM et al.. Characteristics of the Ontario Neurodegenerative Disease Research Initiative cohort. Alzheimers Dement. 2023;19 (1):226-243. doi: 10.1002/alz.12632. PubMed PMID:36318754 .
  10. Dissanayake, AS, Tan, YB, Bowie, CR, Butters, MA, Flint, AJ, Gallagher, D et al.. Sex Modifies the Associations of APOEɛ4 with Neuropsychiatric Symptom Burden in Both At-Risk and Clinical Cohorts of Alzheimer's Disease. J Alzheimers Dis. 2022;90 (4):1571-1588. doi: 10.3233/JAD-220586. PubMed PMID:36314203 .
Search PubMed

Affiliations & Other Activities

  • Head, Division of Pathology, St. Michael’s Hospital
  • Professor, Laboratory Medicine and Pathobiology, University of Toronto