Diana Elizabeth Tullis




As the Director of the Toronto Adult Cystic Fibrosis (CF) Clinic at St. Michael’s Hospital, Dr. Tullis is responsible for the care of 450 adults with CF. Dr. Tullis is a Professor of Medicine at the University of Toronto, the Respirology Division Head at St. Michael’s Hospital, and an Associate Scientist in the Li Ka Shing Knowledge Institute. She is the Cystic Fibrosis Canada Chair in Adult CF Research.

Dr. Tullis has published over 100 articles and book chapters and has lectured nationally and internationally on issues related to CF in adults. She has had 25 years of experience with CF clinical care. She was the Chair of the Clinic Subcommittee of the Medical/Scientific Advisory Board of Cystic Fibrosis Canada from 2005-2011 and in 2010 was a Coach for the Adult Quality Improvement Program run by the American Cystic Fibrosis Foundation.

Recent Publications

  1. Flume, PA, Biner, RF, Downey, DG, Brown, C, Jain, M, Fischer, R et al.. Long-term safety and efficacy of tezacaftor-ivacaftor in individuals with cystic fibrosis aged 12 years or older who are homozygous or heterozygous for Phe508del CFTR (EXTEND): an open-label extension study. Lancet Respir Med. 2021;9 (7):733-746. doi: 10.1016/S2213-2600(20)30510-5. PubMed PMID:33581080 .
  2. Gupta, S, Batt, J, Bourbeau, J, Chapman, KR, Gershon, A, Granton, J et al.. Triaging Access to Critical Care Resources in Patients With Chronic Respiratory Diseases in the Event of a Major COVID-19 Surge: Key Highlights From the Canadian Thoracic Society (CTS) Position Statement. Chest. 2020;158 (6):2270-2274. doi: 10.1016/j.chest.2020.07.018. PubMed PMID:32693101 PubMed Central PMC7368654.
  3. Layeghifard, M, Li, H, Wang, PW, Donaldson, SL, Coburn, B, Clark, ST et al.. Microbiome networks and change-point analysis reveal key community changes associated with cystic fibrosis pulmonary exacerbations. NPJ Biofilms Microbiomes. 2019;5 (1):4. doi: 10.1038/s41522-018-0077-y. PubMed PMID:30675371 PubMed Central PMC6341074.
  4. Clark, ST, Sinha, U, Zhang, Y, Wang, PW, Donaldson, SL, Coburn, B et al.. Penicillin-binding protein 3 is a common adaptive target among Pseudomonas aeruginosa isolates from adult cystic fibrosis patients treated with β-lactams. Int J Antimicrob Agents. 2019;53 (5):620-628. doi: 10.1016/j.ijantimicag.2019.01.009. PubMed PMID:30664925 .
  5. Diaz Caballero, J, Clark, ST, Wang, PW, Donaldson, SL, Coburn, B, Tullis, DE et al.. A genome-wide association analysis reveals a potential role for recombination in the evolution of antimicrobial resistance in Burkholderia multivorans. PLoS Pathog. 2018;14 (12):e1007453. doi: 10.1371/journal.ppat.1007453. PubMed PMID:30532201 PubMed Central PMC6300292.
  6. Christofides, E, Stroud, K, Tullis, DE, O'Doherty, K. The Meanings of Helping: An Analysis of Cystic Fibrosis Patients' Reasons for Participating in Biomedical Research. J Empir Res Hum Res Ethics. 2017;12 (3):180-190. doi: 10.1177/1556264617713098. PubMed PMID:28593817 .
  7. Somayaji, R, Stanojevic, S, Tullis, DE, Stephenson, AL, Ratjen, F, Waters, V et al.. Clinical Outcomes Associated with Achromobacter Species Infection in Patients with Cystic Fibrosis. Ann Am Thorac Soc. 2017;14 (9):1412-1418. doi: 10.1513/AnnalsATS.201701-071OC. PubMed PMID:28406714 .
  8. Chuong, KH, Hwang, DM, Tullis, DE, Waters, VJ, Yau, YC, Guttman, DS et al.. Navigating social and ethical challenges of biobanking for human microbiome research. BMC Med Ethics. 2017;18 (1):1. doi: 10.1186/s12910-016-0160-y. PubMed PMID:28077127 PubMed Central PMC5225618.
  9. Flume, PA, Clancy, JP, Retsch-Bogart, GZ, Tullis, DE, Bresnik, M, Derchak, PA et al.. Continuous alternating inhaled antibiotics for chronic pseudomonal infection in cystic fibrosis. J Cyst Fibros. 2016;15 (6):809-815. doi: 10.1016/j.jcf.2016.05.001. PubMed PMID:27233377 .
  10. Cheng, AH, Manayathu, J, Sinclair, D, Tullis, DE, Bandiera, G. Conducting Effective Physician Performance Feedback: A Primer for Healthcare Leaders. Healthc Q. 2016;18 (4):42-8. doi: 10.12927/hcq.2016.24551. PubMed PMID:27009707 .
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Affiliations & Other Activities

  • Head, Division of Respirology, St. Michael’s Hospital
  • The Cystic Fibrosis Canada Chair in Adult Cystic Fibrosis Research, St. Michael’s Hospital
  • Professor, Department of Medicine, University of Toronto