Eno Hysi


Scientist, Keenan Research Centre for Biomedical Science (core affiliation) I do BOTH Clinical/Health Science Research and Basic Science Research (appointment to LKSKI and KRCBS)


Dr. Eno Hysi is the Canada Research Chair in Quantitative Ultrasound and Photoacoustic Imaging. He is also a Staff Scientist at the Keenan Research Centre for Biomedical Science at St. Michael’s Hospital and an Assistant Professor in the Department of Medical Biophysics at the University of Toronto. A biomedical physicist by training, Dr. Hysi received his PhD from the Department of Physics at the Toronto Metropolitan University, graduating with two Gold Medals in 2020. During his PhD studies, Dr. Hysi was funded by a NSERC Vanier Canada Graduate Scholarship and his research focused on the development of photoacoustic biomarkers of cancer treatment response. Following his doctoral training, Dr. Hysi was recruited to St. Michael’s Hospital’s Division of Nephrology as a CIHR Banting and a Kidney Foundation of Canada KRESCENT Fellow at. In collaboration with the Division of Urology, Dr. Hysi conducted the first-in-the-world clinical trial that explores how photoacoustic imaging innovations can be used to assess the quality of donated kidneys before transplant. This work was recognized with the 2021 John Charles Polanyi Prize in Physics. Dr. Hysi is the only simultaneous recipient of the prestigious Banting and KRESCENT Fellowships and a Polanyi Prize in the history of all three programs. To date, Dr. Hysi has accumulated over $2.4M in competitive research funding, as well as many accolades from the national and international research community.

The overarching goal of Dr. Hysi’s research program is the clinical translation of novel ultrasound and photoacoustic imaging by exploiting the biophysical interplay between acoustic and optical phenomena in tissues. He directs the Translational Ultrasound and Photoacoustic Imaging Laboratory (TUPIL) at the Keenan Research Centre and St. Michael’s Hospital. Working in close collaboration with clinicians across a diverse range of specialties, Dr. Hysi and his team aim to provide novel imaging solutions to address pressing clinical problem including the assessment of kidney transplant quality and fibrosis, lung injuries arising from acute respiratory distress syndrome, liver ischemic reperfusion injuries, and changes in diabetic microvasculature.

Dr. Hysi is currently recruiting Research Assistants, Co-op Students, and Graduate Students.


Recent Publications

  1. Hysi, E, Kaur, H, Young, A. Evolving Medical Imaging Techniques for the Assessment of Delayed Graft Function: A Narrative Review. Can J Kidney Health Dis. 2021;8 :20543581211048341. doi: 10.1177/20543581211048341. PubMed PMID:34707880 PubMed Central PMC8544764.
  2. Wang, Y, Fadhel, MN, Hysi, E, Pastenak, M, Sathiyamoorthy, K, Kolios, MC et al.. In vivo spectroscopic photoacoustic imaging and laser-induced nanoparticle vaporization for anti-HER2 breast cancer. J Biophotonics. 2021;14 (10):e202100099. doi: 10.1002/jbio.202100099. PubMed PMID:34241969 .
  3. Bok, T, Hysi, E, Kolios, MC. In vivo photoacoustic assessment of the oxygen saturation changes in the human radial artery: a preliminary study associated with age. J Biomed Opt. 2021;26 (3):. doi: 10.1117/1.JBO.26.3.036006. PubMed PMID:33754541 PubMed Central PMC7984962.
  4. Hysi, E, Yuen, DA. Imaging of renal fibrosis. Curr Opin Nephrol Hypertens. 2020;29 (6):599-607. doi: 10.1097/MNH.0000000000000650. PubMed PMID:33009130 .
  5. Fadhel, MN, Appak Baskoy, S, Wang, Y, Hysi, E, Kolios, MC. Use of photoacoustic imaging for monitoring vascular disrupting cancer treatments. J Biophotonics. 2023;16 (4):e202000209. doi: 10.1002/jbio.202000209. PubMed PMID:32888381 .
  6. Hysi, E, Fadhel, MN, Wang, Y, Sebastian, JA, Giles, A, Czarnota, GJ et al.. Photoacoustic imaging biomarkers for monitoring biophysical changes during nanobubble-mediated radiation treatment. Photoacoustics. 2020;20 :100201. doi: 10.1016/j.pacs.2020.100201. PubMed PMID:32775198 PubMed Central PMC7393572.
  7. Fadhel, MN, Hysi, E, Assi, H, Kolios, MC. Fluence-matching technique using photoacoustic radiofrequency spectra for improving estimates of oxygen saturation. Photoacoustics. 2020;19 :100182. doi: 10.1016/j.pacs.2020.100182. PubMed PMID:32547922 PubMed Central PMC7284135.
  8. Hysi, E, He, X, Fadhel, MN, Zhang, T, Krizova, A, Ordon, M et al.. Photoacoustic imaging of kidney fibrosis for assessing pretransplant organ quality. JCI Insight. 2020;5 (10):. doi: 10.1172/jci.insight.136995. PubMed PMID:32298239 PubMed Central PMC7259526.
  9. Alnazer, I, Falou, O, Nasr, R, Azar, D, Hysi, E, Wirtzfeld, L et al.. Quantitative Ultrasound Imaging for the Differentiation between Fresh and Decellularized Mouse Kidneys. Annu Int Conf IEEE Eng Med Biol Soc. 2019;2019 :6624-6627. doi: 10.1109/EMBC.2019.8856518. PubMed PMID:31947360 .
  10. Nasr, R, Falou, O, Shahin, A, Hysi, E, Wirtzfeld, LA, Berndl, ESL et al.. Mean Scatterer Spacing Estimation Using Cepstrum-Based Continuous Wavelet Transform. IEEE Trans Ultrason Ferroelectr Freq Control. 2020;67 (6):1118-1126. doi: 10.1109/TUFFC.2020.2963955. PubMed PMID:31905136 .
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Affiliations & Other Activities

  • Assistant Professor, Department of Medical Biophysics, Temerty Faculty of Medicine, University of Toronto
  • Adjunct Professor, Department of Physics, Toronto Metropolitan University
  • Biomedical Imaging & Therapy Theme Co-Lead, Institute for Biomedical Engineering, Science and Technology (iBEST), a partnership between Toronto Metropolitan University and St. Michael’s Hospital, Unity Health Toronto