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Gerard Curley

MB, PhD, MSc

Affiliate Scientist

Email: Gerard.Curley@unityhealth.to
Tel: 416-864-6060 Ext. 5071

Research Programs

Biography

Research Interests

Mesenchymal stem/stromal cell therapy for sepsis and Acute Respiratory Distress Syndrome, macrophage biology, ex-vivo lung perfusion, carbon dioxide and critical illness, systematic review/meta-analysis of interventions in anesthesia and intensive care

Selected Research

1. Curley GF, Ansari B, Hayes M, Devaney J, O’Toole D, O’Brien T, Laffey JG. Effects of intra-tracheal Mesenchymal Stem Cells therapy during recovery and resolution following Ventilator Induced Lung Injury. Anesthesiology 2013 Apr;118(4):924-932

2. Curley GF, Hayes M, Ansari B, Shaw G, Ryan A, Barry F, O’Brien T, O’Toole D, Laffey JG. Mesenchymal stem cells enhance recovery and repair following ventilator-induced lung injury in the rat. Thorax. 2012 Jun;67(6):496-501

3. Curley G, Contreras M, O’Toole B, Higgins B, O’Kane C, McAuley D, Laffey JG. Evolution of the inflammatory and fibroproliferative responses during resolution and repair following Ventilator Induced Lung Injury. Anesthesiology 2011 Nov;115(5):1022-32

4. Curley G, Kavanagh BP, Laffey JG. Hypocapnia and the injured brain: More harm than benefit. Crit Care Med. 2010 May;38(5):1348-59.2010 Mar 11

5. Curley GF, Laffey JG, Kavanagh BP. Point-Counterpoint Series: There IS added benefit to providing permissive hypercapnia in the treatment of ARDS. Journal of Physiology, Jun 1;591(Pt 11):2763-5

Recent Publications

  1. REMAP-CAP Investigators, Hills, TE, Lorenzi, E, Berry, LR, Shyamsundar, M, Al-Beidh, F et al.. Simvastatin in Critically Ill Patients with Covid-19. N Engl J Med. 2023;389 (25):2341-2354. doi: 10.1056/NEJMoa2309995. PubMed PMID:37888913 PubMed Central PMC10755839.
  2. LOVIT-COVID Investigators, on behalf of the Canadian Critical Care Trials Group, and the REMAP-CAP Investigators, Adhikari, NKJ, Hashmi, M, Tirupakuzhi Vijayaraghavan, BK, Haniffa, R, Beane, A et al.. Intravenous Vitamin C for Patients Hospitalized With COVID-19: Two Harmonized Randomized Clinical Trials. JAMA. 2023;330 (18):1745-1759. doi: 10.1001/jama.2023.21407. PubMed PMID:37877585 PubMed Central PMC10600726.
  3. Writing Committee for the REMAP-CAP Investigators, Lawler, PR, Derde, LPG, van de Veerdonk, FL, McVerry, BJ, Huang, DT et al.. Effect of Angiotensin-Converting Enzyme Inhibitor and Angiotensin Receptor Blocker Initiation on Organ Support-Free Days in Patients Hospitalized With COVID-19: A Randomized Clinical Trial. JAMA. 2023;329 (14):1183-1196. doi: 10.1001/jama.2023.4480. PubMed PMID:37039790 PubMed Central PMC10326520.
  4. Kartsonaki, C, Baillie, JK, Barrio, NG, Baruch, J, Beane, A, Blumberg, L et al.. Characteristics and outcomes of an international cohort of 600 000 hospitalized patients with COVID-19. Int J Epidemiol. 2023;52 (2):355-376. doi: 10.1093/ije/dyad012. PubMed PMID:36850054 PubMed Central PMC10114094.
  5. Amado-Rodríguez, L, Rodríguez-Garcia, R, Bellani, G, Pham, T, Fan, E, Madotto, F et al.. Mechanical ventilation in patients with cardiogenic pulmonary edema: a sub-analysis of the LUNG SAFE study. J Intensive Care. 2022;10 (1):55. doi: 10.1186/s40560-022-00648-x. PubMed PMID:36567347 PubMed Central PMC9791731.
  6. Writing Committee for the REMAP-CAP Investigators, Higgins, AM, Berry, LR, Lorenzi, E, Murthy, S, McQuilten, Z et al.. Long-term (180-Day) Outcomes in Critically Ill Patients With COVID-19 in the REMAP-CAP Randomized Clinical Trial. JAMA. 2023;329 (1):39-51. doi: 10.1001/jama.2022.23257. PubMed PMID:36525245 PubMed Central PMC9857594.
  7. ISARIC Clinical Characterization Group, Garcia-Gallo, E, Merson, L, Kennon, K, Kelly, S, Citarella, BW et al.. ISARIC-COVID-19 dataset: A Prospective, Standardized, Global Dataset of Patients Hospitalized with COVID-19. Sci Data. 2022;9 (1):454. doi: 10.1038/s41597-022-01534-9. PubMed PMID:35908040 PubMed Central PMC9339000.
  8. REMAP-CAP Writing Committee for the REMAP-CAP Investigators, Bradbury, CA, Lawler, PR, Stanworth, SJ, McVerry, BJ, McQuilten, Z et al.. Effect of Antiplatelet Therapy on Survival and Organ Support-Free Days in Critically Ill Patients With COVID-19: A Randomized Clinical Trial. JAMA. 2022;327 (13):1247-1259. doi: 10.1001/jama.2022.2910. PubMed PMID:35315874 PubMed Central PMC8941448.
  9. Maddali, MV, Churpek, M, Pham, T, Rezoagli, E, Zhuo, H, Zhao, W et al.. Validation and utility of ARDS subphenotypes identified by machine-learning models using clinical data: an observational, multicohort, retrospective analysis. Lancet Respir Med. 2022;10 (4):367-377. doi: 10.1016/S2213-2600(21)00461-6. PubMed PMID:35026177 PubMed Central PMC8976729.
  10. Pisani, L, Algera, AG, Neto, AS, Azevedo, L, Pham, T, Paulus, F et al.. Geoeconomic variations in epidemiology, ventilation management, and outcomes in invasively ventilated intensive care unit patients without acute respiratory distress syndrome: a pooled analysis of four observational studies. Lancet Glob Health. 2022;10 (2):e227-e235. doi: 10.1016/S2214-109X(21)00485-X. PubMed PMID:34914899 PubMed Central PMC8766316.
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Affiliations & Other Activities

  • Associate Professor, Department of Anesthesia, University of Toronto