Dr. Haibo Zhang is a Staff Scientist in the Keenan Research Centre for Biomedical Science of St. Michael’s Hospital. He is a Professor of Anesthesia, Medicine and Physiology at the University of Toronto. His translational research program focuses on the mechanisms and therapy of acute lung injury and sepsis. He has published over 250 peer-reviewed articles, and is the recipient of enormous research grants and a number of research awards, including Premier’s Research Excellence Award (Ontario), a New Investigator Award from the Canadian Institutes of Health Research (CIHR), and Fellow of Canadian Academy of Health Science. He serves on a number of academic and appointment committees at the Institute of Medical Sciences (IMS), University of Toronto and at St. Michael’s Hospital. He has trained over 90 MSc and PhD students, and post-doctoral fellows.

He has served on the Standing Committee of Critical Care Assembly, the American Thoracic Society in 2005-2006, Associate Editor, Intensive Care Medicine in 2007-2013, and Editorial Boards on a number of medical journals. He was a member of grant and award committees of CIHR since 2012 and is a member of College of Reviewer since 2016, a guest grant reviewer for European nations (Austria, Belgium, Germany, Holland, Israel, UK and Italy) since 2010. He is Theme Lead of Biomaterial, Tissue Injury and Repair at the Institute of Biomedical Engineering, Science and Technology (iBEST), a partnership between Ryerson University and St. Michael’s Hospital since 2017.

Recent Publications

  1. Li, J, Karakas, D, Xue, F, Chen, Y, Zhu, G, Yucel, YH et al.. Desialylated Platelet Clearance in the Liver is a Novel Mechanism of Systemic Immunosuppression. Research (Wash D C). 2023;6 :0236. doi: 10.34133/research.0236. PubMed PMID:37808178 PubMed Central PMC10551749.
  2. Xu, Y, Zhang, Y, Zhang, J, Liang, W, Wang, Y, Zeng, Z et al.. High driving pressure ventilation induces pulmonary hypertension in a rabbit model of acute lung injury. J Intensive Care. 2023;11 (1):42. doi: 10.1186/s40560-023-00689-w. PubMed PMID:37749622 PubMed Central PMC10518953.
  3. Abbott, M, Li, Y, Brochard, L, Zhang, H. Precision Medicine Using Simultaneous Monitoring and Assessment with Imaging and Biomarkers to Manage Mechanical Ventilation in ARDS. Intensive Care Res. 2023;3 (3):195-203. doi: 10.1007/s44231-023-00045-4. PubMed PMID:37664686 PubMed Central PMC10471647.
  4. Jin, F, Li, Y, Gao, X, Yang, X, Li, T, Liu, S et al.. Exercise training inhibits macrophage-derived IL-17A-CXCL5-CXCR2 inflammatory axis to attenuate pulmonary fibrosis in mice exposed to silica. Sci Total Environ. 2023;902 :166443. doi: 10.1016/j.scitotenv.2023.166443. PubMed PMID:37611700 .
  5. Onodera, Y, Liang, J, Li, Y, Griffin, B, Thanabalasingam, T, Lu, C et al.. Inhalation of ACE2 as a therapeutic target on sex-bias differences in SARS-CoV-2 infection and variant of concern. iScience. 2023;26 (8):107470. doi: 10.1016/j.isci.2023.107470. PubMed PMID:37609639 PubMed Central PMC10440513.
  6. McColman, S, Shkalla, K, Sidhu, P, Liang, J, Osman, S, Kovacs, N et al.. SARS-CoV-2 virus-like-particles via liposomal reconstitution of spike glycoproteins. Nanoscale Adv. 2023;5 (16):4167-4181. doi: 10.1039/d3na00190c. PubMed PMID:37560413 PubMed Central PMC10408587.
  7. Stone, GW, Ali, ZA, O'Brien, SM, Rhodes, G, Genereux, P, Bangalore, S et al.. Impact of Complete Revascularization in the ISCHEMIA Trial. J Am Coll Cardiol. 2023;82 (12):1175-1188. doi: 10.1016/j.jacc.2023.06.015. PubMed PMID:37462593 PubMed Central PMC10529674.
  8. Zhang, H, Slutsky, AS. Enhancing the Efficacy of Mesenchymal Stromal Cells in COVID-19-related Acute Respiratory Distress Syndrome. Am J Respir Crit Care Med. 2023;208 (3):222-224. doi: 10.1164/rccm.202306-0969ED. PubMed PMID:37321255 PubMed Central PMC10395721.
  9. Ma, X, Liang, J, Zhu, G, Bhoria, P, Shoara, AA, MacKeigan, DT et al.. SARS-CoV-2 RBD and Its Variants Can Induce Platelet Activation and Clearance: Implications for Antibody Therapy and Vaccinations against COVID-19. Research (Wash D C). 2023;6 :0124. doi: 10.34133/research.0124. PubMed PMID:37223472 PubMed Central PMC10202384.
  10. Jerkic, M, Szaszi, K, Laffey, JG, Rotstein, O, Zhang, H. Key Role of Mesenchymal Stromal Cell Interaction with Macrophages in Promoting Repair of Lung Injury. Int J Mol Sci. 2023;24 (4):. doi: 10.3390/ijms24043376. PubMed PMID:36834784 PubMed Central PMC9965074.
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Affiliations & Other Activities

  • Professor, Department of Anesthesia, University of Toronto
  • Professor, Department of Medicine, University of Toronto
  • Professor, Department of Physiology, University of Toronto
  • Faculty Member, Institute of Medical Sciences, School of Graduate Studies, University of Toronto