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Howard Leong-Poi

MD, FRCPC, FACC, FASE

Scientist

Email: Howard.Leong-Poi@unityhealth.to
Tel: 416-864-5201

Research Programs

Biography

Dr. Howard Leong-Poi is a Clinician Scientist in the Keenan Research Centre for Biomedical Science and Head of the Division of Cardiology at St. Michael’s Hospital. He is also an Associate Professor of Medicine at the University of Toronto. He is the current incumbent of the Brazilian Ball Chair in Cardiology at St. Michael’s Hospital. His research has been funded by the Canadian Institutes for Health Research (CIHR), Heart and Stroke Foundation of Canada (HSFC) and the Canadian Foundation for Innovation. He has held personnel support from the CIHR (New Investigator), HSFC (Clinician Scientist – Phase II Award) and the Ministry of Research and Innovation (Early Researcher Award). He has published over 100 articles in peer-reviewed journals, and serves on the editorial board of the Canadian Journal of Cardiology. Dr. Leong-Poi has served on numerous grant review panels, including the Canadian Institutes of Health Research (CIHR) Cardiovascular B (CSB) – Chair 2012-2015, and Heart & Stroke Foundation of Canada (Committees I and II). His basic biomedical research focuses on ultrasound-targeted gene- and cell-based therapies for cardiovascular disease and cancer. His clinical research interests revolve around cardiac imaging, predominantly echocardiography, in ischemic heart disease, heart failure and valvular heart disease.

Recent Publications

  1. Rumman, RK, Verma, S, Chan, V, Mazer, D, Quan, A, Hibino, M et al.. Predictors of mitral valve haemodynamics after mitral valve repair for degenerative mitral regurgitation. Heart. 2023; :. doi: 10.1136/heartjnl-2022-321753. PubMed PMID:36750353 .
  2. Mauro, AN, Turgeon, PJ, Gupta, S, Brand-Arzamendi, K, Chen, H, Malone, JH et al.. Automated in vivo compound screening with zebrafish and the discovery and validation of PD 81,723 as a novel angiogenesis inhibitor. Sci Rep. 2022;12 (1):14537. doi: 10.1038/s41598-022-18230-8. PubMed PMID:36008455 PubMed Central PMC9411172.
  3. Hibino, M, Pandey, AK, Chan, V, Mazer, CD, Rumman, R, Dhingra, NK et al.. Risk Factors for Postrepair Elevated Mitral Gradient: A Post-hoc Analysis of a Randomized Trial. Ann Thorac Surg. 2023;115 (2):437-443. doi: 10.1016/j.athoracsur.2022.05.053. PubMed PMID:35779599 .
  4. Hibino, M, Dhingra, NK, Chan, V, Mazer, CD, Teoh, H, Quan, A et al.. Stage-based approach to predict left ventricular reverse remodeling after mitral repair. Clin Cardiol. 2022;45 (9):921-927. doi: 10.1002/clc.23879. PubMed PMID:35748086 PubMed Central PMC9451668.
  5. Cosyns, B, Helfen, A, Leong-Poi, H, Senior, R. How to perform an ultrasound contrast myocardial perfusion examination?. Eur Heart J Cardiovasc Imaging. 2022;23 (6):727-729. doi: 10.1093/ehjci/jeac028. PubMed PMID:35213705 .
  6. Hibino, M, Pandey, A, Chan, V, Mazer, CD, Dhingra, NK, Bonneau, C et al.. Leaflet Resection vs Preservation for Degenerative Mitral Regurgitation: Functional Outcomes and Mitral Stenosis at 12 Months in a Randomized Trial. Can J Cardiol. 2022;38 (6):808-814. doi: 10.1016/j.cjca.2022.01.013. PubMed PMID:35074417 .
  7. Hibino, M, Dhingra, NK, Verma, S, Chan, V, Quan, A, Gregory, AJ et al.. Mitral repair with leaflet preservation versus leaflet resection and ventricular reverse remodeling from a randomized trial. J Thorac Cardiovasc Surg. 2021; :. doi: 10.1016/j.jtcvs.2021.08.081. PubMed PMID:34702564 .
  8. Meagher, P, Civitarese, R, Lee, X, Gordon, M, Bugyei-Twum, A, Desjardins, JF et al.. The Goto Kakizaki rat: Impact of age upon changes in cardiac and renal structure, function. PLoS One. 2021;16 (6):e0252711. doi: 10.1371/journal.pone.0252711. PubMed PMID:34166385 PubMed Central PMC8224913.
  9. Roifman, I, Arora, RC, Bewick, D, Chow, CM, Clarke, B, Cowan, S et al.. Cardiovascular Care Delivery During the Second Wave of COVID-19 in Canada. Can J Cardiol. 2021;37 (5):790-793. doi: 10.1016/j.cjca.2020.11.016. PubMed PMID:33307163 PubMed Central PMC7836859.
  10. Sanfilippo, AJ, Kolos, A, Chan, K, Leong-Poi, H, Sasson, Z, Wald, R et al.. Impact of a Mandated Accreditation Process on 1,045 Registered Echocardiographic Service Providers in a Previously Unregulated, Publicly Funded Environment. J Am Soc Echocardiogr. 2021;34 (3):308-315. doi: 10.1016/j.echo.2020.09.018. PubMed PMID:33191003 .
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Affiliations & Other Activities

  • Chair, The Brazilian Ball Chair in Cardiology Research, St. Michael’s Hospital
  • Head, Division of Cardiology, St. Michael’s Hospital
  • Associate Professor of Medicine, Medicine/Cardiology, St. Michael’s Hospital
  • Adjunct Scientist, Ryerson University