Jan O. Friedrich

MD, PhD, MSc



I have an interest in clinical epidemiologic techniques to evaluate the effectiveness of therapies in critical care. Current areas of interest include use and development of meta-analytic techniques, evaluation of treatments to treat acute lung injury, septic shock, and acute renal failure in intensive care unit patients.

Please note: Dr. Friedrich is not taking any summer students.

Recent Publications

  1. Zampieri, FG, da Costa, BR, Vaara, ST, Lamontagne, F, Rochwerg, B, Nichol, AD et al.. A Bayesian reanalysis of the Standard versus Accelerated Initiation of Renal-Replacement Therapy in Acute Kidney Injury (STARRT-AKI) trial. Crit Care. 2022;26 (1):255. doi: 10.1186/s13054-022-04120-y. PubMed PMID:36008827 PubMed Central PMC9404618.
  2. Ribeiro, RVP, Lee, J, Elbatarny, M, Friedrich, JO, Singh, S, Yau, T et al.. Left ventricular assist device implantation via lateral thoracotomy: A systematic review and meta-analysis. J Heart Lung Transplant. 2022;41 (10):1440-1458. doi: 10.1016/j.healun.2022.07.006. PubMed PMID:35953353 .
  3. Tam, DY, Friedrich, JO, Arora, RC, Yanagawa, B. Frequentist or Bayesian: Coronary artery bypass grafting offers advantages over percutaneous coronary intervention in left main coronary disease. J Thorac Cardiovasc Surg. 2022; :. doi: 10.1016/j.jtcvs.2022.04.045. PubMed PMID:35715275 .
  4. Angriman, F, Ferreyro, BL, Angeloni, N, da Costa, BR, Wald, R, Bagshaw, SM et al.. The Effect of an Accelerated Renal Replacement Therapy Initiation Is Not Modified by Baseline Risk. Ann Am Thorac Soc. 2022;19 (9):1613-1618. doi: 10.1513/AnnalsATS.202201-046RL. PubMed PMID:35587363 .
  5. Burns, KEA, Laird, M, Stevenson, J, Honarmand, K, Granton, D, Kho, ME et al.. Adherence of Clinical Practice Guidelines for Pharmacologic Treatments of Hospitalized Patients With COVID-19 to Trustworthy Standards: A Systematic Review. JAMA Netw Open. 2021;4 (12):e2136263. doi: 10.1001/jamanetworkopen.2021.36263. PubMed PMID:34889948 PubMed Central PMC8665373.
  6. Burns, KEA, Stevenson, J, Laird, M, Adhikari, NKJ, Li, Y, Lu, C et al.. Non-invasive ventilation versus invasive weaning in critically ill adults: a systematic review and meta-analysis. Thorax. 2022;77 (8):752-761. doi: 10.1136/thoraxjnl-2021-216993. PubMed PMID:34716282 .
  7. Schreiber, AF, Garlasco, J, Vieira, F, Lau, YH, Stavi, D, Lightfoot, D et al.. Separation from mechanical ventilation and survival after spinal cord injury: a systematic review and meta-analysis. Ann Intensive Care. 2021;11 (1):149. doi: 10.1186/s13613-021-00938-x. PubMed PMID:34693485 PubMed Central PMC8542415.
  8. Johnstone, J, Meade, M, Lauzier, F, Marshall, J, Duan, E, Dionne, J et al.. Effect of Probiotics on Incident Ventilator-Associated Pneumonia in Critically Ill Patients: A Randomized Clinical Trial. JAMA. 2021;326 (11):1024-1033. doi: 10.1001/jama.2021.13355. PubMed PMID:34546300 PubMed Central PMC8456390.
  9. Mehta, S, Zhou, Q, Pinto, R, Friedrich, JO, Lamontagne, F, Ferguson, ND et al.. Utilization and effect of neuromuscular blockade in a randomized trial of high-frequency oscillation. J Crit Care. 2021;66 :86-92. doi: 10.1016/j.jcrc.2021.08.006. PubMed PMID:34474282 .
  10. Trivedi, V, Chaudhuri, D, Jinah, R, Piticaru, J, Agarwal, A, Liu, K et al.. The Usefulness of the Rapid Shallow Breathing Index in Predicting Successful Extubation: A Systematic Review and Meta-analysis. Chest. 2022;161 (1):97-111. doi: 10.1016/j.chest.2021.06.030. PubMed PMID:34181953 .
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Affiliations & Other Activities

  • Medical Director, Medical-Surgical Intensive Care Unit (MSICU), Critical Care and Medicine Departments, St. Michael’s Hospital
  • Associate Professor, Medicine and Interdepartmental Division of Critical Care, University of Toronto