Jan O. Friedrich

MD, PhD, MSc



I have an interest in clinical epidemiologic techniques to evaluate the effectiveness of therapies in critical care. Current areas of interest include use and development of meta-analytic techniques, evaluation of treatments to treat acute lung injury, septic shock, and acute renal failure in intensive care unit patients.

Please note: Dr. Friedrich is not taking any summer students.

Recent Publications

  1. Friedrich, JO, Harhay, MO, Angus, DC, Burns, KEA, Cook, DJ, Fergusson, DA et al.. Mortality As a Measure of Treatment Effect in Clinical Trials Recruiting Critically Ill Patients. Crit Care Med. 2023;51 (2):222-230. doi: 10.1097/CCM.0000000000005721. PubMed PMID:36661450 .
  2. Bodley, T, Levi, O, Chan, M, Friedrich, JO, Hicks, LK. Reducing unnecessary diagnostic phlebotomy in intensive care: a prospective quality improvement intervention. BMJ Qual Saf. 2023; :. doi: 10.1136/bmjqs-2022-015358. PubMed PMID:36657786 .
  3. Bagshaw, SM, Neto, AS, Smith, O, Weir, M, Qiu, H, Du, B et al.. Impact of renal-replacement therapy strategies on outcomes for patients with chronic kidney disease: a secondary analysis of the STARRT-AKI trial. Intensive Care Med. 2022;48 (12):1736-1750. doi: 10.1007/s00134-022-06912-w. PubMed PMID:36331570 .
  4. Mehta, S, Brondani, A, Tomlinson, G, Chu, L, Burns, S, Matte, A et al.. Association Between Tracheostomy and Functional, Neuropsychological, and Healthcare Utilization Outcomes in the RECOVER Cohort. Crit Care Explor. 2022;4 (10):e0768. doi: 10.1097/CCE.0000000000000768. PubMed PMID:36248317 PubMed Central PMC9553381.
  5. Zampieri, FG, da Costa, BR, Vaara, ST, Lamontagne, F, Rochwerg, B, Nichol, AD et al.. A Bayesian reanalysis of the Standard versus Accelerated Initiation of Renal-Replacement Therapy in Acute Kidney Injury (STARRT-AKI) trial. Crit Care. 2022;26 (1):255. doi: 10.1186/s13054-022-04120-y. PubMed PMID:36008827 PubMed Central PMC9404618.
  6. Ribeiro, RVP, Lee, J, Elbatarny, M, Friedrich, JO, Singh, S, Yau, T et al.. Left ventricular assist device implantation via lateral thoracotomy: A systematic review and meta-analysis. J Heart Lung Transplant. 2022;41 (10):1440-1458. doi: 10.1016/j.healun.2022.07.006. PubMed PMID:35953353 .
  7. Tam, DY, Friedrich, JO, Arora, RC, Yanagawa, B. Frequentist or Bayesian: Coronary artery bypass grafting offers advantages over percutaneous coronary intervention in left main coronary disease. J Thorac Cardiovasc Surg. 2022; :. doi: 10.1016/j.jtcvs.2022.04.045. PubMed PMID:35715275 .
  8. Angriman, F, Ferreyro, BL, Angeloni, N, da Costa, BR, Wald, R, Bagshaw, SM et al.. The Effect of an Accelerated Renal Replacement Therapy Initiation Is Not Modified by Baseline Risk. Ann Am Thorac Soc. 2022;19 (9):1613-1618. doi: 10.1513/AnnalsATS.202201-046RL. PubMed PMID:35587363 .
  9. Burns, KEA, Laird, M, Stevenson, J, Honarmand, K, Granton, D, Kho, ME et al.. Adherence of Clinical Practice Guidelines for Pharmacologic Treatments of Hospitalized Patients With COVID-19 to Trustworthy Standards: A Systematic Review. JAMA Netw Open. 2021;4 (12):e2136263. doi: 10.1001/jamanetworkopen.2021.36263. PubMed PMID:34889948 PubMed Central PMC8665373.
  10. Burns, KEA, Stevenson, J, Laird, M, Adhikari, NKJ, Li, Y, Lu, C et al.. Non-invasive ventilation versus invasive weaning in critically ill adults: a systematic review and meta-analysis. Thorax. 2022;77 (8):752-761. doi: 10.1136/thoraxjnl-2021-216993. PubMed PMID:34716282 .
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Affiliations & Other Activities

  • Medical Director, Medical-Surgical Intensive Care Unit (MSICU), Critical Care and Medicine Departments, St. Michael’s Hospital
  • Associate Professor, Medicine and Interdepartmental Division of Critical Care, University of Toronto