Jan O. Friedrich

MD, PhD, MSc



I have an interest in clinical epidemiologic techniques to evaluate the effectiveness of therapies in critical care. Current areas of interest include use and development of meta-analytic techniques, evaluation of treatments to treat acute lung injury, septic shock, and acute renal failure in intensive care unit patients.

Please note: Dr. Friedrich is not taking any summer students.

Recent Publications

  1. Burns, KEA, Khan, J, Phoophiboon, V, Trivedi, V, Gomez-Builes, JC, Giammarioli, B et al.. Spontaneous Breathing Trial Techniques for Extubating Adults and Children Who Are Critically Ill: A Systematic Review and Meta-Analysis. JAMA Netw Open. 2024;7 (2):e2356794. doi: 10.1001/jamanetworkopen.2023.56794. PubMed PMID:38393729 PubMed Central PMC10891471.
  2. Vaara, ST, Serpa Neto, A, Bellomo, R, Adhikari, NKJ, Dreyfuss, D, Gallagher, M et al.. Regional Practice Variation and Outcomes in the Standard Versus Accelerated Initiation of Renal Replacement Therapy in Acute Kidney Injury (STARRT-AKI) Trial: A Post Hoc Secondary Analysis. Crit Care Explor. 2024;6 (2):e1053. doi: 10.1097/CCE.0000000000001053. PubMed PMID:38380940 PubMed Central PMC10878545.
  3. Carson, JL, Brooks, MM, Hébert, PC, Goodman, SG, Bertolet, M, Glynn, SA et al.. Restrictive or Liberal Transfusion Strategy in Myocardial Infarction and Anemia. N Engl J Med. 2023;389 (26):2446-2456. doi: 10.1056/NEJMoa2307983. PubMed PMID:37952133 PubMed Central PMC10837004.
  4. Wald, R, Gaudry, S, da Costa, BR, Adhikari, NKJ, Bellomo, R, Du, B et al.. Initiation of continuous renal replacement therapy versus intermittent hemodialysis in critically ill patients with severe acute kidney injury: a secondary analysis of STARRT-AKI trial. Intensive Care Med. 2023;49 (11):1305-1316. doi: 10.1007/s00134-023-07211-8. PubMed PMID:37815560 .
  5. Almonroeder, TG, Friedrich, JO, Hyoda, H, Grabowski, P, Jagim, A, Dobbs, W et al.. Inter-limb kinetic asymmetries during sit-to-stand performance persist following unilateral total knee arthroplasty: A systematic review and meta-analysis. Clin Biomech (Bristol, Avon). 2023;110 :106103. doi: 10.1016/j.clinbiomech.2023.106103. PubMed PMID:37774467 .
  6. Friedrich, JO, Gouvêa Bogossian, E. Hydrocortisone in Severe Community-Acquired Pneumonia. N Engl J Med. 2023;389 (7):670-671. doi: 10.1056/NEJMc2307400. PubMed PMID:37585638 .
  7. Verma, AA, Pou-Prom, C, McCoy, LG, Murray, J, Nestor, B, Bell, S et al.. Developing and Validating a Prediction Model For Death or Critical Illness in Hospitalized Adults, an Opportunity for Human-Computer Collaboration. Crit Care Explor. 2023;5 (5):e0897. doi: 10.1097/CCE.0000000000000897. PubMed PMID:37151895 PubMed Central PMC10155889.
  8. Bagshaw, SM, Neto, AS, Smith, O, Weir, M, Qiu, H, Du, B et al.. Correction: Impact of renal-replacement therapy strategies on outcomes for patients with chronic kidney disease: a secondary analysis of the STARRT-AKI trial. Intensive Care Med. 2023;49 (3):381-383. doi: 10.1007/s00134-023-06976-2. PubMed PMID:36757471 .
  9. Friedrich, JO, Harhay, MO, Angus, DC, Burns, KEA, Cook, DJ, Fergusson, DA et al.. Mortality As a Measure of Treatment Effect in Clinical Trials Recruiting Critically Ill Patients. Crit Care Med. 2023;51 (2):222-230. doi: 10.1097/CCM.0000000000005721. PubMed PMID:36661450 .
  10. Bodley, T, Levi, O, Chan, M, Friedrich, JO, Hicks, LK. Reducing unnecessary diagnostic phlebotomy in intensive care: a prospective quality improvement intervention. BMJ Qual Saf. 2023;32 (8):485-494. doi: 10.1136/bmjqs-2022-015358. PubMed PMID:36657786 .
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Affiliations & Other Activities

  • Medical Director, Medical-Surgical Intensive Care Unit (MSICU), Critical Care and Medicine Departments, St. Michael’s Hospital
  • Associate Professor, Medicine and Interdepartmental Division of Critical Care, University of Toronto