Jan O. Friedrich

MD, PhD, MSc



I have an interest in clinical epidemiologic techniques to evaluate the effectiveness of therapies in critical care. Current areas of interest include use and development of meta-analytic techniques, evaluation of treatments to treat acute lung injury, septic shock, and acute renal failure in intensive care unit patients.

Please note: Dr. Friedrich is not taking any summer students.

Recent Publications

  1. Burns, KEA, Sadeghirad, B, Ghadimi, M, Khan, J, Phoophiboon, V, Trivedi, V et al.. Comparative effectiveness of alternative spontaneous breathing trial techniques: a systematic review and network meta-analysis of randomized trials. Crit Care. 2024;28 (1):194. doi: 10.1186/s13054-024-04958-4. PubMed PMID:38849936 PubMed Central PMC11162018.
  2. Sud, S, Fan, E, Adhikari, NKJ, Friedrich, JO, Ferguson, ND, Combes, A et al.. Comparison of venovenous extracorporeal membrane oxygenation, prone position and supine mechanical ventilation for severely hypoxemic acute respiratory distress syndrome: a network meta-analysis. Intensive Care Med. 2024; :. doi: 10.1007/s00134-024-07492-7. PubMed PMID:38842731 .
  3. Tanaka, D, Vervoort, D, Mazine, A, Elfaki, L, Chung, JCY, Friedrich, JO et al.. Early and mid-term outcomes of aortic annular enlargement: a systematic review and meta-analysis. Ann Cardiothorac Surg. 2024;13 (3):187-205. doi: 10.21037/acs-2024-aae-0023. PubMed PMID:38841080 PubMed Central PMC11148750.
  4. Jackson, R, Kim, A, Moroz, N, Damiani, LF, Grieco, DL, Piraino, T et al.. Reverse triggering ? a novel or previously missed phenomenon?. Ann Intensive Care. 2024;14 (1):78. doi: 10.1186/s13613-024-01303-4. PubMed PMID:38776032 PubMed Central PMC11111438.
  5. Granton, D, Rodrigues, M, Raparelli, V, Honarmand, K, Agarwal, A, Friedrich, JO et al.. Sex and gender-based analysis and diversity metric reporting in acute care trials published in high-impact journals: a systematic review. BMJ Open. 2024;14 (5):e081118. doi: 10.1136/bmjopen-2023-081118. PubMed PMID:38719297 PubMed Central PMC11103199.
  6. Burns, KEA, Khan, J, Phoophiboon, V, Trivedi, V, Gomez-Builes, JC, Giammarioli, B et al.. Spontaneous Breathing Trial Techniques for Extubating Adults and Children Who Are Critically Ill: A Systematic Review and Meta-Analysis. JAMA Netw Open. 2024;7 (2):e2356794. doi: 10.1001/jamanetworkopen.2023.56794. PubMed PMID:38393729 PubMed Central PMC10891471.
  7. Vaara, ST, Serpa Neto, A, Bellomo, R, Adhikari, NKJ, Dreyfuss, D, Gallagher, M et al.. Regional Practice Variation and Outcomes in the Standard Versus Accelerated Initiation of Renal Replacement Therapy in Acute Kidney Injury (STARRT-AKI) Trial: A Post Hoc Secondary Analysis. Crit Care Explor. 2024;6 (2):e1053. doi: 10.1097/CCE.0000000000001053. PubMed PMID:38380940 PubMed Central PMC10878545.
  8. Carson, JL, Brooks, MM, Hébert, PC, Goodman, SG, Bertolet, M, Glynn, SA et al.. Restrictive or Liberal Transfusion Strategy in Myocardial Infarction and Anemia. N Engl J Med. 2023;389 (26):2446-2456. doi: 10.1056/NEJMoa2307983. PubMed PMID:37952133 PubMed Central PMC10837004.
  9. Wald, R, Gaudry, S, da Costa, BR, Adhikari, NKJ, Bellomo, R, Du, B et al.. Initiation of continuous renal replacement therapy versus intermittent hemodialysis in critically ill patients with severe acute kidney injury: a secondary analysis of STARRT-AKI trial. Intensive Care Med. 2023;49 (11):1305-1316. doi: 10.1007/s00134-023-07211-8. PubMed PMID:37815560 .
  10. Almonroeder, TG, Friedrich, JO, Hyoda, H, Grabowski, P, Jagim, A, Dobbs, W et al.. Inter-limb kinetic asymmetries during sit-to-stand performance persist following unilateral total knee arthroplasty: A systematic review and meta-analysis. Clin Biomech (Bristol, Avon). 2023;110 :106103. doi: 10.1016/j.clinbiomech.2023.106103. PubMed PMID:37774467 .
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Affiliations & Other Activities

  • Medical Director, Medical-Surgical Intensive Care Unit (MSICU), Critical Care and Medicine Departments, St. Michael’s Hospital
  • Associate Professor, Medicine and Interdepartmental Division of Critical Care, University of Toronto