Jane Batt

MD, PhD

Scientist

Biography

Dr. Jane Batt is a Respirologist and Scientist at St. Michael’s Hospital and Associate Professor of Medicine, University of Toronto. Her research focuses on delineating the molecular mechanisms underlying the development of skeletal muscle atrophy and dysfunction in chronic respiratory illness and acute injury. Examples of current projects in the lab include 1) MEND-ICU – a study of  the molecular mechanisms underpinning  Intensive Care Unit Acquired Weakness (ICUAW), a complication of critical care that results in lifelong disability due to sustained muscle wasting and contractile dysfunction 2) the development of “Smart Garments” (arm sleeves and leg stockings) that will automate the delivery of neuromuscular electrical stimulation (NMES) therapy to ICU patients using artificial intelligence/machine learning techniques, to prevent ICUAW and 3) applying ultrasound mediated gene delivery (UMGD) to promote the repair and regeneration of denervated muscle and sustain its receptivity to reinnervation.  Working in a rat model of tibial nerve transection, genes in minicircle plasmids coupled to carrier microbubbles are systemically administered, and directed to induce muscle specific transfection and temporary (6-8 week) gene expression by high-power ultrasound mediated microbubble destruction over the target tissue.

Dr Batt is also the Medical Director of the SMH Tuberculosis (TB) Clinic and in collaboration with other SMH scientists is developing a digital database of all patients seen in the TB clinic to enable collaborative clinical research projects. The database consists of variables (clinical, demographic, imaging, lab values, visits/admissions) that are derived from clinical dictations using natural language processing tools and electronic medical records, with digital dashboard navigation capabilities.

Dr. Batt’s research is consistently awarded peer-review funding including grants from the Canadian Institutes of Health Research (CIHR), OLA/Ontario Thoracic Society, New Frontiers in Research-Exploration and Physician Services Incorporation. She has served on several hospital and University of Toronto advisory committees and is Chair, Division of Respirology Research Advisory Committee (2014 – present).

Recent Publications

  1. Ahmed, W, Batt, J, Seemangal, J, Sabur, NF, Vozoris, NT. Interferon Gamma Release Assay Test Performance among Immunosuppressant Drug Recipients. Ann Am Thorac Soc. 2022; :. doi: 10.1513/AnnalsATS.202207-592RL. PubMed PMID:36442149 .
  2. Wu, K, Michalski, A, Sykes, J, Batt, J, Stephenson, AL, Mathur, S et al.. Comparison of quadriceps muscle size and quality in adults with cystic fibrosis with different severities of cystic fibrosis transmembrane conductance regulator protein dysfunction. Chron Respir Dis. 2022;19 :14799731221131330. doi: 10.1177/14799731221131330. PubMed PMID:36380568 PubMed Central PMC9669672.
  3. Waglechner, N, Tullis, E, Stephenson, AL, Waters, V, McIntosh, F, Ma, J et al.. Genomic epidemiology of Mycobacterium abscessus in a Canadian cystic fibrosis centre. Sci Rep. 2022;12 (1):16116. doi: 10.1038/s41598-022-19666-8. PubMed PMID:36167715 PubMed Central PMC9514693.
  4. Walsh, CJ, Batt, J, Herridge, MS, Mathur, S, Bader, GD, Hu, P et al.. Comprehensive multi-cohort transcriptional meta-analysis of muscle diseases identifies a signature of disease severity. Sci Rep. 2022;12 (1):11260. doi: 10.1038/s41598-022-15003-1. PubMed PMID:35789175 PubMed Central PMC9253003.
  5. Walsh, CJ, Escudero King, C, Gupta, M, Plant, PJ, Herridge, MJ, Mathur, S et al.. MicroRNA regulatory networks associated with abnormal muscle repair in survivors of critical illness. J Cachexia Sarcopenia Muscle. 2022;13 (2):1262-1276. doi: 10.1002/jcsm.12903. PubMed PMID:35092190 PubMed Central PMC8977950.
  6. Geric, C, Saroufim, M, Landsman, D, Richard, J, Benedetti, A, Batt, J et al.. Impact of COVID-19 on Tuberculosis Prevention and Treatment in Canada: A Multicenter Analysis of 10 833 Patients. J Infect Dis. 2022;225 (8):1317-1320. doi: 10.1093/infdis/jiab608. PubMed PMID:34919700 PubMed Central PMC8755327.
  7. Te, LJI, Doherty, C, Correa, J, Batt, J. Identification, Isolation, and Characterization of Fibro-Adipogenic Progenitors (FAPs) and Myogenic Progenitors (MPs) in Skeletal Muscle in the Rat. J Vis Exp. 2021; (172):. doi: 10.3791/61750. PubMed PMID:34180887 .
  8. Landsman, D, Abdelbasit, A, Wang, C, Guerzhoy, M, Joshi, U, Mathew, S et al.. Cohort profile: St. Michael's Hospital Tuberculosis Database (SMH-TB), a retrospective cohort of electronic health record data and variables extracted using natural language processing. PLoS One. 2021;16 (3):e0247872. doi: 10.1371/journal.pone.0247872. PubMed PMID:33657184 PubMed Central PMC7928444.
  9. Tran, A, Walsh, CJ, Batt, J, Dos Santos, CC, Hu, P. A machine learning-based clinical tool for diagnosing myopathy using multi-cohort microarray expression profiles. J Transl Med. 2020;18 (1):454. doi: 10.1186/s12967-020-02630-3. PubMed PMID:33256785 PubMed Central PMC7708151.
  10. Lad, H, Saumur, TM, Herridge, MS, Dos Santos, CC, Mathur, S, Batt, J et al.. Intensive Care Unit-Acquired Weakness: Not just Another Muscle Atrophying Condition. Int J Mol Sci. 2020;21 (21):. doi: 10.3390/ijms21217840. PubMed PMID:33105809 PubMed Central PMC7660068.
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Affiliations & Other Activities

  • Respirologist and Clinician Scientist, Division of Respirology, Department of Medicine, St. Michael’s Hospital
  • Medical Director, Tuberculosis Program, St. Michael’s Hospital
  • Associate Professor, Faculty of Medicine, University of Toronto
  • Cross appointed to the to the IDCCM