John J. Graham




Research Interests

Interventional cardiology, primary angioplasty, radial access Percutaneous Coronary Intervention (PCI), MRI assessment of PCI outcomes, renal denervation for resistant hypertension

Research Activities

Within interventional cardiology, my research interests include:

1. Chronically occluded coronary arteries (‘CTO’) and the potential benefits of percutaneously revascularising these;

2. Fibromuscular dysplasia – an increasingly recognized cause of myocardial infarction in (predominantly) young females

3. Renal Denervation therapy for resistant hypertension.

In all of these, my interests include the use of MRI to assess outcomes and response to therapy.

Recent Publications

  1. Siu, V, Parfrey, S, Li, C, Graham, JJ, Wijeysundera, HC, Bagai, A et al.. First In-Human Use of a Novel Perfusion Balloon Catheter in the Management of Coronary Perforation. Can J Cardiol. 2024; :. doi: 10.1016/j.cjca.2024.01.041. PubMed PMID:38378081 .
  2. Parfrey, S, Siu, V, Graham, JJ, Vijayaraghavan, R, Li, C, Pang, J et al.. Evaluation and management of drug-eluting stent in-stent restenosis. Curr Opin Cardiol. 2023;38 (5):433-440. doi: 10.1097/HCO.0000000000001073. PubMed PMID:37477129 .
  3. Graham, JJ, Bagai, A, Wijeysundera, H, Weisz, G, Rinfret, S, Dick, A et al.. Collagenase to facilitate guidewire crossing in chronic total occlusion PCI-The Total Occlusion Study in Coronary Arteries-5 (TOSCA-5) trial. Catheter Cardiovasc Interv. 2022;99 (4):1065-1073. doi: 10.1002/ccd.30101. PubMed PMID:35077606 .
  4. Aljabbary, T, Katyukha, A, Elbaz-Greener, G, Gressmann, K, Bagai, A, Graham, JJ et al.. Overview of Contemporary Chronic Total Occlusion Percutaneous Coronary Intervention Techniques: A Narrative Systematic Review. CJC Open. 2021;3 (10):1273-1281. doi: 10.1016/j.cjco.2021.05.018. PubMed PMID:34888507 PubMed Central PMC8636234.
  5. Burke, L, Graham, JJ. Percutaneous management of calcified coronary arteries - review of atherectomy and lithotripsy devices and why it is important. Curr Opin Cardiol. 2021;36 (5):630-636. doi: 10.1097/HCO.0000000000000871. PubMed PMID:33929366 .
  6. Boukhris, M, Potter, BJ, Fam, NP, Matteau, A, Graham, JJ, Gobeil, F et al.. Safety and Performance of the Orsiro Sirolimus-Eluting Stent in the Treatment of All-Comers Patient Population in Daily Clinical Practice. Cardiovasc Revasc Med. 2020;21 (11):1348-1354. doi: 10.1016/j.carrev.2020.04.021. PubMed PMID:32354583 .
  7. Gong, IY, Ong, G, Brezden-Masley, C, Dhir, V, Deva, DP, Chan, KKW et al.. Early diastolic strain rate measurements by cardiac MRI in breast cancer patients treated with trastuzumab: a longitudinal study. Int J Cardiovasc Imaging. 2019;35 (4):653-662. doi: 10.1007/s10554-018-1482-2. PubMed PMID:30390170 .
  8. Kotha, VK, Deva, DP, Connelly, KA, Freeman, MR, Yan, RT, Mangat, I et al.. Cardiac MRI and radionuclide ventriculography for measurement of left ventricular ejection fraction in ICD candidates. Magn Reson Imaging. 2018;52 :69-74. doi: 10.1016/j.mri.2018.05.012. PubMed PMID:29859946 .
  9. Shuvy, M, Qiu, F, Chee-A-Tow, A, Graham, JJ, Abuzeid, W, Buller, C et al.. Management of Chronic Total Coronary Occlusion in Stable Ischemic Heart Disease by Percutaneous Coronary Intervention Versus Coronary Artery Bypass Grafting Versus Medical Therapy. Am J Cardiol. 2017;120 (5):759-764. doi: 10.1016/j.amjcard.2017.05.061. PubMed PMID:28716335 .
  10. Ellis, SG, Burke, MN, Murad, MB, Graham, JJ, Badawi, R, Toma, C et al.. Predictors of Successful Hybrid-Approach Chronic Total Coronary Artery Occlusion Stenting: An Improved Model With Novel Correlates. JACC Cardiovasc Interv. 2017;10 (11):1089-1098. doi: 10.1016/j.jcin.2017.03.016. PubMed PMID:28595879 .
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Affiliations & Other Activities

  • Staff Cardiologist, Division of Cardiology, St. Michael’s Hospital
  • Assistant Professor, Faculty of Medicine, University of Toronto