John Marshall




Dr. John Marshall is a Professor of Surgery at the University of Toronto, and an Intensivist at St. Michael’s Hospital in Toronto, Canada.  His academic interests are sepsis, trauma, and the innate immune response.  His laboratory studies the cellular mechanisms that prolong neutrophil survival in critical illness by preventing neutrophil programmed cell death, or apoptosis.  Professor Marshall has an active clinical research interest in sepsis and Intensive Care Unit-acquired infection, and in the design of clinical trials and outcome measures.  He has published 440 manuscripts, and 85 book chapters, and is the editor of 2 books.  He is the founding chair of the International Forum of Acute Care Trialists (InFACT) – a global network of investigator-led critical care clinical research groups, and past Secretary-General of the World Federation of Societies of Intensive and Critical Care Medicine.  He co-chairs the WHO R&D Working Group on the Clinical Characterization and Management of COVID-19.  He is past-chair of the International Sepsis Forum, past-President of the Surgical Infection Society, and past-chair of the Canadian Critical Care Trials Group.  He has given invited lectures at more than 540 meetings around the world, and is an Associate Editor of the journals Critical Care Medicine and Critical care.”

Recent Publications

  1. Xue, M, Leibovitzh, H, Jingcheng, S, Neustaeter, A, Dong, M, Xu, W et al.. Environmental Factors Associated with Risk of Crohn's Disease Development in the CCC-GEM Project. Clin Gastroenterol Hepatol. 2024; :. doi: 10.1016/j.cgh.2024.03.049. PubMed PMID:38759825 .
  2. Dennis, B, Deane, A, Lauzier, F, Zytaruk, N, Hardie, M, Hammond, N et al.. Protocol implementation during the COVID-19 pandemic: experiences from a randomized trial of stress ulcer prophylaxis. BMC Med Res Methodol. 2024;24 (1):109. doi: 10.1186/s12874-024-02233-2. PubMed PMID:38704520 PubMed Central PMC11069460.
  3. Gordon, AC, Alipanah-Lechner, N, Bos, LD, Dianti, J, Diaz, JV, Finfer, S et al.. From ICU Syndromes to ICU Subphenotypes: Consensus Report and Recommendations For Developing Precision Medicine in ICU. Am J Respir Crit Care Med. 2024; :. doi: 10.1164/rccm.202311-2086SO. PubMed PMID:38687499 .
  4. Cook, D, Deane, A, Dionne, JC, Lauzier, F, Marshall, JC, Arabi, YM et al.. Adjudication of a primary trial outcome: Results of a calibration exercise and protocol for a large international trial. Contemp Clin Trials Commun. 2024;39 :101284. doi: 10.1016/j.conctc.2024.101284. PubMed PMID:38559746 PubMed Central PMC10979133.
  5. Chen, ZZ, Dufresne, J, Bowden, P, Miao, M, Marshall, JG. Extraction of naturally occurring peptides versus the tryptic digestion of proteins from fetal versus adult bovine serum for LC-ESI-MS/MS. Anal Biochem. 2024;689 :115497. doi: 10.1016/j.ab.2024.115497. PubMed PMID:38461948 .
  6. Vanstone, MG, Krewulak, K, Taneja, S, Swinton, M, Fiest, K, Burns, KEA et al.. Patient-important upper gastrointestinal bleeding in the ICU: A mixed-methods study of patient and family perspectives. J Crit Care. 2024;81 :154761. doi: 10.1016/j.jcrc.2024.154761. PubMed PMID:38447306 .
  7. Lee, CH, Banoei, MM, Ansari, M, Cheng, MP, Lamontagne, F, Griesdale, D et al.. Using a targeted metabolomics approach to explore differences in ARDS associated with COVID-19 compared to ARDS caused by H1N1 influenza and bacterial pneumonia. Crit Care. 2024;28 (1):63. doi: 10.1186/s13054-024-04843-0. PubMed PMID:38414082 PubMed Central PMC10900651.
  8. Shankar-Hari, M, Calandra, T, Soares, MP, Bauer, M, Wiersinga, WJ, Prescott, HC et al.. Reframing sepsis immunobiology for translation: towards informative subtyping and targeted immunomodulatory therapies. Lancet Respir Med. 2024;12 (4):323-336. doi: 10.1016/S2213-2600(23)00468-X. PubMed PMID:38408467 PubMed Central PMC11025021.
  9. Hum, C, Tahir, U, Mei, SHJ, Champagne, J, Fergusson, DA, Lalu, M et al.. Efficacy and Safety of Umbilical Cord-Derived Mesenchymal Stromal Cell Therapy in Preclinical Models of Sepsis: A Systematic Review and Meta-analysis. Stem Cells Transl Med. 2024;13 (4):346-361. doi: 10.1093/stcltm/szae003. PubMed PMID:38381583 PubMed Central PMC11016835.
  10. Yarnell, CJ, Saito, H, Marshall, JC. Understanding Heterogeneity in Acute Care Trials: Resource Availability Impacts Outcomes. Am J Respir Crit Care Med. 2024;209 (5):469-471. doi: 10.1164/rccm.202401-0232ED. PubMed PMID:38300151 PubMed Central PMC10919105.
Search PubMed

Affiliations & Other Activities

  • Scientist, Keenan Research Centre for Biomedical Science
  • Trauma Surgeon and Intensivist, St. Michael’s Hospital
  • Professor, Department of Surgery, University of Toronto