John Marshall

MD, FRCSC, FACS, FCAHS

Scientist

Biography

Dr. John Marshall is a Professor of Surgery at the University of Toronto, and an Intensivist at St. Michael’s Hospital in Toronto, Canada.  His academic interests are sepsis, trauma, and the innate immune response.  His laboratory studies the cellular mechanisms that prolong neutrophil survival in critical illness by preventing neutrophil programmed cell death, or apoptosis.  Professor Marshall has an active clinical research interest in sepsis and Intensive Care Unit-acquired infection, and in the design of clinical trials and outcome measures.  He has published 440 manuscripts, and 85 book chapters, and is the editor of 2 books.  He is the founding chair of the International Forum of Acute Care Trialists (InFACT) – a global network of investigator-led critical care clinical research groups, and past Secretary-General of the World Federation of Societies of Intensive and Critical Care Medicine.  He co-chairs the WHO R&D Working Group on the Clinical Characterization and Management of COVID-19.  He is past-chair of the International Sepsis Forum, past-President of the Surgical Infection Society, and past-chair of the Canadian Critical Care Trials Group.  He has given invited lectures at more than 540 meetings around the world, and is an Associate Editor of the journals Critical Care Medicine and Critical care.”

Recent Publications

  1. Gleave, A, Shah, A, Tahir, U, Blom, JJ, Dong, E, Patel, A et al.. Using Diet to Treat Inflammatory Bowel Disease: A Systematic Review. Am J Gastroenterol. 2024; :. doi: 10.14309/ajg.0000000000002973. PubMed PMID:39056556 .
  2. Krewulak, KD, Sheikh, F, Heirali, A, Marshall, JC, Burns, KEA, Kupsch, S et al.. Core socioDemographic data variables in ICU Trials (CoDe-IT): a protocol for generating core data variables using a Delphi consensus process. BMJ Open. 2024;14 (7):e082912. doi: 10.1136/bmjopen-2023-082912. PubMed PMID:39043595 PubMed Central PMC11268068.
  3. Andersen, CR, Presseau, J, Shea, B, Marti, ML, McCoy, M, Fernie, G et al.. What to Measure in Aneurysmal Subarachnoid Haemorrhage Research-An International Delphi Survey. Transl Stroke Res. 2024; :. doi: 10.1007/s12975-024-01271-8. PubMed PMID:38997598 .
  4. Kain, T, Dionne, JC, Marshall, JC. Critical illness and the gut microbiome. Intensive Care Med. 2024; :. doi: 10.1007/s00134-024-07513-5. PubMed PMID:38900282 .
  5. Lamontagne, F, Masse, MH, Yarnell, C, Camirand-Lemyre, F, Lévesque, S, Domingue, MP et al.. The response of Canada's clinical health research ecosystem to the COVID-19 pandemic. CMAJ. 2024;196 (23):E779-E788. doi: 10.1503/cmaj.230760. PubMed PMID:38885975 PubMed Central PMC11182674.
  6. Cook, D, Deane, A, Lauzier, F, Zytaruk, N, Guyatt, G, Saunders, L et al.. Stress Ulcer Prophylaxis during Invasive Mechanical Ventilation. N Engl J Med. 2024;391 (1):9-20. doi: 10.1056/NEJMoa2404245. PubMed PMID:38875111 .
  7. Turgeon, AF, Fergusson, DA, Clayton, L, Patton, MP, Neveu, X, Walsh, TS et al.. Liberal or Restrictive Transfusion Strategy in Patients with Traumatic Brain Injury. N Engl J Med. 2024; :. doi: 10.1056/NEJMoa2404360. PubMed PMID:38869931 .
  8. Xue, M, Leibovitzh, H, Jingcheng, S, Neustaeter, A, Dong, M, Xu, W et al.. Environmental Factors Associated with Risk of Crohn's Disease Development in the Crohn's and Colitis Canada - Genetic, Environmental, Microbial Project. Clin Gastroenterol Hepatol. 2024; :. doi: 10.1016/j.cgh.2024.03.049. PubMed PMID:38759825 .
  9. Dennis, B, Deane, A, Lauzier, F, Zytaruk, N, Hardie, M, Hammond, N et al.. Protocol implementation during the COVID-19 pandemic: experiences from a randomized trial of stress ulcer prophylaxis. BMC Med Res Methodol. 2024;24 (1):109. doi: 10.1186/s12874-024-02233-2. PubMed PMID:38704520 PubMed Central PMC11069460.
  10. Gordon, AC, Alipanah-Lechner, N, Bos, LD, Dianti, J, Diaz, JV, Finfer, S et al.. From ICU Syndromes to ICU Subphenotypes: Consensus Report and Recommendations for Developing Precision Medicine in the ICU. Am J Respir Crit Care Med. 2024;210 (2):155-166. doi: 10.1164/rccm.202311-2086SO. PubMed PMID:38687499 .
Search PubMed

Affiliations & Other Activities

  • Scientist, Keenan Research Centre for Biomedical Science
  • Trauma Surgeon and Intensivist, St. Michael’s Hospital
  • Professor, Department of Surgery, University of Toronto