John Marshall

MD, FRCSC, FACS, FCAHS

Scientist

Biography

Dr. John Marshall is a Professor of Surgery at the University of Toronto, and an Intensivist at St. Michael’s Hospital in Toronto, Canada.  His academic interests are sepsis, trauma, and the innate immune response.  His laboratory studies the cellular mechanisms that prolong neutrophil survival in critical illness by preventing neutrophil programmed cell death, or apoptosis.  Professor Marshall has an active clinical research interest in sepsis and Intensive Care Unit-acquired infection, and in the design of clinical trials and outcome measures.  He has published 440 manuscripts, and 85 book chapters, and is the editor of 2 books.  He is the founding chair of the International Forum of Acute Care Trialists (InFACT) – a global network of investigator-led critical care clinical research groups, and past Secretary-General of the World Federation of Societies of Intensive and Critical Care Medicine.  He co-chairs the WHO R&D Working Group on the Clinical Characterization and Management of COVID-19.  He is past-chair of the International Sepsis Forum, past-President of the Surgical Infection Society, and past-chair of the Canadian Critical Care Trials Group.  He has given invited lectures at more than 540 meetings around the world, and is an Associate Editor of the journals Critical Care Medicine and Critical care.”

Recent Publications

  1. McIntyre, LA, Fergusson, DA, McArdle, T, Fox-Robichaud, A, English, SW, Martin, C et al.. FLUID trial: a hospital-wide open-label cluster cross-over pragmatic comparative effectiveness randomised pilot trial comparing normal saline to Ringer's lactate. BMJ Open. 2023;13 (2):e067142. doi: 10.1136/bmjopen-2022-067142. PubMed PMID:36737087 .
  2. Dionne, JC, Johnstone, J, Heels-Ansdell, D, Duan, E, Lauzier, F, Arabi, YM et al.. Clostridioides difficile infection in mechanically ventilated critically ill patients: A nested cohort study. J Crit Care. 2023; :154254. doi: 10.1016/j.jcrc.2023.154254. PubMed PMID:36682909 .
  3. Friedrich, JO, Harhay, MO, Angus, DC, Burns, KEA, Cook, DJ, Fergusson, DA et al.. Mortality As a Measure of Treatment Effect in Clinical Trials Recruiting Critically Ill Patients. Crit Care Med. 2023;51 (2):222-230. doi: 10.1097/CCM.0000000000005721. PubMed PMID:36661450 .
  4. Writing Committee for the REMAP-CAP Investigators, Higgins, AM, Berry, LR, Lorenzi, E, Murthy, S, McQuilten, Z et al.. Long-term (180-Day) Outcomes in Critically Ill Patients With COVID-19 in the REMAP-CAP Randomized Clinical Trial. JAMA. 2023;329 (1):39-51. doi: 10.1001/jama.2022.23257. PubMed PMID:36525245 PubMed Central PMC9857594.
  5. Marshall, JC, Leligdowicz, A. Gaps and opportunities in sepsis translational research. EBioMedicine. 2022;86 :104387. doi: 10.1016/j.ebiom.2022.104387. PubMed PMID:36470831 PubMed Central PMC9783171.
  6. Lau, VI, Xie, F, Fowler, RA, Rochwerg, B, Johnstone, J, Lauzier, F et al.. Health economic evaluation alongside the Probiotics to Prevent Severe Pneumonia and Endotracheal Colonization Trial (E-PROSPECT): a cost-effectiveness analysis. Can J Anaesth. 2022;69 (12):1515-1526. doi: 10.1007/s12630-022-02335-9. PubMed PMID:36289153 .
  7. Turgeon, AF, Fergusson, DA, Clayton, L, Patton, MP, Zarychanski, R, English, S et al.. Haemoglobin transfusion threshold in traumatic brain injury optimisation (HEMOTION): a multicentre, randomised, clinical trial protocol. BMJ Open. 2022;12 (10):e067117. doi: 10.1136/bmjopen-2022-067117. PubMed PMID:36216432 PubMed Central PMC9557781.
  8. Vincent, JL, van der Poll, T, Marshall, JC. The End of "One Size Fits All" Sepsis Therapies: Toward an Individualized Approach. Biomedicines. 2022;10 (9):. doi: 10.3390/biomedicines10092260. PubMed PMID:36140361 PubMed Central PMC9496597.
  9. Reyes, LF, Murthy, S, Garcia-Gallo, E, Merson, L, Ibáñez-Prada, ED, Rello, J et al.. Respiratory support in patients with severe COVID-19 in the International Severe Acute Respiratory and Emerging Infection (ISARIC) COVID-19 study: a prospective, multinational, observational study. Crit Care. 2022;26 (1):276. doi: 10.1186/s13054-022-04155-1. PubMed PMID:36100904 PubMed Central PMC9469080.
  10. Mauro, AN, Turgeon, PJ, Gupta, S, Brand-Arzamendi, K, Chen, H, Malone, JH et al.. Automated in vivo compound screening with zebrafish and the discovery and validation of PD 81,723 as a novel angiogenesis inhibitor. Sci Rep. 2022;12 (1):14537. doi: 10.1038/s41598-022-18230-8. PubMed PMID:36008455 PubMed Central PMC9411172.
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Affiliations & Other Activities

  • Scientist, Keenan Research Centre for Biomedical Science
  • Trauma Surgeon and Intensivist, St. Michael’s Hospital
  • Professor, Department of Surgery, University of Toronto