John Marshall




Dr. John Marshall is a Professor of Surgery at the University of Toronto, and an Intensivist at St. Michael’s Hospital in Toronto, Canada.  His academic interests are sepsis, trauma, and the innate immune response.  His laboratory studies the cellular mechanisms that prolong neutrophil survival in critical illness by preventing neutrophil programmed cell death, or apoptosis.  Professor Marshall has an active clinical research interest in sepsis and Intensive Care Unit-acquired infection, and in the design of clinical trials and outcome measures.  He has published 440 manuscripts, and 85 book chapters, and is the editor of 2 books.  He is the founding chair of the International Forum of Acute Care Trialists (InFACT) – a global network of investigator-led critical care clinical research groups, and past Secretary-General of the World Federation of Societies of Intensive and Critical Care Medicine.  He co-chairs the WHO R&D Working Group on the Clinical Characterization and Management of COVID-19.  He is past-chair of the International Sepsis Forum, past-President of the Surgical Infection Society, and past-chair of the Canadian Critical Care Trials Group.  He has given invited lectures at more than 540 meetings around the world, and is an Associate Editor of the journals Critical Care Medicine and Critical care.”

Recent Publications

  1. Cook, DJ, Swinton, M, Krewulak, KD, Fiest, K, Dionne, J, Debigare, S et al.. What counts as patient-important upper gastrointestinal bleeding in the ICU? A mixed-methods study protocol of patient and family perspectives. BMJ Open. 2023;13 (5):e070966. doi: 10.1136/bmjopen-2022-070966. PubMed PMID:37208143 PubMed Central PMC10201253.
  2. O'Grady, HK, Bhimani, Z, Dalziel, S, Dolanjski, B, Sandhu, G, Santos, M et al.. Co-designing and pilot testing an infographic to support patients/families through the REMAP-CAP consent process: a mixed-methods study protocol. Pilot Feasibility Stud. 2023;9 (1):58. doi: 10.1186/s40814-023-01290-6. PubMed PMID:37055859 PubMed Central PMC10098229.
  3. Writing Committee for the REMAP-CAP Investigators, Lawler, PR, Derde, LPG, van de Veerdonk, FL, McVerry, BJ, Huang, DT et al.. Effect of Angiotensin-Converting Enzyme Inhibitor and Angiotensin Receptor Blocker Initiation on Organ Support-Free Days in Patients Hospitalized With COVID-19: A Randomized Clinical Trial. JAMA. 2023;329 (14):1183-1196. doi: 10.1001/jama.2023.4480. PubMed PMID:37039790 .
  4. Chen, ZZ, Johnson, L, Trahtemberg, U, Baker, A, Huq, S, Dufresne, J et al.. Mitochondria and cytochrome components released into the plasma of severe COVID-19 and ICU acute respiratory distress syndrome patients. Clin Proteomics. 2023;20 (1):17. doi: 10.1186/s12014-023-09394-0. PubMed PMID:37031181 PubMed Central PMC10082440.
  5. Wang, JF, Sun, BW, Marshall, JC. Editorial: Neutrophil death regulation in critical illness. Front Immunol. 2023;14 :1181056. doi: 10.3389/fimmu.2023.1181056. PubMed PMID:37006251 PubMed Central PMC10050726.
  6. Tsoporis, JN, Amatullah, H, Gupta, S, Izhar, S, Ektesabi, AM, Vaswani, CM et al.. DJ-1 Deficiency Protects against Sepsis-Induced Myocardial Depression. Antioxidants (Basel). 2023;12 (3):. doi: 10.3390/antiox12030561. PubMed PMID:36978809 PubMed Central PMC10045744.
  7. Piva, S, Pozzi, M, Bellani, G, Peli, E, Gitti, N, Lucchini, A et al.. Long-term physical impairments in survivors of COVID-19-associated ARDS compared with classic ARDS: A two-center study. J Crit Care. 2023;76 :154285. doi: 10.1016/j.jcrc.2023.154285. PubMed PMID:36889040 .
  8. Johnstone, J, Muscedere, J, Dionne, J, Duan, E, Rochwerg, B, Centofanti, J et al.. Definitions, rates and associated mortality of ICU-acquired pneumonia: A multicenter cohort study. J Crit Care. 2023;75 :154284. doi: 10.1016/j.jcrc.2023.154284. PubMed PMID:36870801 .
  9. McIntyre, LA, Fergusson, DA, McArdle, T, Fox-Robichaud, A, English, SW, Martin, C et al.. FLUID trial: a hospital-wide open-label cluster cross-over pragmatic comparative effectiveness randomised pilot trial comparing normal saline to Ringer's lactate. BMJ Open. 2023;13 (2):e067142. doi: 10.1136/bmjopen-2022-067142. PubMed PMID:36737087 PubMed Central PMC9900065.
  10. Dionne, JC, Johnstone, J, Heels-Ansdell, D, Duan, E, Lauzier, F, Arabi, YM et al.. Clostridioides difficile infection in mechanically ventilated critically ill patients: A nested cohort study. J Crit Care. 2023;75 :154254. doi: 10.1016/j.jcrc.2023.154254. PubMed PMID:36682909 .
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Affiliations & Other Activities

  • Scientist, Keenan Research Centre for Biomedical Science
  • Trauma Surgeon and Intensivist, St. Michael’s Hospital
  • Professor, Department of Surgery, University of Toronto