Jose Danilo Diestro


Investigator, Li Ka Shing Knowledge Institute


Dr. Jose Danilo B. Diestro is a vascular neurologist with subspecialty training in interventional neuroradiology working as a staff physician at St. Michael’s Hospital and an investigator at the Li Ka Shing Knowledge Institute. He holds the rank of Assistant Professor at the University of Toronto, Department of Medicine, Division of Neurology as a Clinician Investigator. He received academic training from the University of the Philippines (Doctor of Medicine, Adult Neurology Residency, Stroke Fellowship), University of Toronto and Université de Montréal (Interventional Neuroradiology Fellowships) and, McMaster University (Master of Science in Health Research Methodology- Clinical Epidemiology).

His clinical research is dedicated to three key areas: 1) exploring outcomes and decision-making in endovascular stroke treatment, 2) investigating innovative devices for aneurysm treatment, and 3) studying the long-term clinical consequences of subarachnoid hemorrhage. His overarching goal is to impact clinical practice by actively participating in and leading randomized controlled trials.

Recent Publications

  1. Boisseau, W, Benomar, A, Ducroux, C, Fahed, R, Smajda, S, Diestro, JDB et al.. The Management of Persistent Distal Occlusions after Mechanical Thrombectomy and Thrombolysis: An Inter- and Intrarater Agreement Study. AJNR Am J Neuroradiol. 2024; :. doi: 10.3174/ajnr.A8149. PubMed PMID:38388684 .
  2. Benomar, A, Diestro, JDB, Darabid, H, Saydy, K, Tzaneva, L, Li, J et al.. Nonaneurysmal perimesencephalic subarachnoid hemorrhage on noncontrast head CT: An accuracy, inter-rater, and intra-rater reliability study. J Neuroradiol. 2024; :. doi: 10.1016/j.neurad.2024.02.002. PubMed PMID:38387650 .
  3. Wang, M, Henkes, H, Ghozy, S, Siegler, JE, Shaikh, H, Khalife, J et al.. Use of the pRESET LITE thrombectomy device in combined approach for medium vessel occlusions: A multicenter evaluation. Neuroradiology. 2024; :. doi: 10.1007/s00234-024-03302-5. PubMed PMID:38381145 .
  4. Diestro, JDB, Fahed, R, Benomar, A, Omar, AT 2nd, Pereira, VM, Spears, J et al.. Clinical Uncertainty in Large Vessel Occlusion ischemic stroke (CULVO): Does automated perfusion scanning make a difference? Protocol of an intrarater and interrater agreement study. PLoS One. 2024;19 (1):e0297520. doi: 10.1371/journal.pone.0297520. PubMed PMID:38289912 PubMed Central PMC10826946.
  5. Jung, Y, Dhillon, PS, Akarsu, FG, Omar, AT, Marotta, TR, Spears, J et al.. Balloon Guide Catheters: To Inflate or not to Inflate?. World Neurosurg. 2023; :. doi: 10.1016/j.wneu.2023.12.112. PubMed PMID:38245484 .
  6. Dmytriw, AA, Musmar, B, Salim, H, Aslan, A, Cancelliere, NM, McLellan, RM et al.. The impact of postoperative aspirin in patients undergoing Woven EndoBridge: a multicenter, institutional, propensity score-matched analysis. J Neurointerv Surg. 2024; :. doi: 10.1136/jnis-2023-021082. PubMed PMID:38238006 .
  7. Diestro, JDB, Omar, AT 2nd, Zhang, YQ, Kishibe, T, Mastrolonardo, A, Lannon, MM et al.. Perfusion vs non-perfusion computed tomography imaging in the late window of emergent large vessel ischemic stroke: A systematic review and meta-analysis. PLoS One. 2024;19 (1):e0294127. doi: 10.1371/journal.pone.0294127. PubMed PMID:38166040 PubMed Central PMC10760723.
  8. Benali, F, Singh, N, Fladt, J, Jaroenngarmsamer, T, Bala, F, Ospel, JM et al.. Mediation of Age and Thrombectomy Outcome by Neuroimaging Markers of Frailty in Patients With Stroke. JAMA Netw Open. 2024;7 (1):e2349628. doi: 10.1001/jamanetworkopen.2023.49628. PubMed PMID:38165676 PubMed Central PMC10762575.
  9. Radu, RA, Costalat, V, Fahed, R, Ghozy, S, Siegler, JE, Shaikh, H et al.. First pass effect as an independent predictor of functional outcomes in medium vessel occlusions: An analysis of an international multicenter study. Eur Stroke J. 2023; :23969873231208276. doi: 10.1177/23969873231208276. PubMed PMID:37885243 .
  10. Diestro, JDB, Dibas, M, Adeeb, N, Regenhardt, RW, Vranic, JE, Guenego, A et al.. Stent-assisted Woven EndoBridge device for the treatment of intracranial aneurysms: an international multicenter study. J Neurosurg. 2023; :1-9. doi: 10.3171/2023.8.JNS235. PubMed PMID:37862717 .
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Affiliations & Other Activities

  • Assistant Professor, Department of Medicine, University of Toronto