Karim Ladha


Scientist, Li Ka Shing Knowledge Institute


Dr. Karim Ladha is a clinician-scientist and staff anesthesiologist at St. Michael’s Hospital and the University of Toronto. Dr. Ladha received his medical degree from the Johns Hopkins University School of Medicine. He then completed his anesthesia training at Massachusetts General Hospital and obtained a fellowship in cardiac anesthesia at Toronto General Hospital. He also holds a Master’s degree in clinical epidemiology from the Harvard School of Public Health. His program of research uses mixed methodologies to obtain a multifaceted view of pain and recovery after surgery including retrospective analyses of administrative databases, prospective observational studies, and multi-center randomized controlled trials. His research has been published in top-tier journals including JAMA, BMJ, British Journal of Anesthesia and Anesthesiology. He has received numerous awards for his work including the International Anesthesia Research Society Mentored Research Award, a new investigator award from the Canadian Anesthesiologists’ Society and the IMPACT award in anesthesia.

His current research interests include:

–       Exploring the use of anesthetic drugs such as ketamine and nitrous oxide to treat depression

–       Understanding the role of cannabis in mitigating pain

–       Using wearable technology and mobile applications to track recovery after surgery

Please note: Dr. Ladha is not accepting any students at this time.

Recent Publications

  1. Haas, S, Camm, JA, Harald, D, Steffel, J, Virdone, S, Pieper, K et al.. GARFIELD-AF: risk profiles, treatment patterns and 2-year outcomes in patients with atrial fibrillation in Germany, Austria and Switzerland (DACH) compared to 32 countries in other regions worldwide. Clin Res Cardiol. 2022; :. doi: 10.1007/s00392-022-02079-y. PubMed PMID:36094573 .
  2. Kuburi, S, Di Passa, AM, Tassone, VK, Mahmood, R, Lalovic, A, Ladha, KS et al.. Neuroimaging Correlates of Treatment Response with Psychedelics in Major Depressive Disorder: A Systematic Review. Chronic Stress (Thousand Oaks). ;6 :24705470221115342. doi: 10.1177/24705470221115342. PubMed PMID:35936944 PubMed Central PMC9350516.
  3. Chesney, TR, Wong, C, Tricco, AC, Wijeysundera, DN, Ladha, KS, Kishibe, T et al.. Frailty assessment tools for use by surgeons when evaluating older adults prior to surgery: a scoping review protocol. BMJ Open. 2022;12 (7):e061951. doi: 10.1136/bmjopen-2022-061951. PubMed PMID:35896291 PubMed Central PMC9335057.
  4. Sankar, A, Ladha, KS, Grover, SC, Jogendran, R, Tamming, D, Razak, F et al.. Predictors of ICU admission associated with gastrointestinal endoscopy in medical inpatients: A retrospective cohort study. J Gastroenterol Hepatol. 2022; :. doi: 10.1111/jgh.15969. PubMed PMID:35869833 .
  5. McIsaac, DI, Ladha, KS. Postoperative Opioid Prescribing: Finding the Balance. Anesthesiology. 2022;137 (2):131-133. doi: 10.1097/ALN.0000000000004297. PubMed PMID:35819864 .
  6. Daza, JF, Bartoszko, J, Van Klei, W, Ladha, K, McCluskey, S, Wijeysundera, DN et al.. Improved Re-estimation of Perioperative Cardiac Risk Using the Surgical Apgar Score: A Retrospective Cohort Study. Ann Surg. 2022; :. doi: 10.1097/SLA.0000000000005509. PubMed PMID:35801710 .
  7. Drozdz, SJ, Goel, A, McGarr, MW, Katz, J, Ritvo, P, Mattina, GF et al.. Ketamine Assisted Psychotherapy: A Systematic Narrative Review of the Literature. J Pain Res. 2022;15 :1691-1706. doi: 10.2147/JPR.S360733. PubMed PMID:35734507 PubMed Central PMC9207256.
  8. Wijeysundera, DN, Alibhai, SMH, Ladha, KS, Puts, MTE, Chesney, TR, Daza, JF et al.. Functional Improvement Trajectories After Surgery (FIT After Surgery) study: protocol for a multicentre prospective cohort study to evaluate significant new disability after major surgery in older adults. BMJ Open. 2022;12 (6):e062524. doi: 10.1136/bmjopen-2022-062524. PubMed PMID:35732384 PubMed Central PMC9226941.
  9. Lee, BH, Sideris, A, Ladha, KS, Johnson, RL, Wu, CL. Cannabis and Cannabinoids in the Perioperative Period. Anesth Analg. 2022; :. doi: 10.1213/ANE.0000000000006070. PubMed PMID:35551150 .
  10. Jivraj, NK, Ladha, K, Goel, A, Hill, A, Wijeysundera, DN, Bateman, BT et al.. Trends in postoperative opioid prescribing in Ontario between 2013 and 2019: a population-based cohort study. Can J Anaesth. 2022;69 (8):974-985. doi: 10.1007/s12630-022-02266-5. PubMed PMID:35534769 .
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Affiliations & Other Activities

  • Department of Anesthesia and Pain Management – University of Toronto and St. Michael’s Hospital