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Laurent J. Brochard

MD, HDR

Scientist

Email: Laurent.Brochard@unityhealth.to
Tel: 416-864-5686

Research Programs

Labs

Dr. Laurent Brochard Lab ❯

Biography

Research Interests

Mechanical ventilation, acute respiratory failure, patient-ventilator interaction, Acute Respiratory Distress Syndrome

Research Activities

Bench models: simulation of patient-ventilator interaction; performance assessment of mechanical ventilators and related devices.

Bench experimental studies: collaboration with several groups on acute lung injury
Physiological studies in critically ill patients (respiratory mechanics, respiratory muscle activity, sleep, etc.)
Epidemiological studies on mechanical ventilation
Randomized clinical trials on mechanical ventilation

Recent Publications

  1. Docci, M, Foti, G, Brochard, L, Bellani, G. Pressure support, patient effort and tidal volume: a conceptual model for a non linear interaction. Crit Care. 2024;28 (1):358. doi: 10.1186/s13054-024-05144-2. PubMed PMID:39506755 PubMed Central PMC11539557.
  2. Capdevila, M, Aarab, Y, Monet, C, De Jong, A, Vonarb, A, Carr, J et al.. Spontaneous breathing trials should be adapted for each patient according to the critical illness. A new individualised approach: the GLOBAL WEAN study. Intensive Care Med. 2024; :. doi: 10.1007/s00134-024-07657-4. PubMed PMID:39453494 .
  3. Docci, M, Rodrigues, A, Dubo, S, Ko, M, Brochard, L. Does patient-ventilator asynchrony really matter?. Curr Opin Crit Care. 2024; :. doi: 10.1097/MCC.0000000000001225. PubMed PMID:39445589 .
  4. Rozé, H, Bonnardel, E, Gallo, E, Boisselier, C, Khan, P, Perrier, V et al.. Inter-lung asymmetrical airway closure cause insufflation delay between lungs in acute hypoxemic respiratory failure. Ann Intensive Care. 2024;14 (1):162. doi: 10.1186/s13613-024-01379-y. PubMed PMID:39441425 PubMed Central PMC11499510.
  5. Machado-Junior, PA, Dias, MSS, de Souza, ABF, Lopes, LSE, Menezes, TP, Talvani, A et al.. A short duration of mechanical ventilation alters redox status in the diaphragm and aggravates inflammation in septic mice. Respir Physiol Neurobiol. 2024;331 :104361. doi: 10.1016/j.resp.2024.104361. PubMed PMID:39433197 .
  6. Wisse, JJ, Scaramuzzo, G, Pellegrini, M, Heunks, L, Piraino, T, Somhorst, P et al.. Clinical implementation of advanced respiratory monitoring with esophageal pressure and electrical impedance tomography: results from an international survey and focus group discussion. Intensive Care Med Exp. 2024;12 (1):93. doi: 10.1186/s40635-024-00686-9. PubMed PMID:39432136 PubMed Central PMC11493933.
  7. Rezoagli, E, Fornari, C, Fumagalli, R, Grasselli, G, Volta, CA, Navalesi, P et al.. Heterogeneous impact of Sighs on mortality in patients with acute hypoxemic respiratory failure: insights from the PROTECTION study. Ann Intensive Care. 2024;14 (1):153. doi: 10.1186/s13613-024-01385-0. PubMed PMID:39368033 PubMed Central PMC11456003.
  8. Pellegrini, M, Sousa, MLA, Dubo, S, Menga, LS, Hsing, V, Post, M et al.. Impact of airway closure and lung collapse on inhaled nitric oxide effect in acute lung injury: an experimental study. Ann Intensive Care. 2024;14 (1):149. doi: 10.1186/s13613-024-01378-z. PubMed PMID:39312044 PubMed Central PMC11420414.
  9. Rodrigues, A, Vieira, F, Sklar, MC, Damiani, LF, Piraino, T, Telias, I et al.. Post-insufflation diaphragm contractions in patients receiving various modes of mechanical ventilation. Crit Care. 2024;28 (1):310. doi: 10.1186/s13054-024-05091-y. PubMed PMID:39294653 PubMed Central PMC11411742.
  10. Richard, JM, Beloncle, FM, Béduneau, G, Mortaza, S, Ehrmann, S, Diehl, JL et al.. Pressure control plus spontaneous ventilation versus volume assist-control ventilation in acute respiratory distress syndrome. A randomised clinical trial. Intensive Care Med. 2024;50 (10):1647-1656. doi: 10.1007/s00134-024-07612-3. PubMed PMID:39287651 PubMed Central PMC11457688.
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Affiliations & Other Activities

  • Staff Physician, Critical Care Department, St. Michael’s Hospital
  • Keenan Chair in Critical Care and Respiratory Medicine, St. Michael’s Hospital and University of Toronto
  • Head, Interdepartmental Division of Critical Care Medicine, University of Toronto
  • Deputy Editor of the American Journal Of Respiratory and Critical Care Medicine
  • Head of the PLUG Working Group on pleural pressure (ESICM)
  • Former Head and Member of the REVA (European Research Network on Mechanical Ventilation)
  • Member of the Canadian Critical Care Trial Group