Laurent J. Brochard




Research Interests

Mechanical ventilation, acute respiratory failure, patient-ventilator interaction, Acute Respiratory Distress Syndrome

Research Activities

Bench models: simulation of patient-ventilator interaction; performance assessment of mechanical ventilators and related devices.

Bench experimental studies: collaboration with several groups on acute lung injury
Physiological studies in critically ill patients (respiratory mechanics, respiratory muscle activity, sleep, etc.)
Epidemiological studies on mechanical ventilation
Randomized clinical trials on mechanical ventilation

Recent Publications

  1. Duggal, A, Conrad, SA, Brochard, L, Brodie, D, Hill, NS. Reply to Tiruvoipati et al.: VENT-AVOID Trial - Avoiding Acute Hypercapnic Respiratory Failure!. Am J Respir Crit Care Med. 2024; :. doi: 10.1164/rccm.202403-0618LE. PubMed PMID:38608271 .
  2. Coiffard, B, Dianti, J, Telias, I, Brochard, LJ, Slutsky, AS, Beck, J et al.. Dyssynchronous diaphragm contractions impair diaphragm function in mechanically ventilated patients. Crit Care. 2024;28 (1):107. doi: 10.1186/s13054-024-04894-3. PubMed PMID:38566126 PubMed Central PMC10988824.
  3. Vieira, FN, Masy, V, LaRue, RJ, Laengert, SE, De Lannoy, CF, Rodrigues, A et al.. An Individual Barrier Enclosure Actively Removing Aerosols for Airborne Isolation: A Vacuum Tent. Respir Care. 2024;69 (4):395-406. doi: 10.4187/respcare.11094. PubMed PMID:38538026 .
  4. Gómez, CA, Brochard, L, Goligher, EC, Rozenberg, D, Reid, WD, Roblyer, D et al.. Combined frequency domain near-infrared spectroscopy and diffuse correlation spectroscopy system for comprehensive metabolic monitoring of inspiratory muscles during loading. J Biomed Opt. 2024;29 (3):035002. doi: 10.1117/1.JBO.29.3.035002. PubMed PMID:38532926 PubMed Central PMC10965138.
  5. Songsangvorn, N, Xu, Y, Lu, C, Rotstein, O, Brochard, L, Slutsky, AS et al.. Electrical impedance tomography-guided positive end-expiratory pressure titration in ARDS: a systematic review and meta-analysis. Intensive Care Med. 2024; :. doi: 10.1007/s00134-024-07362-2. PubMed PMID:38512400 .
  6. Calfee, CS, Harhay, MO, Schenck, EJ, Ferguson, ND, Heunks, L, White, D et al.. Critical Care: A Second Special Issue of the Blue Journal. Am J Respir Crit Care Med. 2024;209 (7):769-771. doi: 10.1164/rccm.202402-0460ED. PubMed PMID:38501798 PubMed Central PMC10995575.
  7. de Haro, C, Santos-Pulpón, V, Telías, I, Xifra-Porxas, A, Subirà, C, Batlle, M et al.. Flow starvation during square-flow assisted ventilation detected by supervised deep learning techniques. Crit Care. 2024;28 (1):75. doi: 10.1186/s13054-024-04845-y. PubMed PMID:38486268 PubMed Central PMC10938655.
  8. Cornejo, R, Telias, I, Brochard, L. Measuring patient's effort on the ventilator. Intensive Care Med. 2024;50 (4):573-576. doi: 10.1007/s00134-024-07352-4. PubMed PMID:38436722 .
  9. Ratano, D, Zhang, B, Dianti, J, Georgopoulos, D, Brochard, LJ, Chan, TCY et al.. Lung- and diaphragm-protective strategies in acute respiratory failure: an in silico trial. Intensive Care Med Exp. 2024;12 (1):20. doi: 10.1186/s40635-024-00606-x. PubMed PMID:38416269 PubMed Central PMC10902250.
  10. Panelli, A, Grimm, AM, Krause, S, Verfuß, MA, Ulm, B, Grunow, JJ et al.. Noninvasive Electromagnetic Phrenic Nerve Stimulation in Critically Ill Patients: A Feasibility Study. Chest. 2024; :. doi: 10.1016/j.chest.2024.02.035. PubMed PMID:38403186 .
Search PubMed

Affiliations & Other Activities

  • Staff Physician, Critical Care Department, St. Michael’s Hospital
  • Keenan Chair in Critical Care and Respiratory Medicine, St. Michael’s Hospital and University of Toronto
  • Head, Interdepartmental Division of Critical Care Medicine, University of Toronto
  • Deputy Editor of the American Journal Of Respiratory and Critical Care Medicine
  • Head of the PLUG Working Group on pleural pressure (ESICM)
  • Former Head and Member of the REVA (European Research Network on Mechanical Ventilation)
  • Member of the Canadian Critical Care Trial Group