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Laurent J. Brochard

MD, HDR

Scientist

Email: Laurent.Brochard@unityhealth.to
Tel: 416-864-5686

Research Programs

Labs

Dr. Laurent Brochard Lab ❯

Biography

Research Interests

Mechanical ventilation, acute respiratory failure, patient-ventilator interaction, Acute Respiratory Distress Syndrome

Research Activities

Bench models: simulation of patient-ventilator interaction; performance assessment of mechanical ventilators and related devices.

Bench experimental studies: collaboration with several groups on acute lung injury
Physiological studies in critically ill patients (respiratory mechanics, respiratory muscle activity, sleep, etc.)
Epidemiological studies on mechanical ventilation
Randomized clinical trials on mechanical ventilation

Recent Publications

  1. Cook, D, Taneja, S, Krewulak, K, Zytaruk, N, Menon, K, Fowler, R et al.. Barriers, Solutions, and Opportunities for Adapting Critical Care Clinical Trials in the COVID-19 Pandemic. JAMA Netw Open. 2024;7 (7):e2420458. doi: 10.1001/jamanetworkopen.2024.20458. PubMed PMID:38995645 PubMed Central PMC11245722.
  2. Rodrigues, A, Shingai, K, Gomez, CA, Rassam, P, Rozenberg, D, Goligher, E et al.. Continuous measurements of respiratory muscle blood flow & oxygen consumption using non-invasive FD-NIRS & DCS. J Appl Physiol (1985). 2024; :. doi: 10.1152/japplphysiol.00871.2023. PubMed PMID:38867669 .
  3. Jackson, R, Kim, A, Moroz, N, Damiani, LF, Grieco, DL, Piraino, T et al.. Reverse triggering ? a novel or previously missed phenomenon?. Ann Intensive Care. 2024;14 (1):78. doi: 10.1186/s13613-024-01303-4. PubMed PMID:38776032 PubMed Central PMC11111438.
  4. Junhasavasdikul, D, Kasemchaiyanun, A, Tassaneyasin, T, Petnak, T, Bezerra, FS, Mellado-Artigas, R et al.. Expiratory flow limitation during mechanical ventilation: real-time detection and physiological subtypes. Crit Care. 2024;28 (1):171. doi: 10.1186/s13054-024-04953-9. PubMed PMID:38773629 PubMed Central PMC11106966.
  5. Mellado-Artigas, R, Borrat, X, Ferreyro, BL, Yarnell, C, Hao, S, Wanis, KN et al.. Effect of immediate initiation of invasive ventilation on mortality in acute hypoxemic respiratory failure: a target trial emulation. Crit Care. 2024;28 (1):157. doi: 10.1186/s13054-024-04926-y. PubMed PMID:38730306 PubMed Central PMC11088053.
  6. Duggal, A, Conrad, SA, Brochard, L, Brodie, D, Hill, NS. Reply to Tiruvoipati et al.: VENT-AVOID Trial: Avoiding Acute Hypercapnic Respiratory Failure!. Am J Respir Crit Care Med. 2024;209 (12):1515. doi: 10.1164/rccm.202403-0618LE. PubMed PMID:38608271 PubMed Central PMC11208957.
  7. Coiffard, B, Dianti, J, Telias, I, Brochard, LJ, Slutsky, AS, Beck, J et al.. Dyssynchronous diaphragm contractions impair diaphragm function in mechanically ventilated patients. Crit Care. 2024;28 (1):107. doi: 10.1186/s13054-024-04894-3. PubMed PMID:38566126 PubMed Central PMC10988824.
  8. Vieira, FN, Masy, V, LaRue, RJ, Laengert, SE, De Lannoy, CF, Rodrigues, A et al.. An Individual Barrier Enclosure Actively Removing Aerosols for Airborne Isolation: A Vacuum Tent. Respir Care. 2024;69 (4):395-406. doi: 10.4187/respcare.11094. PubMed PMID:38538026 PubMed Central PMC11108102.
  9. Gómez, CA, Brochard, L, Goligher, EC, Rozenberg, D, Reid, WD, Roblyer, D et al.. Combined frequency domain near-infrared spectroscopy and diffuse correlation spectroscopy system for comprehensive metabolic monitoring of inspiratory muscles during loading. J Biomed Opt. 2024;29 (3):035002. doi: 10.1117/1.JBO.29.3.035002. PubMed PMID:38532926 PubMed Central PMC10965138.
  10. Songsangvorn, N, Xu, Y, Lu, C, Rotstein, O, Brochard, L, Slutsky, AS et al.. Electrical impedance tomography-guided positive end-expiratory pressure titration in ARDS: a systematic review and meta-analysis. Intensive Care Med. 2024;50 (5):617-631. doi: 10.1007/s00134-024-07362-2. PubMed PMID:38512400 PubMed Central PMC11078723.
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Affiliations & Other Activities

  • Staff Physician, Critical Care Department, St. Michael’s Hospital
  • Keenan Chair in Critical Care and Respiratory Medicine, St. Michael’s Hospital and University of Toronto
  • Head, Interdepartmental Division of Critical Care Medicine, University of Toronto
  • Deputy Editor of the American Journal Of Respiratory and Critical Care Medicine
  • Head of the PLUG Working Group on pleural pressure (ESICM)
  • Former Head and Member of the REVA (European Research Network on Mechanical Ventilation)
  • Member of the Canadian Critical Care Trial Group