Laurent J. Brochard




Research Interests

Mechanical ventilation, acute respiratory failure, patient-ventilator interaction, Acute Respiratory Distress Syndrome

Research Activities

Bench models: simulation of patient-ventilator interaction; performance assessment of mechanical ventilators and related devices.

Bench experimental studies: collaboration with several groups on acute lung injury
Physiological studies in critically ill patients (respiratory mechanics, respiratory muscle activity, sleep, etc.)
Epidemiological studies on mechanical ventilation
Randomized clinical trials on mechanical ventilation

Recent Publications

  1. Ali, A, Nykanen, AI, Beroncal, E, Brambate, E, Mariscal, A, Michaelsen, V et al.. Successful 3-day lung preservation using a cyclic normothermic ex vivo lung perfusion strategy. EBioMedicine. 2022;83 :104210. doi: 10.1016/j.ebiom.2022.104210. PubMed PMID:35952495 .
  2. Rittayamai, N, Grieco, DL, Brochard, L. Correction to: Noninvasive respiratory support in intensive care medicine. Intensive Care Med. 2022; :. doi: 10.1007/s00134-022-06828-5. PubMed PMID:35916914 .
  3. Maggiore, SM, Jaber, S, Grieco, DL, Mancebo, J, Zakynthinos, S, Demoule, A et al.. High-Flow Versus VenturiMask Oxygen Therapy to Prevent Re-Intubation in Hypoxemic Patients After Extubation: A Multicenter, Randomized Clinical Trial. Am J Respir Crit Care Med. 2022; :. doi: 10.1164/rccm.202201-0065OC. PubMed PMID:35849787 .
  4. Bastia, L, Rozé, H, Brochard, LJ. Asymmetrical Lung Injury: Management and Outcome. Semin Respir Crit Care Med. 2022;43 (3):369-378. doi: 10.1055/s-0042-1744303. PubMed PMID:35785812 .
  5. Rittayamai, N, Grieco, DL, Brochard, L. Noninvasive respiratory support in intensive care medicine. Intensive Care Med. 2022; :. doi: 10.1007/s00134-022-06762-6. PubMed PMID:35759009 PubMed Central PMC9244137.
  6. Brault, C, Mancebo, J, Suarez Montero, JC, Bentall, T, Burns, KEA, Piraino, T et al.. The PROMIZING trial enrollment algorithm for early identification of patients ready for unassisted breathing. Crit Care. 2022;26 (1):188. doi: 10.1186/s13054-022-04063-4. PubMed PMID:35739553 PubMed Central PMC9219177.
  7. Telias, I, Brochard, LJ, Gattarello, S, Wunsch, H, Junhasavasdikul, D, Bosma, KJ et al.. The physiological underpinnings of life-saving respiratory support. Intensive Care Med. 2022; :. doi: 10.1007/s00134-022-06749-3. PubMed PMID:35690953 PubMed Central PMC9188674.
  8. Honorio, T, Brochard, L. Drained and undrained heat capacity of swelling clays. Phys Chem Chem Phys. 2022;24 (24):15003-15014. doi: 10.1039/d2cp01419j. PubMed PMID:35687497 .
  9. Mellado-Artigas, R, Ferrando, C, Martino, F, Delbove, A, Ferreyro, BL, Darreau, C et al.. Early intubation and patient-centered outcomes in septic shock: a secondary analysis of a prospective multicenter study. Crit Care. 2022;26 (1):163. doi: 10.1186/s13054-022-04029-6. PubMed PMID:35672860 PubMed Central PMC9171484.
  10. Chen, L, Grieco, DL, Beloncle, F, Chen, GQ, Tiribelli, N, Madotto, F et al.. Partition of respiratory mechanics in patients with acute respiratory distress syndrome and association with outcome: a multicentre clinical study. Intensive Care Med. 2022;48 (7):888-898. doi: 10.1007/s00134-022-06724-y. PubMed PMID:35670818 PubMed Central PMC9171739.
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Affiliations & Other Activities

  • Staff Physician, Critical Care Department, St. Michael’s Hospital
  • Keenan Chair in Critical Care and Respiratory Medicine, St. Michael’s Hospital and University of Toronto
  • Head, Interdepartmental Division of Critical Care Medicine, University of Toronto
  • Deputy Editor of the American Journal Of Respiratory and Critical Care Medicine
  • Head of the PLUG Working Group on pleural pressure (ESICM)
  • Former Head and Member of the REVA (European Research Network on Mechanical Ventilation)
  • Member of the Canadian Critical Care Trial Group