Laurent J. Brochard

MD, HDR

Scientist

Biography

Research Interests

Mechanical ventilation, acute respiratory failure, patient-ventilator interaction, Acute Respiratory Distress Syndrome

Research Activities

Bench models: simulation of patient-ventilator interaction; performance assessment of mechanical ventilators and related devices.

Bench experimental studies: collaboration with several groups on acute lung injury
Physiological studies in critically ill patients (respiratory mechanics, respiratory muscle activity, sleep, etc.)
Epidemiological studies on mechanical ventilation
Randomized clinical trials on mechanical ventilation

Recent Publications

  1. Chen, L, Grieco, DL, Beloncle, F, Chen, GQ, Tiribelli, N, Madotto, F et al.. Correction: Partition of respiratory mechanics in patients with acute respiratory distress syndrome and association with outcome: a multicentre clinical study. Intensive Care Med. 2023; :. doi: 10.1007/s00134-023-06985-1. PubMed PMID:36729185 .
  2. Pham, T, Heunks, L, Bellani, G, Madotto, F, Aragao, I, Beduneau, G et al.. Weaning from mechanical ventilation in intensive care units across 50 countries (WEAN SAFE): a multicentre, prospective, observational cohort study. Lancet Respir Med. 2023; :. doi: 10.1016/S2213-2600(22)00449-0. PubMed PMID:36693401 .
  3. Tisminetzky, M, Ferreyro, BL, Sklar, MC, Chen, L, Keshavjee, S, Cypel, M et al.. Low-Flow Inflation Pressure-Time Curve to Identify Airway Opening Pressure in a Patient on Veno-Venous ECMO. Am J Respir Crit Care Med. 2023; :. doi: 10.1164/rccm.202204-0647IM. PubMed PMID:36693031 .
  4. Chen, L, Grieco, DL, Brochard, LJ. Possible overestimation of chest wall driving pressure and underestimation of airway closure. Author's reply. Intensive Care Med. 2023; :. doi: 10.1007/s00134-022-06973-x. PubMed PMID:36629880 .
  5. Amado-RodrĂ­guez, L, RodrĂ­guez-Garcia, R, Bellani, G, Pham, T, Fan, E, Madotto, F et al.. Mechanical ventilation in patients with cardiogenic pulmonary edema: a sub-analysis of the LUNG SAFE study. J Intensive Care. 2022;10 (1):55. doi: 10.1186/s40560-022-00648-x. PubMed PMID:36567347 PubMed Central PMC9791731.
  6. Writing Committee for the REMAP-CAP Investigators, Higgins, AM, Berry, LR, Lorenzi, E, Murthy, S, McQuilten, Z et al.. Long-term (180-Day) Outcomes in Critically Ill Patients With COVID-19 in the REMAP-CAP Randomized Clinical Trial. JAMA. 2023;329 (1):39-51. doi: 10.1001/jama.2022.23257. PubMed PMID:36525245 PubMed Central PMC9857594.
  7. Ponomarev, D, Brochard, L, Goligher, E. Expiratory Muscle Relaxation-Induced Ventilator Triggering: A New Dyssynchrony or an Established Physiological Phenomenon?. Chest. 2022;162 (6):e342-e343. doi: 10.1016/j.chest.2022.08.2224. PubMed PMID:36494140 .
  8. Damiani, LF, Brochard, L. Reply to: Interpretation of Diaphragmatic Force Measurements in Reverse Triggering in a Porcine Model. Am J Respir Crit Care Med. 2022; :. doi: 10.1164/rccm.202211-2129LE. PubMed PMID:36493770 .
  9. Rodrigues, A, Telias, I, Damiani, LF, Brochard, L. Reverse Triggering During Controlled Ventilation: From Physiology to Clinical Management. Am J Respir Crit Care Med. 2022; :. doi: 10.1164/rccm.202208-1477CI. PubMed PMID:36470240 .
  10. Sousa, MLA, Katira, BH, Engelberts, D, Hsing, V, Schreiber, A, Jonkman, AH et al.. Mechanical ventilation in ARDS with an automatic resuscitator. Respir Care. 2022; :. doi: 10.4187/respcare.10389. PubMed PMID:36368776 .
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Affiliations & Other Activities

  • Staff Physician, Critical Care Department, St. Michael’s Hospital
  • Keenan Chair in Critical Care and Respiratory Medicine, St. Michael’s Hospital and University of Toronto
  • Head, Interdepartmental Division of Critical Care Medicine, University of Toronto
  • Deputy Editor of the American Journal Of Respiratory and Critical Care Medicine
  • Head of the PLUG Working Group on pleural pressure (ESICM)
  • Former Head and Member of the REVA (European Research Network on Mechanical Ventilation)
  • Member of the Canadian Critical Care Trial Group