Laurent J. Brochard




Research Interests

Mechanical ventilation, acute respiratory failure, patient-ventilator interaction, Acute Respiratory Distress Syndrome

Research Activities

Bench models: simulation of patient-ventilator interaction; performance assessment of mechanical ventilators and related devices.

Bench experimental studies: collaboration with several groups on acute lung injury
Physiological studies in critically ill patients (respiratory mechanics, respiratory muscle activity, sleep, etc.)
Epidemiological studies on mechanical ventilation
Randomized clinical trials on mechanical ventilation

Recent Publications

  1. Schreiber, AF, Garlasco, J, Urner, M, McFarlan, A, Baker, A, Rigamonti, A et al.. Mechanical Ventilation after Traumatic Spinal Cord Injury - A Multicentric Cohort Study-based Prediction Model for Weaning Success: The BICYCLE Score. Ann Am Thorac Soc. 2023; :. doi: 10.1513/AnnalsATS.202301-022OC. PubMed PMID:37236632 .
  2. Brochard, LJ. Mechanical Ventilation: Negative to Positive and Back Again. Crit Care Clin. 2023;39 (3):437-449. doi: 10.1016/j.ccc.2022.12.002. PubMed PMID:37230549 .
  3. Rezoagli, E, Bastia, L, Brochard, L, Bellani, G. Physical manoeuvres in patients with ARDS and low compliance: bedside approaches to detect lung hyperinflation and optimise mechanical ventilation. Eur Respir J. 2023;61 (5):. doi: 10.1183/13993003.02169-2022. PubMed PMID:37208034 .
  4. Jonkman, AH, Alcala, GC, Pavlovsky, B, Roca, O, Spadaro, S, Scaramuzzo, G et al.. Lung RecruitmEnt Assessed by EleCtRical Impedance Tomography (RECRUIT): A Multicenter Study of COVID-19 ARDS. Am J Respir Crit Care Med. 2023; :. doi: 10.1164/rccm.202212-2300OC. PubMed PMID:37097986 .
  5. Panelli, A, Bartels, HG, Krause, S, Verfuß, MA, Grimm, AM, Carbon, NM et al.. First non-invasive magnetic phrenic nerve and diaphragm stimulation in anaesthetized patients: a proof-of-concept study. Intensive Care Med Exp. 2023;11 (1):20. doi: 10.1186/s40635-023-00506-6. PubMed PMID:37081235 PubMed Central PMC10118662.
  6. Del Sorbo, L, Tisminetzky, M, Chen, L, Brochard, L, Arellano, D, Brito, R et al.. Association of lung recruitment and change in recruitment-to-inflation ratio from supine to prone position in acute respiratory distress syndrome. Crit Care. 2023;27 (1):140. doi: 10.1186/s13054-023-04428-3. PubMed PMID:37055792 PubMed Central PMC10098997.
  7. Spinelli, E, Pesenti, A, Slobod, D, Fornari, C, Fumagalli, R, Grasselli, G et al.. Clinical risk factors for increased respiratory drive in intubated hypoxemic patients. Crit Care. 2023;27 (1):138. doi: 10.1186/s13054-023-04402-z. PubMed PMID:37041553 PubMed Central PMC10088111.
  8. Writing Committee for the REMAP-CAP Investigators, Lawler, PR, Derde, LPG, van de Veerdonk, FL, McVerry, BJ, Huang, DT et al.. Effect of Angiotensin-Converting Enzyme Inhibitor and Angiotensin Receptor Blocker Initiation on Organ Support-Free Days in Patients Hospitalized With COVID-19: A Randomized Clinical Trial. JAMA. 2023;329 (14):1183-1196. doi: 10.1001/jama.2023.4480. PubMed PMID:37039790 .
  9. Bosma, KJ, Martin, CM, Burns, KEA, Mancebo Cortes, J, Suárez Montero, JC, Skrobik, Y et al.. Study protocol for a randomized controlled trial of Proportional Assist Ventilation for Minimizing the Duration of Mechanical Ventilation: the PROMIZING study. Trials. 2023;24 (1):232. doi: 10.1186/s13063-023-07163-w. PubMed PMID:36973743 PubMed Central PMC10041480.
  10. Urner, M, Jüni, P, Rojas-Saunero, LP, Hansen, B, Brochard, LJ, Ferguson, ND et al.. Limiting Dynamic Driving Pressure in Patients Requiring Mechanical Ventilation. Crit Care Med. 2023; :. doi: 10.1097/CCM.0000000000005844. PubMed PMID:36971437 .
Search PubMed

Affiliations & Other Activities

  • Staff Physician, Critical Care Department, St. Michael’s Hospital
  • Keenan Chair in Critical Care and Respiratory Medicine, St. Michael’s Hospital and University of Toronto
  • Head, Interdepartmental Division of Critical Care Medicine, University of Toronto
  • Deputy Editor of the American Journal Of Respiratory and Critical Care Medicine
  • Head of the PLUG Working Group on pleural pressure (ESICM)
  • Former Head and Member of the REVA (European Research Network on Mechanical Ventilation)
  • Member of the Canadian Critical Care Trial Group