Laurent J. Brochard




Research Interests

Mechanical ventilation, acute respiratory failure, patient-ventilator interaction, Acute Respiratory Distress Syndrome

Research Activities

Bench models: simulation of patient-ventilator interaction; performance assessment of mechanical ventilators and related devices.

Bench experimental studies: collaboration with several groups on acute lung injury
Physiological studies in critically ill patients (respiratory mechanics, respiratory muscle activity, sleep, etc.)
Epidemiological studies on mechanical ventilation
Randomized clinical trials on mechanical ventilation

Recent Publications

  1. Abroug, F, Hammouda, Z, Lahmar, M, Nouira, W, Maatouk, S, Youssef, SB et al.. Early Variation of ROX Index Predicts High-Flow Nasal Cannula Outcome in Awake Subjects With Severe Hypoxemic COVID-19. Respir Care. 2022; :. doi: 10.4187/respcare.10125. PubMed PMID:36167850 .
  2. Lesimple, A, Fritz, C, Hutin, A, Charbonney, E, Savary, D, Delisle, S et al.. A novel capnogram analysis to guide ventilation during cardiopulmonary resuscitation: clinical and experimental observations. Crit Care. 2022;26 (1):287. doi: 10.1186/s13054-022-04156-0. PubMed PMID:36151559 PubMed Central PMC9508761.
  3. Yarnell, CJ, Johnson, A, Dam, T, Jonkman, A, Liu, K, Wunsch, H et al.. Do Thresholds for Invasive Ventilation in Hypoxemic Respiratory Failure exist? A Cohort Study. Am J Respir Crit Care Med. 2022; :. doi: 10.1164/rccm.202206-1092OC. PubMed PMID:36150166 .
  4. Brochard, L, Mercat, A. Jordi Mancebo, in memoriam (August 06 2022). Ann Intensive Care. 2022;12 (1):85. doi: 10.1186/s13613-022-01061-1. PubMed PMID:36103001 PubMed Central PMC9470510.
  5. Brochard, L, Antonelli, M, Azoulay, E. Jordi Mancebo, a man of science, compassion and friendship. Intensive Care Med. 2022; :. doi: 10.1007/s00134-022-06875-y. PubMed PMID:36083299 PubMed Central PMC9461460.
  6. Dianti, J, Fard, S, Wong, J, Chan, TCY, Del Sorbo, L, Fan, E et al.. Strategies for lung- and diaphragm-protective ventilation in acute hypoxemic respiratory failure: a physiological trial. Crit Care. 2022;26 (1):259. doi: 10.1186/s13054-022-04123-9. PubMed PMID:36038890 PubMed Central PMC9422941.
  7. Ali, A, Nykanen, AI, Beroncal, E, Brambate, E, Mariscal, A, Michaelsen, V et al.. Successful 3-day lung preservation using a cyclic normothermic ex vivo lung perfusion strategy. EBioMedicine. 2022;83 :104210. doi: 10.1016/j.ebiom.2022.104210. PubMed PMID:35952495 PubMed Central PMC9385559.
  8. Rittayamai, N, Grieco, DL, Brochard, L. Correction to: Noninvasive respiratory support in intensive care medicine. Intensive Care Med. 2022;48 (9):1268-1269. doi: 10.1007/s00134-022-06828-5. PubMed PMID:35916914 .
  9. Maggiore, SM, Jaber, S, Grieco, DL, Mancebo, J, Zakynthinos, S, Demoule, A et al.. High-Flow Versus VenturiMask Oxygen Therapy to Prevent Re-Intubation in Hypoxemic Patients After Extubation: A Multicenter, Randomized Clinical Trial. Am J Respir Crit Care Med. 2022; :. doi: 10.1164/rccm.202201-0065OC. PubMed PMID:35849787 .
  10. Bastia, L, Rozé, H, Brochard, LJ. Asymmetrical Lung Injury: Management and Outcome. Semin Respir Crit Care Med. 2022;43 (3):369-378. doi: 10.1055/s-0042-1744303. PubMed PMID:35785812 .
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Affiliations & Other Activities

  • Staff Physician, Critical Care Department, St. Michael’s Hospital
  • Keenan Chair in Critical Care and Respiratory Medicine, St. Michael’s Hospital and University of Toronto
  • Head, Interdepartmental Division of Critical Care Medicine, University of Toronto
  • Deputy Editor of the American Journal Of Respiratory and Critical Care Medicine
  • Head of the PLUG Working Group on pleural pressure (ESICM)
  • Former Head and Member of the REVA (European Research Network on Mechanical Ventilation)
  • Member of the Canadian Critical Care Trial Group