Laurent J. Brochard




Research Interests

Mechanical ventilation, acute respiratory failure, patient-ventilator interaction, Acute Respiratory Distress Syndrome

Research Activities

Bench models: simulation of patient-ventilator interaction; performance assessment of mechanical ventilators and related devices.

Bench experimental studies: collaboration with several groups on acute lung injury
Physiological studies in critically ill patients (respiratory mechanics, respiratory muscle activity, sleep, etc.)
Epidemiological studies on mechanical ventilation
Randomized clinical trials on mechanical ventilation

Recent Publications

  1. Pozzi, M, Cominesi, DR, Giani, M, Avalli, L, Foti, G, Brochard, LJ et al.. Airway Closure in Patients With Cardiogenic Pulmonary Edema as a Cause of Driving Pressure Overestimation: The "Uncorking Effect". Chest. 2023;164 (5):e125-e130. doi: 10.1016/j.chest.2023.07.008. PubMed PMID:37945193 .
  2. LOVIT-COVID Investigators, on behalf of the Canadian Critical Care Trials Group, and the REMAP-CAP Investigators, Adhikari, NKJ, Hashmi, M, Tirupakuzhi Vijayaraghavan, BK, Haniffa, R, Beane, A et al.. Intravenous Vitamin C for Patients Hospitalized With COVID-19: Two Harmonized Randomized Clinical Trials. JAMA. 2023;330 (18):1745-1759. doi: 10.1001/jama.2023.21407. PubMed PMID:37877585 PubMed Central PMC10600726.
  3. Zhu, X, Vandamme, M, Jiang, Z, Brochard, L. Molecular simulation of the confined crystallization of ice in cement nanopore. J Chem Phys. 2023;159 (15):. doi: 10.1063/5.0169783. PubMed PMID:37850696 .
  4. Bonny, V, Joffre, J, Gabarre, P, Urbina, T, Missri, L, Ladoire, M et al.. Sonometric assessment of cough predicts extubation failure: SonoWean-a proof-of-concept study. Crit Care. 2023;27 (1):368. doi: 10.1186/s13054-023-04653-w. PubMed PMID:37749612 PubMed Central PMC10521471.
  5. Abbott, M, Li, Y, Brochard, L, Zhang, H. Precision Medicine Using Simultaneous Monitoring and Assessment with Imaging and Biomarkers to Manage Mechanical Ventilation in ARDS. Intensive Care Res. 2023;3 (3):195-203. doi: 10.1007/s44231-023-00045-4. PubMed PMID:37664686 PubMed Central PMC10471647.
  6. Pérez, J, Accoce, M, Dorado, JH, Gilgado, DI, Navarro, E, Cardoso, GP et al.. Failure of First Transition to Pressure Support Ventilation After Spontaneous Awakening Trials in Hypoxemic Respiratory Failure: Influence of COVID-19. Crit Care Explor. 2023;5 (9):e0968. doi: 10.1097/CCE.0000000000000968. PubMed PMID:37644972 PubMed Central PMC10461949.
  7. Morris, IS, Bassi, T, Bellissimo, CA, de Perrot, M, Donahoe, L, Brochard, L et al.. Proof of Concept for Continuous On-Demand Phrenic Nerve Stimulation to Prevent Diaphragm Disuse during Mechanical Ventilation (STIMULUS): A Phase 1 Clinical Trial. Am J Respir Crit Care Med. 2023;208 (9):992-995. doi: 10.1164/rccm.202305-0791LE. PubMed PMID:37642635 .
  8. Arunsurat, I, Rittayamai, N, Chuaychoo, B, Tangchityongsiva, S, Promsarn, S, Yuenyong, S et al.. Bronchodilator Efficacy of High-Flow Nasal Cannula in COPD: Vibrating Mesh Nebulizer Versus Jet Nebulizer. Respir Care. 2023; :. doi: 10.4187/respcare.11139. PubMed PMID:37607815 .
  9. Edginton, S, Kruger, N, Stelfox, HT, Brochard, L, Zuege, DJ, Gaudet, J et al.. Methods for determination of optimal positive end-expiratory pressure: a protocol for a scoping review. BMJ Open. 2023;13 (8):e071871. doi: 10.1136/bmjopen-2023-071871. PubMed PMID:37527894 PubMed Central PMC10401233.
  10. Saha, R, Pham, T, Sinha, P, Maddali, MV, Bellani, G, Fan, E et al.. Estimating the attributable fraction of mortality from acute respiratory distress syndrome to inform enrichment in future randomised clinical trials. Thorax. 2023;78 (10):990-1003. doi: 10.1136/thorax-2023-220262. PubMed PMID:37495364 PubMed Central PMC10581447.
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Affiliations & Other Activities

  • Staff Physician, Critical Care Department, St. Michael’s Hospital
  • Keenan Chair in Critical Care and Respiratory Medicine, St. Michael’s Hospital and University of Toronto
  • Head, Interdepartmental Division of Critical Care Medicine, University of Toronto
  • Deputy Editor of the American Journal Of Respiratory and Critical Care Medicine
  • Head of the PLUG Working Group on pleural pressure (ESICM)
  • Former Head and Member of the REVA (European Research Network on Mechanical Ventilation)
  • Member of the Canadian Critical Care Trial Group