Marie E. Faughnan




Dr. Marie E. Faughnan is a Respirologist and an Associate Scientist in the Li Ka Shing Knowledge Institute of St. Michael’s Hospital. She is an Associate Professor at the University of Toronto. Dr. Faughnan is a clinical epidemiologist, with a research focus on clinical and mechanistic aspects of vascular malformations, with a specific expertise in hereditary hemorrhagic telangiectasia (HHT). Dr. Faughnan is the Director of the Toronto Hereditary Hemorrhagic Telangiectasia Centre and the Scientific Director for CureHHT. Dr. Faughnan has also led the development and publication of the first International HHT Guidelines.

Recent Publications

  1. Beslow, LA, Krings, T, Kim, H, Hetts, SW, Lawton, MT, Ratjen, F et al.. De Novo Brain Vascular Malformations in Hereditary Hemorrhagic Telangiectasia. Pediatr Neurol. 2024;155 :120-125. doi: 10.1016/j.pediatrneurol.2024.03.013. PubMed PMID:38631080 .
  2. Beslow, LA, Vossough, A, Kim, H, Nelson, J, Lawton, MT, Pollak, J et al.. Brain AVM compactness score in children with hereditary hemorrhagic telangiectasia. Childs Nerv Syst. 2024; :. doi: 10.1007/s00381-024-06366-z. PubMed PMID:38517485 .
  3. Kilian, A, Latino, GA, White, AJ, Ratjen, F, McDonald, J, Whitehead, KJ et al.. Reply to Eker et al. Comment on "Kilian et al. Comparing Characteristics and Treatment of Brain Vascular Malformations in Children and Adults with HHT. J. Clin. Med. 2023, 12, 2704". J Clin Med. 2023;12 (23):. doi: 10.3390/jcm12237462. PubMed PMID:38068512 PubMed Central PMC10706914.
  4. Cheng, HC, Faughnan, ME, terBrugge, KG, Liu, HM, Krings, T, Brain Vascular Malformation Consortium Hereditary Hemorrhagic Telangiectasia Investigator Group et al.. Prevalence and Characteristics of Intracranial Aneurysms in Hereditary Hemorrhagic Telangiectasia. AJNR Am J Neuroradiol. 2023;44 (12):1367-1372. doi: 10.3174/ajnr.A8058. PubMed PMID:38050014 PubMed Central PMC10714847.
  5. Botsford, A, Tradi, F, Loubet, A, Tantawi, S, Soulez, G, Giroux, MF et al.. Transarterial Embolization of Simple Pulmonary Arteriovenous Malformations: Long-Term Outcomes of 0.018-Inch Coils versus Vascular Plugs. J Vasc Interv Radiol. 2024;35 (3):349-360. doi: 10.1016/j.jvir.2023.11.018. PubMed PMID:38013007 .
  6. Brassil, M, Li, Y, Ko, M, Faughnan, ME, Prabhudesai, V. Pre-operative embolization of a complex systemic to pulmonary vascular malformation. BJR Case Rep. 2023;9 (5):20230056. doi: 10.1259/bjrcr.20230056. PubMed PMID:37780979 PubMed Central PMC10513012.
  7. Dinakaran, S, Zhao, H, Tang, Y, Wang, Z, Ruiz, S, Nomura-Kitabayashi, A et al.. CDK6-mediated endothelial cell cycle acceleration drives arteriovenous malformations in hereditary hemorrhagic telangiectasia. bioRxiv. 2023; :. doi: 10.1101/2023.09.15.554413. PubMed PMID:37745444 PubMed Central PMC10515892.
  8. Tuff-Gordon, E, Faughnan, ME, Kim, H, Lawton, MT, Vozoris, NT, Brain Vascular Malformation Consortium HHT Investigator Group et al.. An analysis of sex differences in pulmonary arteriovenous malformation presentation, complications and management in a large, multinational registry of patients with hereditary haemorrhagic telangiectasia. ERJ Open Res. 2023;9 (3):. doi: 10.1183/23120541.00751-2022. PubMed PMID:37483279 PubMed Central PMC10359038.
  9. Kilian, A, Latino, GA, White, AJ, Ratjen, F, McDonald, J, Whitehead, KJ et al.. Comparing Characteristics and Treatment of Brain Vascular Malformations in Children and Adults with HHT. J Clin Med. 2023;12 (7):. doi: 10.3390/jcm12072704. PubMed PMID:37048789 PubMed Central PMC10094792.
  10. Thompson, KP, Sykes, J, Chandakkar, P, Marambaud, P, Vozoris, NT, Marchuk, DA et al.. Randomized, double-blind, placebo-controlled, crossover trial of oral doxycycline for epistaxis in hereditary hemorrhagic telangiectasia. Orphanet J Rare Dis. 2022;17 (1):405. doi: 10.1186/s13023-022-02539-8. PubMed PMID:36344987 PubMed Central PMC9640829.
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Affiliations & Other Activities

  • Director, Pulmonary Function Laboratory, St. Michael’s Hospital
  • Director, Toronto Hereditary Hemorrhagic Telangiectasia, The Hospital for Sick Children