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Matthew Lincoln

MD, DPhil, FRCPC

Scientist, Keenan Research Centre for Biomedical Science (KRCBS)

Email: matthew.lincoln@unityhealth.to
Other: lincolnlab.ca

Biography

Dr. Lincoln is a geneticist and neurologist at the BARLO Multiple Sclerosis Centre at St. Michael’s Hospital and a scientist at the Keenan Research Centre for Biomedical Science. He is an assistant professor in the Department of Medicine and Institute of Medical Science at the University of Toronto. His laboratory research uses transcriptomic and epigenetic assays, analyzed with modern genetic analysis techniques, to identify molecular mechanisms that drive multiple sclerosis and other autoimmune diseases. His lab is particularly interested in molecular interactions between genetic and environmental risk factors.

He has co-authored over 40 peer-reviewed articles and book chapters on multiple sclerosis and autoimmunity. He holds an Early Career award from the Waugh Family Foundation and a Career Transition Fellowship from the National Multiple Sclerosis Society and the Consortium of Multiple Sclerosis Centers. Postdoctoral research was funded by the MS Society of Canada.

Recent Publications

  1. Levit, E, Leon, J, Lincoln, MR. Pearls & Oy-sters: Homozygous Complement Factor I Deficiency Presenting as Fulminant Relapsing Complement-Mediated CNS Vasculitis. Neurology. 2023;101 (2):e220-e223. doi: 10.1212/WNL.0000000000207079. PubMed PMID:36941072 PubMed Central PMC10351560.
  2. Axisa, PP, Yoshida, TM, Lucca, LE, Kasler, HG, Lincoln, MR, Pham, GH et al.. A multiple sclerosis-protective coding variant reveals an essential role for HDAC7 in regulatory T cells. Sci Transl Med. 2022;14 (675):eabl3651. doi: 10.1126/scitranslmed.abl3651. PubMed PMID:36516268 .
  3. Pitt, D, Lo, CH, Gauthier, SA, Hickman, RA, Longbrake, E, Airas, LM et al.. Toward Precision Phenotyping of Multiple Sclerosis. Neurol Neuroimmunol Neuroinflamm. 2022;9 (6):. doi: 10.1212/NXI.0000000000200025. PubMed PMID:36041861 PubMed Central PMC9427000.
  4. Sumida, TS, Dulberg, S, Schupp, JC, Lincoln, MR, Stillwell, HA, Axisa, PP et al.. Type I interferon transcriptional network regulates expression of coinhibitory receptors in human T cells. Nat Immunol. 2022;23 (4):632-642. doi: 10.1038/s41590-022-01152-y. PubMed PMID:35301508 PubMed Central PMC8989655.
  5. Lincoln, MR, Schneider, R, Oh, J. Vitamin D as disease-modifying therapy for multiple sclerosis?. Expert Rev Clin Immunol. 2021;17 (7):691-693. doi: 10.1080/1744666X.2021.1915772. PubMed PMID:33836645 .
  6. Lincoln, MR, Axisa, PP, Hafler, DA. Epigenetic fine-mapping: identification of causal mechanisms for autoimmunity. Curr Opin Immunol. 2020;67 :50-56. doi: 10.1016/j.coi.2020.09.002. PubMed PMID:32977183 .
  7. International Multiple Sclerosis Genetics Consortium. Author Correction: A systems biology approach uncovers cell-specific gene regulatory effects of genetic associations in multiple sclerosis. Nat Commun. 2019;10 (1):2956. doi: 10.1038/s41467-019-10951-1. PubMed PMID:31263110 PubMed Central PMC6602957.
  8. Sumida, T, Lincoln, MR, Ukeje, CM, Rodriguez, DM, Akazawa, H, Noda, T et al.. Author Correction: Activated β-catenin in Foxp3+ regulatory T cells links inflammatory environments to autoimmunity. Nat Immunol. 2019;20 (7):943. doi: 10.1038/s41590-019-0438-6. PubMed PMID:31175348 .
  9. International Multiple Sclerosis Genetics Consortium. A systems biology approach uncovers cell-specific gene regulatory effects of genetic associations in multiple sclerosis. Nat Commun. 2019;10 (1):2236. doi: 10.1038/s41467-019-09773-y. PubMed PMID:31110181 PubMed Central PMC6527683.
  10. Ponath, G, Lincoln, MR, Levine-Ritterman, M, Park, C, Dahlawi, S, Mubarak, M et al.. Enhanced astrocyte responses are driven by a genetic risk allele associated with multiple sclerosis. Nat Commun. 2018;9 (1):5337. doi: 10.1038/s41467-018-07785-8. PubMed PMID:30559390 PubMed Central PMC6297228.
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Affiliations & Other Activities

  • Division of Neurology, Department of Medicine, University of Toronto
  • Institute of Medical Science, University of Toronto