Matthew Muller




Dr. Matthew Muller is an infectious diseases physician and the Medical Director of Infection Prevention and Control at Unity Health Toronto. He is an Associate Professor at the University of Toronto in the Department of Medicine. His research interests are focused on the epidemiology and previous of hospital-acquired infections including C. difficile, infections due to common antibiotic-resistant organisms and emerging infectious threats such as MERS-CoV and SARS-CoV2. Dr. Muller has a particular interest in hand hygiene measurement and improvement including the use of novel technological approaches to hand hygiene improvement. Dr. Muller chairs the Provincial Infectious Diseases Advisory Committee on Infection Prevention and Control, and is also interested in guideline and policy development with respect to infection prevention for Ontario hospitals.

Recent Publications

  1. Soe, P, Wong, H, Naus, M, Muller, MP, Vanderkooi, OG, Kellner, JD et al.. mRNA COVID-19 vaccine safety among older adults from the Canadian National Vaccine Safety Network. Vaccine. 2024;42 (18):3819-3829. doi: 10.1016/j.vaccine.2024.04.096. PubMed PMID:38714447 .
  2. Veroniki, AA, Thirugnanasampanthar, SS, Konstantinidis, M, Dourka, J, Ghassemi, M, Neupane, D et al.. Trivalent and quadrivalent seasonal influenza vaccine in adults aged 60 and older: a systematic review and network meta-analysis. BMJ Evid Based Med. 2024; :. doi: 10.1136/bmjebm-2023-112767. PubMed PMID:38604619 .
  3. Sukhdeo, S, Muller, M, McGeer, A, Leis, JA, Chan, A, Gubbay, JB et al.. Environmental Surface Contamination With Monkeypox Virus in the Ambulatory Setting in Toronto, Canada. Open Forum Infect Dis. 2023;10 (2):ofac648. doi: 10.1093/ofid/ofac648. PubMed PMID:36756631 PubMed Central PMC9901272.
  4. Airo, AM, Barker, KR, Muller, MP, Taggart, LR, Boissinot, K, Fattouh, R et al.. Detection of SARS-CoV-2 from combined nasal/rectal swabs. Antimicrob Steward Healthc Epidemiol. 2023;3 (1):e7. doi: 10.1017/ash.2022.321. PubMed PMID:36714296 PubMed Central PMC9879873.
  5. Loeb, M, Bartholomew, A, Hashmi, M, Tarhuni, W, Hassany, M, Youngster, I et al.. Medical Masks Versus N95 Respirators for Preventing COVID-19 Among Health Care Workers : A Randomized Trial. Ann Intern Med. 2022;175 (12):1629-1638. doi: 10.7326/M22-1966. PubMed PMID:36442064 PubMed Central PMC9707441.
  6. Bettinger, JA, Irvine, MA, Shulha, HP, Valiquette, L, Muller, MP, Vanderkooi, OG et al.. Adverse Events Following Immunization With mRNA and Viral Vector Vaccines in Individuals With Previous Severe Acute Respiratory Syndrome Coronavirus 2 Infection From the Canadian National Vaccine Safety Network. Clin Infect Dis. 2023;76 (6):1088-1102. doi: 10.1093/cid/ciac852. PubMed PMID:36310514 PubMed Central PMC9620384.
  7. Muller, MP, Mishra, S, McGeer, A, Patel, S, Gubbay, J, Hasso, M et al.. Environmental Testing of Surfaces in the Room of a Patient With Mpox. Clin Infect Dis. 2023;76 (1):179-181. doi: 10.1093/cid/ciac654. PubMed PMID:35982540 .
  8. Sadarangani, M, Soe, P, Shulha, HP, Valiquette, L, Vanderkooi, OG, Kellner, JD et al.. Safety of COVID-19 vaccines in pregnancy: a Canadian National Vaccine Safety (CANVAS) network cohort study. Lancet Infect Dis. 2022;22 (11):1553-1564. doi: 10.1016/S1473-3099(22)00426-1. PubMed PMID:35964614 PubMed Central PMC9371587.
  9. Pham, B, Rios, P, Radhakrishnan, A, Darvesh, N, Antony, J, Williams, C et al.. Comparative-effectiveness research of COVID-19 treatment: a rapid scoping review. BMJ Open. 2022;12 (6):e045115. doi: 10.1136/bmjopen-2020-045115. PubMed PMID:35947494 PubMed Central PMC9170799.
  10. Casalino, M, Jegathesan, T, Sgro, M, Rea, E, Muller, M, Campbell, DM et al.. Tuberculosis Exposure from a Healthcare Worker to Patients in a Neonatal Intensive Care Unit (NICU). Can J Infect Dis Med Microbiol. 2022;2022 :2659883. doi: 10.1155/2022/2659883. PubMed PMID:35812013 PubMed Central PMC9259362.
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Affiliations & Other Activities

  • Medical Director, Infection Prevention and Control, St. Michael’s Hospital
  • Assistant Professor, Department of Medicine, University of Toronto