Paul Dorian

MD, MSc, FRCP(C)

Scientist

Research Programs

Biography

Dr. Dorian received his medical degree from McGill University in Montreal in 1976.  He completed training in Internal Medicine, Clinical Pharmacology, and Cardiology at the University of Toronto and completed a Fellowship in Cardiac Electrophysiology at Stanford University.  He is a Professor of Medicine in the Division of Cardiology and in the Division of Clinical Pharmacology at the University of Toronto, and a Staff Scientist at the Li Ka Shing Knowledge Institute, and is Staff Cardiac Electrophysiologist at St. Michael’s Hospital.

Dr. Paul Dorian was the Department Director, Division of Cardiology, University of Toronto (2009-2019), and President of the Canadian Heart Rhythm Society (2013-2014).

He is a recipient of the University of Toronto Department of Medicine Research Award, and the Canadian Cardiovascular Society and Canadian Heart Rhythm Society Achievement Awards.

He has served and continues to serve on the steering committees of multiple multicenter clinical trials in arrhythmia care.

He was the principal investigator of the ALIVE RCT of antiarrhythmic drugs in cardiac arrest, the Family study on predicting and preventing sudden cardiac death, the CIHR funded EpiDOSE Trial, and the Program to reduce sudden death funded by the Canadian Arrhythmia Network.

He has led a basic science research program on the mechanisms of ventricular fibrillation, treatment of experimental cardiac arrest, and the circulatory and electrophysiology of cardio pulmonary resuscitation.

He has also been active in a research program on the establishment of optimum systems of care for patients with atrial fibrillation, including assessment of quality of life in patient reported outcomes.  He designed and led the implementation of scales to measure quality of life in AF, including the Canadian Cardiovascular Society Severity in Atrial Fibrillation (CCS-SAF) score, The AFSS scale, and the AFEQT scale, which are the most used methods for the measurement of quality of life in patients with AF.

He is one of the core participants of the University of Toronto Sports Cardiology Program which brings together academic researchers, academic and community cardiologists, physiology researchers, students, and patients in the establishment of a clinical and research program in sports cardiology.  He has led studies on the incidence and causes of sudden death in competitive sport, and the diagnostic accuracy of the ECG in athlete screening.

He has served on the CCS guidelines/position paper writing panel committee for atrial fibrillation, heart failure, ventricular arrhythmia, and athlete preparticipation screening.

He has published over 500 peer reviewed papers and is Associate Editor of the textbook Electrophysiological Disorders of the Heart.

Recent Publications

  1. Buckley, BJR, Lane, DA, Calvert, P, Zhang, J, Gent, D, Mullins, CD et al.. Effectiveness and Safety of Apixaban in over 3.9 Million People with Atrial Fibrillation: A Systematic Review and Meta-Analysis. J Clin Med. 2022;11 (13):. doi: 10.3390/jcm11133788. PubMed PMID:35807073 PubMed Central PMC9267894.
  2. Malik, A, Gewarges, M, Pezzutti, O, Allan, KS, Samman, A, Akioyamen, LE et al.. Association between sex and survival after non-traumatic out of hospital cardiac arrest: A systematic review and meta-analysis. Resuscitation. 2022; :. doi: 10.1016/j.resuscitation.2022.06.011. PubMed PMID:35728744 .
  3. Kulangareth, NV, Magtibay, K, Massé, S, Krishnakumar Nair,, Dorian, P, Nanthakumar, K et al.. An In-Silico model for evaluating the directional shock vectors in terminating and modulating rotors. Comput Biol Med. 2022;146 :105665. doi: 10.1016/j.compbiomed.2022.105665. PubMed PMID:35654624 .
  4. Moulson, N, Connelly, KA, Dorian, P, Fournier, A, Goodman, JM, Grubic, N et al.. COVID-19, Inflammatory Heart Disease, and Vaccination in the Athlete and Highly Active Person: An Update and Further Considerations. Can J Cardiol. 2022; :. doi: 10.1016/j.cjca.2022.05.019. PubMed PMID:35643383 PubMed Central PMC9132493.
  5. Way, KL, Birnie, D, Blanchard, C, Wells, G, Dorian, P, Jorstad, HT et al.. The Physical Activity Levels and Sitting Time of Adults Living With Atrial Fibrillation: The CHAMPLAIN-AF Study. CJC Open. 2022;4 (5):449-465. doi: 10.1016/j.cjco.2022.01.004. PubMed PMID:35607489 PubMed Central PMC9123363.
  6. Lin, S, Ramadeen, A, Sundermann, ML, Dorian, P, Fink, S, Halperin, HR et al.. Establishing a multicenter, preclinical consortium in resuscitation: A pilot experimental trial evaluating epinephrine in cardiac arrest. Resuscitation. 2022;175 :57-63. doi: 10.1016/j.resuscitation.2022.04.016. PubMed PMID:35472628 .
  7. Rahimi, M, Dorian, P, Cheskes, S, Lebovic, G, Lin, S. Effect of Time to Treatment With Antiarrhythmic Drugs on Return of Spontaneous Circulation in Shock-Refractory Out-of-Hospital Cardiac Arrest. J Am Heart Assoc. 2022;11 (6):e023958. doi: 10.1161/JAHA.121.023958. PubMed PMID:35243875 PubMed Central PMC9075276.
  8. Lane, DJ, Grunau, B, Kudenchuk, P, Dorian, P, Wang, HE, Daya, MR et al.. Bayesian analysis of amiodarone or lidocaine versus placebo for out-of-hospital cardiac arrest. Heart. 2022; :. doi: 10.1136/heartjnl-2021-320513. PubMed PMID:35236764 .
  9. Abdel-Qadir, H, Gunn, M, Lega, IC, Pang, A, Austin, PC, Singh, SM et al.. Association of Diabetes Duration and Glycemic Control With Stroke Rate in Patients With Atrial Fibrillation and Diabetes: A Population-Based Cohort Study. J Am Heart Assoc. 2022;11 (4):e023643. doi: 10.1161/JAHA.121.023643. PubMed PMID:35132863 PubMed Central PMC9245806.
  10. Vrinceanu, T, Khairy, P, Roy, D, Payer, M, Gagnon, C, Kaushal, N et al.. Pattern of Atrial Fibrillation and Cognitive Function in Young Patients With Atrial Fibrillation and Low CHADS2 Score: Insights From the BRAIN-AF Trial. Circ Arrhythm Electrophysiol. 2022;15 (2):e010462. doi: 10.1161/CIRCEP.121.010462. PubMed PMID:35089051 .
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Affiliations & Other Activities

  • Staff Cardiac Electrophysiologist, St. Michael’s Hospital
  • Professor, Medicine and Cardiology, St. Michael’s Hospital, University of Toronto
  • Director, Division of Cardiology, University of Toronto