Philip Connelly

PhD, BA

Affiliate Scientist

Biography

Dr. Phil Connelly is a Staff Scientist in the Keenan Research Centre for Biomedical Science of St. Michael’s Hospital. He has a primary academic appointment in the Department of Medicine at the University of Toronto, as well as a graduate appointment in the Department of Laboratory Medicine and Pathobiology. Dr. Connelly’s current basic research is focused on the metabolism of hydroxy fatty aldehydes. The chemistry of this system involves glutathione and the products are readily exported from the cells to undergo further metabolism. The products are known to be proinflammatory and, we hypothesize, atherothrombotic.

Collaborative research on patient populations is focused on renal transplant recipients, women with gestational diabetes and subjects with pre-diabetes.

Recent Publications

  1. Retnakaran, R, Pu, J, Hanley, AJ, Connelly, PW, Sermer, M, Zinman, B et al.. Future cardiometabolic implications of insulin hypersecretion in response to oral glucose: a prospective cohort study. EClinicalMedicine. 2024;67 :102363. doi: 10.1016/j.eclinm.2023.102363. PubMed PMID:38314059 PubMed Central PMC10837529.
  2. Mehmood, S, Ye, C, Hanley, AJ, Connelly, PW, Sermer, M, Zinman, B et al.. Impact of the diagnosis of gestational diabetes on maternal physical activity after pregnancy. Diabetes Obes Metab. 2023; :. doi: 10.1111/dom.15415. PubMed PMID:38116699 .
  3. Retnakaran, R, Ye, C, Kramer, CK, Hanley, AJ, Connelly, PW, Sermer, M et al.. Deteriorating beta cell function is the dominant determinant of progression from normal glucose tolerance to prediabetes/diabetes in young women following pregnancy. Diabetologia. 2023;66 (11):2154-2163. doi: 10.1007/s00125-023-05994-5. PubMed PMID:37612415 .
  4. Retnakaran, R, Ye, C, Hanley, AJ, Connelly, PW, Sermer, M, Zinman, B et al.. Treatment of Gestational Diabetes Mellitus and Maternal Risk of Diabetes After Pregnancy. Diabetes Care. 2023;46 (3):587-592. doi: 10.2337/dc22-1786. PubMed PMID:36602334 .
  5. Jenkins, DJA, Chiavaroli, L, Mirrahimi, A, Mitchell, S, Faulkner, D, Sahye-Pudaruth, S et al.. Glycemic Index Versus Wheat Fiber on Arterial Wall Damage in Diabetes: A Randomized Controlled Trial. Diabetes Care. 2022;45 (12):2862-2870. doi: 10.2337/dc22-1028. PubMed PMID:36326712 PubMed Central PMC9862401.
  6. Retnakaran, R, Ye, C, Hanley, AJ, Connelly, PW, Sermer, M, Zinman, B et al.. Treating Gestational Diabetes Reduces Birth Weight but Does Not Affect Infant Adiposity Across the 1st Year of Life. Diabetes Care. 2022;45 (5):1230-1238. doi: 10.2337/dc21-2640. PubMed PMID:35259243 .
  7. Cai, S, Mahmood, T, Hashi, AA, Prasad, R, Connelly, PW, Connelly, KA et al.. Assessments of right ventricular strain using cardiac magnetic resonance imaging following kidney transplantation. Nephrology (Carlton). 2022;27 (4):371-375. doi: 10.1111/nep.14015. PubMed PMID:34939711 .
  8. Connelly, PW, Yan, AT, Nash, MM, Wald, RM, Lok, C, Gunaratnam, L et al.. The Increase in Paraoxonase 1 Is Associated With Decrease in Left Ventricular Volume in Kidney Transplant Recipients. Front Cardiovasc Med. 2021;8 :763389. doi: 10.3389/fcvm.2021.763389. PubMed PMID:34926614 PubMed Central PMC8674585.
  9. Retnakaran, R, Ye, C, Hanley, AJ, Connelly, PW, Sermer, M, Zinman, B et al.. Subtypes of gestational diabetes and future risk of pre-diabetes or diabetes. EClinicalMedicine. 2021;40 :101087. doi: 10.1016/j.eclinm.2021.101087. PubMed PMID:34746711 PubMed Central PMC8548926.
  10. Semnani-Azad, Z, Connelly, PW, Bazinet, RP, Retnakaran, R, Jenkins, DJA, Harris, SB et al.. Adipose Tissue Insulin Resistance Is Longitudinally Associated With Adipose Tissue Dysfunction, Circulating Lipids, and Dysglycemia: The PROMISE Cohort. Diabetes Care. 2021;44 (7):1682-1691. doi: 10.2337/dc20-1918. PubMed PMID:34001534 .
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Affiliations & Other Activities

  • Director, J. Alick Little Lipid Research Laboratory, St. Michael’s Hospital
  • Professor, Department of Medicine, Division of Endocrinology, University of Toronto
  • Professor, Laboratory Medicine and Pathobiology, University of Toronto