Philip Connelly


Affiliate Scientist


Dr. Phil Connelly is a Staff ScientistĀ in the Keenan Research Centre for Biomedical Science of St. Michael’s Hospital.Ā HeĀ has a primary academic appointment in the Department of Medicine atĀ the University of Toronto, as well as a graduate appointment in the Department of Laboratory Medicine and Pathobiology. Dr. Connelly’s current basic research is focused on the metabolism of hydroxy fatty aldehydes. The chemistry of this system involves glutathione and the products are readily exported from the cells to undergo further metabolism. The products are known to be proinflammatory and, we hypothesize, atherothrombotic.

Collaborative research on patient populations is focused on renal transplant recipients, women with gestational diabetes and subjects with pre-diabetes.

Recent Publications

  1. Retnakaran, R, Ye, C, Hanley, AJ, Connelly, PW, Sermer, M, Zinman, B et al.. Treating Gestational Diabetes Reduces Birth Weight but Does Not Affect Infant Adiposity Across the 1st Year of Life. Diabetes Care. 2022;45 (5):1230-1238. doi: 10.2337/dc21-2640. PubMed PMID:35259243 .
  2. Cai, S, Mahmood, T, Hashi, AA, Prasad, R, Connelly, PW, Connelly, KA et al.. Assessments of right ventricular strain using cardiac magnetic resonance imaging following kidney transplantation. Nephrology (Carlton). 2022;27 (4):371-375. doi: 10.1111/nep.14015. PubMed PMID:34939711 .
  3. Connelly, PW, Yan, AT, Nash, MM, Wald, RM, Lok, C, Gunaratnam, L et al.. The Increase in Paraoxonase 1 Is Associated With Decrease in Left Ventricular Volume in Kidney Transplant Recipients. Front Cardiovasc Med. 2021;8 :763389. doi: 10.3389/fcvm.2021.763389. PubMed PMID:34926614 PubMed Central PMC8674585.
  4. Retnakaran, R, Ye, C, Hanley, AJ, Connelly, PW, Sermer, M, Zinman, B et al.. Subtypes of gestational diabetes and future risk of pre-diabetes or diabetes. EClinicalMedicine. 2021;40 :101087. doi: 10.1016/j.eclinm.2021.101087. PubMed PMID:34746711 PubMed Central PMC8548926.
  5. Semnani-Azad, Z, Connelly, PW, Bazinet, RP, Retnakaran, R, Jenkins, DJA, Harris, SB et al.. Adipose Tissue Insulin Resistance Is Longitudinally Associated With Adipose Tissue Dysfunction, Circulating Lipids, and Dysglycemia: The PROMISE Cohort. Diabetes Care. 2021;44 (7):1682-1691. doi: 10.2337/dc20-1918. PubMed PMID:34001534 .
  6. Semnani-Azad, Z, Blanco Mejia, S, Connelly, PW, Bazinet, RP, Retnakaran, R, Jenkins, DJA et al.. The association of soluble CD163, a novel biomarker of macrophage activation, with type 2 diabetes mellitus and its underlying physiological disorders: A systematic review. Obes Rev. 2021;22 (9):e13257. doi: 10.1111/obr.13257. PubMed PMID:33913230 .
  7. Mutch, DM, Lowry, DE, Roth, M, Sihag, J, Hammad, SS, Taylor, CG et al.. Polymorphisms in the stearoyl-CoA desaturase gene modify blood glucose response to dietary oils varying in MUFA content in adults with obesity. Br J Nutr. 2022;127 (4):503-512. doi: 10.1017/S0007114521001264. PubMed PMID:33829984 .
  8. Hashi, AA, Ramesh Prasad, GV, Connelly, PW, Deva, DP, Nash, MM, Yuan, W et al.. Cardiac MRI assessment of the right ventricle pre-and post-kidney transplant. Int J Cardiovasc Imaging. 2021;37 (5):1757-1766. doi: 10.1007/s10554-020-02153-4. PubMed PMID:33475872 .
  9. Huang, F, Connelly, PW, Prasad, GVR, Nash, MM, Gunaratnam, L, Deva, DP et al.. Evaluation of left atrial remodeling in kidney transplant patients using cardiac magnetic resonance imaging. J Nephrol. 2021;34 (3):851-859. doi: 10.1007/s40620-020-00853-7. PubMed PMID:32910428 .
  10. Semnani-Azad, Z, Johnston, LW, Lee, C, Retnakaran, R, Connelly, PW, Harris, SB et al.. Determinants of longitudinal change in insulin clearance: the Prospective Metabolism and Islet Cell Evaluation cohort. BMJ Open Diabetes Res Care. 2019;7 (1):e000825. doi: 10.1136/bmjdrc-2019-000825. PubMed PMID:31803485 PubMed Central PMC6887510.
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Affiliations & Other Activities

  • Director, J. Alick Little Lipid Research Laboratory, St. Michael’s Hospital
  • Professor, Department of Medicine, Division of Endocrinology, University of Toronto
  • Professor, Laboratory Medicine and Pathobiology, University of Toronto