Raphael Schneider


Investigator, Li Ka Shing Knowledge Institute


Dr. Raphael Schneider is a neurologist and researcher working in the BARLO MS Centre at St. Michael’s Hospital. He is an assistant professor at the University of Toronto in both the Department of Medicine and the Institute of Medical Science. He completed a Ph.D. in the Department of Laboratory Medicine and Pathobiology (neuroscience) at the University of Toronto, focusing on extracellular vesicles as biomarkers in neurological diseases and a postdoctoral fellowship in neuroimmunology at the Université de Montréal where he studied the role of CD8+ T lymphocytes in multiple sclerosis (MS). Before joining the MS group at St. Michael’s Hospital, Dr. Schneider completed the Clinical Investigator Program of the Royal College of Physicians and Surgeons of Canada supported by a Phillipson Clinician-Scientist scholarship.

Dr. Schneider’s primary research focus is finding new blood and spinal fluid biomarkers for people with MS. He is particularly interested in early diagnosis and estimation of prognosis. He has recently been awarded a Slamen-Fast New Initiatives in Neurology Award and a Medical Research Grant from the J.P. Bickell Foundation.

Recent Publications

  1. Lee, S, Muccilli, A, Schneider, R, Selchen, D, Krysko, KM. Acute central nervous system inflammation following COVID-19 vaccination: An observational cohort study. Mult Scler. 2023;29 (4-5):595-605. doi: 10.1177/13524585231154780. PubMed PMID:36840605 PubMed Central PMC9969223.
  2. Kim, ST, Muñoz-Grajales, C, Dunn, SE, Schneider, R, Johnson, SR, Touma, Z et al.. Interferon and interferon-induced cytokines as markers of impending clinical progression in ANA+ individuals without a systemic autoimmune rheumatic disease diagnosis. Arthritis Res Ther. 2023;25 (1):21. doi: 10.1186/s13075-023-02997-w. PubMed PMID:36765391 PubMed Central PMC9912609.
  3. Schneider, R, Oh, J. Bruton's Tyrosine Kinase Inhibition in Multiple Sclerosis. Curr Neurol Neurosci Rep. 2022;22 (11):721-734. doi: 10.1007/s11910-022-01229-z. PubMed PMID:36301434 PubMed Central PMC9607648.
  4. Vosoughi, AR, Muccilli, A, Schneider, R, Rotstein, D, Micieli, JA. Recovery of Vision in Myelin Oligodendrocyte Glycoprotein-IgG Optic Neuritis Without Treatment: A Case Series. J Neuroophthalmol. 2022; :. doi: 10.1097/WNO.0000000000001583. PubMed PMID:36166801 .
  5. Morrow, SA, Clift, F, Devonshire, V, Lapointe, E, Schneider, R, Stefanelli, M et al.. Use of natalizumab in persons with multiple sclerosis: 2022 update. Mult Scler Relat Disord. 2022;65 :103995. doi: 10.1016/j.msard.2022.103995. PubMed PMID:35810718 .
  6. Menon, BK, Buck, BH, Singh, N, Deschaintre, Y, Almekhlafi, MA, Coutts, SB et al.. Intravenous tenecteplase compared with alteplase for acute ischaemic stroke in Canada (AcT): a pragmatic, multicentre, open-label, registry-linked, randomised, controlled, non-inferiority trial. Lancet. 2022;400 (10347):161-169. doi: 10.1016/S0140-6736(22)01054-6. PubMed PMID:35779553 .
  7. Kuntz, S, Saab, G, Schneider, R. Antibody-Positive Neuromyelitis Optica Spectrum Disorder After Second COVID-19 Vaccination: a Case Report. SN Compr Clin Med. 2022;4 (1):130. doi: 10.1007/s42399-022-01213-1. PubMed PMID:35761845 PubMed Central PMC9219391.
  8. Solomon, JM, Jones, A, Hohol, M, Krysko, KM, Muccilli, A, Roll, A et al.. Clinical characteristics and outcomes of multiple sclerosis patients with COVID-19 in Toronto, Canada. Mult Scler Relat Disord. 2022;58 :103509. doi: 10.1016/j.msard.2022.103509. PubMed PMID:35030366 PubMed Central PMC8741626.
  9. Gilani, K, Kuntz, S, Munoz, DG, Schneider, R. Pearls & Oy-sters: Rosai-Dorfman Disease of the Central Nervous System. Neurology. 2021; :. doi: 10.1212/WNL.0000000000012035. PubMed PMID:33849989 .
  10. Lincoln, MR, Schneider, R, Oh, J. Vitamin D as disease-modifying therapy for multiple sclerosis?. Expert Rev Clin Immunol. 2021;17 (7):691-693. doi: 10.1080/1744666X.2021.1915772. PubMed PMID:33836645 .
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Affiliations & Other Activities

  • Assistant Professor, Department of Medicine, University of Toronto
  • Assistant Professor, Institute of Medical Science, University of Toronto