Rola Saleeb

MD, PhD, FRCPC

Investigator

Biography

Dr. Saleeb received her Medical degree from the Kasr Al-Einy Faculty of Medicine, Cairo University. She completed a combined Anatomical Pathology postgraduate training/PhD training at University of Toronto. She has also completed the one-year Transformative Pathology molecular fellowship granted by the Ontario Institute of Cancer Research. Dr. Saleeb’s research focus is Genitourinary Pathology and Kidney cancer. Dr. Saleeb’s research focus is translational research in the fields of Molecular Pathology and Genitourinary pathology. She believes in the importance of integrating the tumor’s morphology with its molecular makeup to define and determine its characteristics. Her doctorate research was focused on studying Papillary Renal Cell Carcinoma, for which the authors have proposed a combined molecular and morphological classification, (“biological classification”) that would better stratify patients from prognostic and predictive aspects.

Saleeb, Rola M., Fadi Brimo, Mina Farag, Alexis Rompré-Brodeur, Fabio Rotondo, Vidya Beharry, Samantha Wala et al. “Toward Biological Subtyping of Papillary Renal Cell Carcinoma With Clinical Implications Through Histologic, Immunohistochemical, and Molecular Analysis.” The American journal of surgical pathology 41, no. 12 (2017): 1618-1629.

Recent Publications

  1. Castillo, VF, Masoomian, M, Trpkov, K, Downes, M, Brimo, F, van der Kwast, T et al.. ABCC2 brush-border expression predicts outcome in papillary renal cell carcinoma: a multi-institutional study of 254 cases. Histopathology. 2023;83 (6):949-958. doi: 10.1111/his.15042. PubMed PMID:37680023 .
  2. Mimosa, ML, Al-Ameri, W, Simpson, JT, Nakhla, M, Boissinot, K, Munoz, DG et al.. A Novel Approach to Detect IDH Point Mutations in Gliomas Using Nanopore Sequencing: Test Validation for the Clinical Laboratory. J Mol Diagn. 2023;25 (3):133-142. doi: 10.1016/j.jmoldx.2022.12.001. PubMed PMID:36565986 .
  3. Al-Obaidy, KI, Saleeb, RM, Trpkov, K, Williamson, SR, Sangoi, AR, Nassiri, M et al.. Recurrent KRAS mutations are early events in the development of papillary renal neoplasm with reverse polarity. Mod Pathol. 2022;35 (9):1279-1286. doi: 10.1038/s41379-022-01018-6. PubMed PMID:35152262 .
  4. Saleeb, RM, Brimo, F, Gao, Y, Boulos, C, Kim, SS, Al Bashir, S et al.. ABCC2 expression in papillary renal cell carcinoma provides better prognostic stratification than WHO/ISUP nucleolar grade. Hum Pathol. 2022;120 :57-70. doi: 10.1016/j.humpath.2021.12.006. PubMed PMID:34958810 .
  5. Thoeni, C, Ordon, M, Krizova, A, Jakate, K, Saleeb, RM. Perinephric myxoid pseudotumour of fat - first described case in allograft kidney, a mimicker of malignancy. Histopathology. 2021;79 (6):1108-1110. doi: 10.1111/his.14382. PubMed PMID:33835530 .
  6. Trpkov, K, Williamson, SR, Gill, AJ, Adeniran, AJ, Agaimy, A, Alaghehbandan, R et al.. Correction to: Novel, emerging and provisional renal entities: the Genitourinary Pathology Society (GUPS) update on renal neoplasia. Mod Pathol. 2021;34 (5):1037. doi: 10.1038/s41379-021-00775-0. PubMed PMID:33727698 .
  7. Trpkov, K, Hes, O, Williamson, SR, Adeniran, AJ, Agaimy, A, Alaghehbandan, R et al.. New developments in existing WHO entities and evolving molecular concepts: The Genitourinary Pathology Society (GUPS) update on renal neoplasia. Mod Pathol. 2021;34 (7):1392-1424. doi: 10.1038/s41379-021-00779-w. PubMed PMID:33664427 .
  8. Trpkov, K, Williamson, SR, Gill, AJ, Adeniran, AJ, Agaimy, A, Alaghehbandan, R et al.. Novel, emerging and provisional renal entities: The Genitourinary Pathology Society (GUPS) update on renal neoplasia. Mod Pathol. 2021;34 (6):1167-1184. doi: 10.1038/s41379-021-00737-6. PubMed PMID:33526874 .
  9. Saleeb, RM, Farag, M, Ding, Q, Downes, M, Bjarnason, G, Brimo, F et al.. Integrated Molecular Analysis of Papillary Renal Cell Carcinoma and Precursor Lesions Unfolds Evolutionary Process from Kidney Progenitor-Like Cells. Am J Pathol. 2019;189 (10):2046-2060. doi: 10.1016/j.ajpath.2019.07.002. PubMed PMID:31381885 .
  10. Saleeb, RM, Farag, M, Lichner, Z, Brimo, F, Bartlett, J, Bjarnason, G et al.. Modulating ATP binding cassette transporters in papillary renal cell carcinoma type 2 enhances its response to targeted molecular therapy. Mol Oncol. 2018;12 (10):1673-1688. doi: 10.1002/1878-0261.12346. PubMed PMID:29896907 PubMed Central PMC6165997.
Search PubMed

Affiliations & Other Activities

  • Staff Pathologist, Laboratory Medicine, St. Michael’s Hospital
  • Assistant Professor, University of Toronto