Research Programs

Biography

Dr. Sakina Rizvi is a Scientist and Psychotherapist in the Arthur Sommer Rotenberg (ASR) Suicide and Depression Studies Program at St. Michael’s Hospital, and an Associate Professor of Psychiatry at the University of Toronto. Her research program aims to characterize the neurobiology of suicide risk and treatment resistant depression (TRD), primarily through the use of fMRI and PET neuroimaging. Within her biomarker research, she is evaluating brain reward and pain processing as markers to stratify depression and suicide risk, as well as treatment outcome. In addition to neuroimaging research, Dr. Rizvi develops and tests novel psychotherapies for suicide risk and depression. She also conducts patient-engagement research to create community-based suicide prevention strategies. Dr. Rizvi is actively involved in outreach and advocacy projects with an emphasis on providing mental health education to the community through the creative arts. She led the Storybook Project, a lived experience short story collection on the impact of suicide published in September 2021 as “What it Takes to Make it Through: Stories of Suicide Loss and Resilience”.

Recent Publications

  1. Lin, J, Su, Y, Rizvi, SJ, Jagoda, J, Li, J, Wu, Y et al.. Define and characterize the anhedonia in major depressive disorder: An explorative study. J Affect Disord. 2022;313 :235-242. doi: 10.1016/j.jad.2022.06.082. PubMed PMID:35788366 .
  2. Wang, S, Leri, F, Rizvi, SJ. Clinical and Preclinical Assessments of Anhedonia in Psychiatric Disorders. Curr Top Behav Neurosci. 2022;58 :3-21. doi: 10.1007/7854_2022_318. PubMed PMID:35435647 .
  3. Arrua-Duarte, E, Migoya-Borja, M, Barahona, I, Quilty, LC, Rizvi, SJ, Kennedy, SH et al.. Comparative study of the pencil-and-paper and digital formats of the Spanish DARS scale. Acta Neuropsychiatr. 2021; :1-7. doi: 10.1017/neu.2021.45. PubMed PMID:34939915 .
  4. Lalovic, A, Wang, S, Keilp, JG, Bowie, CR, Kennedy, SH, Rizvi, SJ et al.. A qualitative systematic review of neurocognition in suicide ideators and attempters: Implications for cognitive-based psychotherapeutic interventions. Neurosci Biobehav Rev. 2022;132 :92-109. doi: 10.1016/j.neubiorev.2021.11.007. PubMed PMID:34774586 .
  5. Elias, GJB, Germann, J, Boutet, A, Pancholi, A, Beyn, ME, Bhatia, K et al.. Structuro-functional surrogates of response to subcallosal cingulate deep brain stimulation for depression. Brain. 2022;145 (1):362-377. doi: 10.1093/brain/awab284. PubMed PMID:34324658 .
  6. Rizvi, SJ, Gandhi, W, Salomons, T. Reward processing as a common diathesis for chronic pain and depression. Neurosci Biobehav Rev. 2021;127 :749-760. doi: 10.1016/j.neubiorev.2021.04.033. PubMed PMID:33951413 .
  7. Wang, S, Leri, F, Rizvi, SJ. Anhedonia as a central factor in depression: Neural mechanisms revealed from preclinical to clinical evidence. Prog Neuropsychopharmacol Biol Psychiatry. 2021;110 :110289. doi: 10.1016/j.pnpbp.2021.110289. PubMed PMID:33631251 .
  8. Vaccarino, AL, Kalali, AH, Blier, P, Gilbert Evans, S, Engelhardt, N, Foster, JA et al.. THE DEPRESSION INVENTORY DEVELOPMENT SCALE: Assessment of Psychometric Properties Using Classical and Modern Measurement Theory in a CAN-BIND Trial. Innov Clin Neurosci. 2020;17 (7-9):30-40. . PubMed PMID:33520402 PubMed Central PMC7839654.
  9. Jehan, F, Sazawal, S, Baqui, AH, Nisar, MI, Dhingra, U, Khanam, R et al.. Multiomics Characterization of Preterm Birth in Low- and Middle-Income Countries. JAMA Netw Open. 2020;3 (12):e2029655. doi: 10.1001/jamanetworkopen.2020.29655. PubMed PMID:33337494 PubMed Central PMC7749442.
  10. Hatcher, S, Heisel, M, Ayonrinde, O, Campbell, JK, Colman, I, Corsi, DJ et al.. The BEACON study: protocol for a cohort study as part of an evaluation of the effectiveness of smartphone-assisted problem-solving therapy in men who present with intentional self-harm to emergency departments in Ontario. Trials. 2020;21 (1):925. doi: 10.1186/s13063-020-04424-w. PubMed PMID:33187542 PubMed Central PMC7663866.
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Affiliations & Other Activities

  • Associate Professor, Department of Psychiatry, Faculty of Medicine Collaborative Program in Neuroscience, University of Toronto
  • Scientific Associate, Department of Psychiatry, University Health Network