Samir Gupta



Research Programs


Samir Gupta is a Respirologist and clinician-scientist at the Li Ka Shing Knowledge Institute of St. Michael’s Hospital and an Associate Professor in the Department of Medicine at the University of Toronto.  He completed his Master’s degree in Clinical Epidemiology at the University of Toronto, followed by a fellowship in Knowledge Translation Research.

His main research interest is in knowledge translation across the spectrum of respiratory illness, with a focus on electronic tools for behaviour change. His team built and launched the Electronic Asthma Management System (eAMS) ( He also has an interest in rare lung disease research methods, and is founder and Head of the Canadian Hepatopulmonary Syndrome Program ( He has a specific interest in science communication, and serves as a medical correspondent for various media outlets.  He also serves as Chair of the Canadian Respiratory Guidelines Committee and holds the University of Toronto Michael Locke Term Chair in Knowledge Translation and Rare Lung Disease Research.

Recent Publications

  1. Malecki, S, Loffler, A, Liao, F, Hora, T, Agarwal, A, Lail, S et al.. Real-world use of glucocorticoids and clinical outcomes in adults hospitalized with community-acquired pneumonia on medical wards. J Hosp Med. 2024; :. doi: 10.1002/jhm.13422. PubMed PMID:38824463 .
  2. Aaron, SD, Vandemheen, KL, Whitmore, GA, Bergeron, C, Boulet, LP, Côté, A et al.. Early Diagnosis and Treatment of COPD and Asthma - A Randomized, Controlled Trial. N Engl J Med. 2024;390 (22):2061-2073. doi: 10.1056/NEJMoa2401389. PubMed PMID:38767248 .
  3. Gupta, S, Couillard, S, Digby, G, Tse, SM, Green, S, Penz, E et al.. Climate Change and Inhaler Selection in Patients With Respiratory Disease. Chest. 2024;165 (3):503-506. doi: 10.1016/j.chest.2023.09.025. PubMed PMID:38461016 .
  4. Moloney, M, Morra, A, Morkem, R, Queenan, J, Gupta, S, To, T et al.. Validation of adult asthma case definitions for primary care sentinel surveillance. Allergy Asthma Clin Immunol. 2023;19 (1):95. doi: 10.1186/s13223-023-00854-8. PubMed PMID:37957742 PubMed Central PMC10644606.
  5. Yamada, J, Kouri, A, Simard, SN, Lam Shin Cheung, J, Segovia, S, Gupta, S et al.. Improving computerized decision support system interventions: a qualitative study combining the theoretical domains framework with the GUIDES Checklist. BMC Med Inform Decis Mak. 2023;23 (1):226. doi: 10.1186/s12911-023-02273-6. PubMed PMID:37853386 PubMed Central PMC10585867.
  6. Gerstein, E, Bierbrier, J, Whitmore, GA, Vandemheen, KL, Bergeron, C, Boulet, LP et al.. Impact of Undiagnosed Chronic Obstructive Pulmonary Disease and Asthma on Symptoms, Quality of Life, Healthcare Use, and Work Productivity. Am J Respir Crit Care Med. 2023;208 (12):1271-1282. doi: 10.1164/rccm.202307-1264OC. PubMed PMID:37792953 .
  7. Kouri, A, Wong, EKC, Sale, JEM, Straus, SE, Gupta, S. Are older adults considered in asthma and chronic obstructive pulmonary disease mobile health research? A scoping review. Age Ageing. 2023;52 (9):. doi: 10.1093/ageing/afad144. PubMed PMID:37742283 .
  8. Zhao, X, Kotha, S, Nayyar, D, Ma, X, Lilly, L, Castel, H et al.. Physiologic changes in the hepatopulmonary syndrome before and after liver transplant: A longitudinal and predictor analysis. Hepatology. 2024;79 (3):636-649. doi: 10.1097/HEP.0000000000000605. PubMed PMID:37732952 PubMed Central PMC10871618.
  9. Gagné, M, Karanikas, A, Green, S, Gupta, S. Reductions in inhaler greenhouse gas emissions by addressing care gaps in asthma and chronic obstructive pulmonary disease: an analysis. BMJ Open Respir Res. 2023;10 (1):. doi: 10.1136/bmjresp-2023-001716. PubMed PMID:37730281 PubMed Central PMC10510936.
  10. Malecki, SL, Jung, HY, Loffler, A, Green, MA, Gupta, S, MacFadden, D et al.. Identifying clusters of coexisting conditions and outcomes among adults admitted to hospital with community-acquired pneumonia: a multicentre cohort study. CMAJ Open. 2023;11 (5):E799-E808. doi: 10.9778/cmajo.20220193. PubMed PMID:37669812 PubMed Central PMC10482492.
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Affiliations & Other Activities

  • Staff Respirologist, Division of Respirology, St. Michael’s Hospital
  • Michael Locke Chair in Knowledge Translation and Rare Lung Diseases, St. Michael’s Hospital
  • Associate Professor, Department of Medicine, Division of Respirology, University of Toronto
  • Chair, Canadian Respiratory Guidelines Committee