Sheldon Cheskes



Research Programs


Dr. Sheldon Cheskes is an Associate Professor with the Division of Emergency Medicine, Department of Family and Community Medicine at the University of Toronto, and a scientist at the Li Ka Shing Knowledge Institute at St. Michael’s Hospital in Toronto, Ontario, Canada. He is the Medical Director for the Regions of Halton and Peel with the Sunnybrook Centre for Prehospital Medicine. He is one of the principal investigators for the Canadian Resuscitation Outcomes Consortium (CanROC) and is a recognized international authority in the area of CPR quality and out-of-hospital cardiac arrest resuscitation. Dr. Cheskes has published over 100 manuscripts in high impact journals such as the New England Journal of Medicine, Circulation, CMAJ and Resuscitation that have changed resuscitation practice around the world.

He is the principal investigator of the DOuble Sequential External Defibrillation in Refractory Ventricular Fibrillation (DOSE VF) trial. This study will be the first cluster randomized trial to clinically evaluate two novel therapeutic defibrillation strategies (double sequential external defibrillation and vector change defibrillation) against standard practice for patients remaining in refractory ventricular fibrillation during out-of-hospital cardiac arrest. He is also studying methods to improve public access defibrillation in rural and remote areas through the use of community responder programs and drone delivery of automated external defibrillators.

Recent Publications

  1. Cheskes, S, Verbeek, PR, Drennan, IR, McLeod, SL, Turner, L, Pinto, R et al.. Defibrillation Strategies for Refractory Ventricular Fibrillation. N Engl J Med. 2022;387 (21):1947-1956. doi: 10.1056/NEJMoa2207304. PubMed PMID:36342151 .
  2. Heidet, M, Freyssenge, J, Claustre, C, Deakin, J, Helmer, J, Thomas-Lamotte, B et al.. Association between location of out-of-hospital cardiac arrest, on-scene socioeconomic status, and accessibility to public automated defibrillators in two large metropolitan areas in Canada and France. Resuscitation. 2022;181 :97-109. doi: 10.1016/j.resuscitation.2022.10.016. PubMed PMID:36309249 .
  3. Kwong, JL, Drennan, IR, Turner, L, Cheskes, S. Predefibrillation end-tidal CO2 and defibrillation success in out-of-hospital cardiac arrest: an observational cohort study. Emerg Med J. 2022; :. doi: 10.1136/emermed-2021-211951. PubMed PMID:36171074 .
  4. Drennan, IR, Seidler, D, Cheskes, S. A survey of the incidence of defibrillator damage during double sequential external defibrillation for refractory ventricular fibrillation. Resusc Plus. 2022;11 :100287. doi: 10.1016/j.resplu.2022.100287. PubMed PMID:36105412 PubMed Central PMC9464949.
  5. Leung, KHB, Grunau, B, Al Assil, R, Heidet, M, Liang, LD, Deakin, J et al.. Incremental gains in response time with varying base location types for drone-delivered automated external defibrillators. Resuscitation. 2022;174 :24-30. doi: 10.1016/j.resuscitation.2022.03.013. PubMed PMID:35314210 .
  6. Mausz, J, Jackson, NA, Lapalme, C, Piquette, D, Wakely, D, Cheskes, S et al.. Protected 911: Development, Implementation, and Evaluation of a Prehospital COVID-19 High-Risk Response Team. Int J Environ Res Public Health. 2022;19 (5):. doi: 10.3390/ijerph19053004. PubMed PMID:35270696 PubMed Central PMC8910754.
  7. Rahimi, M, Dorian, P, Cheskes, S, Lebovic, G, Lin, S. Effect of Time to Treatment With Antiarrhythmic Drugs on Return of Spontaneous Circulation in Shock-Refractory Out-of-Hospital Cardiac Arrest. J Am Heart Assoc. 2022;11 (6):e023958. doi: 10.1161/JAHA.121.023958. PubMed PMID:35243875 PubMed Central PMC9075276.
  8. Grunau, B, Asamoah-Boaheng, M, Lavoie, PM, Karim, ME, Kirkham, TL, Demers, PA et al.. A Higher Antibody Response Is Generated With a 6- to 7-Week (vs Standard) Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Vaccine Dosing Interval. Clin Infect Dis. 2022;75 (1):e888-e891. doi: 10.1093/cid/ciab938. PubMed PMID:34849655 PubMed Central PMC8690265.
  9. Lapalme, C, Kaw, S, Drennan, I, Cheskes, S. Non-Sustained Polymorphic Ventricular Tachycardia Induced by Modified Valsalva in a Pregnant Patient with Supraventricular Tachycardia. Prehosp Emerg Care. 2021; :1-5. doi: 10.1080/10903127.2021.1999543. PubMed PMID:34709116 .
  10. Stoesser, CE, Boutilier, JJ, Sun, CLF, Brooks, SC, Cheskes, S, Dainty, KN et al.. Moderating effects of out-of-hospital cardiac arrest characteristics on the association between EMS response time and survival. Resuscitation. 2021;169 :31-38. doi: 10.1016/j.resuscitation.2021.10.014. PubMed PMID:34678334 .
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Affiliations & Other Activities

  • Associate Professor, Department of Family and Community Medicine, Division of Emergency Medicine, University of Toronto
  • Medical Director, Sunnybrook Centre for Prehospital Medicine