Sheldon Cheskes



Research Programs


Dr. Sheldon Cheskes is an Associate Professor with the Division of Emergency Medicine, Department of Family and Community Medicine at the University of Toronto, and a scientist at the Li Ka Shing Knowledge Institute at St. Michael’s Hospital in Toronto, Ontario, Canada. He is the Medical Director for the Regions of Halton and Peel with the Sunnybrook Centre for Prehospital Medicine. He is one of the principal investigators for the Canadian Resuscitation Outcomes Consortium (CanROC) and is a recognized international authority in the area of CPR quality and out-of-hospital cardiac arrest resuscitation. Dr. Cheskes has published over 100 manuscripts in high impact journals such as the New England Journal of Medicine, Circulation, CMAJ and Resuscitation that have changed resuscitation practice around the world.

He is the principal investigator of the DOuble Sequential External Defibrillation in Refractory Ventricular Fibrillation (DOSE VF) trial. This study will be the first cluster randomized trial to clinically evaluate two novel therapeutic defibrillation strategies (double sequential external defibrillation and vector change defibrillation) against standard practice for patients remaining in refractory ventricular fibrillation during out-of-hospital cardiac arrest. He is also studying methods to improve public access defibrillation in rural and remote areas through the use of community responder programs and drone delivery of automated external defibrillators.

Recent Publications

  1. Leung, KHB, Grunau, B, Al Assil, R, Heidet, M, Liang, LD, Deakin, J et al.. Incremental gains in response time with varying base location types for drone-delivered automated external defibrillators. Resuscitation. 2022;174 :24-30. doi: 10.1016/j.resuscitation.2022.03.013. PubMed PMID:35314210 .
  2. Mausz, J, Jackson, NA, Lapalme, C, Piquette, D, Wakely, D, Cheskes, S et al.. Protected 911: Development, Implementation, and Evaluation of a Prehospital COVID-19 High-Risk Response Team. Int J Environ Res Public Health. 2022;19 (5):. doi: 10.3390/ijerph19053004. PubMed PMID:35270696 PubMed Central PMC8910754.
  3. Rahimi, M, Dorian, P, Cheskes, S, Lebovic, G, Lin, S. Effect of Time to Treatment With Antiarrhythmic Drugs on Return of Spontaneous Circulation in Shock-Refractory Out-of-Hospital Cardiac Arrest. J Am Heart Assoc. 2022;11 (6):e023958. doi: 10.1161/JAHA.121.023958. PubMed PMID:35243875 PubMed Central PMC9075276.
  4. Grunau, B, Asamoah-Boaheng, M, Lavoie, PM, Karim, ME, Kirkham, TL, Demers, PA et al.. A Higher Antibody Response Is Generated With a 6- to 7-Week (vs Standard) Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Vaccine Dosing Interval. Clin Infect Dis. 2021; :. doi: 10.1093/cid/ciab938. PubMed PMID:34849655 PubMed Central PMC8690265.
  5. Lapalme, C, Kaw, S, Drennan, I, Cheskes, S. Non-Sustained Polymorphic Ventricular Tachycardia Induced by Modified Valsalva in a Pregnant Patient with Supraventricular Tachycardia. Prehosp Emerg Care. 2021; :1-5. doi: 10.1080/10903127.2021.1999543. PubMed PMID:34709116 .
  6. Stoesser, CE, Boutilier, JJ, Sun, CLF, Brooks, SC, Cheskes, S, Dainty, KN et al.. Moderating effects of out-of-hospital cardiac arrest characteristics on the association between EMS response time and survival. Resuscitation. 2021;169 :31-38. doi: 10.1016/j.resuscitation.2021.10.014. PubMed PMID:34678334 .
  7. Grunau, B, Kawano, T, Rea, TD, Okubo, M, Scheuermeyer, FX, Reynolds, JC et al.. Emergency medical services employing intra-arrest transport less frequently for out-of-hospital cardiac arrest have higher survival and favorable neurological outcomes. Resuscitation. 2021;168 :27-34. doi: 10.1016/j.resuscitation.2021.09.004. PubMed PMID:34509554 .
  8. Cheskes, S, Drennan, IR. No flow time, bystander low flow time and EMS system response time: Are we looking at two sides of the same coin?. Resuscitation. 2021;167 :412-413. doi: 10.1016/j.resuscitation.2021.08.033. PubMed PMID:34461204 .
  9. Crickmer, M, Drennan, IR, Turner, L, Cheskes, S. The association between end-tidal CO2 and return of spontaneous circulation after out-of-hospital cardiac arrest with pulseless electrical activity. Resuscitation. 2021;167 :76-81. doi: 10.1016/j.resuscitation.2021.08.014. PubMed PMID:34416306 .
  10. Fernando, SM, Di Santo, P, Sadeghirad, B, Lascarrou, JB, Rochwerg, B, Mathew, R et al.. Targeted temperature management following out-of-hospital cardiac arrest: a systematic review and network meta-analysis of temperature targets. Intensive Care Med. 2021;47 (10):1078-1088. doi: 10.1007/s00134-021-06505-z. PubMed PMID:34389870 .
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Affiliations & Other Activities

  • Associate Professor, Department of Family and Community Medicine, Division of Emergency Medicine, University of Toronto
  • Medical Director, Sunnybrook Centre for Prehospital Medicine