Sidney Kennedy

MD, FRCPC, MRC Psych

Scientist

Research Programs

Biography

Sidney H. Kennedy is Professor of Psychiatry and Arthur Sommer Rotenberg Chair in Depression and Suicide Studies at the University of Toronto, Director of the Centre for Suicide and Depression Studies at St. Michael’s Hospital, and a Scientist at Li Ka Shing Knowledge Institute and Krembil Research Institute in Toronto. Dr. Kennedy is the lead investigator for the Canadian Biomarker Integration Network in Depression (CAN-BIND), a national depression biomarker initiative. He has published extensively on new drug evaluation, neuroimaging and neurostimulation therapies, personality factors in depression, antidepressant effects on sexual function, and treatment guidelines for Major Depressive Disorder and Bipolar Disorder.

Dr. Kennedy is the Immediate Past President of the International Society for Affective Disorders, former President of the Canadian College of Neuropsychopharmacology, and the founding chair of the Canadian Network for Mood and Anxiety Treatments (CANMAT).

Dr. Kennedy has authored close to 500 peer-reviewed publications and 11 books on depression and related topics. He is a Fellow of the Canadian Academy of Health Sciences and the Royal Society of Canada.

Recent Publications

  1. Peters, SJ, Kennedy, SH, Christiansen, CJ. Biaryl Anion Radical Formation by Potassium Metal Reduction of Aryl Isocyanates and Triaryl Isocyanurates. J Org Chem. 2024;89 (21):15708-15717. doi: 10.1021/acs.joc.4c01844. PubMed PMID:39396196 PubMed Central PMC11536357.
  2. Schwartzmann, B, Chatterjee, R, Vaghei, Y, Quilty, LC, Allen, TA, Arnott, SR et al.. Modulation of neural oscillations in escitalopram treatment: a Canadian biomarker integration network in depression study. Transl Psychiatry. 2024;14 (1):432. doi: 10.1038/s41398-024-03110-8. PubMed PMID:39396045 PubMed Central PMC11470922.
  3. Mazurka, R, Harkness, KL, Hassel, S, Stensson, N, Nogovitsyn, N, Poppenk, J et al.. Endocannabinoid concentrations in major depression: effects of childhood maltreatment and relation to hippocampal volume. Transl Psychiatry. 2024;14 (1):431. doi: 10.1038/s41398-024-03151-z. PubMed PMID:39394160 PubMed Central PMC11470058.
  4. Moon, RJ, D' Angelo, S, Curtis, EM, Ward, KA, Crozier, SR, Schoenmakers, I et al.. Pregnancy vitamin D supplementation and offspring bone mineral density in childhood follow-up of a randomized controlled trial. Am J Clin Nutr. 2024; :. doi: 10.1016/j.ajcnut.2024.09.014. PubMed PMID:39306330 .
  5. Demchenko, I, Rampersad, S, Datta, A, Horn, A, Churchill, NW, Kennedy, SH et al.. Target engagement of the subgenual anterior cingulate cortex with transcranial temporal interference stimulation in major depressive disorder: a protocol for a randomized sham-controlled trial. Front Neurosci. 2024;18 :1390250. doi: 10.3389/fnins.2024.1390250. PubMed PMID:39268031 PubMed Central PMC11390435.
  6. Hannan, FM, Leow, MKS, Lee, JKW, Kovats, S, Elajnaf, T, Kennedy, SH et al.. Endocrine effects of heat exposure and relevance to climate change. Nat Rev Endocrinol. 2024;20 (11):673-684. doi: 10.1038/s41574-024-01017-4. PubMed PMID:39080505 .
  7. Kennedy, SH. Correction: Beyond Response: Aiming for Quality Remission in Depression. Adv Ther. 2024;41 (9):3736. doi: 10.1007/s12325-024-02930-w. PubMed PMID:38995325 PubMed Central PMC11349771.
  8. Fu, CHY, Antoniades, M, Erus, G, Garcia, JA, Fan, Y, Arnone, D et al.. Neuroanatomical dimensions in medication-free individuals with major depressive disorder and treatment response to SSRI antidepressant medications or placebo. Nat Ment Health. 2024;2 (2):164-176. doi: 10.1038/s44220-023-00187-w. PubMed PMID:38948238 PubMed Central PMC11211072.
  9. Islam, F, Lisoway, A, Oh, ES, Fiori, LM, Magarbeh, L, Elsheikh, SSM et al.. Integrative Genetic Variation, DNA Methylation, and Gene Expression Analysis of Escitalopram and Aripiprazole Treatment Outcomes in Depression: A CAN-BIND-1 Study. Pharmacopsychiatry. 2024;57 (5):232-244. doi: 10.1055/a-2313-9979. PubMed PMID:38917846 .
  10. Nunes, A, Pavlova, B, Cunningham, JEA, Nuñez, JJ, Quilty, LC, Foster, JA et al.. Depression-Anxiety Coupling Strength as a predictor of relapse in major depressive disorder: A CAN-BIND wellness monitoring study report. J Affect Disord. 2024;361 :189-197. doi: 10.1016/j.jad.2024.06.023. PubMed PMID:38866253 .
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Affiliations & Other Activities

  • Staff Physician, Department of Mental Health, St. Michael’s Hospital
  • Professor, Department of Psychiatry, University of Toronto
  • Research Scientist, Krembil Neurosciences, University Health Network