Sidney Kennedy



Research Programs


Sidney H. Kennedy is Professor of Psychiatry and Arthur Sommer Rotenberg Chair in Depression and Suicide Studies at the University of Toronto, Director of the Centre for Suicide and Depression Studies at St. Michael’s Hospital, and a Scientist at Li Ka Shing Knowledge Institute and Krembil Research Institute in Toronto. Dr. Kennedy is the lead investigator for the Canadian Biomarker Integration Network in Depression (CAN-BIND), a national depression biomarker initiative. He has published extensively on new drug evaluation, neuroimaging and neurostimulation therapies, personality factors in depression, antidepressant effects on sexual function, and treatment guidelines for Major Depressive Disorder and Bipolar Disorder.

Dr. Kennedy is the Immediate Past President of the International Society for Affective Disorders, former President of the Canadian College of Neuropsychopharmacology, and the founding chair of the Canadian Network for Mood and Anxiety Treatments (CANMAT).

Dr. Kennedy has authored close to 500 peer-reviewed publications and 11 books on depression and related topics. He is a Fellow of the Canadian Academy of Health Sciences and the Royal Society of Canada.

Recent Publications

  1. Jones, GL, Budds, K, Taylor, F, Musson, D, Raymer, J, Churchman, D et al.. A systematic review to determine use of the Endometriosis Health Profiles to measure quality of life outcomes in women with endometriosis. Hum Reprod Update. 2023; :. doi: 10.1093/humupd/dmad029. PubMed PMID:38007607 .
  2. Rnic, K, LeMoult, J, Torres, IJ, Chakrabarty, T, Foster, J, Frey, BN et al.. Predicting recurrence of major depressive episodes using the Depression Implicit Association Test: A Canadian biomarker integration network in depression (CAN-BIND) report. Psychiatry Res. 2023;330 :115606. doi: 10.1016/j.psychres.2023.115606. PubMed PMID:37979318 .
  3. Phaterpekar, T, Nunez, JJ, Morton, E, Liu, YS, Cao, B, Frey, BN et al.. Machine Learning Prediction of Quality of Life Improvement During Antidepressant Treatment of Patients With Major Depressive Disorder: A STAR*D and CAN-BIND-1 Report. J Clin Psychiatry. 2023;85 (1):. doi: 10.4088/JCP.23m14864. PubMed PMID:37967350 .
  4. Vairavan, S, Rashidisabet, H, Li, QS, Ness, S, Morrison, RL, Soares, CN et al.. Personalized relapse prediction in patients with major depressive disorder using digital biomarkers. Sci Rep. 2023;13 (1):18596. doi: 10.1038/s41598-023-44592-8. PubMed PMID:37903878 PubMed Central PMC10616277.
  5. Namburete, AIL, Papież, BW, Fernandes, M, Wyburd, MK, Hesse, LS, Moser, FA et al.. Normative spatiotemporal fetal brain maturation with satisfactory development at 2 years. Nature. 2023;623 (7985):106-114. doi: 10.1038/s41586-023-06630-3. PubMed PMID:37880365 PubMed Central PMC10620088.
  6. Rowe, J, Poppenk, J, Squires, S, Mazurka, R, Nogovitsyn, N, Hassel, S et al.. Anxious arousal predicts within-person changes in hippocampal volume in adults with a history of childhood maltreatment: A CAN-BIND4 report. J Psychopathol Clin Sci. 2023;132 (7):797-807. doi: 10.1037/abn0000864. PubMed PMID:37843538 .
  7. Gorostowicz, A, Rizvi, SJ, Kennedy, SH, Chrobak, AA, Dudek, D, Cyranka, K et al.. Polish adaptation of the Dimensional Anhedonia Rating Scale (DARS) - validation in the clinical sample. Front Psychiatry. 2023;14 :1268290. doi: 10.3389/fpsyt.2023.1268290. PubMed PMID:37817828 PubMed Central PMC10561247.
  8. Islam, F, Magarbeh, L, Elsheikh, SSM, Kloiber, S, Espinola, CW, Bhat, V et al.. Influence of CYP2C19, CYP2D6, and ABCB1 Gene Variants and Serum Levels of Escitalopram and Aripiprazole on Treatment-Emergent Sexual Dysfunction: A Canadian Biomarker Integration Network in Depression 1 (CAN-BIND 1) Study. Can J Psychiatry. 2023; :7067437231203433. doi: 10.1177/07067437231203433. PubMed PMID:37796764 .
  9. Schwartzmann, B, Dhami, P, Uher, R, Lam, RW, Frey, BN, Milev, R et al.. Developing an Electroencephalography-Based Model for Predicting Response to Antidepressant Medication. JAMA Netw Open. 2023;6 (9):e2336094. doi: 10.1001/jamanetworkopen.2023.36094. PubMed PMID:37768659 PubMed Central PMC10539986.
  10. Perumal, N, Wang, D, Darling, AM, Liu, E, Wang, M, Ahmed, T et al.. Suboptimal gestational weight gain and neonatal outcomes in low and middle income countries: individual participant data meta-analysis. BMJ. 2023;382 :e072249. doi: 10.1136/bmj-2022-072249. PubMed PMID:37734757 PubMed Central PMC10512803.
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Affiliations & Other Activities

  • Staff Physician, Department of Mental Health, St. Michael’s Hospital
  • Professor, Department of Psychiatry, University of Toronto
  • Research Scientist, Krembil Neurosciences, University Health Network