Sidney Kennedy



Research Programs


Sidney H. Kennedy is Professor of Psychiatry and Arthur Sommer Rotenberg Chair in Depression and Suicide Studies at the University of Toronto, Director of the Centre for Suicide and Depression Studies at St. Michael’s Hospital, and a Scientist at Li Ka Shing Knowledge Institute and Krembil Research Institute in Toronto. Dr. Kennedy is the lead investigator for the Canadian Biomarker Integration Network in Depression (CAN-BIND), a national depression biomarker initiative. He has published extensively on new drug evaluation, neuroimaging and neurostimulation therapies, personality factors in depression, antidepressant effects on sexual function, and treatment guidelines for Major Depressive Disorder and Bipolar Disorder.

Dr. Kennedy is the Immediate Past President of the International Society for Affective Disorders, former President of the Canadian College of Neuropsychopharmacology, and the founding chair of the Canadian Network for Mood and Anxiety Treatments (CANMAT).

Dr. Kennedy has authored close to 500 peer-reviewed publications and 11 books on depression and related topics. He is a Fellow of the Canadian Academy of Health Sciences and the Royal Society of Canada.

Recent Publications

  1. Lam, RW, Kennedy, SH, Adams, C, Bahji, A, Beaulieu, S, Bhat, V et al.. Canadian Network for Mood and Anxiety Treatments (CANMAT) 2023 Update on Clinical Guidelines for Management of Major Depressive Disorder in Adults: Réseau canadien pour les traitements de l'humeur et de l'anxiété (CANMAT) 2023 : Mise à jour des lignes directrices cliniques pour la prise en charge du trouble dépressif majeur chez les adultes. Can J Psychiatry. 2024; :7067437241245384. doi: 10.1177/07067437241245384. PubMed PMID:38711351 .
  2. Villar, J, Cavoretto, PI, Barros, FC, Romero, R, Papageorghiou, AT, Kennedy, SH et al.. Etiologically Based Functional Taxonomy of the Preterm Birth Syndrome. Clin Perinatol. 2024;51 (2):475-495. doi: 10.1016/j.clp.2024.02.014. PubMed PMID:38705653 .
  3. Ho, NCW, Bethlehem, RA, Seidlitz, J, Nogovitsyn, N, Metzak, P, Ballester, PL et al.. Atypical brain aging and its association with working memory performance in major depressive disorder. Biol Psychiatry Cogn Neurosci Neuroimaging. 2024; :. doi: 10.1016/j.bpsc.2024.04.008. PubMed PMID:38679324 .
  4. Hirst, JE, Boniface, JJ, Le, DP, Polpitiya, AD, Fox, AC, Vu, TTK et al.. Validating the ratio of insulin like growth factor binding protein 4 to sex hormone binding globulin as a prognostic predictor of preterm birth in Viet Nam: a case-cohort study. J Matern Fetal Neonatal Med. 2024;37 (1):2333923. doi: 10.1080/14767058.2024.2333923. PubMed PMID:38584143 .
  5. Barros, FC, Gunier, RB, Rego, A, Sentilhes, L, Rauch, S, Gandino, S et al.. Maternal vaccination against COVID-19 and neonatal outcomes during Omicron: INTERCOVID-2022 study. Am J Obstet Gynecol. 2024; :. doi: 10.1016/j.ajog.2024.02.008. PubMed PMID:38367758 .
  6. Minian, N, Gayapersad, A, Coroiu, A, Dragonetti, R, Zawertailo, L, Zaheer, J et al.. Prototyping the implementation of a suicide prevention protocol in primary care settings using PDSA cycles: a mixed method study. Front Psychiatry. 2024;15 :1286078. doi: 10.3389/fpsyt.2024.1286078. PubMed PMID:38333892 PubMed Central PMC10850298.
  7. Ayyash, S, Davis, AD, Alders, GL, MacQueen, G, Strother, SC, Hassel, S et al.. Assessing remission in major depressive disorder using a functional-structural data fusion pipeline: A CAN-BIND-1 study. IBRO Neurosci Rep. 2024;16 :135-146. doi: 10.1016/j.ibneur.2023.12.011. PubMed PMID:38293679 PubMed Central PMC10826332.
  8. Nogovitsyn, N, Ballester, P, Lasby, M, Dunlop, K, Ceniti, AK, Squires, S et al.. An empirical analysis of structural neuroimaging profiles in a staging model of depression. J Affect Disord. 2024;351 :631-640. doi: 10.1016/j.jad.2024.01.246. PubMed PMID:38290583 .
  9. Vaccarino, SR, Wang, S, Rizvi, SJ, Lou, W, Hassel, S, MacQueen, GM et al.. Functional neuroimaging biomarkers of anhedonia response to escitalopram plus adjunct aripiprazole treatment for major depressive disorder. BJPsych Open. 2024;10 (1):e18. doi: 10.1192/bjo.2023.588. PubMed PMID:38179598 PubMed Central PMC10790221.
  10. Mazurka, R, Cunningham, S, Hassel, S, Foster, JA, Nogovitsyn, N, Fiori, LM et al.. Relation of hippocampal volume and SGK1 gene expression to treatment remission in major depression is moderated by childhood maltreatment: A CAN-BIND-1 report. Eur Neuropsychopharmacol. 2024;78 :71-80. doi: 10.1016/j.euroneuro.2023.12.003. PubMed PMID:38128154 .
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Affiliations & Other Activities

  • Staff Physician, Department of Mental Health, St. Michael’s Hospital
  • Professor, Department of Psychiatry, University of Toronto
  • Research Scientist, Krembil Neurosciences, University Health Network