Sidney Kennedy



Research Programs


Sidney H. Kennedy is Professor of Psychiatry and Arthur Sommer Rotenberg Chair in Depression and Suicide Studies at the University of Toronto, Director of the Centre for Suicide and Depression Studies at St. Michael’s Hospital, and a Scientist at Li Ka Shing Knowledge Institute and Krembil Research Institute in Toronto. Dr. Kennedy is the lead investigator for the Canadian Biomarker Integration Network in Depression (CAN-BIND), a national depression biomarker initiative. He has published extensively on new drug evaluation, neuroimaging and neurostimulation therapies, personality factors in depression, antidepressant effects on sexual function, and treatment guidelines for Major Depressive Disorder and Bipolar Disorder.

Dr. Kennedy is the Immediate Past President of the International Society for Affective Disorders, former President of the Canadian College of Neuropsychopharmacology, and the founding chair of the Canadian Network for Mood and Anxiety Treatments (CANMAT).

Dr. Kennedy has authored close to 500 peer-reviewed publications and 11 books on depression and related topics. He is a Fellow of the Canadian Academy of Health Sciences and the Royal Society of Canada.

Recent Publications

  1. Ali, M, Suh, JS, Ramonas, M, Hassel, S, Arnott, SR, Strother, SC et al.. A detailed manual segmentation procedure for the hypothalamus for 3T T1-weighted MRI. MethodsX. 2022;9 :101864. doi: 10.1016/j.mex.2022.101864. PubMed PMID:36193115 PubMed Central PMC9526169.
  2. Hannan, FM, Elajnaf, T, Vandenberg, LN, Kennedy, SH, Thakker, RV. Hormonal regulation of mammary gland development and lactation. Nat Rev Endocrinol. 2022; :. doi: 10.1038/s41574-022-00742-y. PubMed PMID:36192506 .
  3. de Kat, AC, Hirst, JE, Woodward, M, Barros, FC, Barsosio, HC, Berkley, JA et al.. Preeclampsia prediction with blood pressure measurements: A global external validation of the ALSPAC models. Pregnancy Hypertens. 2022;30 :124-129. doi: 10.1016/j.preghy.2022.09.005. PubMed PMID:36179538 .
  4. Metzak, PD, Shakeel, MK, Long, X, Lasby, M, Souza, R, Bray, S et al.. Brain connectomes in youth at risk for serious mental illness: an exploratory analysis. BMC Psychiatry. 2022;22 (1):611. doi: 10.1186/s12888-022-04118-4. PubMed PMID:36109720 PubMed Central PMC9476574.
  5. Islam, F, Marshe, VS, Magarbeh, L, Frey, BN, Milev, RV, Soares, CN et al.. Effects of CYP2C19 and CYP2D6 gene variants on escitalopram and aripiprazole treatment outcome and serum levels: results from the CAN-BIND 1 study. Transl Psychiatry. 2022;12 (1):366. doi: 10.1038/s41398-022-02124-4. PubMed PMID:36068210 PubMed Central PMC9448818.
  6. Rostom, H, Meng, X, Price, H, Fry, A, Elajnaf, T, Humphrey, R et al.. Protocol for an observational study investigating hormones triggering the onset of sustained lactation: the INSIGHT study. BMJ Open. 2022;12 (8):e062478. doi: 10.1136/bmjopen-2022-062478. PubMed PMID:36041762 PubMed Central PMC9438014.
  7. Villar, J, Ochieng, R, Gunier, RB, Papageorghiou, AT, Rauch, S, McGready, R et al.. Association between fetal abdominal growth trajectories, maternal metabolite signatures early in pregnancy, and childhood growth and adiposity: prospective observational multinational INTERBIO-21st fetal study. Lancet Diabetes Endocrinol. 2022;10 (10):710-719. doi: 10.1016/S2213-8587(22)00215-7. PubMed PMID:36030799 .
  8. Sajjadian, M, Uher, R, Ho, K, Hassel, S, Milev, R, Frey, BN et al.. Prediction of depression treatment outcome from multimodal data: a CAN-BIND-1 report. Psychol Med. 2022; :1-11. doi: 10.1017/S0033291722002124. PubMed PMID:36004538 .
  9. Holman, S, Steinberg, R, Sinyor, M, Lane, H, Starritt, K, Kennedy, SH et al.. Caring Contacts to Reduce Psychiatric Morbidity Following Hospitalization During the COVID-19 Pandemic: A Pilot Randomized Controlled Trial. Can J Psychiatry. 2022; :7067437221121111. doi: 10.1177/07067437221121111. PubMed PMID:35996823 PubMed Central PMC9412148.
  10. Rosenblat, JD, Husain, MI, Lee, Y, McIntyre, RS, Mansur, RB, Castle, D et al.. The Canadian Network for Mood and Anxiety Treatments (CANMAT) Task Force Report: Serotonergic Psychedelic Treatments for Major Depressive Disorder. Can J Psychiatry. 2022; :7067437221111371. doi: 10.1177/07067437221111371. PubMed PMID:35975555 .
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Affiliations & Other Activities

  • Staff Physician, Department of Mental Health, St. Michael’s Hospital
  • Professor, Department of Psychiatry, University of Toronto
  • Research Scientist, Krembil Neurosciences, University Health Network