Sidney Kennedy



Research Programs


Sidney H. Kennedy is Professor of Psychiatry and Arthur Sommer Rotenberg Chair in Depression and Suicide Studies at the University of Toronto, Director of the Centre for Suicide and Depression Studies at St. Michael’s Hospital, and a Scientist at Li Ka Shing Knowledge Institute and Krembil Research Institute in Toronto. Dr. Kennedy is the lead investigator for the Canadian Biomarker Integration Network in Depression (CAN-BIND), a national depression biomarker initiative. He has published extensively on new drug evaluation, neuroimaging and neurostimulation therapies, personality factors in depression, antidepressant effects on sexual function, and treatment guidelines for Major Depressive Disorder and Bipolar Disorder.

Dr. Kennedy is the Immediate Past President of the International Society for Affective Disorders, former President of the Canadian College of Neuropsychopharmacology, and the founding chair of the Canadian Network for Mood and Anxiety Treatments (CANMAT).

Dr. Kennedy has authored close to 500 peer-reviewed publications and 11 books on depression and related topics. He is a Fellow of the Canadian Academy of Health Sciences and the Royal Society of Canada.

Recent Publications

  1. Fu, CHY, Erus, G, Fan, Y, Antoniades, M, Arnone, D, Arnott, SR et al.. AI-based dimensional neuroimaging system for characterizing heterogeneity in brain structure and function in major depressive disorder: COORDINATE-MDD consortium design and rationale. BMC Psychiatry. 2023;23 (1):59. doi: 10.1186/s12888-022-04509-7. PubMed PMID:36690972 PubMed Central PMC9869598.
  2. Magarbeh, L, Hassel, C, Choi, M, Islam, F, Marshe, VS, Zai, CC et al.. ABCB1 gene variants and Antidepressant Treatment Outcomes: A Systematic Review and Meta-analysis including results from the CAN-BIND-1 Study. Clin Pharmacol Ther. 2023; :. doi: 10.1002/cpt.2854. PubMed PMID:36681895 .
  3. Villar, J, Soto Conti, CP, Gunier, RB, Ariff, S, Craik, R, Cavoretto, PI et al.. Pregnancy outcomes and vaccine effectiveness during the period of omicron as the variant of concern, INTERCOVID-2022: a multinational, observational study. Lancet. 2023; :. doi: 10.1016/S0140-6736(22)02467-9. PubMed PMID:36669520 .
  4. Ballester, PL, Suh, JS, Ho, NCW, Liang, L, Hassel, S, Strother, SC et al.. Gray matter volume drives the brain age gap in schizophrenia: a SHAP study. Schizophrenia (Heidelb). 2023;9 (1):3. doi: 10.1038/s41537-022-00330-z. PubMed PMID:36624107 PubMed Central PMC9829754.
  5. Moon, RJ, D'Angelo, S, Crozier, SR, Curtis, EM, Fernandes, M, Kermack, AJ et al.. Does antenatal cholecalciferol supplementation affect the mode or timing of delivery? Post hoc analyses of the MAVIDOS randomized controlled trial. J Public Health (Oxf). 2022; :. doi: 10.1093/pubmed/fdac160. PubMed PMID:36585903 .
  6. Pandi-Perumal, SR, Zaki, NFW, Qasim, M, Elsayed Morsy, N, Manzar, MD, BaHammam, AS et al.. Neuropsychiatric Consequences of COVID-19 Pandemic: A Synthetic Review from a Global Perspective. Alpha Psychiatry. 2022;23 (4):144-154. doi: 10.5152/alphapsychiatry.2022.21783. PubMed PMID:36425743 PubMed Central PMC9590656.
  7. Hatcher, S, Heisel, MJ, Ayonrinde, O, Corsi, D, Edgar, NE, Kennedy, SH et al.. The BEACON study: an update to the protocol for a cohort study as part of an evaluation of the effectiveness of smartphone-assisted problem-solving therapy in men who present with intentional self-harm to emergency departments in Ontario. Trials. 2022;23 (1):849. doi: 10.1186/s13063-022-06788-7. PubMed PMID:36199120 PubMed Central PMC9532822.
  8. Ali, M, Suh, JS, Ramonas, M, Hassel, S, Arnott, SR, Strother, SC et al.. A detailed manual segmentation procedure for the hypothalamus for 3T T1-weighted MRI. MethodsX. 2022;9 :101864. doi: 10.1016/j.mex.2022.101864. PubMed PMID:36193115 PubMed Central PMC9526169.
  9. Hannan, FM, Elajnaf, T, Vandenberg, LN, Kennedy, SH, Thakker, RV. Hormonal regulation of mammary gland development and lactation. Nat Rev Endocrinol. 2023;19 (1):46-61. doi: 10.1038/s41574-022-00742-y. PubMed PMID:36192506 .
  10. de Kat, AC, Hirst, JE, Woodward, M, Barros, FC, Barsosio, HC, Berkley, JA et al.. Preeclampsia prediction with blood pressure measurements: A global external validation of the ALSPAC models. Pregnancy Hypertens. 2022;30 :124-129. doi: 10.1016/j.preghy.2022.09.005. PubMed PMID:36179538 .
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Affiliations & Other Activities

  • Staff Physician, Department of Mental Health, St. Michael’s Hospital
  • Professor, Department of Psychiatry, University of Toronto
  • Research Scientist, Krembil Neurosciences, University Health Network