Sunit Das

MD, PhD, MA, BA

Scientist

Biography

Sunit Das is a neurosurgeon and scientist at St. Michael’s Hospital and the Hospital for Sick Kids, and Associate Professor in the Department of Surgery at the University of Toronto. He currently serves as the CNS Tumours Lead at Ontario Health (Cancer Care Ontario). Dr. Das studied English Literature at the University of Michigan and Philosophy at Harvard University before moving to Chicago for medical school at Northwestern University. He completed his doctoral studies in Neurobiology at the National Institutes of Health, where he studied the molecular processes that underlie adult neurogenesis in the lab of Dr. ZuHang Sheng. He returned to Chicago for his neurosurgical residency, during which time he also began work on cancer stem cells in primary brain tumours in the lab of Dr. John Kessler. He was recruited to the University of Toronto in 2010. Dr. Das’s clinical practice is focused on the care of patients with benign and malignant brain tumours. His laboratory in the Arthur and Sonia Labatt Brain Tumour Centre at the Hospital for Sick Kids focuses on the molecular and genetic mechanisms that regulate cellular plasticity, fate specification and treatment resistance in glioblastoma. His research group at the Li Ka Shing Knowledge Institute is focused on using real-world data and meta-analysis for knowledge translation. His work has been published in many high impact journals, including Nature, Nature Genetics, Cell Stem Cell, Cancer Cell, JAMA, JAMA Neurology, and the New England Journal of Medicine. In 2017, Dr. Das joined the Centre for Ethics at the University of Toronto. His work at the Centre for Ethics focuses on the interface of AI with medicine, issues that underlie professional identity in medical practice, and the ethics of surgical innovation. Dr. Das was recently named a Senior Fellow at Massey College.

Recent Publications

  1. Premachandran, S, Haldavnekar, R, Das, S, Venkatakrishnan, K, Tan, B. DEEP Surveillance of Brain Cancer Using Self-Functionalized 3D Nanoprobes for Noninvasive Liquid Biopsy. ACS Nano. 2022; :. doi: 10.1021/acsnano.2c04187. PubMed PMID:36112671 .
  2. Dhinakaran, AK, Dharmalingam, P, Ganesh, S, Venkatakrishnan, K, Das, S, Tan, B et al.. Molecular Crosstalk between T Cells and Tumor Uncovers GBM-Specific T Cell Signatures in Blood: Noninvasive GBM Diagnosis Using Immunosensors. ACS Nano. 2022;16 (9):14134-14148. doi: 10.1021/acsnano.2c04160. PubMed PMID:36040842 .
  3. Yan, M, Holden, L, Wang, M, Soliman, H, Myrehaug, S, Tseng, CL et al.. Gamma knife icon based hypofractionated stereotactic radiosurgery (GKI-HSRS) for brain metastases: impact of dose and volume. J Neurooncol. 2022;159 (3):705-712. doi: 10.1007/s11060-022-04115-3. PubMed PMID:35999435 .
  4. Yan, M, Holden, L, Detsky, J, Tseng, CL, Soliman, H, Myrehaug, S et al.. Conventionally fully fractionated Gamma Knife Icon re-irradiation of primary recurrent intracranial tumors: the first report indicating feasibility and safety. J Neurosurg. 2022; :1-9. doi: 10.3171/2022.6.JNS22998. PubMed PMID:35986735 .
  5. Atkins, CGK, Das, S. What Should Clinicians and Patients Know About the Clinical Gaze, Disability, and Iatrogenic Harm When Making Decisions?. AMA J Ethics. 2022;24 (8):E762-767. doi: 10.1001/amajethics.2022.762. PubMed PMID:35976933 .
  6. Wang, XY, Rosen, MN, Chehade, R, Sahgal, A, Das, S, Warner, E et al.. Analysis of Rates of Brain Metastases and Association With Breast Cancer Subtypes in Ontario, Canada. JAMA Netw Open. 2022;5 (8):e2225424. doi: 10.1001/jamanetworkopen.2022.25424. PubMed PMID:35960523 PubMed Central PMC9375172.
  7. Chen, SS, Das, S. "What are my options?": Physicians as ontological decision architects in surgical informed consent. Bioethics. 2022; :. doi: 10.1111/bioe.13076. PubMed PMID:35912521 .
  8. Dhinakaran, AK, Ganesh, S, Haldavnekar, R, Tan, B, Das, S, Venkatakrishnan, K et al.. Holistic Analysis of Glioblastoma Stem Cell DNA Using Nanoengineered Plasmonic Metasensor for Glioblastoma Diagnosis. Small Methods. 2022;6 (9):e2200547. doi: 10.1002/smtd.202200547. PubMed PMID:35908161 .
  9. Ishwar, D, Haldavnekar, R, Das, S, Tan, B, Venkatakrishnan, K. Glioblastoma Associated Natural Killer Cell EVs Generating Tumour-Specific Signatures: Noninvasive GBM Liquid Biopsy with Self-Functionalized Quantum Probes. ACS Nano. 2022; :. doi: 10.1021/acsnano.2c03055. PubMed PMID:35816089 .
  10. Stewart, J, Sahgal, A, Chan, AKM, Soliman, H, Tseng, CL, Detsky, J et al.. Pattern of Recurrence of Glioblastoma Versus Grade 4 IDH-Mutant Astrocytoma Following Chemoradiation: A Retrospective Matched-Cohort Analysis. Technol Cancer Res Treat. ;21 :15330338221109650. doi: 10.1177/15330338221109650. PubMed PMID:35762826 PubMed Central PMC9247382.
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Affiliations & Other Activities

  • Associate Professor, Division of Neurosurgery, Department of Surgery, St. Michael’s Hospital
  • Adjunct Scientist, Brain Tumour Research Centre, Hospital for Sick Children