Sunit Das




Sunit Das is a neurosurgeon and scientist at St. Michael’s Hospital and the Hospital for Sick Kids, and Associate Professor in the Department of Surgery at the University of Toronto. He currently serves as the CNS Tumours Lead at Ontario Health (Cancer Care Ontario). Dr. Das studied English Literature at the University of Michigan and Philosophy at Harvard University before moving to Chicago for medical school at Northwestern University. He completed his doctoral studies in Neurobiology at the National Institutes of Health, where he studied the molecular processes that underlie adult neurogenesis in the lab of Dr. ZuHang Sheng. He returned to Chicago for his neurosurgical residency, during which time he also began work on cancer stem cells in primary brain tumours in the lab of Dr. John Kessler. He was recruited to the University of Toronto in 2010. Dr. Das’s clinical practice is focused on the care of patients with benign and malignant brain tumours. His laboratory in the Arthur and Sonia Labatt Brain Tumour Centre at the Hospital for Sick Kids focuses on the molecular and genetic mechanisms that regulate cellular plasticity, fate specification and treatment resistance in glioblastoma. His research group at the Li Ka Shing Knowledge Institute is focused on using real-world data and meta-analysis for knowledge translation. His work has been published in many high impact journals, including Nature, Nature Genetics, Cell Stem Cell, Cancer Cell, JAMA, JAMA Neurology, and the New England Journal of Medicine. In 2017, Dr. Das joined the Centre for Ethics at the University of Toronto. His work at the Centre for Ethics focuses on the interface of AI with medicine, issues that underlie professional identity in medical practice, and the ethics of surgical innovation. Dr. Das was recently named a Senior Fellow at Massey College.

Recent Publications

  1. Baqri, W, Rzadki, K, Habbous, S, Das, S. Treatment, healthcare utilization and outcomes in patients with glioblastoma in Ontario: a 10-year cohort study. J Neurooncol. 2024; :. doi: 10.1007/s11060-024-04690-7. PubMed PMID:38702569 .
  2. Ong, WL, Stewart, J, Sahgal, A, Soliman, H, Tseng, CL, Detsky, J et al.. Predictors of Tumor Dynamics Over a 6-Week Course of Concurrent Chemoradiotherapy for Glioblastoma and the Effect on Survival. Int J Radiat Oncol Biol Phys. 2024; :. doi: 10.1016/j.ijrobp.2024.03.036. PubMed PMID:38561051 .
  3. Chehade, R, Nofech-Mozes, S, Plotkin, A, Fan, KY, Das, S, Sahgal, A et al.. Human Epidermal Growth Factor Receptor 2-Low Breast Cancer Brain Metastases: An Opportunity for Targeted Systemic Therapies in a High-Need Patient Population. JCO Precis Oncol. 2024;8 :e2300487. doi: 10.1200/PO.23.00487. PubMed PMID:38547418 PubMed Central PMC10994430.
  4. Ayan, S, Rotaru, AM, Kaye, EG, Juneau, G, Das, S, Wilds, CJ et al.. A chloromethyl-triazole fluorescent chemosensor for O6-methylguanine DNA methyltransferase. Org Biomol Chem. 2024;22 (14):2749-2753. doi: 10.1039/d4ob00120f. PubMed PMID:38502038 .
  5. Rzadki, K, Baqri, W, Yermakhanova, O, Habbous, S, Das, S. Choreographed expansion of services results in decreased patient burden without compromise of outcomes: An assessment of the Ontario experience. Neurooncol Pract. 2024;11 (2):178-187. doi: 10.1093/nop/npad076. PubMed PMID:38496909 PubMed Central PMC10940827.
  6. Malik, P, Soliman, R, Chen, YA, Munoz, DG, Das, S, Bharatha, A et al.. Patterns of T2-FLAIR discordance across a cohort of adult-type diffuse gliomas and deviations from the classic T2-FLAIR mismatch sign. Neuroradiology. 2024;66 (4):521-530. doi: 10.1007/s00234-024-03297-z. PubMed PMID:38347151 .
  7. Gaebe, K, Erickson, AW, Li, AY, Youssef, AN, Sharma, B, Chan, KKW et al.. Re-examining prophylactic cranial irradiation in small cell lung cancer: a systematic review and meta-analysis. EClinicalMedicine. 2024;67 :102396. doi: 10.1016/j.eclinm.2023.102396. PubMed PMID:38261885 PubMed Central PMC10796984.
  8. Chen, SS, Brenna, CTA, Cho, M, McCoy, LG, Das, S. The name of the game: a Wittgensteinian view of 'invasiveness'. J Med Ethics. 2024;50 (4):240-241. doi: 10.1136/jme-2023-109739. PubMed PMID:38159936 .
  9. Kojundzic, I, Chehade, R, Gonzalez, CAC, Fritz, J, Moravan, V, Sahgal, A et al.. Brain Metastases in the Setting of Stable Versus Progressing Extracranial Disease Among Patients With Metastatic Breast Cancer. Clin Breast Cancer. 2024;24 (2):156-161. doi: 10.1016/j.clbc.2023.11.008. PubMed PMID:38135543 .
  10. Mofatteh, M, Mashayekhi, MS, Arfaie, S, Wei, H, Kazerouni, A, Skandalakis, GP et al.. Awake craniotomy during pregnancy: A systematic review of the published literature. Neurosurg Rev. 2023;46 (1):290. doi: 10.1007/s10143-023-02187-x. PubMed PMID:37910275 PubMed Central PMC10620271.
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Affiliations & Other Activities

  • Associate Professor, Division of Neurosurgery, Department of Surgery, St. Michael’s Hospital
  • Adjunct Scientist, Brain Tumour Research Centre, Hospital for Sick Children