Sunit Das

MD, PhD, MA, BA

Scientist

Biography

Sunit Das is a neurosurgeon and scientist at St. Michael’s Hospital and the Hospital for Sick Kids, and Associate Professor in the Department of Surgery at the University of Toronto. He currently serves as the CNS Tumours Lead at Ontario Health (Cancer Care Ontario). Dr. Das studied English Literature at the University of Michigan and Philosophy at Harvard University before moving to Chicago for medical school at Northwestern University. He completed his doctoral studies in Neurobiology at the National Institutes of Health, where he studied the molecular processes that underlie adult neurogenesis in the lab of Dr. ZuHang Sheng. He returned to Chicago for his neurosurgical residency, during which time he also began work on cancer stem cells in primary brain tumours in the lab of Dr. John Kessler. He was recruited to the University of Toronto in 2010. Dr. Das’s clinical practice is focused on the care of patients with benign and malignant brain tumours. His laboratory in the Arthur and Sonia Labatt Brain Tumour Centre at the Hospital for Sick Kids focuses on the molecular and genetic mechanisms that regulate cellular plasticity, fate specification and treatment resistance in glioblastoma. His research group at the Li Ka Shing Knowledge Institute is focused on using real-world data and meta-analysis for knowledge translation. His work has been published in many high impact journals, including Nature, Nature Genetics, Cell Stem Cell, Cancer Cell, JAMA, JAMA Neurology, and the New England Journal of Medicine. In 2017, Dr. Das joined the Centre for Ethics at the University of Toronto. His work at the Centre for Ethics focuses on the interface of AI with medicine, issues that underlie professional identity in medical practice, and the ethics of surgical innovation. Dr. Das was recently named a Senior Fellow at Massey College.

Recent Publications

  1. Mimosa, ML, Al-Ameri, W, Simpson, JT, Nakhla, M, Boissinot, K, Munoz, DG et al.. A Novel Approach to Detect IDH Point Mutations in Gliomas Using Nanopore Sequencing: Test Validation for the Clinical Laboratory. J Mol Diagn. 2022; :. doi: 10.1016/j.jmoldx.2022.12.001. PubMed PMID:36565986 .
  2. Messinger, A, Das, S. Erosion of the 'ethical' doctor-patient relationship and the rise of physician burn-out. Med Humanit. 2022; :. doi: 10.1136/medhum-2022-012506. PubMed PMID:36526412 .
  3. Tseng, CL, Chen, H, Stewart, J, Lau, AZ, Chan, RW, Lawrence, LSP et al.. High grade glioma radiation therapy on a high field 1.5 Tesla MR-Linac - workflow and initial experience with daily adapt-to-position (ATP) MR guidance: A first report. Front Oncol. 2022;12 :1060098. doi: 10.3389/fonc.2022.1060098. PubMed PMID:36518316 PubMed Central PMC9742425.
  4. Malhotra, AK, Karthikeyan, V, Zabih, V, Landry, A, Bennett, J, Bartels, U et al.. Adolescent and young adult glioma: systematic review of demographic, disease, and treatment influences on survival. Neurooncol Adv. 2022;4 (1):vdac168. doi: 10.1093/noajnl/vdac168. PubMed PMID:36479061 PubMed Central PMC9721387.
  5. Sherman, M, Gaebe, K, Li, AY, Habbous, S, Sahgal, A, Raphael, MJ et al.. Erythroblastic oncogene B-2 status and intracranial metastatic disease in patients with gastrointestinal cancer: a systematic review. J Neurooncol. 2022;160 (3):735-742. doi: 10.1007/s11060-022-04195-1. PubMed PMID:36372832 .
  6. Meaney, C, Das, S, Colak, E, Kohandel, M. Deep learning characterization of brain tumours with diffusion weighted imaging. J Theor Biol. 2023;557 :111342. doi: 10.1016/j.jtbi.2022.111342. PubMed PMID:36368560 .
  7. Chehade, R, Qazi, MA, Ennis, M, Sahgal, A, Das, S, Nofech-Mozes, S et al.. PD-L1 expression in breast cancer brain metastases. Neurooncol Adv. 2022;4 (1):vdac154. doi: 10.1093/noajnl/vdac154. PubMed PMID:36299795 PubMed Central PMC9587695.
  8. Lim-Fat, MJ, Macdonald, M, Lapointe, S, Climans, SA, Cacciotti, C, Chahal, M et al.. Molecular testing for adolescent and young adult central nervous system tumors: A Canadian guideline. Front Oncol. 2022;12 :960509. doi: 10.3389/fonc.2022.960509. PubMed PMID:36249063 PubMed Central PMC9559579.
  9. Premachandran, S, Haldavnekar, R, Das, S, Venkatakrishnan, K, Tan, B. DEEP Surveillance of Brain Cancer Using Self-Functionalized 3D Nanoprobes for Noninvasive Liquid Biopsy. ACS Nano. 2022;16 (11):17948-17964. doi: 10.1021/acsnano.2c04187. PubMed PMID:36112671 .
  10. Dhinakaran, AK, Dharmalingam, P, Ganesh, S, Venkatakrishnan, K, Das, S, Tan, B et al.. Molecular Crosstalk between T Cells and Tumor Uncovers GBM-Specific T Cell Signatures in Blood: Noninvasive GBM Diagnosis Using Immunosensors. ACS Nano. 2022;16 (9):14134-14148. doi: 10.1021/acsnano.2c04160. PubMed PMID:36040842 .
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Affiliations & Other Activities

  • Associate Professor, Division of Neurosurgery, Department of Surgery, St. Michael’s Hospital
  • Adjunct Scientist, Brain Tumour Research Centre, Hospital for Sick Children