Our research focuses on the molecular regulation of cardiac-specific gene expression in cardiac hypertrophy and failure. This has involved studies of transcriptional control of gene expression in cultured cardiac muscle, analysis of the molecular response to myocardial infarction, elucidation of signal transduction pathways involved in muscle growth and gene expression, and the identification of novel molecules that regulate cardiac hypertrophy and myocyte apoptosis. We apply transgenic and gene knockout strategies in mice to study the molecular physiology of these novel molecules, with a focus on the S100 family of calcium-binding proteins. Ours was the first group to define a role for these proteins in cardiac pathophysiology and more recently, in pulmonary hypertension.
At present, I am not accepting students in my research laboratory.
