Thomas Parker




Our research focuses on the molecular regulation of cardiac-specific gene expression in cardiac hypertrophy and failure. This has involved studies of transcriptional control of gene expression in cultured cardiac muscle, analysis of the molecular response to myocardial infarction, elucidation of signal transduction pathways involved in muscle growth and gene expression, and the identification of novel molecules that regulate cardiac hypertrophy and myocyte apoptosis. We apply transgenic and gene knockout strategies in mice to study the molecular physiology of these novel molecules, with a focus on the S100 family of calcium-binding proteins. Ours was the first group to define a role for these proteins in cardiac pathophysiology and more recently, in pulmonary hypertension.

At present, I am not accepting students in my research laboratory.

Recent Publications

  1. Tsoporis, JN, Triantafyllis, AS, Kalogeropoulos, AS, Izhar, S, Rigopoulos, AG, Rallidis, LS et al.. Differential Expression of Circulating Damage-Associated Molecular Patterns in Patients with Coronary Artery Ectasia. Biomolecules. 2023;14 (1):. doi: 10.3390/biom14010010. PubMed PMID:38275751 PubMed Central PMC10813324.
  2. Gkavogiannakis, NA, Tsoporis, JN, Drosatos, IA, Tsirebolos, G, Izhar, S, Sakadakis, E et al.. Emergent Inflammatory Markers and Echocardiographic Indices in Patients with Bronchial Asthma. Biomolecules. 2023;13 (6):. doi: 10.3390/biom13060955. PubMed PMID:37371535 PubMed Central PMC10296420.
  3. Tsoporis, JN, Amatullah, H, Gupta, S, Izhar, S, Ektesabi, AM, Vaswani, CM et al.. DJ-1 Deficiency Protects against Sepsis-Induced Myocardial Depression. Antioxidants (Basel). 2023;12 (3):. doi: 10.3390/antiox12030561. PubMed PMID:36978809 PubMed Central PMC10045744.
  4. Tsirebolos, G, Tsoporis, JN, Drosatos, IA, Izhar, S, Gkavogiannakis, N, Sakadakis, E et al.. Emerging markers of inflammation and oxidative stress as potential predictors of coronary artery disease. Int J Cardiol. 2023;376 :127-133. doi: 10.1016/j.ijcard.2023.02.005. PubMed PMID:36758863 .
  5. Gupta, S, Amatullah, H, Tsoporis, JN, Wei, K, Monteiro, APT, Ektesabi, AM et al.. DJ-1 binds to Rubicon to Impair LC-3 Associated Phagocytosis. Cell Death Differ. 2022;29 (10):2024-2033. doi: 10.1038/s41418-022-00993-2. PubMed PMID:35641782 PubMed Central PMC9525254.
  6. Tsoporis, JN, Ektesabi, AM, Gupta, S, Izhar, S, Salpeas, V, Rizos, IK et al.. A longitudinal study of alterations of circulating DJ-1 and miR203a-3p in association to olanzapine medication in a sample of first episode patients with schizophrenia. J Psychiatr Res. 2022;146 :109-117. doi: 10.1016/j.jpsychires.2021.12.049. PubMed PMID:34971908 .
  7. Drosatos, IA, Tsoporis, JN, Izhar, S, Gupta, S, Tsirebolos, G, Sakadakis, E et al.. Differential Regulation of Circulating Soluble Receptor for Advanced Glycation End Products (sRAGEs) and Its Ligands S100A8/A9 Four Weeks Post an Exercise Intervention in a Cohort of Young Army Recruits. Biomolecules. 2021;11 (9):. doi: 10.3390/biom11091354. PubMed PMID:34572568 PubMed Central PMC8469473.
  8. Tsoporis, JN, Drosatos, IA, Gupta, S, Amatullah, H, Izhar, S, Dos Santos, CC et al.. Cytoprotective Mechanisms of DJ-1: Implications in Cardiac Pathophysiology. Molecules. 2021;26 (13):. doi: 10.3390/molecules26133795. PubMed PMID:34206441 PubMed Central PMC8270312.
  9. Ektesabi, AM, Mori, K, Tsoporis, JN, Vaswani, CM, Gupta, S, Walsh, C et al.. Mesenchymal Stem/Stromal Cells Increase Cardiac miR-187-3p Expression in a Polymicrobial Animal Model of Sepsis. Shock. 2021;56 (1):133-141. doi: 10.1097/SHK.0000000000001701. PubMed PMID:33378320 PubMed Central PMC8240645.
  10. Gupta, S, Tsoporis, JN, Jia, SH, Dos Santos, CC, Parker, TG, Marshall, JC et al.. Toll-Like Receptors, Associated Biochemical Signaling Networks, and S100 Ligands. Shock. 2021;56 (2):167-177. doi: 10.1097/SHK.0000000000001704. PubMed PMID:33350801 .
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Affiliations & Other Activities

  • Scientist, Li Ka Shing Knowledge Institute, St. Michael’s Hospital
  • Vice President, Programs & Chief Medical Officer, St. Michael’s Hospital