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Veronique Miron

PhD

Scientist, Keenan Research Centre for Biomedical Science

Email: veronique.miron@unityhealth.to
Twitter: @MironLab

Research Programs

Labs

Miron Lab ❯

Biography

Dr. Miron is the John David Eaton Chair in Multiple Sclerosis Research at the BARLO Multiple Sclerosis Centre and Keenan Research Centre for Biomedical Science, and Full Professor in the Department of Immunology at The University of Toronto. Her team aims to identify novel treatment strategies for neurological conditions in which there is damage to myelin – the insulation surrounding nerve fibres required for their health and function, including multiple sclerosis, Alzheimer’s disease, cerebral palsy, and normal ageing. The focus of the lab is to harness the regenerative properties of immune cells and inflammation to support myelin health across the lifespan. She has won several prestigious awards such as the Medical Research Council Senior Research Award, Medical Research Council Career Development Award, the London Institute of Medical Sciences Suffrage Science Award, and the European Charcot Foundation Young Investigator Award. She is an avid champion of gender equality in research and has put in place several initiatives to improve equality and diversity practices both locally and internationally.

Recent Publications

  1. Holloway, RK, Zhang, L, Molina-Gonzalez, I, Ton, K, Nicoll, JAR, Boardman, JP et al.. Localized microglia dysregulation impairs central nervous system myelination in development. Acta Neuropathol Commun. 2023;11 (1):49. doi: 10.1186/s40478-023-01543-8. PubMed PMID:36949514 PubMed Central PMC10035254.
  2. Conole, ELS, Vaher, K, Cabez, MB, Sullivan, G, Stevenson, AJ, Hall, J et al.. Immuno-epigenetic signature derived in saliva associates with the encephalopathy of prematurity and perinatal inflammatory disorders. Brain Behav Immun. 2023;110 :322-338. doi: 10.1016/j.bbi.2023.03.011. PubMed PMID:36948324 .
  3. Massimo, M, Barelli, C, Moreno, C, Collesi, C, Holloway, RK, Crespo, B et al.. Haemorrhage of human foetal cortex associated with SARS-CoV-2 infection. Brain. 2023;146 (3):1175-1185. doi: 10.1093/brain/awac372. PubMed PMID:36642091 PubMed Central PMC9976976.
  4. McNamara, NB, Munro, DAD, Bestard-Cuche, N, Uyeda, A, Bogie, JFJ, Hoffmann, A et al.. Microglia regulate central nervous system myelin growth and integrity. Nature. 2023;613 (7942):120-129. doi: 10.1038/s41586-022-05534-y. PubMed PMID:36517604 PubMed Central PMC9812791.
  5. Molina-Gonzalez, I, Miron, VE, Antel, JP. Chronic oligodendrocyte injury in central nervous system pathologies. Commun Biol. 2022;5 (1):1274. doi: 10.1038/s42003-022-04248-1. PubMed PMID:36402839 PubMed Central PMC9675815.
  6. Paolicelli, RC, Sierra, A, Stevens, B, Tremblay, ME, Aguzzi, A, Ajami, B et al.. Microglia states and nomenclature: A field at its crossroads. Neuron. 2022;110 (21):3458-3483. doi: 10.1016/j.neuron.2022.10.020. PubMed PMID:36327895 PubMed Central PMC9999291.
  7. Edmondson-Stait, AJ, Shen, X, Adams, MJ, Barbu, MC, Jones, HJ, Miron, VE et al.. Early-life inflammatory markers and subsequent psychotic and depressive episodes between 10 to 28 years of age. Brain Behav Immun Health. 2022;26 :100528. doi: 10.1016/j.bbih.2022.100528. PubMed PMID:36277463 PubMed Central PMC9582583.
  8. Smith, KJ, Minns, D, McHugh, BJ, Holloway, RK, O'Connor, R, Williams, A et al.. The antimicrobial peptide cathelicidin drives development of experimental autoimmune encephalomyelitis in mice by affecting Th17 differentiation. PLoS Biol. 2022;20 (8):e3001554. doi: 10.1371/journal.pbio.3001554. PubMed PMID:36026478 PubMed Central PMC9455863.
  9. Labrak, Y, Heurtault, B, Frisch, B, Saulnier, P, Lepeltier, E, Miron, VE et al.. Impact of anti-PDGFRα antibody surface functionalization on LNC uptake by oligodendrocyte progenitor cells. Int J Pharm. 2022;618 :121623. doi: 10.1016/j.ijpharm.2022.121623. PubMed PMID:35231547 .
  10. Mahmood, A, Miron, VE. Microglia as therapeutic targets for central nervous system remyelination. Curr Opin Pharmacol. 2022;63 :102188. doi: 10.1016/j.coph.2022.102188. PubMed PMID:35219055 .
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Affiliations & Other Activities

  • Professor, Department of Immunology, University of Toronto