Wolfgang Kuebler


Affiliate Scientist

Research Programs


Wolfgang Kuebler Lab ❯


Please note Dr. Kuebler will not be accepting summer students.

Dr. Wolfgang Kuebler is an Associate Scientist at the Keenan Research Centre for Biomedical Science of St. Michael’s Hospital. He is a Professor at the University of Toronto in both the Department of Surgery and the Department of Physiology and a Professor of Physiology at the Charité-Universitaetsmedizin Berlin with an endowed professorship by the German Heart Institute Berlin. He is also an Adjunct Professor in the Department of Electrical and Computer Engineering at Ryerson University, and an Adjunct Professor in the College of Graduate Studies and Research at the University of Saskatchewan.

His research interest focuses on translational research in pulmonary and microvascular physiology and pathophysiology, he has published > 120 peer-reviewed articles largely on topics that integrate basic research on intracellular signalling and intercellular communication pathways to the level of the intact organ and organism in complex disease models such as acute lung injury, lung edema, or pulmonary hypertension. A special methodological focus of his work is the use of intravital microscopy and real-time fluorescence imaging techniques in intact organs or life animal models, which he combines with both cell and molecular biology techniques as well as physiological measurements.

He currently serves as Chair of the Section Advisory Committee and as Past-Chair of the Respiration Section for the American Physiological Society. In addition, he is the Chair of the Scientific Advisory Panel for the Ludwig-Boltzmann-Institute for Lung Vascular Research in Graz, Austria, and as Associate Editor for the American Journal of Physiology – Lung Cellular and Molecular Physiology and for Experimental Lung Research. He has served on numerous review panels for Canadian Institutes of Health Research and the Heart & Stroke Foundation, and as ad-hoc reviewer for funding agencies in Canada, UK, Ireland, France, Germany, Austria, Israel, Italy, Poland, and Hungary.

Recent Publications

  1. Hegemann, N, Bintig, W, Perret, PL, Rees, J, Viperino, A, Eickholt, B et al.. In-ovo echocardiography for application in cardiovascular research. Basic Res Cardiol. 2023;118 (1):19. doi: 10.1007/s00395-023-00989-0. PubMed PMID:37193927 PubMed Central PMC10188421.
  2. Bünger, V, Hunsicker, O, Krannich, A, Balzer, F, Spies, CD, Kuebler, WM et al.. Potential of cell-free hemoglobin and haptoglobin as prognostic markers in patients with ARDS and treatment with veno-venous ECMO. J Intensive Care. 2023;11 (1):15. doi: 10.1186/s40560-023-00664-5. PubMed PMID:37081577 PubMed Central PMC10116665.
  3. Asmus, E, Karle, W, Brack, MC, Wittig, C, Behrens, F, Reinshagen, L et al.. Cystic fibrosis transmembrane conductance regulator modulators attenuate platelet activation and aggregation in blood of healthy donors and COVID-19 patients. Eur Respir J. 2023;61 (3):. doi: 10.1183/13993003.02009-2022. PubMed PMID:36958745 PubMed Central PMC10033930.
  4. Böning, D, Kuebler, WM, Vogel, D, Bloch, W. The oxygen dissociation curve of blood in COVID-19-An update. Front Med (Lausanne). 2023;10 :1098547. doi: 10.3389/fmed.2023.1098547. PubMed PMID:36923010 PubMed Central PMC10008909.
  5. Ferrari, D, Sengupta, A, Heo, L, Pethö, L, Michler, J, Geiser, T et al.. Effects of biomechanical and biochemical stimuli on angio- and vasculogenesis in a complex microvasculature-on-chip. iScience. 2023;26 (3):106198. doi: 10.1016/j.isci.2023.106198. PubMed PMID:36879808 PubMed Central PMC9985038.
  6. Hertel, M, Preissner, S, Gohlke, BO, Kuebler, WM, Hernandez, G, Akyüz, M et al.. Real-world evidence for beneficial effects of dipyrone in 4,278 patients with pulmonary hypertension - Analysis of the risk of ventilation, hospitalization, and agranulocytosis. Eur J Pharmacol. 2023;943 :175567. doi: 10.1016/j.ejphar.2023.175567. PubMed PMID:36754194 .
  7. Felten, M, Kramer, A, Kuebler, WM, Witzenrath, M. Reply to: Is BMAL1 Just One Song Impacting the Circadian Dance of Lung Injury?. Am J Respir Crit Care Med. 2023; :. doi: 10.1164/rccm.202301-0148LE. PubMed PMID:36731053 .
  8. Felten, M, Ferencik, S, Teixeira Alves, LG, Letsiou, E, Lienau, J, Müller-Redetzky, HC et al.. Ventilator-induced Lung Injury Is Modulated by the Circadian Clock. Am J Respir Crit Care Med. 2023;207 (11):1464-1474. doi: 10.1164/rccm.202202-0320OC. PubMed PMID:36480958 .
  9. Erfinanda, L, Zou, L, Gutbier, B, Kneller, L, Weidenfeld, S, Michalick, L et al.. Loss of endothelial CFTR drives barrier failure and edema formation in lung infection and can be targeted by CFTR potentiation. Sci Transl Med. 2022;14 (674):eabg8577. doi: 10.1126/scitranslmed.abg8577. PubMed PMID:36475904 .
  10. Sauer, A, Seeliger, B, Jandl, K, Erfinanda, L, Wilhelm, J, Alexopoulos, I et al.. Circulating hyaluronic acid signature in CAP and ARDS - the role of pneumolysin in hyaluronic acid shedding. Matrix Biol. 2022;114 :67-83. doi: 10.1016/j.matbio.2022.11.003. PubMed PMID:36456058 .
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Affiliations & Other Activities


  • Member, Institute for Biomedical Engineering and Science Technology (iBEST) at Ryerson University and St. Michael’s Hospital
  • Professor, Department of Surgery, University of Toronto
  • Professor, Department of Physiology, University of Toronto
  • Full Member, Institute of Medical Sciences Graduate School, University of Toronto
  • Member, Heart & Stroke/Richard Lewar Centre of Excellence in Cardiovascular Research, University of Toronto
  • Professor, Institut of Physiology at the Charité-Universitaetsmedizin Berlin, endowed by the German Heart Institute Berlin
  • Adjunct Professor, Department of Electrical and Computer Engineering, Ryerson University
  • Adjunct Professor, College of Graduate Studies and Research, University of Saskatchewan