Wolfgang Kuebler

MD

Affiliate Scientist

Research Programs

Labs

Wolfgang Kuebler Lab ❯

Biography

Please note Dr. Kuebler will not be accepting summer students.

Dr. Wolfgang Kuebler is an Associate Scientist at the Keenan Research Centre for Biomedical Science of St. Michael’s Hospital. He is a Professor at the University of Toronto in both the Department of Surgery and the Department of Physiology and a Professor of Physiology at the Charité-Universitaetsmedizin Berlin with an endowed professorship by the German Heart Institute Berlin. He is also an Adjunct Professor in the Department of Electrical and Computer Engineering at Ryerson University, and an Adjunct Professor in the College of Graduate Studies and Research at the University of Saskatchewan.

His research interest focuses on translational research in pulmonary and microvascular physiology and pathophysiology, he has published > 120 peer-reviewed articles largely on topics that integrate basic research on intracellular signalling and intercellular communication pathways to the level of the intact organ and organism in complex disease models such as acute lung injury, lung edema, or pulmonary hypertension. A special methodological focus of his work is the use of intravital microscopy and real-time fluorescence imaging techniques in intact organs or life animal models, which he combines with both cell and molecular biology techniques as well as physiological measurements.

He currently serves as Chair of the Section Advisory Committee and as Past-Chair of the Respiration Section for the American Physiological Society. In addition, he is the Chair of the Scientific Advisory Panel for the Ludwig-Boltzmann-Institute for Lung Vascular Research in Graz, Austria, and as Associate Editor for the American Journal of Physiology – Lung Cellular and Molecular Physiology and for Experimental Lung Research. He has served on numerous review panels for Canadian Institutes of Health Research and the Heart & Stroke Foundation, and as ad-hoc reviewer for funding agencies in Canada, UK, Ireland, France, Germany, Austria, Israel, Italy, Poland, and Hungary.

Recent Publications

  1. Pennitz, P, Kirsten, H, Friedrich, VD, Wyler, E, Goekeri, C, Obermayer, B et al.. A pulmonologist's guide to perform and analyse cross-species single lung cell transcriptomics. Eur Respir Rev. 2022;31 (165):. doi: 10.1183/16000617.0056-2022. PubMed PMID:35896273 .
  2. Sinha, M, Zabini, D, Guntur, D, Nagaraj, C, Enyedi, P, Olschewski, H et al.. Chloride channels in the lung: Challenges and perspectives for viral infections, pulmonary arterial hypertension, and cystic fibrosis. Pharmacol Ther. 2022;237 :108249. doi: 10.1016/j.pharmthera.2022.108249. PubMed PMID:35878810 .
  3. Gluschke, H, Siegert, E, Minich, WB, Hackler, J, Riemekasten, G, Kuebler, WM et al.. Autoimmunity to Sphingosine-1-Phosphate-Receptors in Systemic Sclerosis and Pulmonary Arterial Hypertension. Front Immunol. 2022;13 :935787. doi: 10.3389/fimmu.2022.935787. PubMed PMID:35860272 PubMed Central PMC9289471.
  4. Tabeling, C, González Calera, CR, Lienau, J, Höppner, J, Tschernig, T, Kershaw, O et al.. Endothelin B Receptor Immunodynamics in Pulmonary Arterial Hypertension. Front Immunol. 2022;13 :895501. doi: 10.3389/fimmu.2022.895501. PubMed PMID:35757687 PubMed Central PMC9221837.
  5. Böning, D, Bloch, W, Kuebler, WM. Comment on Ceruti et al. Temporal Changes in the Oxyhemoglobin Dissociation Curve of Critically Ill COVID-19 Patients. J. Clin. Med. 2022, 11, 788. J Clin Med. 2022;11 (12):. doi: 10.3390/jcm11123376. PubMed PMID:35743447 PubMed Central PMC9225162.
  6. Ahmad, S, Matalon, S, Kuebler, WM. Understanding COVID-19 susceptibility and presentation based on its underlying physiology. Physiol Rev. 2022;102 (4):1579-1585. doi: 10.1152/physrev.00008.2022. PubMed PMID:35583178 PubMed Central PMC9255705.
  7. Jiang, T, Samapati, R, Klassen, S, Lei, D, Erfinanda, L, Jankowski, V et al.. Stimulation of the EP3 receptor causes lung edema by activation of TRPC6 in pulmonary endothelial cells. Eur Respir J. 2022; :. doi: 10.1183/13993003.02635-2021. PubMed PMID:35450969 .
  8. Wyler, E, Adler, JM, Eschke, K, Teixeira Alves, G, Peidli, S, Pott, F et al.. Key benefits of dexamethasone and antibody treatment in COVID-19 hamster models revealed by single-cell transcriptomics. Mol Ther. 2022;30 (5):1952-1965. doi: 10.1016/j.ymthe.2022.03.014. PubMed PMID:35339689 PubMed Central PMC8942568.
  9. Böning, D, Bloch, W, Kuebler, WM. About «Absence of Relevant Clinical Effects of SARS-CoV-2 on the Affinity of Hemoglobin for O2 in Patients with COVID-19». Arch Bronconeumol. 2022; :. doi: 10.1016/j.arbres.2021.12.011. PubMed PMID:35312516 .
  10. Sang, P, Kucherenko, MM, Yao, J, Li, Q, Simmons, S, Kuebler, WM et al.. A Model of Reverse Vascular Remodeling in Pulmonary Hypertension Due to Left Heart Disease by Aortic Debanding in Rats. J Vis Exp. 2022; (181):. doi: 10.3791/63502. PubMed PMID:35311828 .
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Affiliations & Other Activities

 

  • Member, Institute for Biomedical Engineering and Science Technology (iBEST) at Ryerson University and St. Michael’s Hospital
  • Professor, Department of Surgery, University of Toronto
  • Professor, Department of Physiology, University of Toronto
  • Full Member, Institute of Medical Sciences Graduate School, University of Toronto
  • Member, Heart & Stroke/Richard Lewar Centre of Excellence in Cardiovascular Research, University of Toronto
  • Professor, Institut of Physiology at the Charité-Universitaetsmedizin Berlin, endowed by the German Heart Institute Berlin
  • Adjunct Professor, Department of Electrical and Computer Engineering, Ryerson University
  • Adjunct Professor, College of Graduate Studies and Research, University of Saskatchewan