Wolfgang Kuebler


Affiliate Scientist

Research Programs


Wolfgang Kuebler Lab ❯


Please note Dr. Kuebler will not be accepting summer students.

Dr. Wolfgang Kuebler is an Associate Scientist at the Keenan Research Centre for Biomedical Science of St. Michael’s Hospital. He is a Professor at the University of Toronto in both the Department of Surgery and the Department of Physiology and a Professor of Physiology at the Charité-Universitaetsmedizin Berlin with an endowed professorship by the German Heart Institute Berlin. He is also an Adjunct Professor in the Department of Electrical and Computer Engineering at Ryerson University, and an Adjunct Professor in the College of Graduate Studies and Research at the University of Saskatchewan.

His research interest focuses on translational research in pulmonary and microvascular physiology and pathophysiology, he has published > 120 peer-reviewed articles largely on topics that integrate basic research on intracellular signalling and intercellular communication pathways to the level of the intact organ and organism in complex disease models such as acute lung injury, lung edema, or pulmonary hypertension. A special methodological focus of his work is the use of intravital microscopy and real-time fluorescence imaging techniques in intact organs or life animal models, which he combines with both cell and molecular biology techniques as well as physiological measurements.

He currently serves as Chair of the Section Advisory Committee and as Past-Chair of the Respiration Section for the American Physiological Society. In addition, he is the Chair of the Scientific Advisory Panel for the Ludwig-Boltzmann-Institute for Lung Vascular Research in Graz, Austria, and as Associate Editor for the American Journal of Physiology – Lung Cellular and Molecular Physiology and for Experimental Lung Research. He has served on numerous review panels for Canadian Institutes of Health Research and the Heart & Stroke Foundation, and as ad-hoc reviewer for funding agencies in Canada, UK, Ireland, France, Germany, Austria, Israel, Italy, Poland, and Hungary.

Recent Publications

  1. Felten, M, Kramer, A, Kuebler, WM, Witzenrath, M. Reply to: Is BMAL1 Just One Song Impacting the Circadian Dance of Lung Injury?. Am J Respir Crit Care Med. 2023; :. doi: 10.1164/rccm.202301-0148LE. PubMed PMID:36731053 .
  2. Felten, M, Ferencik, S, Teixeira Alves, LG, Letsiou, E, Lienau, J, MĂĽller-Redetzky, HC et al.. Ventilator-induced Lung Injury Is Modulated by the Circadian Clock. Am J Respir Crit Care Med. 2022; :. doi: 10.1164/rccm.202202-0320OC. PubMed PMID:36480958 .
  3. Erfinanda, L, Zou, L, Gutbier, B, Kneller, L, Weidenfeld, S, Michalick, L et al.. Loss of endothelial CFTR drives barrier failure and edema formation in lung infection and can be targeted by CFTR potentiation. Sci Transl Med. 2022;14 (674):eabg8577. doi: 10.1126/scitranslmed.abg8577. PubMed PMID:36475904 .
  4. Sauer, A, Seeliger, B, Jandl, K, Erfinanda, L, Wilhelm, J, Alexopoulos, I et al.. Circulating hyaluronic acid signature in CAP and ARDS - the role of pneumolysin in hyaluronic acid shedding. Matrix Biol. 2022;114 :67-83. doi: 10.1016/j.matbio.2022.11.003. PubMed PMID:36456058 .
  5. Bartlett, NW, Bastarache, JA, Kuebler, WM, Schmidt, EP. Call for Papers: "In It for the Long Haul: Understanding the Lasting Impact of COVID-19 on Lung Health and Disease". Am J Physiol Lung Cell Mol Physiol. 2022;323 (6):L683-L684. doi: 10.1152/ajplung.00352.2022. PubMed PMID:36346147 PubMed Central PMC9870585.
  6. Fan, Y, Zhang, AM, Wu, XL, Huang, ZS, Kontogianni, K, Sun, K et al.. Transbronchial needle aspiration combined with cryobiopsy in the diagnosis of mediastinal diseases: a multicentre, open-label, randomised trial. Lancet Respir Med. 2022; :. doi: 10.1016/S2213-2600(22)00392-7. PubMed PMID:36279880 .
  7. Liu, SF, Nambiar Veetil, N, Li, Q, Kucherenko, MM, Knosalla, C, Kuebler, WM et al.. Pulmonary hypertension: Linking inflammation and pulmonary arterial stiffening. Front Immunol. 2022;13 :959209. doi: 10.3389/fimmu.2022.959209. PubMed PMID:36275740 PubMed Central PMC9579293.
  8. Peters, L, Kuebler, WM, Simmons, S. Sphingolipids in Atherosclerosis: Chimeras in Structure and Function. Int J Mol Sci. 2022;23 (19):. doi: 10.3390/ijms231911948. PubMed PMID:36233252 PubMed Central PMC9570378.
  9. Pletz, MW, Jensen, AV, Bahrs, C, Davenport, C, Rupp, J, Witzenrath, M et al.. Unmet needs in pneumonia research: a comprehensive approach by the CAPNETZ study group. Respir Res. 2022;23 (1):239. doi: 10.1186/s12931-022-02117-3. PubMed PMID:36088316 PubMed Central PMC9463667.
  10. Voelkel, NF, Bogaard, HJ, Kuebler, WM. ARDS in the time of corona: context and perspective. Am J Physiol Lung Cell Mol Physiol. 2022;323 (4):L431-L437. doi: 10.1152/ajplung.00432.2021. PubMed PMID:35997290 PubMed Central PMC9529269.
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Affiliations & Other Activities


  • Member, Institute for Biomedical Engineering and Science Technology (iBEST) at Ryerson University and St. Michael’s Hospital
  • Professor, Department of Surgery, University of Toronto
  • Professor, Department of Physiology, University of Toronto
  • Full Member, Institute of Medical Sciences Graduate School, University of Toronto
  • Member, Heart & Stroke/Richard Lewar Centre of Excellence in Cardiovascular Research, University of Toronto
  • Professor, Institut of Physiology at the CharitĂ©-Universitaetsmedizin Berlin, endowed by the German Heart Institute Berlin
  • Adjunct Professor, Department of Electrical and Computer Engineering, Ryerson University
  • Adjunct Professor, College of Graduate Studies and Research, University of Saskatchewan