Wolfgang Kuebler


Affiliate Scientist

Research Programs


Wolfgang Kuebler Lab ❯


Please note Dr. Kuebler will not be accepting summer students.

Dr. Wolfgang Kuebler is an Associate Scientist at the Keenan Research Centre for Biomedical Science of St. Michael’s Hospital. He is a Professor at the University of Toronto in both the Department of Surgery and the Department of Physiology and a Professor of Physiology at the Charité-Universitaetsmedizin Berlin with an endowed professorship by the German Heart Institute Berlin. He is also an Adjunct Professor in the Department of Electrical and Computer Engineering at Ryerson University, and an Adjunct Professor in the College of Graduate Studies and Research at the University of Saskatchewan.

His research interest focuses on translational research in pulmonary and microvascular physiology and pathophysiology, he has published > 120 peer-reviewed articles largely on topics that integrate basic research on intracellular signalling and intercellular communication pathways to the level of the intact organ and organism in complex disease models such as acute lung injury, lung edema, or pulmonary hypertension. A special methodological focus of his work is the use of intravital microscopy and real-time fluorescence imaging techniques in intact organs or life animal models, which he combines with both cell and molecular biology techniques as well as physiological measurements.

He currently serves as Chair of the Section Advisory Committee and as Past-Chair of the Respiration Section for the American Physiological Society. In addition, he is the Chair of the Scientific Advisory Panel for the Ludwig-Boltzmann-Institute for Lung Vascular Research in Graz, Austria, and as Associate Editor for the American Journal of Physiology – Lung Cellular and Molecular Physiology and for Experimental Lung Research. He has served on numerous review panels for Canadian Institutes of Health Research and the Heart & Stroke Foundation, and as ad-hoc reviewer for funding agencies in Canada, UK, Ireland, France, Germany, Austria, Israel, Italy, Poland, and Hungary.

Recent Publications

  1. Hansen, CE, Kamermans, A, Mol, K, Berve, K, Rodriguez-Mogeda, C, Fung, WK et al.. Inflammation-induced TRPV4 channels exacerbate blood-brain barrier dysfunction in multiple sclerosis. J Neuroinflammation. 2024;21 (1):72. doi: 10.1186/s12974-024-03069-9. PubMed PMID:38521959 PubMed Central PMC10960997.
  2. Avcibas, R, Vermul, A, Gluhovic, V, Boback, N, Arroyo, R, Kingma, PS et al.. Multivalent, calcium-independent binding of surfactant protein A and D to sulfated glycosaminoglycans of the alveolar epithelial glycocalyx. Am J Physiol Lung Cell Mol Physiol. 2024; :. doi: 10.1152/ajplung.00283.2023. PubMed PMID:38375572 .
  3. Herbst, CJ, Lopez-Rodriguez, E, Gluhovic, V, Schulz, S, Brandt, R, Timm, S et al.. Characterization of Commercially Available Human Primary Alveolar Epithelial Cells. Am J Respir Cell Mol Biol. 2024; :. doi: 10.1165/rcmb.2023-0320MA. PubMed PMID:38207121 .
  4. Cheng, TL, Huang, ZS, Zhang, J, Wang, J, Zhao, J, Kontogianni, K et al.. Comparison of cryobiopsy and forceps biopsy for the diagnosis of mediastinal lesions: A randomised clinical trial. Pulmonology. 2024; :. doi: 10.1016/j.pulmoe.2023.12.002. PubMed PMID:38182469 .
  5. Hou, X, Hashemi, D, Erley, J, Neye, M, Bucius, P, Tanacli, R et al.. Noninvasive evaluation of pulmonary artery stiffness in heart failure patients via cardiovascular magnetic resonance. Sci Rep. 2023;13 (1):22656. doi: 10.1038/s41598-023-49325-5. PubMed PMID:38114509 PubMed Central PMC10730605.
  6. Hegemann, N, Sang, P, Kim, JH, Koçana, C, Momin, N, Klages, J et al.. Ultrasonographic assessment of pulmonary and Central venous congestion in experimental heart failure. Am J Physiol Heart Circ Physiol. 2024;326 (2):H433-H440. doi: 10.1152/ajpheart.00735.2023. PubMed PMID:38099848 .
  7. Schmidt, KH, Bikou, O, Blindt, R, Bruch, L, Felgendreher, R, Hohenforst-Schmidt, W et al.. [Pulmonary hypertension associated with left heart disease (group 2)]. Pneumologie. 2023;77 (11):926-936. doi: 10.1055/a-2145-4792. PubMed PMID:37963482 .
  8. Eichstaedt, CA, Bikou, O, Sommer, N, Schermuly, RT, Pullamsetti, SS, Weissmann, N et al.. [Genetic diagnostics and molecular approaches in pulmonary arterial hypertension]. Pneumologie. 2023;77 (11):862-870. doi: 10.1055/a-2145-4663. PubMed PMID:37963476 .
  9. Grünig, E, Benjamin, N, Behr, J, Skowasch, D, Milger-Kneidinger, K, Halank, M et al.. [The new European Guidelines for Pulmonary Hypertension with Updated Commentary of the PH-DACH Conference - A position paper of the German Society for Pneumology and Respiratory Medicine (DGP)]. Pneumologie. 2023;77 (11):852-853. doi: 10.1055/a-2146-7472. PubMed PMID:37963474 .
  10. Reinshagen, L, Nageswaran, V, Heidecke, H, Schulze-Forster, K, Wilde, AB, Ramezani Rad, P et al.. Protease-Activated Receptor-1 IgG Autoantibodies in Patients with COVID-19. Thromb Haemost. 2023; :. doi: 10.1055/a-2205-0014. PubMed PMID:37931906 .
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Affiliations & Other Activities


  • Member, Institute for Biomedical Engineering and Science Technology (iBEST) at Ryerson University and St. Michael’s Hospital
  • Professor, Department of Surgery, University of Toronto
  • Professor, Department of Physiology, University of Toronto
  • Full Member, Institute of Medical Sciences Graduate School, University of Toronto
  • Member, Heart & Stroke/Richard Lewar Centre of Excellence in Cardiovascular Research, University of Toronto
  • Professor, Institut of Physiology at the Charité-Universitaetsmedizin Berlin, endowed by the German Heart Institute Berlin
  • Adjunct Professor, Department of Electrical and Computer Engineering, Ryerson University
  • Adjunct Professor, College of Graduate Studies and Research, University of Saskatchewan