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Arthur S. Slutsky

MD, M.A.Sc., B.A.Sc.

Scientist

Email: Arthur.Slutsky@unityhealth.to
Tel: 416-864-5637

Research Programs

Biography

My major research interests relate to the lung injury caused by mechanical ventilation: so called ventilator-induced lung injury (VILI). Specifically, my lab is working on (1) biotrauma: the molecular mechanisms by which injurious forms of mechanical ventilation can lead to release of mediators; (2) the mechanisms by which these mediators can affect distal organs (e.g. kidney, liver, etc.) and lead to multiple organ dysfunction syndrome (MODS); and (3) therapeutic approaches (ventilatory and non-ventilatory) to mitigate VILI and biotrauma. My laboratory works very closely with Dr. Zhang’s laboratory, and makes use of a number of model systems including in vitro, ex vivo cell and various animal models. As well, I have a major interest in clinical trials related to mechanical ventilation, acute lung injury (ALI), acute respiratory distress syndrome (ARDS), and COVID-19.

 

Recent Publications

  1. Fernando, SM, Qureshi, D, Talarico, R, Vigod, SN, McIsaac, DI, Sterling, LH et al.. Mental health sequelae in survivors of cardiogenic shock complicating myocardial infarction. A population-based cohort study. Intensive Care Med. 2024; :. doi: 10.1007/s00134-024-07399-3. PubMed PMID:38695924 .
  2. Justice, JM, Slutsky, AS, Stanford, N, Isennock, C, Siddiqui, S, Zamir, H et al.. Assessment of Ventilation Using Adult and Pediatric Manual Resuscitators in a Simulated Adult Patient. Respir Care. 2024; :. doi: 10.4187/respcare.11588. PubMed PMID:38688544 .
  3. Nasa, P, Bos, LD, Estenssoro, E, van Haren, FM, Serpa Neto, A, Rocco, PR et al.. Consensus statements on the utility of defining ARDS and the utility of past and current definitions of ARDS-protocol for a Delphi study. BMJ Open. 2024;14 (4):e082986. doi: 10.1136/bmjopen-2023-082986. PubMed PMID:38670604 PubMed Central PMC11057280.
  4. Coiffard, B, Dianti, J, Telias, I, Brochard, LJ, Slutsky, AS, Beck, J et al.. Dyssynchronous diaphragm contractions impair diaphragm function in mechanically ventilated patients. Crit Care. 2024;28 (1):107. doi: 10.1186/s13054-024-04894-3. PubMed PMID:38566126 PubMed Central PMC10988824.
  5. Songsangvorn, N, Xu, Y, Lu, C, Rotstein, O, Brochard, L, Slutsky, AS et al.. Electrical impedance tomography-guided positive end-expiratory pressure titration in ARDS: a systematic review and meta-analysis. Intensive Care Med. 2024; :. doi: 10.1007/s00134-024-07362-2. PubMed PMID:38512400 .
  6. Dianti, J, McNamee, JJ, Slutsky, AS, Fan, E, Ferguson, ND, McAuley, DF et al.. Determinants of Effect of Extracorporeal CO2 Removal in Hypoxemic Respiratory Failure. NEJM Evid. 2023;2 (5):EVIDoa2200295. doi: 10.1056/EVIDoa2200295. PubMed PMID:38320056 .
  7. Tran, A, Rochwerg, B, Fan, E, Belohlavek, J, Suverein, MM, Poll, MCGV et al.. Prognostic factors associated with favourable functional outcome among adult patients requiring extracorporeal cardiopulmonary resuscitation for out-of-hospital cardiac arrest: A systematic review and meta-analysis. Resuscitation. 2023;193 :110004. doi: 10.1016/j.resuscitation.2023.110004. PubMed PMID:37863420 .
  8. Villar, J, González-Martín, JM, Hernández-González, J, Armengol, MA, Fernández, C, Martín-Rodríguez, C et al.. Predicting ICU Mortality in Acute Respiratory Distress Syndrome Patients Using Machine Learning: The Predicting Outcome and STratifiCation of severity in ARDS (POSTCARDS) Study. Crit Care Med. 2023;51 (12):1638-1649. doi: 10.1097/CCM.0000000000006030. PubMed PMID:37651262 .
  9. Onodera, Y, Liang, J, Li, Y, Griffin, B, Thanabalasingam, T, Lu, C et al.. Inhalation of ACE2 as a therapeutic target on sex-bias differences in SARS-CoV-2 infection and variant of concern. iScience. 2023;26 (8):107470. doi: 10.1016/j.isci.2023.107470. PubMed PMID:37609639 PubMed Central PMC10440513.
  10. Gattinoni, L, Citerio, G, Slutsky, AS. Back to the future: ARDS guidelines, evidence, and opinions. Intensive Care Med. 2023;49 (10):1226-1228. doi: 10.1007/s00134-023-07183-9. PubMed PMID:37578520 .
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Affiliations & Other Activities

  • Scientist, Keenan Research Centre for Biomedical Science, St. Michael’s Hospital
  • Keenan Chair in Medicine, St. Michael’s Hospital
  • Professor, Departments of Medicine, Biomedical Engineering and Surgery, University of Toronto
  • Chair, Clinical Trials Ontario