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Orla Smith

RN, PhD

Investigator

Email: Orla.Smith@unityhealth.to
Tel: 416-864-6060 ext. 3179

Research Programs

Biography

My main areas of research interest are decision-making and psychological outcomes in family members of critically ill patients.

Recent Publications

  1. Rasmussen, LV, Grass, I, Mehrabi, Z, Smith, OM, Bezner-Kerr, R, Blesh, J et al.. Joint environmental and social benefits from diversified agriculture. Science. 2024;384 (6691):87-93. doi: 10.1126/science.adj1914. PubMed PMID:38574149 .
  2. Zakrzewski, JL, Suh, D, Markley, JC, Smith, OM, King, C, Goldberg, GL et al.. Author Correction: Tumor immunotherapy across MHC barriers using allogeneic T-cell precursors. Nat Biotechnol. 2024;42 (4):674. doi: 10.1038/s41587-024-02205-3. PubMed PMID:38531977 .
  3. Vaara, ST, Serpa Neto, A, Bellomo, R, Adhikari, NKJ, Dreyfuss, D, Gallagher, M et al.. Regional Practice Variation and Outcomes in the Standard Versus Accelerated Initiation of Renal Replacement Therapy in Acute Kidney Injury (STARRT-AKI) Trial: A Post Hoc Secondary Analysis. Crit Care Explor. 2024;6 (2):e1053. doi: 10.1097/CCE.0000000000001053. PubMed PMID:38380940 PubMed Central PMC10878545.
  4. Wald, R, Gaudry, S, da Costa, BR, Adhikari, NKJ, Bellomo, R, Du, B et al.. Initiation of continuous renal replacement therapy versus intermittent hemodialysis in critically ill patients with severe acute kidney injury: a secondary analysis of STARRT-AKI trial. Intensive Care Med. 2023;49 (11):1305-1316. doi: 10.1007/s00134-023-07211-8. PubMed PMID:37815560 .
  5. Bagshaw, SM, Neto, AS, Smith, O, Weir, M, Qiu, H, Du, B et al.. Correction: Impact of renal-replacement therapy strategies on outcomes for patients with chronic kidney disease: a secondary analysis of the STARRT-AKI trial. Intensive Care Med. 2023;49 (3):381-383. doi: 10.1007/s00134-023-06976-2. PubMed PMID:36757471 .
  6. Bagshaw, SM, Neto, AS, Smith, O, Weir, M, Qiu, H, Du, B et al.. Impact of renal-replacement therapy strategies on outcomes for patients with chronic kidney disease: a secondary analysis of the STARRT-AKI trial. Intensive Care Med. 2022;48 (12):1736-1750. doi: 10.1007/s00134-022-06912-w. PubMed PMID:36331570 .
  7. Zampieri, FG, da Costa, BR, Vaara, ST, Lamontagne, F, Rochwerg, B, Nichol, AD et al.. A Bayesian reanalysis of the Standard versus Accelerated Initiation of Renal-Replacement Therapy in Acute Kidney Injury (STARRT-AKI) trial. Crit Care. 2022;26 (1):255. doi: 10.1186/s13054-022-04120-y. PubMed PMID:36008827 PubMed Central PMC9404618.
  8. Angriman, F, Ferreyro, BL, Angeloni, N, da Costa, BR, Wald, R, Bagshaw, SM et al.. The Effect of an Accelerated Renal Replacement Therapy Initiation Is Not Modified by Baseline Risk. Ann Am Thorac Soc. 2022;19 (9):1613-1618. doi: 10.1513/AnnalsATS.202201-046RL. PubMed PMID:35587363 .
  9. Rose, L, Sutt, AL, Amaral, AC, Fergusson, DA, Smith, OM, Dale, CM et al.. Interventions to enable communication for adult patients requiring an artificial airway with or without mechanical ventilator support. Cochrane Database Syst Rev. 2021;10 (10):CD013379. doi: 10.1002/14651858.CD013379.pub2. PubMed PMID:34637143 PubMed Central PMC8507432.
  10. Dale, CM, Rose, L, Carbone, S, Pinto, R, Smith, OM, Burry, L et al.. Effect of oral chlorhexidine de-adoption and implementation of an oral care bundle on mortality for mechanically ventilated patients in the intensive care unit (CHORAL): a multi-center stepped wedge cluster-randomized controlled trial. Intensive Care Med. 2021;47 (11):1295-1302. doi: 10.1007/s00134-021-06475-2. PubMed PMID:34609548 PubMed Central PMC8490143.
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Affiliations & Other Activities

  • Research Manager, Critical Care, St. Michael’s Hospital