Karen Burns

MD, FRCPC, MSc ,BA, BSc

Scientist

Biography

Dr. Karen Burns practices critical care medicine at St. Michael’s Hospital in Toronto. She is an Associate Professor of Medicine at the University of Toronto, a Clinician Scientists at the Li Ka Shing Knowledge Institute, and an Associate Member of the Department of Clinical Epidemiology (McMaster University).

Dr. Burns’ research program focuses on evaluation strategies to liberate critically ill patients from mechanical ventilation and characterizing practice variation in weaning critically ill adults from ventilators. Her research program includes large scale observational studies, national and international weaning surveys, meta-analyses, and randomized trials comparing different weaning strategies. She also has developed a research program to characterize the unique aspects of the consent processes in critical care. Additional research interests include the use of artificial intelligence in weaning, helmet NIV, acute kidney injury in the intensive care unit, using noninvasive positive pressure ventilation as a weaning strategy, and methodology issues related to study design, implementation and reporting.

Dr. Burns has been the recipient of several personnel awards including a Canadian Institutes of Health Research Clinician Scientist Award, a Ministry of Research and Innovation Award, PSI – mid career research award, and two University of Toronto Merritt Committee Awards.

Dr. Burns is an Executive Member of the Canadian Critical Care Trials Group, a Treasurer of the Canadian Critical Care Society, and the current Chair of the Women in Critical Care Interest Group for the American Thoracic Society.

Recent Publications

  1. Cook, D, Taneja, S, Krewulak, K, Zytaruk, N, Menon, K, Fowler, R et al.. Barriers, Solutions, and Opportunities for Adapting Critical Care Clinical Trials in the COVID-19 Pandemic. JAMA Netw Open. 2024;7 (7):e2420458. doi: 10.1001/jamanetworkopen.2024.20458. PubMed PMID:38995645 PubMed Central PMC11245722.
  2. Samuels, A, Sygal, V, Burns, KEA, Goldfarb, M. Recruitment and Retention Strategies for Randomized Clinical Trials Involving Family Members of ICU Patients. Crit Care Explor. 2024;6 (7):e1112. doi: 10.1097/CCE.0000000000001112. PubMed PMID:38912720 PubMed Central PMC11199003.
  3. Mehta, S, Ahluwalia, A, Ahluwalia, A, Burns, KEA, O'Hearn, K, Maratta, C et al.. The Diversity of Research Participants in Randomized Controlled Trials and Observational Studies Conducted by the Canadian Critical Care Trials Group. Ann Am Thorac Soc. 2024; :. doi: 10.1513/AnnalsATS.202312-1074OC. PubMed PMID:38889344 .
  4. Cook, D, Deane, A, Lauzier, F, Zytaruk, N, Guyatt, G, Saunders, L et al.. Stress Ulcer Prophylaxis during Invasive Mechanical Ventilation. N Engl J Med. 2024;391 (1):9-20. doi: 10.1056/NEJMoa2404245. PubMed PMID:38875111 .
  5. D'Aragon, F, Selzner, M, Breau, R, Masse, MH, Lamontagne, F, Masse, M et al.. Calcineurin Inhibitor in NEuRoloGically deceased donors to decrease kidney delayed graft function study: study protocol of the CINERGY Pilot randomised controlled trial. BMJ Open. 2024;14 (6):e086777. doi: 10.1136/bmjopen-2024-086777. PubMed PMID:38871657 PubMed Central PMC11177676.
  6. Turgeon, AF, Fergusson, DA, Clayton, L, Patton, MP, Neveu, X, Walsh, TS et al.. Liberal or Restrictive Transfusion Strategy in Patients with Traumatic Brain Injury. N Engl J Med. 2024; :. doi: 10.1056/NEJMoa2404360. PubMed PMID:38869931 .
  7. Kho, ME, Berney, S, Pastva, AM, Kelly, L, Reid, JC, Burns, KEA et al.. Early In-Bed Cycle Ergometry in Mechanically Ventilated Patients. NEJM Evid. 2024;3 (7):EVIDoa2400137. doi: 10.1056/EVIDoa2400137. PubMed PMID:38865147 .
  8. Burns, KEA, Sadeghirad, B, Ghadimi, M, Khan, J, Phoophiboon, V, Trivedi, V et al.. Comparative effectiveness of alternative spontaneous breathing trial techniques: a systematic review and network meta-analysis of randomized trials. Crit Care. 2024;28 (1):194. doi: 10.1186/s13054-024-04958-4. PubMed PMID:38849936 PubMed Central PMC11162018.
  9. Songsangvorn, N, Slutsky, AS, Burns, KEA, Zhang, H. Methodological considerations in meta-analysis: evaluating RCTs, NRS, and crossover trials for electrical impedance tomography in PEEP titration. Intensive Care Med. 2024;50 (7):1188-1189. doi: 10.1007/s00134-024-07462-z. PubMed PMID:38805041 .
  10. Ren, M, Choi, D, Chan, C, Rana, S, Najeeb, U, Norris, M et al.. Optimizing a mentorship program from the perspective of academic medicine leadership - a qualitative study. BMC Med Educ. 2024;24 (1):530. doi: 10.1186/s12909-024-05463-6. PubMed PMID:38741089 PubMed Central PMC11092246.
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Affiliations & Other Activities

  • Clinician Scientist, Interdepartmental Division of Critical Care Medicine, St Michael’s Hospital
  • Clinician Scientist, Canadian Institutes of Health Research (CIHR)
  • Assistant Professor, Interdepartmental Division of Critical Care Medicine, St. Michael’s Hospital
  • Chair, Medical Surgical ICU Knowledge Translation Committee, St. Michael’s Hospital
  • Organizing Member, Critical Care Continuing Medical Education Committee, St. Michael’s Hospital
  • Member, Organ Donation and Transplantation Committee, St. Michael’s Hospital
  • Certification (critical care), University of Western Ontario
  • Member, ACCADEMY (McMaster University)
  • Member, Canadian Critical Care Trials Group
  • Reviewer for several critical care and respirology journals