Labs / Dr. Laurent Brochard Lab / Brochard: Our Publications

Our Publications

  1. Katira BH, Osada K, Engelberts D, Bastia L, Damiani LF, Li X, Chen H, Yoshida T, Amato MBP, Ferguson ND, Post M, Kavanagh BP, Brochard LJ. (2021). Positive End-Expiratory Pressure, Pleural Pressure, and Regional Compliance During Pronation: An Experimental Study.Am J Respir Crit Care Med.Jan 6: online.
  2. Kolb M, Dinh-Xuan AT, Brochard L. (2021). Guideline-directed management of COVID-19: Do’s and Don’ts.Eur Respir J.15: 2100753.
  3. Pinsky MR, Brochard LJ. (2021). CPAP to Counterbalance ElevatedPleural Pressure in Obese Patients: Restoring Functional Residual Capacity orSimply Keeping All Airways Open?. Chest.159: 2145-2146.
  4. REMAP-CAP Investigators; ACTIV-4a Investigators; ATTACC Investigators; (2021). Therapeutic Anticoagulation with Heparin in Critically IllPatients with Covid-19. N Engl J Med. 385: 77 7-789.
  5. Tejerina EE, Pelosi P, Robba C, Peñuelas O, Muriel A, Barrios D, Frutos-Vivar F, Raymondos K, Du B,
  6. Thille AW, Ríos F, González M, Del-Sorbo L, Marín MDC, Valle Pinheiro B, Soares MA, Nin N, Maggiore SM, Bersten A, Amin P, Cakar N, Young Suh G, Abroug F, Jibaja M, Matamis D, Ali Zeggwagh A, Sutherasan Y, Anzueto A, Esteban A; VENTILA Group. (2021). Evolution Over Time of Ventilatory Management and Outcome of Patients With Neurologic Disease.Crit Care Med. 49: 1095-1106.
  7. REMAP-CAP Investigators, (2021). Interleukin-6 Receptor Antagonists in Critically Ill Patientswith Covid-19.N Engl J Med. 384: 1491-1502.
  8. Mellado-Artigas R, Ferreyro BL, Angriman F, Hernández-Sanz M, Arruti E, Torres A, Villar J, Brochard L, Ferrando C; COVID-19 Spanish ICU Network. (2021). High-flow nasal oxygen in patients with COVID-19- associated acute respiratory failure.Crit Care.25: 58.
  9. Coiffard B, Riegler S, Sklar MC, Dres M, Vorona S, Reid WD, Brochard LJ, Ferguson ND, Goligher EC. (2021). Diaphragm echodensity in mechanically ventilated patients: a description of technique and outcomes. Crit Care.25: 64.
  10. Madotto F, McNicholas B, Rezoagli E, Pham T, Laffey JG, Bellani G; LUNG SAFE Investigators; ESICM Trials Group. (2021). Death in hospital following ICU discharge: insights from the LUNG SAFE study. Crit Care.25: 144.
  11. Costa ELV, Slutsky AS, Brochard LJ, Brower R, Serpa-Neto A, Cavalcanti AB, Mercat A, Meade M, Morais CCA, Goligher E, Carvalho CRR, Amato MBP. (2021). Ventilatory Variables and Mechanical Power in Patients with Acute Respiratory Distress Syndrome.Am J Respir Crit Care Med.204: 303-311.
  12. Schreiber AF, Bertoni M, Coiffard B, Fard S, Wong J, Reid WD, Brochard LJ, Piva S, Goligher EC. (2021). Abdominal Muscle Use DuringSpontaneous Breathing and Cough in Patients Who Are Mechanically Ventilated: ABi-center Ultrasound Study.Chest. 6: S0012-3692(21)0108.
  13. Albaiceta GM, Brochard L, Dos Santos CC, Fernández R, Georgopoulos D, Girard T, Jubran A, López-Aguilar J, Mancebo J, Pelosi P, Skrobik Y, Thille AW, Wilcox ME, Blanch. (2021). The central nervous system during lung injury and mechanical ventilation: a narrative review.Br J Anaesth. 30: S0007-0912(21)004.
  14. Chen L, Jonkman A, Pereira SM, Lu C, Brochard L. (2021). Driving pressure monitoring during acute respiratory failure in 2020.Curr Opin Crit Care. 27: 303-310.
  15. Beloncle F, Studer A, Seegers V, Richard JC, Desprez C, Fage N, Merdji H, Pavlovsky B, Helms J, Cunat S, Mortaza S, Demiselle J, Brochard L, Mercat A, Meziani F. (2021). Longitudinal changes in compliance, oxygenation and ventilatory ratio in COVID-19 versus non-COVID-19pulmonary acute respiratory distress syndrome.Crit Care. 15: 248.
  16. Sklar MC, Madotto F, Jonkman A, Rauseo M, Soliman I, Damiani LF, Telias I, Dubo S, Chen L, Rittayamai N, Chen GQ, Goligher EC, Dres M, Coudroy R, Pham T, Artigas RM, Friedrich JO, Sinderby C, Heunks L, Brochard L. (2021). Duration of diaphragmatic inactivity after endotracheal intubation of critically ill patients. Crit Care.25: 26.
  17. Fernando SM, Fan E, Rochwerg B, Burns KEA, Brochard LJ, Cook DJ, Walkey AJ, Ferguson ND, Hough CL, Brodie D, Seely AJE, Thiruganasambandamoorthy V, Perry JJ, Tran A, Tanuseputro P, Kyeremanteng K. (2021). Lung-Protective Ventilation and Associated Outcomes and Costs Among Patients Receiving Invasive Mechanical Ventilation in the ED.Chest.159: 606-618.
  18. Tilmont A, Coiffard B, Yoshida T, Daviet F, Baumstarck K, Brioude G, Hraiech S, Forel JM, Roch A, Brochard L, Papazian L, Guervilly C. (2021). Oesophageal pressure as a surrogate of pleural pressure in mechanically ventilated patients.ERJ Open Res.7: 646-2020.
  19. Akoumianaki E, Jonkman A, Sklar MC, Georgopoulos D, Brochard L. (2021). A rational approach on the use of extracorporeal membrane oxygenation in severe hypoxemia: advanced technology is not a panacea.Ann Intensive Care. 12: 107.
  20. Goligher EC, Costa ELV, Yarnell CJ, Brochard LJ, Stewart TE, Tomlinson G, Brower RG, Slutsky AS, Amato MPB. (2021). Effect of Lowering Tidal Volume on Mortality in ARDS Varies with Respiratory System Elastance.Am J Respir Crit Care Med. Jan 13: online.
  21. Rozé H, Boisselier C, Bonnardel E, Perrier V, Repusseau B, Brochard L, Ouattara A. (2021). Electrical Impedance Tomography to Detect Airway Closure Heterogeneity in Asymmetrical Acute Respiratory Distress Syndrome.Am J Respir Crit Care Med.203: 511-515.
  22. Sakr Y, Midega T, Antoniazzi J, Solé-Violán J, Bauer PR, Ostermann M, Pellis T, Szakmany T, Zacharowski K, Ñamendys-Silva SA, Pham T, Ferrer R, Taccone FS, van Haren F, Brochard L; ICGLOSSARI investigators and the ESICM Trials group. (2021). Do ventilatory parameters influence outcome in patients with severe acute respiratory infection? Secondary analysis of an international,multicentre14-day inception cohort study. J Crit Care. 66: 78-85.
  23. Carteaux G, Pons M, Morin F, Tuffet S, Lesimple A, Badat B, Haudebourg AF, Perier F, Deplante Y, Guillaud C, Schlemmer F, Fois E, Mongardon N, Khellaf M, Jaffal K, Deguillard C, Grimbert P, Huguet R, Razazi K, de Prost N, Templier F, Beloncle F, Mercat A, Brochard L, Audard V, Lim P, Richard JC, Savary D, Mekontso Dessap A. (2021). Continuous positive airway pressure for respiratory support during COVID-19 pandemic: a frugal approach from bench to bedside.Ann Intensive Care.11: 38.
  24. Nasa P, et al (2021). Expert consensus statements for the management of COVID-19-related acute respiratory failure using a Delphi method.Crit Care. 25: 106.
  25. Mellado Artigas R, Damiani LF, Piraino T, Pham T, Chen L, Rauseo M, Telias I, Soliman I, Junhasavasdikul D, Santis C, Smith OM, Goligher E, Comtois N, Sinderby C, Heunks L, Brochard L. (2021). Reverse Triggering Dyssynchrony 24 h after Initiation of Mechanical Ventilation. Anesthesiology. Mar 4.: online.
  26. Pham T, Montanya J, Telias I, Piraino T, Magrans R, Coudroy R, Damiani LF, Mellado Artigas R, Madorno M, Blanch L, Brochard L; BEARDS study investigators. (2021). Automated detection and quantification of reverse triggering effort under mechanical ventilation. Crit Care.25: 60.
  27. Dres M, Similowski T, Goligher EC, Pham T, Sergenyuk L, Telias I, Grieco DL, Ouechani W, Junhasavasdikul D, Sklar MC, Damiani LF, Melo L, Santis C, Degravi L, Decavèle M, Brochard L, Demoule A. (2021). Dyspnea and respiratory muscles ultrasound to predict extubation failure.Eur Respir J. on-line: 2100002.
  28. ATTACC Investigators; ACTIV-4a Investigators; REMAP-CAP Investigators, Lawler PR, Goligher E. (2021). TherapeuticAnticoagulation with Heparin in Noncritically Ill Patients with Covid-19. N Engl J Med .385: 790-802.
  29. REMAP-CAP Investigators (2021). Lopinavir-ritonavir and hydroxychloroquine for criticallyill patients with COVID-19: REMAP-CAP randomized controlled trial. Intensive Care Med. 384: 1491-1502.
  30. Tatham KC, Ko M, Palozzi L, Lapinsky SE, Brochard LJ, Goligher EC. (2020). Helmet interfaceincreases lung volumes at equivalent ventilator pressures compared to the facemask interface during non-invasive ventilation.Crit Care Med. 24: 504.
  31. Hedenstierna G, Chen L, Brochard L. (2020). Airway closure, more harmful than atelectasis in intensive care?. Intensive Care Med. June 20: 1-4.
  32. Dres M, Dubé BP, Goligher E, Vorona S, Demiri S, Morawiec E, Mayaux J, Brochard L, Similowski T, Demoule A. (2020). Usefulness of Parasternal Intercostal Muscle Ultrasound during Weaning from Mechanical Ventilation. Anesthesiology.132: 1114-1125.
  33. Mukhopadhyay SK, Zara M, Telias I, Chen L, Coudroy R, Yoshida T, Brochard L, Krishnan S. (2020). A Singular Spectrum Analysis-Based Data-Driven Technique forthe Removal of Cardiogenic Oscillations in Esophageal Pressure Signals.IEEE J Transl Eng Health Med. 8: 3300211.
  34. Grieco DL, Bongiovanni F, Chen L, Menga LS, Cutuli SL, Pintaudi G, Carelli S, Michi T, Torrini F, Lombardi G, Anzellotti GM, De Pascale G, Urbani A, Bocci MG, Tanzarella ES, Bello G, Dell’Anna AM, Maggiore SM, Brochard L, Antonelli M. (2020). Respiratory physiology of COVID-19-induced respiratoryfailure compared to ARDS of other etiologies. Crit Care. 24: 529.
  35. Chaudhuri D, Granton D, Wang DX, Burns KEA, Helviz Y, Einav S, Trivedi V, Mauri T, Ricard JD, Mancebo J, Frat JP, Jog S, Hernandez G, Maggiore SM, Mbuagbaw L, Hodgson CL, Jaber S, Goligher EC, Brochard L, Rochwerg B. (2020). High-Flow Nasal Cannula in the Immediate PostoperativePeriod: A Systematic Review and Meta-analysis. Chest. Sep 18: Online.
  36. Georgopoulos D, Brochard L. (2020). Dissociation between the brain target and respiratorycapacity in critically ill patients. Intensive Care Med. 46: 1077-1078.
  37. Zhang B, Ratano D, Brochard LJ, Georgopoulos D, Duffin J, Long M, Schepens T, Telias I, Slutsky AS, Goligher EC, Chan TCY. (2020). A physiology-based mathematical model for the selection of appropriate ventilator controls for lung and diaphragm protection. J Clin Monit Comput.: 1-16.
  38. Derbakova A, Khu S, Ho K, Lewis C, Ma T, Melo LT, Zabjek KF, Goligher EC, Brochard L, Fregonezi G, Reid WD. (2020). Neck and Inspiratory Muscle Recruitment during Inspiratory Loading and Neck Flexion.Med Sci Sports Exerc.52: 1610-1616.
  39. Chun Pan, Lu Chen, Cong Lu, Wei Zhang, Jia-An Xia, Michael C. Sklar, Bin Du, Laurent Brochard, Haibo (2020). Lung Recruitability in COVID-19-associated Acute RespiratoryDistress Syndrome: A Single- Center Observational Study.Am J Respir Crit Care Med. Mar 23: doi: 10.1164/rccm.20.
  40. Dianti J, Angriman F, Ferreyro BL, Sklar MC, Brochard L, Ferguson ND, Goligher EC. (2020). Association of Mortality with Neuromuscular Blockade Differs According to Baseline Diaphragm Thickness. Am J Respir Crit Care Med.Jul 27: Online.
  41. Coudroy R, Vimpere D, Aissaoui N, Younan R, Bailleul C, Couteau-Chardon A, Lancelot A, Guerot E, Chen L, Brochard L, Diehl JL. (2020). Prevalence of Complete Airway Closure According to Body Mass Index in Acute Respiratory Distress Syndrome: Pooled Cohort Analysis. Anesthesiology. 133: 867-878.
  42. Dianti J, Matelski J, Tisminetzky M, Walkey AJ, Munshi L, Del Sorbo L, Fan E, Costa EL, Hodgson CL, Brochard L, Goligher EC. (2020). Comparing the Effects of Tidal Volume, Driving Pressure, and Mechanical Power on Mortality in Trials of Lung-Protective Mechanical Ventilation.Respir Care. Aug 25: On line. http://dx.doi.org/doi: 10.4187/respcare.07876
  43. Fan E, Beitler JR, Brochard L, Calfee CS, Ferguson ND, Slutsky AS, Brodie D. (2020). COVID-19- associated acute respiratory distress syndrome: is a different approach to management warranted?. Lancet Respir Med. 8: 816-821.
  44. Ali A, Watanabe Y, Galasso M, Watanabe T, Chen M, Fan E, Brochard L, Ramadan K, Ribeiro RVP, Stansfield W, Gokhale H, Gazzalle A, Waddell T, Liu M, Keshavjee S, Cypel M. (2020). An extracellular oxygen carrier during prolonged pulmonary preservation improves post-transplant lung function.J Heart Lung Transplant. 39: 595-603.
  45. T, Pesenti A, Brochard L; Pleural Pressure Working Group, Acute Respiratory Failure Section of the European Society of Intensive Care Medicine. (2020). Lung and Diaphragm-Protective Ventilation.Am J Respir Crit Care Med. June 9: doi: 10.1164/rccm.20. http://dx.doi.org/doi: 10.1164/rccm.202003-0655CP
  46. Han JS, Mashari A, Singh D, Dianti J, Goligher E, Long M, Ng W, Wasowicz M, Preiss D, Vesely A, Kacmarek R, Keshavjee S, Brochard L, Fisher JA, Slutsky AS. (2020). Personalized Ventilation to Multiple Patients Using a Single Ventilator: Description and Proof of Concept.Crit Care Explor. May 6: e0118.
  47. Chotirmall SH, Martinez FJ, Schumacker PT, Cooke CR, Seam N, Brochard L, Tighe RM, Levy BD, Gern D, Wedzicha JA. (2020). Life at the Editorial “COVID Frontline”. The American Thoracic Society Journal Family.Am J Respir Crit Care Med. 201: 1457-1459. http://dx.doi.org/doi: 10.1164/rccm.202005-1516ED.
  48. Madotto F, Rezoagli E, Pham T, Schmidt M, McNicholas B, Protti A, Panwar R, Bellani G, Fan E, van Haren F, Brochard L, Laffey JG; LUNG SAFE Investigators and the ESICM Trials Group. (2020).

Hyperoxemia and excess oxygen use in early acute respiratorydistress syndrome: insights from the LUNG SAFE study.Crit Care. 24: 125. http://dx.doi.org/doi: 10.1186/s13054-020-2826-6

  1. Lellouche F, Delorme M, Brochard L. (2020). Impact of Respiratory Rate and Dead Space in the Current Era of Lung Protective Mechanical Ventilation.Chest.158: 45-47.
  2. Jonkman AH, Katira BH, Schreiber A, Lu C, Engelberts D, Vieira F, Marquez A, Slutsky AS, Dorian P, Brochard L. (2020). A GAS-POWERED, PATIENT-RESPONSIVE AUTOMATIC RESUSCITATOR

FORUSE IN ACUTE RESPIRATORY FAILURE: A BENCH AND EXPERIMENTAL STUDY.Respir Care.

Aug 18: Online.http://dx.doi.org/doi: 10.4187/respcare.08296

  1. Yoshida T, Grieco DL, Brochard L, Fujino Y. (2020). Patient self-inflicted lung injury and positive end- expiratory pressure for safe spontaneous breathing.Curr Opin Crit Care.26: 59-65.
  2. Citerio G, Bakker J, Brochard L, Buchman TG, Jaber S, Mazzone PJ, Teboul JL, Vincent JL, Azoulay E. (2020). Critical care journals during the COVID-19 pandemic: challenges and responsibilities.Intensive Care 46: 1521-1523.
  3. Rittayamai N, Chuaychoo B, Tscheikuna J, Dres M, Goligher EC, Brochard L. (2020). Ultrasound Evaluation of Diaphragm Force Reserve in Patients with Chronic Obstructive Pulmonary Disease.Ann Am Thorac Soc. Jul 2: online.http://dx.doi.org/doi: 10.1513/AnnalsATS.202002-129OC,
  4. Telias I, Junhasavasdikul D, Rittayamai N, Piquilloud L, Chen L, Ferguson ND, Goligher EC, Brochard
  5. (2020). Airway OcclusionPressure As an Estimate of Respiratory Drive and Inspiratory Effort duringAssisted Ventilation.Am J Respir Crit Care Med.
  6. Rodriguez PO, Tiribelli N, Fredes S, Gogniat E, Plotnikow G, Ceballos IF, Pratto R, Raimondi A, Guaymas M, Ilutovich S, San Roman E, Madorno M, Maskin P, Brochard L, Setten M; GRAAVEplus (Grupo Argentino de estudio de Asincronías en la VEntilación mecánica) study group. (2020). Prevalence of Reverse Triggering in Early ARDS: Results from a Multicenter Observational Study.Chest. Aug 14: Online. http://dx.doi.org/doi: 10.1016/j.chest.2020.08.018.
  7. Jonkman AH, Rauseo M, Carteaux G, Telias I, Sklar MC, Heunks L, Brochard LJ. (2020). Proportional modes of ventilation: technology to assist physiology.Intensive Care Med. Aug 11: Online. http://dx.doi.org/doi: 10.1007/s00134-020-06206-z
  8. Telias I, Katira BH, Brochard L. (2020). Is the Prone Position Helpful During Spontaneous Breathing in Patients With COVID-19?. JAMA.323: 2265-2267.
  9. Chaudhuri D, Granton D, Wang DX, Einav S, Helviz Y, Mauri T, Ricard JD, Mancebo J, Frat JP, Jog S, Hernandez G, Maggiore SM, Hodgson C, Jaber S, Brochard L, Burns KEA, Rochwerg B. (2020). Moderate Certainty Evidence Suggests the Use of High-Flow Nasal Cannula Does Not Decrease Hypoxia When Compared With Conventional Oxygen Therapy in the Peri-Intubation Period: Results of a Systematic Review and Meta-Analysis.Crit Care Med. 48: 571-578.
  10. Adler D, Cavalot G, Brochard L. (2020). Comorbidities and Readmissions in Survivors of AcuteHypercapnic Respiratory Failure.Semin Respir Crit Care Med. Aug 3: Online.
  11. Sklar MC, Dres M, Fan E, Rubenfeld GD, Scales DC, Herridge MS, Rittayamai N, Harhay MO, Reid WD, Tomlinson G, Rozenberg D, McClelland W, Riegler S, Slutsky AS, Brochard L, Ferguson ND, Goligher (2020). Association of Low Baseline Diaphragm Muscle Mass With Prolonged Mechanical Ventilation and Mortality Among Critically Ill Adults. JAMA Netw Open.3(2):e1921520: e1921520. http://dx.doi.org/10.1001/jamanetworkopen.
  12. Savary D, Drennan IR, Badat B, Grieco DL, Piraino T, Lesimple A, Charbonney E, Fritz C, Delisle S, Ouellet P, Mercat A, Bronchti G, Brochard L, Richard JC; CAVIAR group. (2020). Gastricinsufflation during cardiopulmonary resuscitation: A study in human cadavers. Resuscitation.: 111-117.
  13. Lewis KA, Chaudhuri D, Guyatt G, Burns KEA, Bosma K, Ge L, Karachi T, Piraino T, Fernando SM, Ranganath N1, Brochard L, Rochwerg B,. (2019). Comparison of ventilatory modes to facilitate liberation from mechanical ventilation: protocol for a systematic review and network meta-analysis.BMJ Open.Sep 5: doi: 10.1136/bmjopen.
  14. Mancebo J, Mercat A, Brochard L. (2019). Maximal Lung Recruitment in ARDS: A Nail in the Coffin.Am J Respir Crit Care Med.11: 1331-1.
  15. Papazian L, Aubron C, Brochard L, Chiche JD, Combes A, Dreyfuss D, Forel JM, Guérin C, Jaber S, Mekontso-Dessap A, Mercat A, Richard JC, Roux D, Vieillard-Baron A, Faure H. (2019). Formal guidelines: management of acute respiratory distress syndrome.Ann Intensive Care. 9: 69.
  16. Yoshida T, Kavanagh BP, Brochard L. (2019). Early Neuromuscular Blockade in the Acute Respiratory Distress Syndrome.N Engl J Med.381: 786-787.
  17. McNicholas BA, Madotto F, Pham T, Rezoagli E, Masterson CH, Horie S, Bellani G, Brochard L, Laffey JG; LUNG SAFE Investigators and the ESICM Trials Group. (2019). Demographics, management and outcome of women and men with Acute Respiratory Distress Syndrome in the LUNG SAFE prospective cohort study.Eur Respir J.doi: 10.1183: Jul 25.
  18. Vaporidi K, Akoumianaki E, Telias I, Goligher EC, Brochard L, Georgopoulos D. (2019). Respiratory Drive in Critically Ill Patients: Pathophysiology and Clinical Implications.Am J Respir Crit Care Med.doi: 1164: Aug 22.
  19. Heunks L, Bellani G, Pham T, Brochard L, Laffey JG. (2019). The worldwide assessment of separation of patients from ventilatory assistance (WEAN SAFE) ERS Clinical Research Collaboration. Eur Respir J. 53: pii: 1802228.
  20. Goligher EC, et al.. (2019). Determinants of the effect of extracorporeal carbon dioxide removal in the SUPERNOVA trial: implications for trial design.Intensive Care Med.doi: 10.1007/s: 1219-1230.
  21. Shi ZH, Jonkman A, de Vries H, Jansen D, Ottenheijm C, Girbes A, Spoelstra-de Man A, Zhou JX, Brochard L, Heunks L. (2019). Expiratory muscle dysfunction in critically ill patients: towards improved Intensive Care Med.45: 1061-1071.
  22. Rittayamai N, Phuangchoei P, Tscheikuna J, Praphruetkit N, Brochard L. (2019). Effects of high-flow nasal cannula and non-invasive ventilation on inspiratory effort in hypercapnic patients with chronic obstructive pulmonary disease: a preliminary study.Ann Intensive Care.doi: 10.1186/s: 122. doi: 10.1186/s1.
  23. Roesthuis L, van der Hoeven H, Sinderby C, Frenzel T, Ottenheijm C, Brochard L, Doorduin J, Heunks
  24. (2019). Effects of levosimendan on respiratory muscle function in patients weaning from mechanical ventilation.Intensive Care Med.doi: 10.1007/s: 1372-1381.
  25. Chen L, Del Sorbo L, Grieco DL, Junhasavasdikul D, Rittayamai N, Soliman, Sklar MC, Rauseo M, Ferguson ND, Fan E, Richard JM, Brochard L. (2019). Potential for Lung Recruitment Estimated by the Recruitment-to-Inflation Ratio in Acute Respiratory Distress Syndrome.Am J Respir Crit Care Med.doi: 10.1164/rccm.: 178-187.
  26. Rochwerg B, Granton D, Wang DX, Helviz Y, Einav S, Frat JP, Mekontso-Dessap A, Schreiber A, Azoulay E, Mercat A, Demoule A, Lemiale V, Pesenti A, Riviello ED, Mauri T, Mancebo J, Brochard L, Burns
  27. (2019). High flow nasal cannula compared with conventional oxygen therapy for acute hypoxemic respiratory failure: a systematic review and meta-analysis. Intensive Care Med. Mar 19: doi: 1007.
  28. Goligher EC, Brochard LJ, Reid WD, Fan E, Saarela O, Slutsky AS, Kavanagh BP, Rubenfeld GD, Ferguson ND. (2019). Diaphragmatic myotrauma: a mediator of prolonged ventilation and poor patient outcomes in acute respiratory failure.Lancet Respir Med.7: 90-98.
  29. Younes M, Brochard L. (2019). The Control of Breathing During Mechanical Ventilation.Clin Chest 40: 259-267.
  30. Bezerra FS, Ramos CO, Castro TF, Araújo NPDS, de Souza ABF, Bandeira ACB, Costa GP, Cartelle CT, Talvani A, Cangussú SD, Brochard L, Nagato AC. (2019). Exogenous surfactant prevents hyperoxia- induced lung injury in adult mice. Intensive Care Med Exp. 7: 19.
  31. Dres M, Younes M, Rittayamai N, Kendzerska T, Telias I, Grieco DL, Pham T, Junhasavasdikul D, Chau E, Mehta S, Wilcox ME, Leung R, Drouot X, Brochard L. (2019). Sleep and Pathological Wakefulness at Time of Liberation from Mechanical Ventilation (SLEEWE): A Prospective Multicenter Physiological Study. Am J Respir Crit Care Med.199: 1106-1115.
  32. Perren A, Brochard L. (2019). The importance of timing for the spontaneous breathing trial.Ann Transl 7(Suppl 6): S210. Comment on Effect of Pressure Support vs T-Piece Ventilation Strategies During Spontaneous Breathing Trials on Successful Extubation Among Patients Receiving Mechanical Ventilation: A Randomized Clinical Trial.
  33. Bertoni M, Telias I, Urner M, Long M, Del Sorbo L, Fan E, Sinderby C, Beck J, Liu L, Qiu H, Wong J, Slutsky AS, Ferguson ND, Brochard LJ, Goligher EC. (2019). A novel non-invasive method to detect excessively high respiratory effort and dynamic transpulmonary driving pressure during mechanical ventilation.Crit Care.doi: 10.1186/s1354-: 346. doi: 10.1186/s1.
  34. Abrams D, Ferguson ND, Brochard L, Fan E, Mercat A, Combes A, Pellegrino V, Schmidt M, Slutsky AS, Brodie D. (2019). ECMO for ARDS: from salvage to standard of care?. Lancet Respir Med.7: 108-110.
  35. Orser BA, Brochard L. (2019). In Memoriam: Brian Kavanagh, 1962 to 2019.Anesthesiology.doi: 1097
  36. Brochard L, Bersten A. (2019). Mechanical Power: A Biomarker for the Lung?. Anesthesiology. 130: 9-11.
  37. Coudroy R, Chen L, Pham T, Piraino T, Telias I, Brochard L. (2019). Acute Respiratory Distress Syndrome: Respiratory Monitoring and Pulmonary Physiology.Semin Respir Crit Care Med. 40: 66-80.
  38. Coudroy R, Lu C, Chen L, Demoule A, Brochard L. (2019). Mechanism of airway closure in acute respiratory distress syndrome: a possible role of surfactant depletion.Intensive Care Med.45: 290-291.
  39. Yoshida T, Piraino T, Lima CAS, Kavanagh BP, Amato MBP, Brochard L. (2019). Regional Ventilation Displayed by Electrical Impedance Tomography as an Incentive to Decrease PEEP.Am J Respir Crit Care doi: 10.1164.
  40. Younes M, Brochard L. (2019). The Control of Breathing During Mechanical Ventilation.Clin Chest 40: 259-267.
  41. Abrams D, Schmidt M, Pham T, Beitler JR, Fan E, Goligher EC, McNamee JJ, Patroniti N, Wilcox ME, Combes A, Ferguson ND, McAuley DF, Pesenti A, Quintel M, Fraser J, Hodgson CL, Hough CL, Mercat A, Mueller, Pellegrino V, Ranieri VM, Rowan K, Shekar K, Brochard L Brodie D; International ECMO Network (ECMONet). (2019). Mechanical Ventilation for ARDS During Extracorporeal Life Support: Research and Practice.Am J Respir Crit Care Med.20: 514-525.
  42. van Haren F, Pham T, Brochard L, Bellani G, Laffey J, Dres M, Fan E, Goligher EC, Heunks L, Lynch J, Wrigge H, McAuley D; Large observational study to UNderstand the Global impact of Severe Acute respiratory FailurE (LUNG SAFE) Investigators. (2019). Spontaneous Breathing in Early Acute Respiratory Distress Syndrome: Insights From the Large Observational Study to UNderstand the Global Impact of Severe Acute Respiratory FailurE Study.Crit Care Med. 47: 229-238.
  43. Piquilloud L, Beloncle F, Richard JM, Mancebo J, Mercat A, Brochard L. (2019). Information conveyed by electrical diaphragmatic activity during unstressed, stressed and assisted spontaneous breathing: a physiological study.Ann Intensive Care.9: 89.
  44. Pham T, Serpa Neto A, Pelosi P, Laffey JG, De Haro C, Lorente JA, Bellani G, Fan E, Brochard LJ, Pesenti A, Schultz MJ, Artigas A; LUNG SAFE Investigators* and the European Society of Intensive Care Medicine Trials Group. (2019). Outcomes of Patients Presenting with Mild Acute Respiratory Distress Syndrome: Insights from the LUNG SAFE Study.Anesthesiology. 130: 263-283.
  45. Mancebo J, Goligher E, Brochard L. (2019). Spontaneous Breathing Trials and Successful Extubation.JAMA.322: 1716-1717.
  46. Burns KEA, Wong JTY, Dodek P, Cook DJ, Lamontagne F, Cohen A, Mehta S, Kho ME, Hebert PC, Aslanian P, Friedrich JO, Brochard L, Rizvi L, Hand L, Meade MO, Amaral AC, Seely AJ; Canadian Critical Care Trials Group. (2019). Frequency of Screening for Weaning From Mechanical Ventilation: Two Contemporaneous Proof-of-Principle Randomized Controlled Trials.Crit Care Med.47: 817-825.
  47. Combes A, Fanelli V, Pham T, Ranieri VM; European Society of Intensive Care Medicine Trials Group and the “Strategy of Ultra-Protective lung ventilation with Extracorporeal CO2 Removal for New-Onset moderate to severe ARDS” (SUPERNOVA) investigators. (2019). Feasibility and safety of extracorporeal CO2 removal to enhance protective ventilation in acute respiratory distress syndrome: the SUPERNOVA study.Intensive Care Med. doi: 10.1007/s00134-: ahead of print.
  48. Burns KEA, Raptis S, Nisenbaum R, Rizvi L, Jones A, Bakshi J, Tan W, Meret A, Cook DJ, Lellouche F, Epstein SK, Gattas D, Kapadia FN, Villar J, Brochard L, Lessard MR, Meade MO. (2018). International Practice Variation in Weaning Critically Ill Adults from Invasive Mechanical Ventilation.Annals of the American Thoracic Society. 15(4): 494-502.
  49. Junhasavasdikul D, Telias I, Grieco DL, Chen L, Millan Gutierrez C, Piraino T, Brochard L. (2018). Expiratory Flow Limitation during Mechanical Ventilation.Chest. doi: 10.1016/j.: pii: S0012-3692(18)3.
  50. Boyle AJ, Sklar MC, McNamee JJ, Brodie D, Slutsky AS, Brochard L, McAuley DF; International ECMO Network (ECMONet). (2018). Extracorporeal carbon dioxide removal for lowering the risk of mechanical ventilation: research questions and clinical potential for the future.Lancet Respir Med. 6: 874-884.
  51. Sugiyama MG, Mintsopoulos V, Raheel H, Goldenberg NM, Batt JE, Brochard L, Kuebler WM, Leong- Poi H, Karshafian R, Lee WL. (2018). Lung Ultrasound and Microbubbles Enhance Aminoglycoside Efficacy and Delivery to the Lung in E. Coli-induced Pneumonia and ARDS.American journal of respiratory and critical care medicine. doi: 10.1164: xx.
  52. Mauri T, Foti G, Fornari C, Constantin JM, Guerin C, Pelosi P, Ranieri M, Conti S, Tubiolo D, Rondelli E, Lovisari F, Fossali T, Spadaro S, Grieco DL, Navalesi P, Calamai I, Becher T, Roca O, Wang YM, Knafelj R, Cortegiani A, Mancebo J, Brochard L, Pesenti A; Protection Study Group. (2018). Pressure support ventilation + sigh in acute hypoxemic respiratory failure patients: study protocol for a pilot randomized controlled trial, the PROTECTION trial.Trials. 19: 460.
  53. Cordioli RL, Brochard L, Suppan L, Lyazidi A, Templier F, Khoury A, Delisle S, Savary D, Richard JC. (2018). How Ventilation Is Delivered DuringCardiopulmonary Resuscitation: An International Respir Care. 63: 1293-1301.Description of Contribution Role: 2nd author
  54. Grieco DL, Brochard L, Drouet A, Telias I, Delisle S, Bronchti G, Ricard C, Rigollot M, Badat B, Ouellet P, Charbonney E, Mancebo J, Mercat A, Savary D, Richard JM; CAVIAR Group. (2018). Intrathoracic Airway Closure Impacts CO2 Signal and Delivered Ventilation During Cardiopulmonary Resuscitation. Sep 26. doi: 1164/rccm.201806-1111OC. Am J Respir Crit Care Med.Sep 26: doi: 10.1164/rccm.20.
  55. Adler D, Dupuis-Lozeron E, Janssens JP, Soccal PM, Lador F, Brochard L, Pépin JL. (2018). Obstructive sleep apnea in patients surviving acute hypercapnic respiratory failure is best predicted by static hyperinflation.PLoS One. 13: e0205669..
  56. Cortegiani A, Madotto F, Gregoretti C, Bellani G, Laffey JG, Pham T, Van Haren F, Giarratano A, Antonelli M, Pesenti A, Grasselli G; LUNG SAFE Investigators and the ESICM Trials Group. (2018). Immunocompromised patients with acute respiratory distress syndrome: secondary analysis of the LUNG SAFE database.Crit Care. 22: 157.
  57. Yoshida T, Engelberts D, Otulakowski G, Katira B, Post M, Ferguson ND, Brochard L, Amato MBP, Kavanagh BP. (2018). Continuous Negative Abdominal Pressure Reduces Ventilator-induced Lung Injury in a Porcine Model.Anesthesiology. 129: 163-172.
  58. Brochard L, Bersten A. (2018). Mechanical Power: A Biomarker for the Lung?. Anesthesiology. 130: 9-11.

 

  1. Brochard L, Kavanagh BP. (2018). Declaration of conflicts of interest: a ‘crooked’ line towards scientific integrity.Intensive Care Med. 44: 1732-1734.
  2. Abe T, Madotto F, Pham T, Nagata I, Uchida M, Tamiya N, Kurahashi K, Bellani G, Laffey JG; LUNG-SAFE Investigators and the ESICM Trials Group. (2018). Epidemiology and patterns of tracheostomy practice in patients with acute respiratory distress syndrome in ICUs across 50 countries.Crit Care. 22: 195. Description of Contribution
  3. Dres M, Austin PC, Pham T, Aegerter P, Guidet B, Demoule A, Vieillard-Baron A, Brochard L, Geri G, CUB-REA Group. (2018). Acute Respiratory Distress Syndrome Cases Volume and ICU Mortality in Medical Patients.Critical care medicine. 46(1): e33-e40.
  4. Bourke SC, Piraino T, Pisani L, Brochard L, Elliott MW. (2018). Beyond the guidelines for non-invasive ventilation in acute respiratory failure: implications for practice.Lancet Respir Med. 6: 935-947.
  5. Brodie D, Vincent JL, Brochard LJ, Combes A, Ferguson ND, Hodgson CL, Laffey JG, Mercat A, Pesenti A, Quintel M, Slutsky AS, Ranieri VM, International ECMO Network (ECMONet). (2018). Research in Extracorporeal Life Support: A Call to Action.Chest. doi: 10.1016/j: pii: S0012-3692(18)3.
  6. Sklar MC, Dres M, Rittayamai N, West B, Grieco DL, Telias I, Junhasavasdikul D, Rauseo M, Pham T, Madotto F, Campbell C, Tullis E, Brochard L. (2018). High-flow nasal oxygen versus noninvasive ventilation in adult patients with cystic fibrosis: a randomized crossover physiological study.Ann Intensive Care. 5: 85.
  7. Yoshida T, Amato MBP, Grieco DL, Chen L, Lima CAS, Roldan R, Morais CCA, Gomes S, Costa ELV, Cardoso PFG, Charbonney E, Richard JM, Brochard L, Kavanagh BP. (2018). Esophageal Manometry and Regional Transpulmonary Pressure in Lung Injury.American journal of respiratory and critical care medicine. doi: 10.1164/rccm.20(online): online.
  8. van Haren F, Pham T, Brochard L, Bellani G, Laffey J, Dres M, Fan E, Goligher EC, Heunks L, Lynch J, Wrigge H, McAuley D; and the Large observational study to UNderstand the Global impact of Severe Acute respiratory FailurE (LUNG SAFE) and the European Society of Intensive Care Medicine (ESICM) Trials Group. (2018). Spontaneous Breathing in Early Acute Respiratory Distress Syndrome: Insights From the Large Observational Study to UNderstand the Global Impact of Severe Acute Respiratory FailurE Study.Crit Care Med. 47: 229-238.
  9. Combes A, Hajage D, Capellier G, Demoule A, Lavoué S, Guervilly C, Da Silva D, Zafrani L, Tirot P, Veber B, Maury E, Levy B, Cohen Y, Richard C, Kalfon P, Bouadma L, Mehdaoui H, Beduneau G, Lebreton G, Brochard L, Ferguson ND, Fan E, Slutsky AS, Brodie D, Mercat A; EOLIA Trial Group, REVA, and ECMONet. (2018). Extracorporeal Membrane Oxygenation for Severe Acute Respiratory Distress Syndrome.New Engl J Med. 378: 1965-1975.
  10. Roche-Campo F, Bedet A, Vivier E, Brochard L, Mekontso Dessap A. (2018). Cardiac function during weaning failure: the role of diastolic dysfunction. Annals of intensive care. 8(1): 2.
  11. Adler D, Dupuis-Lozeron E, Janssens JP, Soccal PM, Lador F, Brochard L, Pépin JL. (2018). Obstructive sleep apnea in patients surviving acute hypercapnic respiratory failure is best predicted by static hyperinflation. . Oct 25;(10):. PLoS One. 13: e0205669..
  12. Madotto F, Pham T, Bellani G, Bos LD, Simonis FD, Fan E, Artigas A, Brochard L, Schultz MJ, Laffey JG, LUNG SAFE Investigators and the ESICM Trials Group. (2018). Resolved versus confirmed ARDS after 24 h: insights from the LUNG SAFE study.Intensive care medicine. doi: 10.1007: xx.
  13. Yoshida T, Brochard L. (2018). Esophageal pressure monitoring: why, when and how?. Current opinion in critical care. 24(3): 216-222.
  14. Telias I, Brochard L, Goligher EC. (2018). Is my patient’s respiratory drive (too) high?. Intensive care doi: 10.1007/s00134: xx.
  15. Grieco DL, Brochard L, Drouet A, Telias I, Delisle S, Bronchti G, Ricard C, Rigollot M, Badat B, Ouellet P, Charbonney E, Mancebo J, Mercat A, Savary D, Richard JM; CAVIAR Group. (2018). Intrathoracic Airway Closure Impacts CO2 Signal and Delivered Ventilation During Cardiopulmonary Resuscitation.Am J Respir Crit Care Med. (Sep 26): doi: 10.1164/rccm.20.
  16. Vorona S, Sabatini U, Al-Maqbali S, Bertoni M, Dres M, Bissett B, Van Haren F, Martin AD, Urrea C, Brace D, Parotto M, Herridge MS, Adhikari NK, Fan E, Melo LT, Reid WD, Brochard LJ, Ferguson ND, Goligher EC. (2018). Inspiratory Muscle Rehabilitation in Critically Ill Adults: A Systematic Review and Meta-Analysis.Annals of the American Thoracic Society. 15: 735-744.
  17. Pham T, Telias I, Piraino T, Yoshida T, Brochard LJ. (2018). Asynchrony Consequences and Crit Care Clin.34: 325-341.
  18. Sklar MC, Dres M, Rittayamai N, West B, Grieco DL, Telias I, Junhasavasdikul D, Rauseo M, Pham T, Madotto F, Campbell C, Tullis E, Brochard L. (2018). High-flow nasal oxygen versus noninvasive ventilation in adult patients with cystic fibrosis: a randomized crossover physiological study. Ann Intensive Care. 8: 85.
  19. Telias I, Damiani F, Brochard L. (2018). The airway occlusion pressure (P0.1) to monitor respiratory drive during mechanical ventilation: increasing awareness of a not-so-new problem. Intensive care medicine. doi: 1007/s0013(online): online.
  20. Bourke SC, Piraino T, Pisani L, Brochard L, Elliott MW. (2018). Beyond the guidelines for non-invasive ventilation in acute respiratory failure: implications for practice. Lancet Respir Med.6: 935-947.
  21. Rouze A, Voiriot G, Guivarch E, Roux F, Tran Van Nhieu J, Isabey D, Brochard L, Maitre B, Mekontso- Dessap A, Boczkowski J. (2018). Inflammatory Cellular Response to Mechanical Ventilation in Elastase- Induced Experimental Emphysema: Role of Preexisting Alveolar Macrophages Infiltration.Biomed Res doi: 10.1155/2018/57: 5721293.
  22. Boyle AJ, Sklar MC, McNamee JJ, Brodie D, Slutsky AS, Brochard L, McAuley DF; International ECMO Network (ECMONet). (2018). Extracorporeal carbon dioxide removal for lowering the risk of mechanical ventilation: research questions and clinical potential for the future. Lancet Respir Med. 6: 874-884.
  23. Yoshida T, Engelberts D, Otulakowski G, Katira B, Ferguson ND, Brochard L, Amato MBP, Kavanagh BP. (2018). CONTINUOUS NEGATIVE ABDOMINAL PRESSURE: Mechanism of Action and Comparison with Prone Position.Journal of applied physiology (Bethesda, Md. 1985). doi: 10.1152/: xx.
  24. Brochard L, Telias I. (2018). Bedside Detection of Overassistance During Pressure Support Critical care medicine. 46(3): 488-490
  25. Combes A, Hajage D, Capellier G, Demoule A, Lavoué S, Guervilly C, Da Silva D, Zafrani L, Tirot P, Veber B, Maury E, Levy B, Cohen Y, Richard C, Kalfon P, Bouadma L, Mehdaoui H, Beduneau G, Lebreton G, Brochard L, Ferguson ND, Fan E, Slutsky AS, Brodie D, Mercat A; EOLIA Trial Group, REVA, and ECMONet. (2018). Extracorporeal Membrane Oxygenation for Severe Acute Respiratory Distress Syndrome. New Engl J Med. 378: 1965-1975.
  26. Charbonney E, Delisle S, Savary D, Bronchti G, Rigollot M, Drouet A, Badat B, Ouellet P, Gosselin P, Mercat A, Brochard L, Richard JM, CAVIAR. (2018). A new physiological model for studying the effect of chest compression and ventilation during cardiopulmonary resuscitation: The Thiel cadaver.Resuscitation. pii: S0300-9572(18)3(online)
  27. Bourke SC, Piraino T, Pisani L, Brochard L, Elliott MW. (2018). Beyond the guidelines for non-invasive ventilation in acute respiratory failure: implications for practice.Lancet Respir Med. 6: 935-947.

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