Recent publication list of Dr. Alan H. Lazarus.

  1. Cruz-Leal Y, Marjoram D, Lazarus AH. Erythrocyte Saturation with IgG Is Required for Inducing Antibody-Mediated Immune Suppression and Impacts Both Erythrocyte Clearance and Antigen-Modulation Mechanisms. J Immunol. 2018 Feb 15;200(4):1295-1305. doi: 10.4049/jimmunol.1700874. Epub 2018 Jan 22. PubMed PMID: 29358275.


  1. Khan, R., Lazarus, A. (2018). Anti-D: A type of IVIg. Antibody Therapy. Springer International Publishing (1; 61-71).


  1. Marjoram D, Cruz-Leal Y, Bernardo L, Le NPL, Crispin M, Yu X, Uchikawa M, Lazarus AH. Immunoglobulin G Fc glycans are not essential for antibody-mediated immune suppression to murine erythrocytes. Blood. 2017 Dec 28;130(26):2902-2905. doi: 10.1182/blood-2017-06-793729. Epub 2017 Nov 6. PubMed PMID: 29109102.


  1. Cruz-Leal Y, Marjoram D, Lazarus AH. Prevention of hemolytic disease of the fetus and newborn: what have we learned from animal models? Curr Opin Hematol. 2017 Nov;24(6):536-543. doi: 10.1097/MOH.0000000000000374. Review. PubMed PMID: 28719385.


  1. Bernardo L, Amash A, Marjoram D, Lazarus AH. Antibody-mediated immune suppression is improved when blends of anti-RBC monoclonal antibodies are used in mice. Blood. 2016 Aug 25;128(8):1076-80. doi: 10.1182/blood-2016-01-692178. Epub 2016 Jun 21. PubMed PMID: 27330002.


  1. Crow AR, Lazarus AH. Mechanistic properties of intravenous immunoglobulin in murine immune thrombocytopenia: support for FcγRIIB falls by the wayside. Semin Hematol. 2016 Apr;53 Suppl 1:S20-2. doi: 10.1053/j.seminhematol.2016.04.007. Epub 2016 Apr 6. PubMed PMID: 27312158.


  1. Amash A, Wang L, Wang Y, Bhakta V, Fairn GD, Hou M, Peng J, Sheffield WP, Lazarus AH. CD44 Antibody Inhibition of Macrophage Phagocytosis Targets Fcγ Receptor- and Complement Receptor 3-Dependent Mechanisms. J Immunol. 2016 Apr 15;196(8):3331-40. doi: 10.4049/jimmunol.1502198. Epub 2016 Mar 4. PubMed PMID: 26944929.


  1. Yu X, Lazarus AH. Targeting FcγRs to treat antibody-dependent autoimmunity. Autoimmun Rev. 2016 Jun;15(6):510-2. doi: 10.1016/j.autrev.2016.02.006. Epub 2016 Feb 12. Review. PubMed PMID: 26854400.


  1. Yu X, Menard M, Prechl J, Bhakta V, Sheffield WP, Lazarus AH. Monovalent Fc receptor blockade by an anti-Fcγ receptor/albumin fusion protein ameliorates murine ITP with abrogated toxicity. Blood. 2016 Jan 7;127(1):132-8. doi: 10.1182/blood-2015-08-664656. Epub 2015 Oct 23. PubMed PMID: 26500340.


  1. Bernardo L, Yu H, Amash A, Zimring JC, Lazarus AH. IgG-Mediated Immune Suppression to Erythrocytes by Polyclonal Antibodies Can Occur in the Absence of Activating or Inhibitory Fcγ Receptors in a Full Mouse Model. J Immunol. 2015 Sep 1;195(5):2224-30. doi: 10.4049/jimmunol.1500790. Epub 2015 Jul 17. PubMed PMID: 26188060.


  1. Yu X, Menard M, Seabright G, Crispin M, Lazarus AH. A monoclonal antibody with anti-D-like activity in murine immune thrombocytopenia requires Fc domain function for immune thrombocytopenia ameliorative effects. Transfusion. 2015 Jun;55(6 Pt 2):1501-11. doi: 10.1111/trf.13032. Epub 2015 Mar 6. PubMed PMID: 25752470.


  1. Bernardo L, Denomme GA, Shah K, Lazarus AH. RhD Specific Antibodies Are Not Detectable in HLA-DRB1(*)1501 Mice Challenged with Human RhD Positive Erythrocytes. Adv Hematol. 2014;2014:470242. doi: 10.1155/2014/470242. Epub 2014 Dec 31. PubMed PMID: 25628657; PubMed Central PMCID: PMC4297636.


  1. Crow AR, Amash A, Lazarus AH. CD44 antibody-mediated amelioration of murine immune thrombocytopenia (ITP): mouse background determines the effect of FcγRIIb genetic disruption. Transfusion. 2015 Jun;55(6 Pt 2):1492-500. doi:10.1111/trf.12957. Epub 2014 Dec 15. PubMed PMID: 25496771.


  1. Yu H, Stowell SR, Bernardo L, Hendrickson JE, Zimring JC, Amash A, UchikawaM, Lazarus AH. Antibody-mediated immune suppression of erythrocyte alloimmunization can occur independently from red cell clearance or epitope masking in a murine model. J Immunol. 2014 Sep 15;193(6):2902-10. doi: 10.4049/jimmunol.1302287. Epub 2014 Aug 13. PubMed PMID: 25122924.


  1. Crow AR, Yu H, Han D, Lazarus AH. Amelioration of murine passive immune thrombocytopenia by IVIg and a therapeutic monoclonal CD44 antibody does not require the Myd88 signaling pathway. PLoS One. 2013 Aug 5;8(8):e71882. doi: 10.1371/journal.pone.0071882. Print 2013. PubMed PMID: 23940791; PubMed Central PMCID: PMC3733967.


  1. Lazarus AH. Monoclonal versus polyclonal anti-D in the treatment of ITP.Expert Opin Biol Ther. 2013 Oct;13(10):1353-6. doi: 10.1517/14712598.2013.825243. Epub 2013 Aug 7. PubMed PMID: 23919777.


  1. Mott PJ, Lazarus AH. CD44 antibodies and immune thrombocytopenia in the amelioration of murine inflammatory arthritis. PLoS One. 2013 Jun 13;8(6):e65805. doi: 10.1371/journal.pone.0065805. Print 2013. PubMed PMID: 23785450; PubMed Central PMCID: PMC3681793.


  1. Chen X, Ghaffar H, Jen CC, Lazarus AH. Antibody specific for the glycophorin A complex mediates intravenous immune globulin-resistant anemia in a murine model. Transfusion. 2014 Mar;54(3):655-64. doi: 10.1111/trf.12300. Epub 2013 Jun PubMed PMID: 23782137.


  1. Lazarus AH, Semple JW, Cines DB. Innate and adaptive immunity in immune thrombocytopenia. Semin Hematol. 2013 Jan;50 Suppl 1:S68-70. doi: 10.1053/j.seminhematol.2013.03.012. Review. PubMed PMID: 23664521; PubMed Central PMCID: PMC3691820.


  1. Semple JW, Kim M, Hou J, McVey M, Lee YJ, Tabuchi A, Kuebler WM, Chai ZW, Lazarus AH. Intravenous immunoglobulin prevents murine antibody-mediated acute lung injury at the level of neutrophil reactive oxygen species (ROS) production. PLoS One. 2012;7(2):e31357. doi: 10.1371/journal.pone.0031357. Epub 2012 Feb 17. PubMed PMID: 22363629; PubMed Central PMCID: PMC3281967.


  1. Crow AR, Suppa SJ, Chen X, Mott PJ, Lazarus AH. The neonatal Fc receptor (FcRn) is not required for IVIg or anti-CD44 monoclonal antibody-mediated amelioration of murine immune thrombocytopenia. Blood. 2011 Dec 8;118(24):6403-6. doi: 10.1182/blood-2011-08-374223. Epub 2011 Oct 14. PubMed PMID: 22001393.


  1. Lazarus AH. IVIg conducts DC-platelet nuptials. Blood. 2010 Dec 2;116(23):4740-1. doi: 10.1182/blood-2010-09-303420. PubMed PMID: 21127183.


  1. Crow AR, Song S, Suppa SJ, Ma S, Reilly MP, Andre P, McKenzie SE, Lazarus AH. Amelioration of murine immune thrombocytopenia by CD44 antibodies: a potential therapy for ITP? Blood. 2011 Jan 20;117(3):971-4. doi: 0.1182/blood-2010-05-280115. Epub 2010 Nov 2. PubMed PMID: 21045192.


  1. Brinc D, Le-Tien H, Crow AR, Semple JW, Freedman J, Lazarus AH. Transfusion of antibody-opsonized red blood cells results in a shift in the immune response from the red blood cell to the antibody in a murine model. Transfusion. 2010 Sep;50(9):2016-25. doi: 10.1111/j.1537-2995.2010.02645.x. PubMed PMID: 20412528.


  1. Pang SJ, Lazarus AH. Mechanisms of platelet recovery in ITP associated with therapy. Ann Hematol. 2010 Jul;89 Suppl 1:31-5. Epub 2010 Feb 24. Review. PubMed PMID: 20179926.


  1. Brinc D, Lazarus AH. Mechanisms of anti-D action in the prevention of hemolytic disease of the fetus and newborn. Hematology Am Soc Hematol Educ Program. 2009:185-91. doi: 10.1182/asheducation-2009.1.185. Review. PubMed PMID: 20008198.


  1. Brinc D, Denomme GA, Lazarus AH. Mechanisms of anti-D action in the prevention of hemolytic disease of the fetus and newborn: what can we learn from rodent models? Curr Opin Hematol. 2009 Nov;16(6):488-96. doi:10.1097/MOH.0b013e32833199ed. Review. PubMed PMID: 19730101.


  1. Crow AR, Brinc D, Lazarus AH. New insight into the mechanism of action of IVIg: the role of dendritic cells. J Thromb Haemost. 2009 Jul;7 Suppl 1:245-8. doi: 10.1111/j.1538-7836.2009.03420.x. Review. PubMed PMID: 19630809.


  1. Brinc D, Le-Tien H, Crow AR, Siragam V, Freedman J, Lazarus AH. Transfusion of IgG-opsonized foreign red blood cells mediates reduction of antigen-specific B cell priming in a murine model. J Immunol. 2008 Jul 15;181(2):948-53. PubMed PMID: 18606646.


  1. Crow AR, Lazarus AH. The mechanisms of action of intravenous immunoglobulin and polyclonal anti-d immunoglobulin in the amelioration of immune thrombocytopenic purpura: what do we really know? Transfus Med Rev. 2008 Apr;22(2):103-16. doi: 10.1016/j.tmrv.2007.12.001. Review. PubMed PMID: 18353251.


  1. Brinc D, Le-Tien H, Crow AR, Siragam V, Freedman J, Lazarus AH. Immunoglobulin G-mediated regulation of the murine immune response to transfused red blood cells occurs in the absence of active immune suppression: implications for the mechanism of action of anti-D in the prevention of haemolytic disease of the fetus and newborn? Immunology. 2008 May;124(1):141-6. doi: 10.1111/j.1365-2567.2008.02807.x. Epub 2008 Feb 7. PubMed PMID: 18266717; PubMed Central PMCID: PMC2434390.