Our Publications

Selected Publications

  1. Li J, van der Wal DE, Zhu G, Xu M, Yougbare I, Ma L, Vadasz B, Carrim N, Grozovsky R, Ruan M, Zhu L, Zeng Q, Tao L, Zhai ZM, Peng J, Hou M, Leytin V, Freedman J, Hoffmeister KM, Ni H. (2015). Desialylation is a mechanism of Fc-independent platelet clearance and a therapeutic target in immune thrombocytopenia. Nature Communications. 6: 7737. PMID:26185093.
  1. Yougbaré I, Lang S, Yang H, Chen P, Zhao X, Tai WS, Zdravic D, Vadasz B, Li C, Piran S, Marshall A, Zhu G, Tiller H, Killie MK, Boyd S, Leong-Poi H, Wen XY, Skogen B, Adamson SL, Freedman J, Ni H. (2015). Maternal anti-platelet β3 integrins impair angiogenesis and cause intracranial hemorrhage. The Journal of Clinical Investigation. 125(4): 1545-56. Video. PMID:  PMC4396473.
  1. Ma L, Simpson E, Li J, Xuan M, Xu M, Baker L, Shi Y, Yougbaré I, Wang X, Zhu G, Chen P, Prud’homme GJ, Lazarus AH, Freedman J, Ni H. (2015). CD8+ T cells are predominantly protective and required for effective steroid therapy in murine models of immune thrombocytopenia. Blood. 126(2): 247-56. PMID:26036802.
  1. Wang Y, Ni H. (2015). Fibronectin: extra domain brings extra risk?. Blood. 125(20): 3043-4. PMID: 25977580.
  1. Wang Y , Reheman A , Spring CM , Kalantari J , Marshall AH , Wolberg AS , Gross PL , Weitz JI , Rand ML , Mosher DF , Freedman J , Ni H. (2014). Plasma fibronectin supports hemostasis and regulates thrombosis. The Journal of clinical investigation. 124(10): 4281-93. Video. PMID: 25180602.
  1. Lei X, Reheman A, Hou Y, Zhou H, Wang Y, Marshall AH, Liang C, Dai X, Li BX, Vanhoorelbeke K, Ni H. (2014). Anfibatide, a novel GPIb complex antagonist, inhibits platelet adhesion and thrombus formation in vitro and in vivo in murine models of thrombosis. Thrombosis and haemostasis. 111(2): 279-89. PMID: 24172860.
  1. Li J, Callum JL, Lin Y, Zhou Y, Zhu G, Ni H. (2014). Severe platelet desialylation in a patient with glycoprotein Ib/IX antibody-mediated immune thrombocytopenia and fatal pulmonary hemorrhage. Haematologica. 99(4): e61-3. PMID: 24532041.
  1. Reheman A, Xu X, Reddy EC, Ni H. (2014). Targeting activated platelets and fibrinolysis: hitting two birds with one stone. Circulation Research. 114(7): 1070-3. PMID: 24677231.
  1. Li C, Chen P, Vadasz B, Ma L, Zhou H, Lang S, Freedman J, Ni H. (2013). Co-stimulation with LPS or Poly I:C markedly enhances the anti-platelet immune response and severity of fetal and neonatal alloimmune thrombocytopenia. Thrombosis and Haemostasis. 110(6): 1250-8. PMID: 24067944.
  1. Murphy AJ, Bijl N, Yvan-Charvet L, Welch CB, Bhagwat N, Reheman A, Wang Y, Shaw JA, Levine RL, Ni H, Tall AR, Wang N. (2013). Cholesterol efflux in megakaryocyte progenitors suppresses platelet production and thrombocytosis. Nature Medicine. 19(5): 586-94. PMID: 23584088.
  1. Yang Y, Shi Z, Reheman A, Jin JW, Li C, Wang Y, Andrews MC, Chen P, Zhu G, Ling W, Ni H. (2012). Plant Food Delphinidin-3-Glucoside Significantly Inhibits Platelet Activation and Thrombosis: Novel Protective Roles against Cardiovascular Diseases. PLOS ONE. 7(5): PMID: 22624015.
  1. Ni H. (2012). The platelet “sugar high” in diabetes. Blood. 119(25): 5949-51. PMID: 22730524.
  1. Li C, Piran S, Chen P, Lang S, Zarpellon A, Jin JW, Zhu G, Reheman A, van der Wal DE, Simpson EK, Ni R, Gross PL, Ware J, Ruggeri ZM, Freedman J, Ni H. (2011). The maternal immune response to fetal platelet GPIbα causes frequent miscarriage in mice that can be prevented by intravenous IgG and anti-FcRn therapies. The Journal of clinical investigation. 121(11): 4537-47. PMID: 22019589.
  1. Chen J, Reheman A, Gushiken FC, Nolasco L, Fu X, Moake JL, Ni H, López JA. (2011). Nacetylcysteine reduces the size and activity of von Willebrand factor in human plasma and mice. The Journal of Clinical Investigation. 121(2): 593-603. PMID: 21266777.
  1. Reheman A, Yang H, Zhu G, Jin W, He F, Spring CM, Bai X, Gross PL, Freedman J, Ni H. (2009). Plasma fibronectin depletion enhances platelet aggregation and thrombus formation in mice lacking fibrinogen and von Willebrand factor. Blood. 113(8): 1809-17. PMID: 19036705.
  1. Yang H, Lang S, Zhai Z, Li L, Kahr WH, Chen P, Brkíc J, Spring CM, Flick MJ, Degen JL, Freedman J, Ni H. (2009). Fibrinogen is required for maintenance of platelet intracellular and cell-surface P-selectin expression. Blood. 114(2): 425-36. PMID: 19332769.
  1. Zhai Z, Wu J, Xu X, Ding K, Ni R, Hu W, Sun Z, Ni H. (2007). Fibrinogen controls human platelet fibronectin internalization and cell-surface retention. Journal of thrombosis and haemostasis. 5(8): 1740-6. PMCID: PMC2877496.
  1. Yang H, Reheman A, Chen P, Zhu G, Hynes RO, Freedman J, Wagner DD, Ni H. (2006). Fibrinogen and von Willebrand factor-independent platelet aggregation in vitro and in vivo. Journal of thrombosis and haemostasis. 4(10): 2230-7. PMID: 16824188.
  1. Ni H, Chen P, Spring CM, Sayeh E, Semple JW, Lazarus AH, Hynes RO, Freedman J. (2006). A novel murine model of fetal and neonatal alloimmune thrombocytopenia: response to intravenous IgG therapy. Blood. 107(7): 2976-83. PMID: 16317099.
  1. Webster ML, Sayeh E, Crow M, Chen P, Nieswandt B, Freedman J, Ni H. (2006). Relative efficacy of intravenous immunoglobulin G in ameliorating thrombocytopenia induced by antiplatelet GPIIbIIIa versus GPIbalpha antibodies. Blood. 108(3): 943-6. PMID: 16861348.
  1. Xu X, Wu J, Zhai Z, Zhou R, Wang X, Wang H, Ding K, Sun Z, Ni H. (2006). A novel fibrinogen Bbeta chain frameshift mutation in a patient with severe congenital hypofibrinogenaemia. Thrombosis and haemostasis. 95(6): 931-5. PMID: 16732370.
  1. Reheman A, Gross P, Yang H, Chen P, Allen D, Leytin V, Freedman J, Ni H. (2005). Vitronectin stabilizes thrombi and vessel occlusion but plays a dual role in platelet aggregation. Journal of thrombosis and haemostasis. 3(5): 875-83. PMID: 15733060.